{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T16:01:30Z","timestamp":1789142490865,"version":"build-2803163510"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2021,8,28]],"date-time":"2021-08-28T00:00:00Z","timestamp":1630108800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2021,8,28]],"date-time":"2021-08-28T00:00:00Z","timestamp":1630108800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100005881","name":"Emberi Eroforr\u00e1sok Miniszt\u00e9riuma","doi-asserted-by":"publisher","award":["TKP-2020"],"award-info":[{"award-number":["TKP-2020"]}],"id":[{"id":"10.13039\/501100005881","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012825","name":"International Visegrad Fund","doi-asserted-by":"publisher","award":["52010752"],"award-info":[{"award-number":["52010752"]}],"id":[{"id":"10.13039\/100012825","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011019","name":"Nemzeti Kutat\u00e1si Fejleszt\u00e9si \u00e9s Innov\u00e1ci\u00f3s Hivatal","doi-asserted-by":"publisher","award":["FK 124240"],"award-info":[{"award-number":["FK 124240"]}],"id":[{"id":"10.13039\/501100011019","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011019","name":"Nemzeti Kutat\u00e1si Fejleszt\u00e9si \u00e9s Innov\u00e1ci\u00f3s Hivatal","doi-asserted-by":"publisher","award":["GINOP-2.3.2-15-2016-00038"],"award-info":[{"award-number":["GINOP-2.3.2-15-2016-00038"]}],"id":[{"id":"10.13039\/501100011019","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011019","name":"Nemzeti Kutat\u00e1si Fejleszt\u00e9si \u00e9s Innov\u00e1ci\u00f3s Hivatal","doi-asserted-by":"publisher","award":["K124544"],"award-info":[{"award-number":["K124544"]}],"id":[{"id":"10.13039\/501100011019","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Biol Inorg Chem"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1007\/s00775-021-01891-7","type":"journal-article","created":{"date-parts":[[2021,8,28]],"date-time":"2021-08-28T02:02:42Z","timestamp":1630116162000},"page":"775-791","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Estrone\u2013salicylaldehyde N-methylated thiosemicarbazone hybrids and their copper complexes: solution structure, stability and anticancer activity in tumour spheroids"],"prefix":"10.1007","volume":"26","author":[{"given":"Tatsiana V.","family":"Petrasheuskaya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debora","family":"Wernitznig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rton A.","family":"Kiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u00f3ra V.","family":"May","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominik","family":"Wenisch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard K.","family":"Keppler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9va","family":"Frank","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8058-8128","authenticated-orcid":false,"given":"\u00c9va A.","family":"Enyedy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,8,28]]},"reference":[{"key":"1891_CR1","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.4155\/fmc.09.80","volume":"1","author":"DS Kalinowski","year":"2009","unstructured":"Kalinowski DS, Quach P, Richardson DR (2009) Future Med Chem 1:1143\u20131151","journal-title":"Future Med Chem"},{"key":"1891_CR2","doi-asserted-by":"publisher","first-page":"1062","DOI":"10.1089\/ars.2017.7487","volume":"30","author":"P Heffeter","year":"2019","unstructured":"Heffeter P, Pape VFS, Enyedy \u00c9A, Keppler BK, Szak\u00e1cs G, Kowol CR (2019) Antioxid Redox Signal 30:1062\u20131082","journal-title":"Antioxid Redox Signal"},{"key":"1891_CR3","unstructured":"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02466971. Accessed on 18\/05\/2021"},{"key":"1891_CR4","doi-asserted-by":"publisher","first-page":"41363","DOI":"10.18632\/oncotarget.9133","volume":"7","author":"KY Salim","year":"2016","unstructured":"Salim KY, Vareki SM, Danter WR, Koropatnick J (2016) Oncotarget 7:41363","journal-title":"Oncotarget"},{"key":"1891_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13045-016-0330-x","volume":"9","author":"ZL Guo","year":"2016","unstructured":"Guo ZL, Richardson DR, Kalinowski DS, Kovacevic Z, Tan-Un KC, Chan GCF (2016) J Hematol Oncol 9:1\u201316","journal-title":"J Hematol Oncol"},{"key":"1891_CR6","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.ica.2012.02.019","volume":"389","author":"JR Dilworth","year":"2012","unstructured":"Dilworth JR, Hueting R (2012) Inorg Chim Acta 389:3\u201315","journal-title":"Inorg Chim Acta"},{"key":"1891_CR7","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/0010-8545(93)85052-6","volume":"123","author":"DX West","year":"1993","unstructured":"West DX, Liberta AE, Padhye SB, Chikate RC, Sonawane PB, Kumbhar AS, Yerande RG (1993) Coord Chem Rev 123:49\u201371","journal-title":"Coord Chem Rev"},{"key":"1891_CR8","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1158\/1535-7163.MCT-05-0384","volume":"5","author":"J Shao","year":"2006","unstructured":"Shao J, Zhou B, Di Bilio AJ, Zhu L, Wang T, Shih CQJ, Yen Y (2006) Mol Cancer Ther 5:586\u2013592","journal-title":"Mol Cancer Ther"},{"key":"1891_CR9","doi-asserted-by":"publisher","first-page":"874","DOI":"10.1039\/C6MT00105J","volume":"8","author":"KC Park","year":"2016","unstructured":"Park KC, Fouani L, Jansson PJ, Wooi D, Sahni S, Lane DJR, Palanimuthu D, Lok HC, Kova\u010devi\u0107 Z, Huang MLH, Kalinowski DS, Richardson DR (2016) Metallomics 8:874\u2013886","journal-title":"Metallomics"},{"key":"1891_CR10","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.1038\/s41419-018-1102-z","volume":"9","author":"S Hager","year":"2018","unstructured":"Hager S, Korbula K, Bielec B, Grusch M, Pirker C, Schosserer M, Liendl L, Lang M, Grillari J, Nowikovsky K, Pape VFS, Mohr T, Szakacs G, Keppler BK, Berger W, Kowol CR, Heffeter P (2018) Cell Death Dis 9:1052","journal-title":"Cell Death Dis"},{"key":"1891_CR11","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/S0020-1693(98)00383-1","volume":"286","author":"M Belicchi Ferrari","year":"1999","unstructured":"Belicchi Ferrari M, Capacchi S, Pelosi G, Reffo G, Tarasconi P, Albertini R, Pinelli S, Lunghi P (1999) Inorg Chim Acta 286:134\u2013141","journal-title":"Inorg Chim Acta"},{"key":"1891_CR12","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/j.ejmech.2016.05.021","volume":"121","author":"Z Zhang","year":"2016","unstructured":"Zhang Z, Gou Y, Wang J, Yang K, Qi J, Zhou Z, Liang S, Liang H, Yang F (2016) Eur J Med Chem 121:399\u2013409","journal-title":"Eur J Med Chem"},{"key":"1891_CR13","doi-asserted-by":"publisher","first-page":"742592","DOI":"10.1155\/2015\/742592","volume":"2015","author":"Y Huang","year":"2015","unstructured":"Huang Y, Kong E, Gan C, Liu Z, Lin Q, Cui J (2015) Bioinorg Chem Appl 2015:742592","journal-title":"Bioinorg Chem Appl"},{"key":"1891_CR14","doi-asserted-by":"publisher","first-page":"4276919","DOI":"10.1155\/2017\/4276919","volume":"2017","author":"Y Huang","year":"2017","unstructured":"Huang Y, Kong E, Zhan J, Chen S, Gan C, Liu Z, Pang L, Cui J (2017) Bioinorg Chem Appl 2017:4276919","journal-title":"Bioinorg Chem Appl"},{"key":"1891_CR15","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1016\/j.saa.2015.05.095","volume":"150","author":"MP Heng","year":"2015","unstructured":"Heng MP, Sinniah SK, Teoh WY, Sim KS, Ng SW, Cheah YK, Wai Tan K (2015) Spectrochim Acta A Mol Biomol Spectrosc 150:360\u2013372","journal-title":"Spectrochim Acta A Mol Biomol Spectrosc"},{"key":"1891_CR16","doi-asserted-by":"publisher","first-page":"111097","DOI":"10.1016\/j.jinorgbio.2020.111097","volume":"208","author":"MP Heng","year":"2020","unstructured":"Heng MP, Sim KS, Tan KW (2020) J Inorg Biochem 208:111097","journal-title":"J Inorg Biochem"},{"key":"1891_CR17","doi-asserted-by":"publisher","first-page":"12154","DOI":"10.1039\/D0NJ01070G","volume":"44","author":"TV Petrasheuskaya","year":"2020","unstructured":"Petrasheuskaya TV, Kiss MA, D\u00f6m\u00f6t\u00f6r O, Holczbauer T, May NV, Spengler G, Kincses A, \u010cipak Ga\u0161parovi\u0107 A, Frank \u00c9, Enyedy \u00c9A (2020) New J Chem 44:12154\u201312168","journal-title":"New J Chem"},{"key":"1891_CR18","doi-asserted-by":"publisher","first-page":"5032","DOI":"10.1021\/jm900528d","volume":"52","author":"CR Kowol","year":"2009","unstructured":"Kowol CR, Trondl R, Heffeter P, Arion VB, Jakupec MA, Roller A, Galanski M, Berger W, Keppler BK (2009) J Med Chem 52:5032\u20135043","journal-title":"J Med Chem"},{"key":"1891_CR19","doi-asserted-by":"publisher","first-page":"6739","DOI":"10.1021\/acs.jmedchem.6b00342","volume":"59","author":"CR Kowol","year":"2016","unstructured":"Kowol CR, Miklos W, Pfaff S, Hager S, Kallus S, Pelivan K, Kubanik M, Enyedy \u00c9A, Berger W, Heffeter P, Keppler BK (2016) J Med Chem 59:6739\u20136752","journal-title":"J Med Chem"},{"key":"1891_CR20","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1089\/ars.2019.7854","volume":"33","author":"S Hager","year":"2020","unstructured":"Hager S, Pape VFS, P\u00f3sa V, Montsch B, Uhlik L, Szak\u00e1cs G, T\u00f3th S, Jabronka N, Keppler BK, Kowol CR, Enyedy \u00c9A, Heffeter P (2020) Antioxid Redox Signal 33:395\u2013414","journal-title":"Antioxid Redox Signal"},{"key":"1891_CR21","doi-asserted-by":"publisher","first-page":"258","DOI":"10.3891\/acta.chem.scand.53-0258","volume":"53","author":"NU Hofsl\u00f8kken","year":"1999","unstructured":"Hofsl\u00f8kken NU, Skatteb\u00f8l L (1999) Acta Chem Scand 53:258\u2013262","journal-title":"Acta Chem Scand"},{"key":"1891_CR22","doi-asserted-by":"publisher","first-page":"4036","DOI":"10.1002\/ejic.201200360","volume":"2012","author":"\u00c9A Enyedy","year":"2012","unstructured":"Enyedy \u00c9A, Zsig\u00f3 \u00c9, Nagy NV, Kowol CR, Roller A, Keppler BK, Kiss T (2012) Eur J Inorg Chem 2012:4036\u20134047","journal-title":"Eur J Inorg Chem"},{"key":"1891_CR23","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.cbi.2005.10.044","volume":"159","author":"S Majumder","year":"2006","unstructured":"Majumder S, Dutta P, Mookerjee A, Choudhuri SK (2006) Chem Biol Interact 159:90\u2013103","journal-title":"Chem Biol Interact"},{"key":"1891_CR24","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1089\/ars.2010.3663","volume":"15","author":"U Jungwirth","year":"2011","unstructured":"Jungwirth U, Kowol CR, Keppler BK, Hartinger CG, Berger W, Heffeter P (2011) Antioxid Redox Signal 15:1085\u20131127","journal-title":"Antioxid Redox Signal"},{"key":"1891_CR25","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1039\/c9mt00061e","volume":"11","author":"A Santoro","year":"2019","unstructured":"Santoro A, Vileno B, Palacios O, Peris-D\u00edaz MD, Riegel G, Gaiddon C, Kr\u0119\u017cel A, Faller P (2019) Metallomics 11:994\u20131004","journal-title":"Metallomics"},{"key":"1891_CR26","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1002\/biot.201300492","volume":"9","author":"JA Hickman","year":"2014","unstructured":"Hickman JA, Graeser R, de Hoogt R, Vidic S, Brito C, Gutekunst M, van der Kuip H (2014) IMI PREDECT consortium. J Biotechnol 9:1115\u20131128","journal-title":"J Biotechnol"},{"key":"1891_CR27","doi-asserted-by":"publisher","first-page":"2909","DOI":"10.1039\/D0QI00502A","volume":"7","author":"AB Becceneri","year":"2020","unstructured":"Becceneri AB, Fuzer AM, Plutin AM, Batista AA, Leli\u00e8vre SA, Cominetti MR (2020) Inorg Chem Front 7:2909\u20132919","journal-title":"Inorg Chem Front"},{"key":"1891_CR28","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1177\/1087057114532352","volume":"19","author":"A Walzl","year":"2014","unstructured":"Walzl A, Unger C, Kramer N, Unterleuthner D, Scherzer M, Hengstchl\u00e4ger M, Schwanzer-Pfeiffer D, Dolznig H (2014) J Biomol Screen 19:1047\u20131059","journal-title":"J Biomol Screen"},{"key":"1891_CR29","first-page":"5381692","volume":"2019","author":"SJ Kim","year":"2019","unstructured":"Kim SJ, Kim HS, Seo YR (2019) Oxid Med Cell Longev 2019:5381692","journal-title":"Oxid Med Cell Longev"},{"key":"1891_CR30","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.1039\/C5MT00149H","volume":"7","author":"D Denoyer","year":"2015","unstructured":"Denoyer D, Masaldan S, La Fontaine S, Cater MA (2015) Metallomics 7:1459\u20131476","journal-title":"Metallomics"},{"key":"1891_CR31","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1080\/01926230701320337","volume":"35","author":"S Elmore","year":"2007","unstructured":"Elmore S (2007) Toxicol Pathol 35:495\u2013516","journal-title":"Toxicol Pathol"},{"key":"1891_CR32","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1016\/S0008-6363(99)00384-3","volume":"45","author":"A Saraste","year":"2000","unstructured":"Saraste A, Pulkki K (2000) Cardiovasc Res 45:528\u2013537","journal-title":"Cardiovasc Res"},{"key":"1891_CR33","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.1039\/c9mt00051h","volume":"11","author":"D Wernitznig","year":"2019","unstructured":"Wernitznig D, Kiakos K, Del Favero G, Harrer N, Machat H, Osswald A, Jakupec MA, Wernitznig A, Sommergruber W, Keppler BK (2019) Metallomics 11:1044\u20131048","journal-title":"Metallomics"},{"key":"1891_CR34","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1039\/c3mt00225j","volume":"6","author":"CP Tan","year":"2014","unstructured":"Tan CP, Lu YY, Ji LN, Mao ZW (2014) Metallomics 6:978\u2013995","journal-title":"Metallomics"},{"key":"1891_CR35","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/B978-0-12-385493-3.00004-8","volume":"103","author":"D Wlodkowic","year":"2011","unstructured":"Wlodkowic D, Telford W, Skommer J, Darzynkiewicz Z (2011) Method Cell Biol 103:55\u201398","journal-title":"Method Cell Biol"},{"key":"1891_CR36","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1007\/s10495-010-0503-y","volume":"15","author":"K Schutters","year":"2010","unstructured":"Schutters K, Reutelingsperger C (2010) Apoptosis 15:1072\u20131082","journal-title":"Apoptosis"},{"key":"1891_CR37","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1007\/s10741-007-9068-4","volume":"13","author":"EC Korngold","year":"2008","unstructured":"Korngold EC, Jaffer FA, Weissleder R, Sosnovik DE (2008) Heart Fail Rev 13:163\u2013173","journal-title":"Heart Fail Rev"},{"key":"1891_CR38","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1038\/cdd.2016.7","volume":"6","author":"S Nagata","year":"2016","unstructured":"Nagata S, Suzuki J, Segawa K, Fujii T (2016) Cell Death Diff 6:952\u2013961","journal-title":"Cell Death Diff"},{"key":"1891_CR39","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1007\/s00412-018-0659-8","volume":"127","author":"X Sun","year":"2018","unstructured":"Sun X, Kaufman PD (2018) Chromosoma 127:175\u2013186","journal-title":"Chromosoma"},{"key":"1891_CR40","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1007\/BF03163097","volume":"10","author":"A Rockenbauer","year":"1996","unstructured":"Rockenbauer A, Korecz L (1996) Appl Magn Reson 10:29\u201343","journal-title":"Appl Magn Reson"},{"key":"1891_CR41","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1016\/S0003-2670(01)80616-4","volume":"38","author":"HM Irving","year":"1967","unstructured":"Irving HM, Miles MG, Pettit LD (1967) Anal Chim Acta 38:475\u2013488","journal-title":"Anal Chim Acta"},{"key":"1891_CR42","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1007\/978-1-4684-4934-1_8","volume-title":"Computational methods for the determination of stability constants","author":"L Z\u00e9k\u00e1ny","year":"1985","unstructured":"Z\u00e9k\u00e1ny L, Nagyp\u00e1l I (1985). In: Leggett DL (ed) Computational methods for the determination of stability constants. Plenum Press, New York, pp 291\u2013353"}],"container-title":["JBIC Journal of Biological Inorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00775-021-01891-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00775-021-01891-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00775-021-01891-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,6]],"date-time":"2023-02-06T01:07:06Z","timestamp":1675645626000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00775-021-01891-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,28]]},"references-count":42,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["1891"],"URL":"https:\/\/doi.org\/10.1007\/s00775-021-01891-7","relation":{},"ISSN":["0949-8257","1432-1327"],"issn-type":[{"value":"0949-8257","type":"print"},{"value":"1432-1327","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,28]]},"assertion":[{"value":"19 May 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 August 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 August 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"There are no conflicts to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}