{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T17:20:09Z","timestamp":1778779209335,"version":"3.51.4"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2005,11,3]],"date-time":"2005-11-03T00:00:00Z","timestamp":1130976000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biol Inorg Chem"],"published-print":{"date-parts":[[2005,12]]},"DOI":"10.1007\/s00775-005-0045-x","type":"journal-article","created":{"date-parts":[[2005,11,2]],"date-time":"2005-11-02T13:15:33Z","timestamp":1130937333000},"page":"924-934","source":"Crossref","is-referenced-by-count":39,"title":["Synthesis, structure and biological activity of a new and efficient Cd(II)\u2013uracil derivative complex system for cleavage of DNA"],"prefix":"10.1007","volume":"10","author":[{"given":"Nuria A.","family":"Ill\u00e1n-Cabeza","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosario A.","family":"Vilaplana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ysmael","family":"Alvarez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khalid","family":"Akdi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanae","family":"Kamah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Hueso-Ure\u00f1a","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Quir\u00f3s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Gonz\u00e1lez-V\u00edlchez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel N.","family":"Moreno-Carretero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2005,11,3]]},"reference":[{"key":"45_CR1","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1021\/cr980421n","volume":"99","author":"ER Jamieson","year":"1999","unstructured":"Jamieson ER, Lippard SJ (1999) Chem Rev 99:2467\u20132498","journal-title":"Chem Rev"},{"key":"45_CR2","doi-asserted-by":"crossref","unstructured":"Farrell N (2000) In: Kelland LR, Farrell N (eds) Platinum-based drugs in cancer chemotherapy. Humana Press, Totowa, pp 321\u2013338","DOI":"10.1385\/1-59259-012-8:321"},{"key":"45_CR3","doi-asserted-by":"crossref","unstructured":"Gonz\u00e1lez-V\u00edlchez F, Vilaplana R (2005) In: Gielen M, Tiekink ERT (eds) Metallotherapeutic drugs and metal-based diagnostic agents. Wiley, Chichester, pp 219\u2013236","DOI":"10.1002\/0470864052.ch12"},{"key":"45_CR4","unstructured":"Gonz\u00e1lez-V\u00edlchez F, Vilaplana R (2005) In: P\u00e9rez-Mart\u00edn JM (ed) Metal compounds in cancer chemotherapy. Research Signpost, Kerala, pp 149\u2013180"},{"key":"45_CR5","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1021\/cr980420v","volume":"99","author":"E Wong","year":"1999","unstructured":"Wong E, Giandomenico CM (1999) Chem Rev 99:2451\u20132466","journal-title":"Chem Rev"},{"key":"45_CR6","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1021\/ic048356p","volume":"44","author":"A Harris","year":"2005","unstructured":"Harris A, Qu Y, Farrell N (2005) Inorg Chem 44:1196\u20131198","journal-title":"Inorg Chem"},{"key":"45_CR7","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1021\/jm970358e","volume":"41","author":"JAR Navarro","year":"1998","unstructured":"Navarro JAR, Salas JM, Romero MA, Vilaplana R, Gonz\u00e1lez-V\u00edlchez F, Faure R (1998) J Med Chem 41:332\u2013338","journal-title":"J Med Chem"},{"key":"45_CR8","unstructured":"Eastman A (1999) In: Lippert B (ed) 30\u00a0years of cisplatin: chemistry and biochemistry of a leading anticancer drug. Verlag, Helv Chim Acta, Z\u00fcrich, pp 111\u2013134"},{"key":"45_CR9","doi-asserted-by":"crossref","first-page":"7265","DOI":"10.1038\/sj.onc.1206933","volume":"22","author":"ZH Siddik","year":"2003","unstructured":"Siddik ZH (2003) Oncogene 22:7265\u20137279","journal-title":"Oncogene"},{"key":"45_CR10","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1007\/s00775-004-0572-x","volume":"9","author":"FP Intini","year":"2004","unstructured":"Intini FP, Boccarelli A, Francia VC, Pacifico C, Sivo MF, Natile G, Giordano D, De Rinaldis P, Coluccia M (2004) J Biol Inorg Chem 9:768\u2013780","journal-title":"J Biol Inorg Chem"},{"key":"45_CR11","doi-asserted-by":"crossref","first-page":"47516","DOI":"10.1074\/jbc.M304720200","volume":"278","author":"J Kasparkova","year":"2003","unstructured":"Kasparkova J, Novakova J, Marini V, Najajreh Y, Gibson D, P\u00e9rez JM, Brabec V (2003) J Biol Chem 278:47516\u201347525","journal-title":"J Biol Chem"},{"key":"45_CR12","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1021\/ar0302078","volume":"38","author":"HT Chifotides","year":"2005","unstructured":"Chifotides HT, Dunbar KR (2005) Acc Chem Res 38:146\u2013156","journal-title":"Acc Chem Res"},{"key":"45_CR13","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0162-0134(03)00281-2","volume":"97","author":"SR Grguric-Sipka","year":"2003","unstructured":"Grguric-Sipka SR, Vilaplana RA, P\u00e9rez JM, Fuertes MA, Alonso C, Alvarez Y, Sabo TJ, Gonz\u00e1lez-V\u00edlchez F (2003) J Inorg Biochem 97:215\u2013220","journal-title":"J Inorg Biochem"},{"key":"45_CR14","doi-asserted-by":"crossref","first-page":"2511","DOI":"10.1021\/cr9804238","volume":"99","author":"MJ Clarke","year":"1999","unstructured":"Clarke MJ, Zhu F, Frasca DR (1999) Chem Rev 99:2511\u20132533","journal-title":"Chem Rev"},{"key":"45_CR15","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1155\/MBD.1995.211","volume":"2","author":"RA Vilaplana","year":"1995","unstructured":"Vilaplana RA, Romero MA, Quir\u00f3s M, Salas JM, Gonz\u00e1lez-V\u00edlchez F (1995) Metal Based Drugs 2:211\u2013219","journal-title":"Metal Based Drugs"},{"key":"45_CR16","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0162-0134(98)10031-4","volume":"71","author":"F Gonz\u00e1lez-V\u00edlchez","year":"1998","unstructured":"Gonz\u00e1lez-V\u00edlchez F, Vilaplana R, Blasco G, Messori L (1998) J Inorg Biochem 71:45\u201351","journal-title":"J Inorg Biochem"},{"key":"45_CR17","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1006\/abbi.1999.1654","volume":"376","author":"E Gallori","year":"2000","unstructured":"Gallori E, Vettori C, Alessio E, Gonz\u00e1lez-V\u00edlchez F, Vilaplana R, Orioli P, Casini A, Messori L (2000) Arch Biochem Biophys 376:156\u2013162","journal-title":"Arch Biochem Biophys"},{"key":"45_CR18","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1042\/bj3280559","volume":"328","author":"M Carballo","year":"1997","unstructured":"Carballo M, Vilaplana R, M\u00e1rquez G, Conde M, Bedoya FJ, Gonz\u00e1lez-V\u00edlchez F, Sobrino F (1997) Biochem J 328:559\u2013564","journal-title":"Biochem J"},{"key":"45_CR19","doi-asserted-by":"crossref","first-page":"3711","DOI":"10.1021\/bi00837a033","volume":"8","author":"AT Tan","year":"1969","unstructured":"Tan AT, Woodworth RC (1969) Biochemistry 8:3711\u20133716","journal-title":"Biochemistry"},{"key":"45_CR20","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1152\/ajplegacy.1974.227.5.1033","volume":"227","author":"DL Hamilton","year":"1974","unstructured":"Hamilton DL, Valberg LS (1974) Am J Physiol 227:1033\u20131037","journal-title":"Am J Physiol"},{"key":"45_CR21","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0162-0134(02)00412-9","volume":"90","author":"Z Hossain","year":"2002","unstructured":"Hossain Z, Huq F (2002) J Inorg Biochem 90:85\u2013105","journal-title":"J Inorg Biochem"},{"key":"45_CR22","doi-asserted-by":"crossref","first-page":"24792","DOI":"10.1016\/S0021-9258(17)31461-8","volume":"269","author":"DC Lemkuil","year":"1994","unstructured":"Lemkuil DC, Nettesheim D, Shaw CF III, Petering DH (1994) J Biol Chem 269:24792\u201324797","journal-title":"J Biol Chem"},{"key":"45_CR23","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/1439-7633(20010202)2:2<119::AID-CBIC119>3.0.CO;2-5","volume":"2","author":"JM P\u00e9rez","year":"2001","unstructured":"P\u00e9rez JM, Cerrillo V, Matesanz AI, Mill\u00e1n JM, Navarro P, Alonso C, Souza P (2001) ChemBiochem 2:119\u2013123","journal-title":"ChemBiochem"},{"key":"45_CR24","first-page":"373","volume":"18","author":"ZS Yang","year":"2002","unstructured":"Yang ZS, Yu JS, Chen HY (2002) Chin J Inorg Chem 18:373\u2013377","journal-title":"Chin J Inorg Chem"},{"key":"45_CR25","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1007\/s00775-004-0545-0","volume":"9","author":"O Iranzo","year":"2004","unstructured":"Iranzo O, Khalili H, Epstein DM, Morrow JR (2004) J Biol Inorg Chem 9:462\u2013470","journal-title":"J Biol Inorg Chem"},{"key":"45_CR26","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1007\/s00775-004-0591-7","volume":"9","author":"RB G\u00f3mez-Coca","year":"2004","unstructured":"G\u00f3mez-Coca RB, Kapinos LE, Hol\u00fd A, Vilaplana RA, Gonz\u00e1lez-V\u00edlchez F, Sigel H (2004) J Biol Inorg Chem 9:961\u2013972","journal-title":"J Biol Inorg Chem"},{"key":"45_CR27","unstructured":"Sheldrick GM (1997) SHELXS-97 program for crystal structure solution, University of G\u00f6ttingen"},{"key":"45_CR28","unstructured":"Sheldrick GM (1997) SHELXL-97 program for crystal structure refinement, University of G\u00f6ttingen"},{"key":"45_CR29","unstructured":"Spek AL (1999) PLATON-99 a multipurpose crystallographic tool, University of Utrecht"},{"key":"45_CR30","volume-title":"Molecular cloning: a laboratory manual","author":"J Sambrook","year":"1989","unstructured":"Sambrook J, Fritsche EF, Maniatis T (1989) Molecular cloning: a laboratory manual, 2nd edn. Cold Spring Harbor, New York","edition":"2"},{"key":"45_CR31","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1023\/A:1006914203028","volume":"23","author":"M Maji","year":"1998","unstructured":"Maji M, Ghosh S, Chattopadhyay SK (1998) Transit Metal Chem 23:81\u201385","journal-title":"Transit Metal Chem"},{"key":"45_CR32","doi-asserted-by":"crossref","first-page":"3934","DOI":"10.1021\/bi00312a022","volume":"23","author":"RP Hertzberg","year":"1984","unstructured":"Hertzberg RP, Derwan PB (1984) Biochemistry 23:3934\u20133945","journal-title":"Biochemistry"},{"key":"45_CR33","unstructured":"Boyd MR, Paull KD, Rubinstein LR (1990) In: Valeriote FA, Corbett TH, Baker LH (eds) Cytotoxic anticancer drugs: models and concepts for drug discovery and development in vitro antitumor drug screen. Kluwer, New York, pp 11\u201334"},{"key":"45_CR34","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S1387-7003(99)00081-7","volume":"2","author":"F Hueso-Ure\u00f1a","year":"1999","unstructured":"Hueso-Ure\u00f1a F, Ill\u00e1n-Cabeza NA, Moreno-Carretero MN, Pe\u00f1as-Chamorro AL, Faure R (1999) Inorg Chem Commun 2:323\u2013326","journal-title":"Inorg Chem Commun"},{"key":"45_CR35","first-page":"155","volume":"215","author":"F Hueso-Ure\u00f1a","year":"2000","unstructured":"Hueso-Ure\u00f1a F, Moreno-Carretero MN, Pe\u00f1as-Chamorro AL, Debaerdemaeker T, Esteve V, Amig\u00f3 JM (2000) Z Kristallogr NCS 215:155\u2013156","journal-title":"Z Kristallogr NCS"},{"key":"45_CR36","first-page":"153","volume-title":"Infrared and raman spectra of inorganic and coordination compounds","author":"K. Nakamoto","year":"1997","unstructured":"Nakamoto K. (1997) Infrared and raman spectra of inorganic and coordination compounds, 5th edn. Wiley, New York, pp 153\u2013321","edition":"5"},{"key":"45_CR37","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1007\/978-1-4684-1809-5","volume-title":"Low-frequency vibrations of inorganic and coordination compounds","author":"JF Ferraro","year":"1971","unstructured":"Ferraro JF (1971) Low-frequency vibrations of inorganic and coordination compounds. Plenum, New York, pp 204\u2013220"},{"key":"45_CR38","first-page":"205","volume-title":"Inorganic electronic spectroscopy","author":"ABP Lever","year":"1984","unstructured":"Lever ABP (1984) Inorganic electronic spectroscopy, 2nd edn. Elsevier, New York, pp 205\u2013207","edition":"2"},{"key":"45_CR39","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1021\/ja00522a086","volume":"102","author":"LG Marzilli","year":"1980","unstructured":"Marzilli LG, Chalilpoyil PJ (1980) J Am Chem Soc 102:872\u2013875","journal-title":"J Am Chem Soc"},{"key":"45_CR40","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1155\/MBD.2000.225","volume":"7","author":"T Pieper","year":"2000","unstructured":"Pieper T, Peti W, Keppler BK (2000) Metal Based Drugs 7:225\u2013232","journal-title":"Metal Based Drugs"},{"key":"45_CR41","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1021\/jm970520d","volume":"41","author":"AG Quiroga","year":"1998","unstructured":"Quiroga AG, P\u00e9rez JM, L\u00f3pez-Solera I, Masaguer JR, Luque A, Rom\u00e1n P, Edwards A, Alonso C, Navarro-Ranninger C (1998) J Med Chem 41:1399\u20131408","journal-title":"J Med Chem"},{"key":"45_CR42","doi-asserted-by":"crossref","first-page":"7535","DOI":"10.1021\/jp001711m","volume":"104","author":"J Sponer","year":"2000","unstructured":"Sponer J, Sabat M, Gorb L, Leszczynski J, Lippert B, Hobza P (2000) J Phys Chem B 104:7535\u20137544","journal-title":"J Phys Chem B"},{"key":"45_CR43","first-page":"269","volume":"102","author":"RD Lohmann","year":"1994","unstructured":"Lohmann RD, Beyersmann D (1994) Environ Health Perspect 102:269\u2013271","journal-title":"Environ Health Perspect"},{"key":"45_CR44","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1016\/j.jinorgbio.2005.04.014","volume":"99","author":"P Amo-Ochoa","year":"2005","unstructured":"Amo-Ochoa P, Rodr\u00edguez-Tapiador MI, Alexandre SS, Pastor C, Zamora F (2005) J Inorg Biochem 99:1540\u20131547","journal-title":"J Inorg Biochem"},{"key":"45_CR45","doi-asserted-by":"crossref","first-page":"2466","DOI":"10.1021\/ja00320a058","volume":"106","author":"JK Barton","year":"1984","unstructured":"Barton JK, Raphael AI (1984) J Am Chem Soc 106:2466\u20132468","journal-title":"J Am Chem Soc"},{"key":"45_CR46","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.1021\/ic00037a008","volume":"31","author":"N Grover","year":"1992","unstructured":"Grover N, Gupta N, Singh P, Thorp H (1992) Inorg Chem 31:2014\u20132020","journal-title":"Inorg Chem"},{"key":"45_CR47","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1021\/cr960437i","volume":"98","author":"WK Pogozelski","year":"1998","unstructured":"Pogozelski WK, Tullius TD (1998) Chem Rev 98:1089\u20131107","journal-title":"Chem Rev"},{"key":"45_CR48","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1021\/cr00014a008","volume":"92","author":"B Munier","year":"1992","unstructured":"Munier B (1992) Chem Rev 92:1411\u20131456","journal-title":"Chem Rev"},{"key":"45_CR49","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1002\/jpp.557","volume":"5","author":"E Nyarko","year":"2001","unstructured":"Nyarko E, Tabata M (2001) J Porphrines Phthalocyanines 5:873\u2013880","journal-title":"J Porphirines Phthalocyanines"},{"key":"45_CR50","unstructured":"Sauvant MP, P\u00e9pin D, Gardes A (1992) In: Anastassopoulou J, Collery Ph, Etienne JC, Theophanides Th (eds) Metal ions in biology and medicine. John Libbey, Montrouge, pp 287\u2013289"},{"key":"45_CR51","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1006\/enrs.2002.4354","volume":"89","author":"Y Takano","year":"2002","unstructured":"Takano Y, Taguchi T, Suzuki I, Balis JU, Yuri K (2002) Environm Res 89:138\u2013145","journal-title":"Environm Res"}],"container-title":["JBIC Journal of Biological Inorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00775-005-0045-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00775-005-0045-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00775-005-0045-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T10:52:57Z","timestamp":1706698377000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00775-005-0045-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,11,3]]},"references-count":51,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2005,12]]}},"alternative-id":["45"],"URL":"https:\/\/doi.org\/10.1007\/s00775-005-0045-x","relation":{},"ISSN":["0949-8257","1432-1327"],"issn-type":[{"value":"0949-8257","type":"print"},{"value":"1432-1327","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,11,3]]}}}