{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T12:54:31Z","timestamp":1765976071518,"version":"3.41.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2015,5,16]],"date-time":"2015-05-16T00:00:00Z","timestamp":1431734400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Biol Inorg Chem"],"published-print":{"date-parts":[[2015,7]]},"DOI":"10.1007\/s00775-015-1269-z","type":"journal-article","created":{"date-parts":[[2015,5,15]],"date-time":"2015-05-15T05:45:29Z","timestamp":1431668729000},"page":"831-840","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The antimetastatic drug NAMI-A potentiates the phenylephrine-induced contraction of aortic smooth muscle cells and induces a transient increase in systolic blood pressure"],"prefix":"10.1007","volume":"20","author":[{"given":"M.","family":"Vadori","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Florio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Groppo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Cocchietto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Pacor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Zorzet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Candussio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Sava","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,5,16]]},"reference":[{"key":"1269_CR1","doi-asserted-by":"crossref","first-page":"949","DOI":"10.2174\/187152012802650039","volume":"12","author":"A Bergamo","year":"2012","unstructured":"Bergamo A, Delfino R, Casarsa C, Sava G (2012) Anticancer Agents Med Chem 12:949\u2013958","journal-title":"Anticancer Agents Med Chem"},{"key":"1269_CR2","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.drup.2006.05.002","volume":"9","author":"V Brabec","year":"2006","unstructured":"Brabec V, Novakova O (2006) Drug Resist Updat 9:111\u2013122","journal-title":"Drug Resist Updat"},{"key":"1269_CR3","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1039\/b904071d","volume":"1","author":"A Levina","year":"2009","unstructured":"Levina A, Mitra A, Lay PA (2009) Metallomics 1:458\u2013470","journal-title":"Metallomics"},{"key":"1269_CR4","first-page":"969","volume":"19","author":"G Sava","year":"1999","unstructured":"Sava G, Gagliardi R, Bergamo A, Alessio E, Mestroni G (1999) Anticancer Res 19:969\u2013972","journal-title":"Anticancer Res"},{"key":"1269_CR5","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.2174\/092986706776360941","volume":"13","author":"I Kostova","year":"2006","unstructured":"Kostova I (2006) Curr Med Chem 13:1085\u20131107","journal-title":"Curr Med Chem"},{"key":"1269_CR6","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/j.mehy.2013.03.029","volume":"80","author":"RK Koiri","year":"2013","unstructured":"Koiri RK, Mehrotra A, Trigun SK (2013) Med Hypotheses 80:841\u2013846","journal-title":"Med Hypotheses"},{"key":"1269_CR7","doi-asserted-by":"crossref","first-page":"7817","DOI":"10.1039\/c0dt01816c","volume":"40","author":"A Bergamo","year":"2011","unstructured":"Bergamo A, Sava G (2011) Dalton Trans 40:7817\u20137823","journal-title":"Dalton Trans"},{"key":"1269_CR8","doi-asserted-by":"crossref","first-page":"8226","DOI":"10.1039\/c2dt30075c","volume":"41","author":"G Sava","year":"2012","unstructured":"Sava G, Jaouen G, Hillard EA, Bergamo A (2012) Dalton Trans 41:8226\u20138234","journal-title":"Dalton Trans"},{"key":"1269_CR9","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s10637-014-0179-1","volume":"33","author":"S Leijen","year":"2015","unstructured":"Leijen S, Burgers SA, Baas P, Pluim D, Tibben M, van Werkhoven E, Alessio E, Sava G, Beijnen JH, Schellens JH (2015) Invest New Drugs 33:201\u2013214","journal-title":"Invest New Drugs"},{"key":"1269_CR10","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1023\/A:1006521715400","volume":"16","author":"G Sava","year":"1998","unstructured":"Sava G, Capozzi I, Clerici K, Gagliardi G, Alessio E, Mestroni G (1998) Clin Exp Metastasis 16:371\u2013379","journal-title":"Clin Exp Metastasis"},{"key":"1269_CR11","first-page":"1898","volume":"9","author":"G Sava","year":"2003","unstructured":"Sava G, Zorzet S, Turrin C, Vita F, Soranzo M, Zabucchi G, Cocchietto M, Bergamo A, DiGiovine S, Pezzoni G, Sartor L, Garbisa S (2003) Clin Cancer Res 9:1898\u20131905","journal-title":"Clin Cancer Res"},{"key":"1269_CR12","doi-asserted-by":"crossref","first-page":"3717","DOI":"10.1158\/1078-0432.CCR-03-0746","volume":"10","author":"JM Rademaker-Lakhai","year":"2004","unstructured":"Rademaker-Lakhai JM, van den Bongard D, Pluim D, Beijnen JH, Schellens JH (2004) Clin Cancer Res 10:3717\u20133727","journal-title":"Clin Cancer Res"},{"key":"1269_CR13","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/S0022-3565(24)38169-8","volume":"289","author":"A Bergamo","year":"1999","unstructured":"Bergamo A, Gagliardi R, Scarcia V, Furlani A, Alessio E, Mestroni G, Sava G (1999) J Pharmacol Exp Ther 289:559\u2013564","journal-title":"J Pharmacol Exp Ther"},{"key":"1269_CR14","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jinorgbio.2012.09.018","volume":"118","author":"M Vadori","year":"2013","unstructured":"Vadori M, Pacor S, Vita F, Zorzet S, Cocchietto M, Sava G (2013) J Inorg Biochem 118:21\u201327","journal-title":"J Inorg Biochem"},{"key":"1269_CR15","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s10637-014-0175-5","volume":"33","author":"A Bergamo","year":"2015","unstructured":"Bergamo A, Riedel T, Dyson PJ, Sava G (2015) Invest New Drugs 33:53\u201363","journal-title":"Invest New Drugs"},{"key":"1269_CR16","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1155\/MBD.1995.195","volume":"2","author":"M Coluccia","year":"1995","unstructured":"Coluccia M, Sava G, Salerno G, Bergamo A, Pacor S, Mestroni G, Alessio E (1995) Met Based Drugs 2:195\u2013199","journal-title":"Met Based Drugs"},{"key":"1269_CR17","first-page":"261","volume":"29","author":"I Khalaila","year":"2006","unstructured":"Khalaila I, Bergamo A, Bussy F, Sava G, Dyson PJ (2006) Int J Oncol 29:261\u2013268","journal-title":"Int J Oncol"},{"key":"1269_CR18","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1159\/000265166","volume":"115","author":"K Chatterjee","year":"2010","unstructured":"Chatterjee K, Zhang J, Honbo N, Karliner JS (2010) Cardiology 115:155\u2013162","journal-title":"Cardiology"},{"key":"1269_CR19","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1038\/sj.bjc.6605642","volume":"102","author":"P Workman","year":"2010","unstructured":"Workman P, Aboagye EO, Balkwill F, Balmain A, Bruder G, Chaplin DJ, Double JA, Everitt J, Farningham DA, Glennie MJ, Kelland LR, Robinson V, Stratford IJ, Tozer GM, Watson S, Wedge SR, Eccles SA (2010) Br J Cancer 102:1555\u20131577","journal-title":"Br J Cancer"},{"key":"1269_CR20","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/S0022-3565(24)37193-9","volume":"284","author":"FR Stassen","year":"1998","unstructured":"Stassen FR, Maas RG, Schiffers PM, Janssen GM, De Mey JG (1998) J Pharmacol Exp Ther 284:399\u2013405","journal-title":"J Pharmacol Exp Ther"},{"key":"1269_CR21","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0378-5173(02)00459-3","volume":"248","author":"M Bouma","year":"2002","unstructured":"Bouma M, Nuijen B, Sava G, Perbellini A, Flaibani A, van Steenbergen MJ, Talsma H, Ketten-van den Bosch JJ, Bult A, Beijnen JH (2002) Int J Pharm 248:247\u2013259","journal-title":"Int J Pharm"},{"key":"1269_CR22","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0031-6997(24)01321-8","volume":"49","author":"H Karaki","year":"1997","unstructured":"Karaki H, Ozaki H, Hori M, Mitsui-Saito M, Amano K, Harada K, Miyamoto S, Nakazawa H, Won KJ, Sato K (1997) Pharmacol Rev 49:157\u2013230","journal-title":"Pharmacol Rev"},{"key":"1269_CR23","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/BF00550873","volume":"418","author":"A Herrmann-Frank","year":"1991","unstructured":"Herrmann-Frank A, Darling E, Meissner G (1991) Pflugers Arch 418:353\u2013359","journal-title":"Pflugers Arch"},{"key":"1269_CR24","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/0922-4106(94)90056-6","volume":"268","author":"RS Garcha","year":"1994","unstructured":"Garcha RS, Hughes AD (1994) Eur J Pharmacol 268:319\u2013325","journal-title":"Eur J Pharmacol"},{"key":"1269_CR25","doi-asserted-by":"crossref","first-page":"25798","DOI":"10.1016\/S0021-9258(18)35680-1","volume":"267","author":"D Wu","year":"1992","unstructured":"Wu D, Katz A, Lee CH, Simon MI (1992) J Biol Chem 267:25798\u201325802","journal-title":"J Biol Chem"},{"issue":"Pt 1","key":"1269_CR26","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.1469-7793.2000.00057.x","volume":"529","author":"MR Duchen","year":"2000","unstructured":"Duchen MR (2000) J Physiol (Lond) 529(Pt 1):57\u201368","journal-title":"J Physiol (Lond)"},{"key":"1269_CR27","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1016\/S0968-0896(99)00166-2","volume":"7","author":"JF Unitt","year":"1999","unstructured":"Unitt JF, Boden KL, Wallace AV, Ingall AH, Coombs ME, Ince F (1999) Bioorg Med Chem 7:1891\u20131896","journal-title":"Bioorg Med Chem"},{"key":"1269_CR28","doi-asserted-by":"crossref","first-page":"10223","DOI":"10.1074\/jbc.273.17.10223","volume":"273","author":"MA Matlib","year":"1998","unstructured":"Matlib MA, Zhou Z, Knight S, Ahmed S, Choi KM, Krause-Bauer J, Phillips R, Altschuld R, Katsube Y, Sperelakis N, Bers DM (1998) J Biol Chem 273:10223\u201310231","journal-title":"J Biol Chem"},{"key":"1269_CR29","first-page":"23","volume":"3","author":"S Katsuki","year":"1977","unstructured":"Katsuki S, Arnold W, Mittal C, Murad F (1977) J Cyclic Nucleotide Res 3:23\u201335","journal-title":"J Cyclic Nucleotide Res"},{"key":"1269_CR30","doi-asserted-by":"crossref","first-page":"3203","DOI":"10.1073\/pnas.74.8.3203","volume":"74","author":"WP Arnold","year":"1977","unstructured":"Arnold WP, Mittal CK, Katsuki S, Murad F (1977) Proc Natl Acad Sci USA 74:3203\u20133207","journal-title":"Proc Natl Acad Sci USA"},{"key":"1269_CR31","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/0006-291X(77)91460-7","volume":"75","author":"N Miki","year":"1977","unstructured":"Miki N, Kawabe Y, Kuriyama K (1977) Biochem Biophys Res Commun 75:851\u2013856","journal-title":"Biochem Biophys Res Commun"},{"key":"1269_CR32","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1038\/sj.bjc.6600906","volume":"88","author":"L Morbidelli","year":"2003","unstructured":"Morbidelli L, Donnini S, Filippi S, Messori L, Piccioli F, Orioli P, Sava G, Ziche M (2003) Br J Cancer 88:1484\u20131491","journal-title":"Br J Cancer"},{"key":"1269_CR33","doi-asserted-by":"crossref","first-page":"5861","DOI":"10.1046\/j.1432-1033.2002.03307.x","volume":"269","author":"G Pintus","year":"2002","unstructured":"Pintus G, Tadolini B, Posadino AM, Sanna B, Debidda M, Bennardini F, Sava G, Ventura C (2002) Eur J Biochem 269:5861\u20135870","journal-title":"Eur J Biochem"},{"key":"1269_CR34","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0003-9861(02)00218-7","volume":"403","author":"B Sanna","year":"2002","unstructured":"Sanna B, Debidda M, Pintus G, Tadolini B, Posadino AM, Bennardini F, Sava G, Ventura C (2002) Arch Biochem Biophys 403:209\u2013218","journal-title":"Arch Biochem Biophys"},{"key":"1269_CR35","doi-asserted-by":"crossref","first-page":"12150","DOI":"10.1039\/C4DT01356E","volume":"43","author":"S Pillozzi","year":"2014","unstructured":"Pillozzi S, Gasparoli L, Stefanini M, Ristori M, D\u2019Amico M, Alessio E, Scaletti F, Becchetti A, Arcangeli A, Messori L (2014) Dalton Trans 43:12150\u201312155","journal-title":"Dalton Trans"},{"key":"1269_CR36","first-page":"197","volume":"20","author":"M Cocchietto","year":"2000","unstructured":"Cocchietto M, Salerno G, Alessio E, Mestroni G, Sava G (2000) Anticancer Res 20:197\u2013202","journal-title":"Anticancer Res"},{"key":"1269_CR37","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0162-0134(00)00062-3","volume":"78","author":"L Trynda-Lemiesz","year":"2000","unstructured":"Trynda-Lemiesz L, Karaczyn A, Keppler BK, Kozlowski H (2000) J Inorg Biochem 78:341\u2013346","journal-title":"J Inorg Biochem"},{"key":"1269_CR38","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1046\/j.1432-1327.2000.01121.x","volume":"267","author":"L Messori","year":"2000","unstructured":"Messori L, Orioli P, Vullo D, Alessio E, Iengo E (2000) Eur J Biochem 267:1206\u20131213","journal-title":"Eur J Biochem"}],"container-title":["JBIC Journal of Biological Inorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00775-015-1269-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00775-015-1269-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00775-015-1269-z","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T00:12:09Z","timestamp":1748391129000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00775-015-1269-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,16]]},"references-count":38,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["1269"],"URL":"https:\/\/doi.org\/10.1007\/s00775-015-1269-z","relation":{},"ISSN":["0949-8257","1432-1327"],"issn-type":[{"type":"print","value":"0949-8257"},{"type":"electronic","value":"1432-1327"}],"subject":[],"published":{"date-parts":[[2015,5,16]]}}}