{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T05:26:16Z","timestamp":1778822776751,"version":"3.51.4"},"reference-count":84,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T00:00:00Z","timestamp":1670198400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T00:00:00Z","timestamp":1670198400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["DP160104172"],"award-info":[{"award-number":["DP160104172"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Biol Inorg Chem"],"DOI":"10.1007\/s00775-022-01978-9","type":"journal-article","created":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T06:02:57Z","timestamp":1670220177000},"page":"43-55","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Investigations of cellular copper metabolism in ovarian cancer cells using a ratiometric fluorescent copper dye"],"prefix":"10.1007","volume":"28","author":[{"given":"Sumayah","family":"Mohammed Asiri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aviva","family":"Levina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth J.","family":"New","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter A.","family":"Lay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,12,5]]},"reference":[{"issue":"3","key":"1978_CR1","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","volume":"71","author":"H Sung","year":"2021","unstructured":"Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F (2021) Global cancer statistics 2020: Globocan estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 71(3):209\u2013249. https:\/\/doi.org\/10.3322\/caac.21660","journal-title":"CA Cancer J Clin"},{"issue":"2","key":"1978_CR2","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1007\/s00204-016-1912-7","volume":"91","author":"A Brozovic","year":"2016","unstructured":"Brozovic A (2016) The relationship between platinum drug resistance and epithelial\u2013mesenchymal transition. Arch Toxicol 91(2):605\u2013619. https:\/\/doi.org\/10.1007\/s00204-016-1912-7","journal-title":"Arch Toxicol"},{"key":"1978_CR3","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1038\/nrd1691","volume":"4","author":"D Wang","year":"2005","unstructured":"Wang D, Lippard SJ (2005) Cellular processing of platinum anticancer drugs. Nat Rev Drug Discov 4:307\u2013320. https:\/\/doi.org\/10.1038\/nrd1691","journal-title":"Nat Rev Drug Discov"},{"issue":"2","key":"1978_CR4","doi-asserted-by":"publisher","first-page":"1780","DOI":"10.3892\/ol.2017.6348","volume":"14","author":"Y Liu","year":"2017","unstructured":"Liu Y, Han S, Li Y, Liu Y, Zhang D, Li Y, Zhang J (2017) MicroRNA-20A contributes to cisplatin-resistance and migration of OVCAR3 ovarian cancer cell line. Oncol Lett 14(2):1780\u20131786. https:\/\/doi.org\/10.3892\/ol.2017.6348","journal-title":"Oncol Lett"},{"issue":"1","key":"1978_CR5","doi-asserted-by":"publisher","first-page":"07","DOI":"10.13005\/bpj\/1608","volume":"12","author":"SA Aldossary","year":"2019","unstructured":"Aldossary SA (2019) Review on pharmacology of cisplatin: clinical use, toxicity and mechanism of resistance of cisplatin. Biomed Pharmacol J 12(1):07\u201315. https:\/\/doi.org\/10.13005\/bpj\/1608","journal-title":"Biomed Pharmacol J"},{"issue":"11","key":"1978_CR6","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.1039\/c5mt00149h","volume":"7","author":"D Denoyer","year":"2015","unstructured":"Denoyer D, Masaldan S, La Fontaine S, Cater MA (2015) Targeting copper in cancer therapy: \u2018copper that cancer. Metallomics 7(11):1459\u20131476. https:\/\/doi.org\/10.1039\/c5mt00149h","journal-title":"Metallomics"},{"issue":"9","key":"1978_CR7","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1039\/c6mt00076b","volume":"8","author":"KM Bompiani","year":"2016","unstructured":"Bompiani KM, Tsai C-Y, Achatz FP, Liebig JK, Howell SB (2016) Copper transporters and chaperones CTR1, CTR2, ATOX1, and CCS as determinants of cisplatin sensitivity. Metallomics 8(9):951\u2013962. https:\/\/doi.org\/10.1039\/c6mt00076b","journal-title":"Metallomics"},{"issue":"5","key":"1978_CR8","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1007\/s00775-017-1467-y","volume":"22","author":"MC Akerfeldt","year":"2017","unstructured":"Akerfeldt MC, Tran CM-N, Shen C, Hambley TW, New EJ (2017) Interactions of cisplatin and the copper transporter CTR1 in human colon cancer cells. J Biol Inorg Chem 22(5):765\u2013774. https:\/\/doi.org\/10.1007\/s00775-017-1467-y","journal-title":"J Biol Inorg Chem"},{"issue":"3","key":"1978_CR9","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.jconrel.2008.05.010","volume":"132","author":"F Kratz","year":"2008","unstructured":"Kratz F (2008) Albumin as a drug carrier: design of prodrugs, drug conjugates and nanoparticles. J Control Release 132(3):171\u2013183. https:\/\/doi.org\/10.1016\/j.jconrel.2008.05.010","journal-title":"J Control Release"},{"issue":"1","key":"1978_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-020-62560-4","volume":"10","author":"T Kirsipuu","year":"2020","unstructured":"Kirsipuu T, Zadoro\u017enaja A, Smirnova J, Friedemann M, Plitz T, T\u00f5ugu V, Palumaa P (2020) Copper(II)-binding equilibria in human blood. Sci Rep 10(1):1\u201311. https:\/\/doi.org\/10.1038\/s41598-020-62560-4","journal-title":"Sci Rep"},{"key":"1978_CR11","doi-asserted-by":"publisher","unstructured":"Eid C, H\u00e9madi M, Ha-Duong N.-T, El Hage Chahine J.-M (2014) Iron uptake and transfer from ceruloplasmin to transferrin. Biochimica et Biophysica Acta (BBA) General Subjects 1840(6):771\u20131781. https:\/\/doi.org\/10.1016\/j.bbagen.2014.01.011","DOI":"10.1016\/j.bbagen.2014.01.011"},{"issue":"10","key":"1978_CR12","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1007\/s00424-020-02412-2","volume":"472","author":"J Chen","year":"2020","unstructured":"Chen J, Jiang Y, Shi H, Peng Y, Fan X, Li C (2020) The molecular mechanisms of copper metabolism and its roles in human diseases. Pfl\u00fcgers Arch Eur J Physiol 472(10):1415\u20131429. https:\/\/doi.org\/10.1007\/s00424-020-02412-2","journal-title":"Pfl\u00fcgers Arch Eur J Physiol"},{"issue":"3","key":"1978_CR13","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1002\/iub.1722","volume":"70","author":"Y-Q Li","year":"2018","unstructured":"Li Y-Q, Yin J-Y, Liu Z-Q, Li X-P (2018) Copper efflux transporters ATP7A and ATP7B: novel biomarkers for platinum drug resistance and targets for therapy. IUBMB Life 70(3):183\u2013191. https:\/\/doi.org\/10.1002\/iub.1722","journal-title":"IUBMB Life"},{"key":"1978_CR14","doi-asserted-by":"publisher","first-page":"E4","DOI":"10.1017\/S0033583518000021","volume":"51","author":"C Ari\u00f6z","year":"2018","unstructured":"Ari\u00f6z C, Wittung-Stafshede P (2018) Folding of copper proteins: role of the metal? Q Rev Biophys 51:E4. https:\/\/doi.org\/10.1017\/S0033583518000021","journal-title":"Q Rev Biophys"},{"issue":"9","key":"1978_CR15","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1016\/s0753-3322(03)00012-x","volume":"57","author":"H Tapiero","year":"2003","unstructured":"Tapiero H, Townsend DM, Tew KD (2003) Trace elements in human physiology and pathology. Copper Biomed Pharmacother 57(9):386\u2013398","journal-title":"Copper Biomed Pharmacother"},{"issue":"6","key":"1978_CR16","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.4155\/fmc.09.84.Human","volume":"1","author":"A Gupta","year":"2009","unstructured":"Gupta A, Lutsenko S (2009) Human copper transporters: mechanism, role in human diseases and therapeutic potential. Future Med Chem 1(6):1125\u20131142. https:\/\/doi.org\/10.4155\/fmc.09.84.Human","journal-title":"Future Med Chem"},{"issue":"2","key":"1978_CR17","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1139\/O10-150","volume":"89","author":"OY Dmitriev","year":"2011","unstructured":"Dmitriev OY (2011) Mechanism of tumor resistance to cisplatin mediated by the copper transporter ATP7B. Biochem Cell Biol 89(2):138\u2013147. https:\/\/doi.org\/10.1139\/O10-150","journal-title":"Biochem Cell Biol"},{"issue":"6","key":"1978_CR18","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1016\/j.ccr.2010.04.011","volume":"17","author":"S Ishida","year":"2010","unstructured":"Ishida S, McCormick F, Smith-McCune K, Hanahan D (2010) Enhancing tumor-specific uptake of the anticancer drug cisplatin with a copper chelator. Cancer Cell 17(6):574\u2013583. https:\/\/doi.org\/10.1016\/j.ccr.2010.04.011","journal-title":"Cancer Cell"},{"issue":"6","key":"1978_CR19","doi-asserted-by":"publisher","first-page":"85","DOI":"10.3389\/fphar.2015.00085","volume":"24","author":"S Harrach","year":"2015","unstructured":"Harrach S, Ciarimboli G (2015) Role of transporters in the distribution of platinum-based drugs. Front Pharmacol 24(6):85. https:\/\/doi.org\/10.3389\/fphar.2015.00085","journal-title":"Front Pharmacol"},{"issue":"9","key":"1978_CR20","doi-asserted-by":"publisher","first-page":"3210","DOI":"10.1039\/c2dt31933k","volume":"42","author":"EJ New","year":"2013","unstructured":"New EJ (2013) Tools to study distinct metal pools in biology. Dalton Trans 42(9):3210\u20133219. https:\/\/doi.org\/10.1039\/c2dt31933k","journal-title":"Dalton Trans"},{"issue":"5415","key":"1978_CR21","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1126\/science.284.5415.805","volume":"284","author":"TD Rae","year":"1999","unstructured":"Rae TD, Schmidt PJ, Pufahl RA, Culotta VC, O\u2019Halloran TV (1999) Undetectable intracellular free copper: the requirement of a copper chaperone for superoxide dismutase. Science 284(5415):805\u2013808. https:\/\/doi.org\/10.1126\/science.284.5415.805","journal-title":"Science"},{"issue":"8","key":"1978_CR22","doi-asserted-by":"publisher","first-page":"4564","DOI":"10.1021\/cr400546e","volume":"114","author":"KP Carter","year":"2014","unstructured":"Carter KP, Young AM, Palmer AE (2014) Fluorescent sensors for measuring metal ions in living systems. Chem Rev 114(8):4564\u20134601. https:\/\/doi.org\/10.1021\/cr400546e","journal-title":"Chem Rev"},{"issue":"13","key":"1978_CR23","doi-asserted-by":"publisher","first-page":"4400","DOI":"10.1039\/c4cs00346b","volume":"44","author":"JA Cotruvo Jr","year":"2015","unstructured":"Cotruvo JA Jr, Aron AT, Ramos-Torres KM, Chang CJ (2015) Synthetic fluorescent probes for studying copper in biological systems. Chem Soc Rev 44(13):4400\u20134414. https:\/\/doi.org\/10.1039\/c4cs00346b","journal-title":"Chem Soc Rev"},{"issue":"4","key":"1978_CR24","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1016\/j.cbpa.2013.05.019","volume":"17","author":"CJ Fahrni","year":"2013","unstructured":"Fahrni CJ (2013) Synthetic fluorescent probes for monovalent copper. Curr Opin Chem Biol 17(4):656\u2013662. https:\/\/doi.org\/10.1016\/j.cbpa.2013.05.019","journal-title":"Curr Opin Chem Biol"},{"issue":"9","key":"1978_CR25","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1039\/x0xx00000x","volume":"8","author":"C Shen","year":"2016","unstructured":"Shen C, Kolanowski JL, Tran CM-N, Kaur A, Akerfeldt MC, Rahme MS, Hambley TW, New EJ (2016) A ratiometric fluorescent sensor for the mitochondrial copper pool. Metallomics 8(9):915\u2013919. https:\/\/doi.org\/10.1039\/x0xx00000x","journal-title":"Metallomics"},{"issue":"1","key":"1978_CR26","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1039\/c9cs00243j","volume":"49","author":"S-H Park","year":"2020","unstructured":"Park S-H, Kwon N, Lee J-H, Yoon J, Shin I (2020) Synthetic ratiometric fluorescent probes for detection of ions. Chem Soc Rev 49(1):143\u2013179. https:\/\/doi.org\/10.1039\/c9cs00243j","journal-title":"Chem Soc Rev"},{"issue":"11","key":"1978_CR27","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.4155\/fmc-2017-0308","volume":"10","author":"E Comsa","year":"2018","unstructured":"Comsa E, Nguyen K-A, Loghin F, Boumendjel A, Peuchmaur M, Andrieu T, Falson P (2018) Ovarian cancer cells cisplatin sensitization agents selected by mass cytometry target ABCC2 inhibition. Future Med Chem 10(11):1349\u20131360. https:\/\/doi.org\/10.4155\/fmc-2017-0308","journal-title":"Future Med Chem"},{"issue":"22","key":"1978_CR28","first-page":"6559","volume":"62","author":"K Katano","year":"2002","unstructured":"Katano K, Kondo A, Safaei R, Holzer A, Samimi G, Mishima M, Kuo Y, Rochdi M, Howell SB (2002) Acquisition of resistance to cisplatin is accompanied by changes in the cellular pharmacology of copper. Can Res 62(22):6559\u20136565","journal-title":"Can Res"},{"issue":"9","key":"1978_CR29","doi-asserted-by":"publisher","first-page":"1723","DOI":"10.1002\/(SICI)1097-0142(19970501)79:9<1723::AID-CNCR13>3.0.CO;2-%23","volume":"79","author":"H Schuldes","year":"1997","unstructured":"Schuldes H, Bade S, Knobloch J, Jonas D (1997) Loss of in vitro cytotoxicity of cisplatin after storage as stock solution in cell culture medium at various temperatures. Cancer 79(9):1723\u20131728. https:\/\/doi.org\/10.1002\/(SICI)1097-0142(19970501)79:9%3c1723::AID-CNCR13%3e3.0.CO;2-%23","journal-title":"Cancer"},{"issue":"10","key":"1978_CR30","doi-asserted-by":"publisher","first-page":"4519","DOI":"10.1128\/AAC.00569-11","volume":"55","author":"SB Han","year":"2011","unstructured":"Han SB, Shin YJ, Hyon JY, Wee WR (2011) Cytotoxicity of voriconazole on cultured human corneal endothelial cells. Antimicrob Agents Chemother 55(10):4519\u20134523. https:\/\/doi.org\/10.1128\/AAC.00569-11","journal-title":"Antimicrob Agents Chemother"},{"issue":"7","key":"1978_CR31","doi-asserted-by":"publisher","first-page":"12036","DOI":"10.1021\/acsomega.9b01142","volume":"4","author":"L Cai","year":"2019","unstructured":"Cai L, Qin X, Xu Z, Song Y, Jiang H, Wu Y, Ruan H, Chen J (2019) Comparison of cytotoxicity evaluation of anticancer drugs between real-time cell analysis and CCK-8 Method. ACS Omega 4(7):12036\u201312042. https:\/\/doi.org\/10.1021\/acsomega.9b01142","journal-title":"ACS Omega"},{"key":"1978_CR32","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1016\/j.ccr.2017.01.002","volume":"352","author":"A Levina","year":"2017","unstructured":"Levina A, Crans DC, Lay PA (2017) Speciation of metal drugs, supplements and toxins in media and bodily fluids controls in vitro activities. Coord Chem Rev 352:473\u2013498. https:\/\/doi.org\/10.1016\/j.ccr.2017.01.002","journal-title":"Coord Chem Rev"},{"issue":"22","key":"1978_CR33","doi-asserted-by":"publisher","first-page":"16143","DOI":"10.1021\/acs.inorgchem.0c00926","volume":"59","author":"A Levina","year":"2020","unstructured":"Levina A, Lay PA (2020) Vanadium(V\/IV)\u2013transferrin binding disrupts the transferrin cycle and reduces vanadium uptake and antiproliferative activity in human lung cancer cells. Inorg Chem 59(22):16143\u201316153. https:\/\/doi.org\/10.1021\/acs.inorgchem.0c00926","journal-title":"Inorg Chem"},{"issue":"28","key":"1978_CR34","doi-asserted-by":"publisher","first-page":"8104","DOI":"10.1002\/anie.201602996","volume":"55","author":"A Levina","year":"2016","unstructured":"Levina A, Pham TH, Lay PA (2016) Binding of chromium(III) to transferrin could be involved in detoxification of dietary chromium(III) rather than transport of an essential trace element. Angew Chem 128(28):8236\u20138239. https:\/\/doi.org\/10.1002\/ange.201602996","journal-title":"Angew Chem"},{"issue":"1\u20132","key":"1978_CR35","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1006\/abio.1976.9999","volume":"72","author":"MM Bradford","year":"1976","unstructured":"Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72(1\u20132):248\u2013254","journal-title":"Anal Biochem"},{"issue":"6","key":"1978_CR36","doi-asserted-by":"publisher","first-page":"e45","DOI":"10.21769\/BioProtoc.e45","volume":"1","author":"H Fanglian","year":"2011","unstructured":"Fanglian H (2011) Bradford protein assay. Bio-Protoc 1(6):e45. https:\/\/doi.org\/10.21769\/BioProtoc.e45","journal-title":"Bio-Protoc"},{"key":"1978_CR37","unstructured":"Shen C (2017) Fluorescent strategies to study the labile copper pool. PhD Thesis, The University of Sydney"},{"issue":"14","key":"1978_CR38","doi-asserted-by":"publisher","first-page":"4726","DOI":"10.3390\/app10144726","volume":"10","author":"S Kamlund","year":"2020","unstructured":"Kamlund S, Janicke B, Alm K, Judson-Torres RL, Oredsson S (2020) Quantifying the rate, degree, and heterogeneity of morphological change during an epithelial to mesenchymal transition using digital holographic cytometry. Appl Sci 10(14):4726. https:\/\/doi.org\/10.3390\/app10144726","journal-title":"Appl Sci"},{"issue":"1","key":"1978_CR39","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1186\/1471-2407-12-91","volume":"12","author":"AM Haslehurst","year":"2012","unstructured":"Haslehurst AM, Koti M, Dharsee M, Nuin P, Evans K, Geraci J, Childs T, Chen J, Li J, Weberpals J, Davey S, Squire J, Park PC, Feilotter H (2012) EMT transcription factors snail and slug directly contribute to cisplatin resistance in ovarian cancer. BMC Cancer 12(1):91. https:\/\/doi.org\/10.1186\/1471-2407-12-91","journal-title":"BMC Cancer"},{"issue":"4","key":"1978_CR40","doi-asserted-by":"publisher","first-page":"3342","DOI":"10.3892\/mmr.2016.4897","volume":"13","author":"S Ma","year":"2016","unstructured":"Ma S, Tan W, Du B, Liu W, Li W, Che D, Zhang G (2016) Oridonin effectively reverses cisplatin drug resistance in human ovarian cancer cells via induction of cell apoptosis and inhibition of matrix metalloproteinase expression. Mol Med Rep 13(4):3342\u20133348. https:\/\/doi.org\/10.3892\/mmr.2016.4897","journal-title":"Mol Med Rep"},{"key":"1978_CR41","doi-asserted-by":"publisher","first-page":"2211","DOI":"10.2147\/DDDT.S288707","volume":"15","author":"S Sarwar","year":"2021","unstructured":"Sarwar S, Alamro AA, Alghamdi AA, Naeem K, Ullah S, Arif M, Yu JQ, Huq F (2021) Enhanced accumulation of cisplatin in ovarian cancer cells from combination with wedelolactone and resulting inhibition of multiple epigenetic drivers. Drug Des Dev Ther 15:2211\u20132227. https:\/\/doi.org\/10.2147\/DDDT.S288707","journal-title":"Drug Des Dev Ther"},{"issue":"21","key":"1978_CR42","doi-asserted-by":"publisher","first-page":"11491","DOI":"10.1021\/acs.analchem.7b02746","volume":"89","author":"M Corte Rodr\u00edguez","year":"2017","unstructured":"Corte Rodr\u00edguez M, \u00c1lvarez-Fern\u00e1ndez Garc\u00eda R, Blanco E, Bettmer J, Montes-Bay\u00f3n M (2017) Quantitative evaluation of cisplatin uptake in sensitive and resistant individual cells by single-cell ICP-MS (SC-ICP-MS). Anal Chem 89(21):11491\u201311497. https:\/\/doi.org\/10.1021\/acs.analchem.7b02746","journal-title":"Anal Chem"},{"issue":"10","key":"1978_CR43","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.1039\/c7mt00153c","volume":"9","author":"RF Lee","year":"2017","unstructured":"Lee RF, Riedel T, Escrig S, Maclachlan C, Knott GW, Davey CA, Johnsson K, Meibom A, Dyson PJ (2017) Differences in cisplatin distribution in sensitive and resistant ovarian cancer cells: a TEM\/NanoSIMS study. Metallomics 9(10):1413\u20131420. https:\/\/doi.org\/10.1039\/c7mt00153c","journal-title":"Metallomics"},{"issue":"10","key":"1978_CR44","doi-asserted-by":"publisher","first-page":"1607","DOI":"10.1016\/j.jinorgbio.2004.05.006","volume":"98","author":"R Safaei","year":"2004","unstructured":"Safaei R, Holzer AK, Katano K, Samimi G, Howell SB (2004) The role of copper transporters in the development of resistance to Pt drugs. J Inorg Biochem 98(10):1607\u20131613. https:\/\/doi.org\/10.1016\/j.jinorgbio.2004.05.006","journal-title":"J Inorg Biochem"},{"issue":"14","key":"1978_CR45","doi-asserted-by":"publisher","first-page":"4661","DOI":"10.1158\/1078-0432.CCR-04-0137","volume":"10","author":"G Samimi","year":"2004","unstructured":"Samimi G, Safaei R, Katano K, Holzer AK, Rochdi M, Tomioka M, Goodman M, Howell SB (2004) Increased expression of the copper efflux transporter ATP7A mediates resistance to cisplatin, carboplatin, and oxaliplatin in ovarian cancer cells. Clin Cancer Res 10(14):4661\u20134669. https:\/\/doi.org\/10.1158\/1078-0432.CCR-04-0137","journal-title":"Clin Cancer Res"},{"issue":"1","key":"1978_CR46","doi-asserted-by":"publisher","first-page":"743","DOI":"10.18632\/oncotarget.23142","volume":"9","author":"S Guttmann","year":"2017","unstructured":"Guttmann S, Chandhok G, Groba SR, Niemietz C, Sauer V, Gomes A, Ciarimboli G, Karst U, Zibert A, Schmidt HH (2017) Organic cation transporter 3 mediates cisplatin and copper cross-resistance in Hepatoma cells. Oncotarget 9(1):743\u2013754. https:\/\/doi.org\/10.18632\/oncotarget.23142","journal-title":"Oncotarget"},{"issue":"3","key":"1978_CR47","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1007\/s00280-003-0736-3","volume":"53","author":"R Safaei","year":"2004","unstructured":"Safaei R, Katano K, Samimi G, Naerdemann W, Stevenson JL, Rochdi M, Howell SB (2004) Cross-resistance to cisplatin in cells with acquired resistance to copper. Cancer Chemother Pharmacol 53(3):239\u2013246. https:\/\/doi.org\/10.1007\/s00280-003-0736-3","journal-title":"Cancer Chemother Pharmacol"},{"issue":"5","key":"1978_CR48","doi-asserted-by":"publisher","first-page":"1154","DOI":"10.1124\/mol.62.5.1154","volume":"62","author":"X Lin","year":"2002","unstructured":"Lin X, Okuda T, Holzer A, Howell SB (2002) The copper transporter ctr1 regulates cisplatin uptake in Saccharomyces cerevisiae. Mol Pharmacol 62(5):1154\u20131159. https:\/\/doi.org\/10.1124\/mol.62.5.1154","journal-title":"Mol Pharmacol"},{"key":"1978_CR49","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-59745-035-5_17","author":"R Safaei","year":"2006","unstructured":"Safaei R, Howell SB (2006) Regulation of the cellular pharmacology and cytotoxicity of cisplatin by copper transporters. Cancer Drug Discov Dev. https:\/\/doi.org\/10.1007\/978-1-59745-035-5_17","journal-title":"Cancer Drug Discov Dev"},{"issue":"10","key":"1978_CR50","doi-asserted-by":"publisher","first-page":"1405","DOI":"10.1016\/S0959-8049(02)00096-5","volume":"38","author":"M Mishima","year":"2002","unstructured":"Mishima M, Samimi G, Kondo A, Lin X, Howell SB (2002) The cellular pharmacology of oxaliplatin resistance. Eur J Cancer 38(10):1405\u20131412. https:\/\/doi.org\/10.1016\/S0959-8049(02)00096-5","journal-title":"Eur J Cancer"},{"issue":"11","key":"1978_CR51","doi-asserted-by":"publisher","first-page":"4100","DOI":"10.1039\/c7fo00882a","volume":"8","author":"F Aqil","year":"2017","unstructured":"Aqil F, Jeyabalan J, Agrawal AK, Kyakulaga A-H, Munagala R, Parker L, Gupta RC (2017) Exosomal delivery of berry anthocyanidins for the management of ovarian cancer. Food Funct 8(11):4100\u20134107. https:\/\/doi.org\/10.1039\/c7fo00882a","journal-title":"Food Funct"},{"issue":"7","key":"1978_CR52","doi-asserted-by":"publisher","first-page":"1927","DOI":"10.7150\/jca.36919","volume":"11","author":"A De","year":"2020","unstructured":"De A, De A, Sharma R, Suo W, Sharma M (2020) Sensitization of carboplatinum- and taxol-resistant high-grade serous ovarian cancer cells carrying p53, BRCA1\/2 mutations by Emblica officinalis (AMLA) via multiple targets. J Cancer 11(7):1927\u20131939. https:\/\/doi.org\/10.7150\/jca.36919","journal-title":"J Cancer"},{"key":"1978_CR53","doi-asserted-by":"publisher","first-page":"12500","DOI":"10.1021\/bi0604375","volume":"45","author":"PK Witting","year":"2006","unstructured":"Witting PK, Harris HH, Rayner BS, Aitken JB, Dillon CT, Stocker R, Lai B, Cai Z, Lay PA (2006) The endothelium-derived hyperpolarizing factor, H2O2, promotes metal-ion efflux in aortic endothelial cells: elemental mapping by a hard X-ray microscope. Biochemistry 45:12500\u201312509. https:\/\/doi.org\/10.1021\/bi0604375","journal-title":"Biochemistry"},{"key":"1978_CR54","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2012\/424072","volume":"2012","author":"G Santin","year":"2012","unstructured":"Santin G, Scietti L, Veneroni P, Barni S, Bernocchi G, Bottone MG (2012) Effects of cisplatin in neuroblastoma rat cells: damage to cellular organelles. Int J Cell Biol 2012:1\u20136. https:\/\/doi.org\/10.1155\/2012\/424072","journal-title":"Int J Cell Biol"},{"key":"1978_CR55","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.3389\/fpls.2016.01192","volume":"7","author":"K Bashir","year":"2016","unstructured":"Bashir K, Rasheed S, Kobayashi T, Seki M, Nishizawa NK (2016) Regulating subcellular metal homeostasis: the key to crop improvement. Front Plant Sci 7:1192. https:\/\/doi.org\/10.3389\/fpls.2016.01192","journal-title":"Front Plant Sci"},{"issue":"46","key":"1978_CR56","doi-asserted-by":"publisher","first-page":"16280","DOI":"10.1073\/pnas.1409796111","volume":"111","author":"SC Dodani","year":"2014","unstructured":"Dodani SC, Firl A, Chan J, Nam CI, Aron AT, Onak CS, Ramos-Torres KM, Paek J, Webster CM, Feller MB, Chang CJ (2014) Copper is an endogenous modulator of neural circuit spontaneous activity. Proc Natl Acad Sci 111(46):16280\u201316285. https:\/\/doi.org\/10.1073\/pnas.1409796111","journal-title":"Proc Natl Acad Sci"},{"issue":"1","key":"1978_CR57","doi-asserted-by":"publisher","first-page":"12410","DOI":"10.1038\/srep12410","volume":"5","author":"S Li","year":"2015","unstructured":"Li S, Zhang J, Yang H, Wu C, Dang X, Liu Y (2015) Copper depletion inhibits cocl2-induced aggressive phenotype of MCF-7 cells via downregulation of HIF-1 and inhibition of snail\/twist-mediated epithelial-mesenchymal transition. Sci Rep 5(1):12410. https:\/\/doi.org\/10.1038\/srep12410","journal-title":"Sci Rep"},{"issue":"1","key":"1978_CR58","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1515\/revac-2020-0118","volume":"39","author":"X Zheng","year":"2020","unstructured":"Zheng X, Cheng W, Ji C, Zhang J, Yin M (2020) Detection of metal ions in biological systems: a review. Rev Anal Chem 39(1):231\u2013246. https:\/\/doi.org\/10.1515\/revac-2020-0118","journal-title":"Rev Anal Chem"},{"key":"1978_CR59","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.cbpa.2016.12.011","volume":"37","author":"CM Weekley","year":"2017","unstructured":"Weekley CM, He C (2017) Developing drugs targeting transition metal homeostasis. Curr Opin Chem Biol 37:26\u201332. https:\/\/doi.org\/10.1016\/j.cbpa.2016.12.011","journal-title":"Curr Opin Chem Biol"},{"issue":"3","key":"1978_CR60","doi-asserted-by":"publisher","first-page":"826S","DOI":"10.1093\/ajcn\/88.3.826S","volume":"88","author":"JR Prohaska","year":"2008","unstructured":"Prohaska JR (2008) Role of copper transporters in copper homeostasis. Am J Clin Nutr 88(3):826S-829S. https:\/\/doi.org\/10.1093\/ajcn\/88.3.826S","journal-title":"Am J Clin Nutr"},{"issue":"9","key":"1978_CR61","doi-asserted-by":"publisher","first-page":"1406","DOI":"10.1016\/j.bbamcr.2012.04.001","volume":"1823","author":"KM Dean","year":"2012","unstructured":"Dean KM, Qin Y, Palmer AE (2012) Visualizing metal ions in cells: an overview of analytical techniques, approaches, and probes. Biochim Biophys Acta (BBA) Mol Cell Res 1823(9):1406\u20131415. https:\/\/doi.org\/10.1016\/j.bbamcr.2012.04.001","journal-title":"Biochim Biophys Acta (BBA) Mol Cell Res"},{"issue":"1","key":"1978_CR62","doi-asserted-by":"publisher","first-page":"106","DOI":"10.5306\/wjco.v7.i1.106","volume":"7","author":"D Kilari","year":"2016","unstructured":"Kilari D (2016) Role of copper transporters in platinum resistance. World J Clin Oncol 7(1):106. https:\/\/doi.org\/10.5306\/wjco.v7.i1.106","journal-title":"World J Clin Oncol"},{"issue":"1","key":"1978_CR63","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.jinorgbio.2003.08.014","volume":"98","author":"AR Ghezzi","year":"2004","unstructured":"Ghezzi AR, Aceto M, Cassino C, Gabano E, Osella D (2004) Uptake of antitumor platinum(ii)-complexes by cancer cells, assayed by inductively coupled plasma mass spectrometry (ICP-MS). J Inorg Biochem 98(1):73\u201378. https:\/\/doi.org\/10.1016\/j.jinorgbio.2003.08.014","journal-title":"J Inorg Biochem"},{"issue":"1","key":"1978_CR64","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1007\/s10555-007-9045-3","volume":"26","author":"MT Kuo","year":"2007","unstructured":"Kuo MT, Chen HH, Song I-S, Savaraj N, Ishikawa T (2007) The roles of copper transporters in cisplatin resistance. Cancer Metastasis Rev 26(1):71\u201383. https:\/\/doi.org\/10.1007\/s10555-007-9045-3","journal-title":"Cancer Metastasis Rev"},{"issue":"12","key":"1978_CR65","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.1158\/1535-7163.1543.3.12","volume":"3","author":"I-S Song","year":"2004","unstructured":"Song I-S, Savaraj N, Siddik ZH, Liu P, Wei Y, Wu CJ, Kuo MT (2004) Role of human copper transporter CTR1 in the transport of platinum-based antitumor agents in cisplatin-sensitive and cisplatin-resistant cells. Mol Cancer Ther 3(12):1543\u20131549","journal-title":"Mol Cancer Ther"},{"key":"1978_CR66","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jinorgbio.2012.07.010","volume":"116","author":"GV Kalayda","year":"2012","unstructured":"Kalayda GV, Wagner CH, Jaehde U (2012) Relevance of copper transporter 1 for cisplatin resistance in human ovarian carcinoma cells. J Inorg Biochem 116:1\u201310. https:\/\/doi.org\/10.1016\/j.jinorgbio.2012.07.010","journal-title":"J Inorg Biochem"},{"issue":"14","key":"1978_CR67","doi-asserted-by":"publisher","first-page":"2085","DOI":"10.7150\/jca.16117","volume":"7","author":"Z-H Li","year":"2016","unstructured":"Li Z-H, Zheng R, Chen J-T, Jia J, Qiu M (2016) The role of copper transporter ATP7A in platinum-resistance of esophageal squamous cell cancer (ESCC). J Cancer 7(14):2085\u20132092. https:\/\/doi.org\/10.7150\/jca.16117","journal-title":"J Cancer"},{"issue":"5","key":"1978_CR68","first-page":"1312","volume":"60","author":"M Komatsu","year":"2000","unstructured":"Komatsu M, Sumizawa T, Mutoh M, Chen Z, Terada K, Furukawa T, Yang X, Gao H, Miura N, Sugiyama T, Akiyama S-I (2000) Copper-transporting P-type adenosine triphosphatase (ATP7B) is associated with cisplatin resistance. Can Res 60(5):1312\u20131316","journal-title":"Can Res"},{"issue":"6","key":"1978_CR69","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1007\/s10585-008-9171-5","volume":"25","author":"LG Hudson","year":"2008","unstructured":"Hudson LG, Zeineldin R, Stack MS (2008) Phenotypic plasticity of neoplastic ovarian epithelium: unique cadherin profiles in tumor progression. Clin Exp Metas 25(6):643\u2013655. https:\/\/doi.org\/10.1007\/s10585-008-9171-5","journal-title":"Clin Exp Metas"},{"issue":"12","key":"1978_CR70","doi-asserted-by":"publisher","first-page":"2889","DOI":"10.3390\/cancers13122889","volume":"13","author":"P Wang","year":"2021","unstructured":"Wang P, Zhou R, Thomas P, Zhao L, Zhou R, Mandal S, Jolly M, Richard D, Rehm B, Ostrikov K, Dai X, Williams E, Thompson E (2021) Epithelial-to-mesenchymal transition enhances cancer cell sensitivity to cytotoxic effects of cold atmospheric plasmas in breast and bladder cancer systems. Cancers 13(12):2889. https:\/\/doi.org\/10.3390\/cancers13122889","journal-title":"Cancers"},{"issue":"9","key":"1978_CR71","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.3390\/cells8091080","volume":"8","author":"R Petruzzelli","year":"2019","unstructured":"Petruzzelli R, Polishchuk RS (2019) Activity and trafficking of copper-transporting ATPases in tumor development and defence against platinum-based drugs. Cells 8(9):1080. https:\/\/doi.org\/10.3390\/cells8091080","journal-title":"Cells"},{"issue":"4","key":"1978_CR72","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1124\/mol.104.001198","volume":"66","author":"AK Holzer","year":"2004","unstructured":"Holzer AK, Samimi G, Katano K, Naerdemann W, Lin X, Safaei R, Howell SB (2004) The copper influx transporter human copper transport protein 1 regulates the uptake of cisplatin in human ovarian carcinoma cells. Mol Pharmacol 66(4):817\u2013823. https:\/\/doi.org\/10.1124\/mol.104.001198","journal-title":"Mol Pharmacol"},{"issue":"25","key":"1978_CR73","doi-asserted-by":"publisher","first-page":"12167","DOI":"10.1073\/pnas.1900172116","volume":"116","author":"MT Morgan","year":"2019","unstructured":"Morgan MT, Bourassa D, Harankhedkar S, McCallum AM, Zlatic SA, Calvo JS, Meloni G, Faundez V, Fahrni CJ (2019) Ratiometric two-photon microscopy reveals attomolar copper buffering in normal and Menkes mutant cells. Proc Natl Acad Sci 116(25):12167\u201312172. https:\/\/doi.org\/10.1073\/pnas.1900172116","journal-title":"Proc Natl Acad Sci"},{"issue":"37","key":"1978_CR74","doi-asserted-by":"publisher","first-page":"18285","DOI":"10.1073\/pnas.1904610116","volume":"116","author":"CY-S Chung","year":"2019","unstructured":"Chung CY-S, Posimo JM, Lee S, Tsang T, Davis JM, Brady DC, Chang CJ (2019) Activity-based ratiometric fret probe reveals oncogene-driven changes in labile copper pools induced by altered glutathione metabolism. Proc Natl Acad Sci 116(37):18285\u201318294. https:\/\/doi.org\/10.1073\/pnas.1904610116","journal-title":"Proc Natl Acad Sci"},{"issue":"1","key":"1978_CR75","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1039\/C4MT00288A","volume":"7","author":"C Shen","year":"2015","unstructured":"Shen C, New EJ (2015) What has fluorescent sensing told us about copper and brain malfunction? Metallomics 7(1):56\u201365. https:\/\/doi.org\/10.1039\/C4MT00288A","journal-title":"Metallomics"},{"issue":"1\u20133","key":"1978_CR76","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/S0048-9697(01)00970-6","volume":"286","author":"E B\u00e1r\u00e1ny","year":"2002","unstructured":"B\u00e1r\u00e1ny E, Bergdahl IA, Bratteby L-E, Lundh T, Samuelson G, Sch\u00fctz A, Skerfving S, Oskarsson A (2002) Trace element levels in whole blood and serum from Swedish adolescents. Sci Total Environ 286(1\u20133):129\u2013141. https:\/\/doi.org\/10.1016\/S0048-9697(01)00970-6","journal-title":"Sci Total Environ"},{"issue":"15","key":"1978_CR77","doi-asserted-by":"publisher","first-page":"5980","DOI":"10.1073\/pnas.1009932108","volume":"108","author":"SC Dodani","year":"2011","unstructured":"Dodani SC, Domaille DW, Nam CI, Miller EW, Finney LA, Vogt S, Chang CJ (2011) Calcium-dependent copper redistributions in neuronal cells revealed by a fluorescent copper sensor and X-ray fluorescence microscopy. Proc Natl Acad Sci 108(15):5980\u20135985. https:\/\/doi.org\/10.1073\/pnas.1009932108","journal-title":"Proc Natl Acad Sci"},{"issue":"10","key":"1978_CR78","doi-asserted-by":"publisher","first-page":"1535","DOI":"10.1016\/s0959-8049(98)00227-5","volume":"34","author":"RP Perez","year":"1998","unstructured":"Perez RP (1998) Cellular and molecular determinants of cisplatin resistance. Eur J Cancer 34(10):1535\u20131542. https:\/\/doi.org\/10.1016\/s0959-8049(98)00227-5","journal-title":"Eur J Cancer"},{"key":"1978_CR79","doi-asserted-by":"publisher","first-page":"343","DOI":"10.3389\/fphar.2020.00343","volume":"11","author":"J Zhou","year":"2020","unstructured":"Zhou J, Kang Y, Chen L, Wang H, Liu J, Zeng S, Yu L (2020) The drug-resistance mechanisms of five platinum-based antitumor agents. Front Pharmacol 11:343. https:\/\/doi.org\/10.3389\/fphar.2020.00343","journal-title":"Front Pharmacol"},{"issue":"28","key":"1978_CR80","doi-asserted-by":"publisher","first-page":"13943","DOI":"10.1073\/pnas.1903297116","volume":"116","author":"A De Luca","year":"2019","unstructured":"De Luca A, Parker LJ, Ang WH, Rodolfo C, Gabbarini V, Hancock NC, Palone F, Mazzetti AP, Menin L, Morton CJ, Parker MW, Lo Bello M, Dyson PJ (2019) A structure-based mechanism of cisplatin resistance mediated by glutathione transferase P1\u20131. Proc Natl Acad Sci 116(28):13943\u201313951. https:\/\/doi.org\/10.1073\/pnas.1903297116","journal-title":"Proc Natl Acad Sci"},{"issue":"6","key":"1978_CR81","doi-asserted-by":"publisher","first-page":"549","DOI":"10.3390\/ph14060549","volume":"14","author":"MT Kuo","year":"2021","unstructured":"Kuo MT, Huang Y-F, Chou C-Y, Chen HH (2021) Targeting the copper transport system to improve treatment efficacies of platinum-containing drugs in cancer chemotherapy. Pharmaceuticals 14(6):549. https:\/\/doi.org\/10.3390\/ph14060549","journal-title":"Pharmaceuticals"},{"issue":"1","key":"1978_CR82","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.chembiol.2017.10.006","volume":"25","author":"EJ New","year":"2018","unstructured":"New EJ, Wimmer VC, Hare DJ (2018) Promises and pitfalls of metal imaging in biology. Cell Chem Biol 25(1):7\u201318. https:\/\/doi.org\/10.1016\/j.chembiol.2017.10.006","journal-title":"Cell Chem Biol"},{"issue":"5","key":"1978_CR83","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1039\/d0mt00056f","volume":"12","author":"J Zhu","year":"2020","unstructured":"Zhu J, Yeo JH, Bowyer AA, Proschogo N, New EJ (2020) Studies of the labile lead pool using a rhodamine-based fluorescent probe. Metallomics 12(5):644\u2013648. https:\/\/doi.org\/10.1039\/d0mt00056f","journal-title":"Metallomics"},{"issue":"9","key":"1978_CR84","doi-asserted-by":"publisher","first-page":"e72162","DOI":"10.1371\/journal.pone.0072162","volume":"8","author":"MS Anglesio","year":"2013","unstructured":"Anglesio MS, Wiegand KC, Melnyk N, Chow C, Salamanca C, Prentice LM, Senz J, Yang W, Spillman MA, Cochrane DR, Shumansky K, Shah SP, Kalloger SE, Huntsman DG (2013) Type-specific cell line models for type-specific ovarian cancer research. PLoS ONE 8(9):e72162. https:\/\/doi.org\/10.1371\/journal.pone.0072162","journal-title":"PLoS ONE"}],"container-title":["JBIC Journal of Biological Inorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00775-022-01978-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00775-022-01978-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00775-022-01978-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T08:01:17Z","timestamp":1676620877000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00775-022-01978-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,5]]},"references-count":84,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,2]]}},"alternative-id":["1978"],"URL":"https:\/\/doi.org\/10.1007\/s00775-022-01978-9","relation":{},"ISSN":["1432-1327"],"issn-type":[{"value":"1432-1327","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,5]]},"assertion":[{"value":"11 July 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 November 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 December 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declared that there are no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}