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Resokaempferol was synthesized from 2,2\u0384,4-trihydroxychalcone by H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>\/NaOH. The rhenium\u2013tricarbonyl complexes of the type<jats:italic>fac<\/jats:italic>-[Re(CO)<jats:sub>3<\/jats:sub>(Fl)(sol)] were synthesized by reacting the precursor<jats:italic>fac<\/jats:italic>-[Re(CO)<jats:sub>3<\/jats:sub>(sol)<jats:sub>3<\/jats:sub>]<jats:sup>+<\/jats:sup>with an equimolar amount of the flavonoids (Fl) quercetin, resokaempferol, chrysin and naringenin and the solvent (sol) was methanol or water. The respective Re\u2013flavonoid complexes were purified by semi-preparative HPLC and characterized by spectroscopic methods. Furthermore, the structure of Re\u2013chrysin was elucidated by X-ray crystallography. Initial screening of the neuroprotective properties of these compounds included the in vitro assessment of the antioxidant properties by the DPPH assay as well as the anti-lipid peroxidation of linoleic acid in the presence of AAPH and their ability to inhibit soybean lipoxygenase. From the above studies, it was concluded that the complexes\u2019 properties are mainly correlated with the structural characteristics and the presence of the flavonoids. The flavonoids and their respective Re-complexes were also tested in vitro for their ability to inhibit the formation and aggregation of the amyloid-like abnormal prion protein, PrP<jats:sup>Sc<\/jats:sup>, by employing the real-time quaking-induced conversion assay with recombinant PrP seeded with cerebrospinal fluid from patients with Creutzfeldt\u2013Jakob disease. All the compounds blocked de novo abnormal PrP formation and aggregation.<\/jats:p><jats:p><jats:bold>Graphical abstract<\/jats:bold><\/jats:p>","DOI":"10.1007\/s00775-022-01986-9","type":"journal-article","created":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T15:04:05Z","timestamp":1674659045000},"page":"235-247","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Synthesis, structural characterization and study of antioxidant and anti-PrPSc properties of flavonoids and their rhenium(I)\u2013tricarbonyl complexes"],"prefix":"10.1007","volume":"28","author":[{"given":"Pigi","family":"Glykofridi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vassiliki-Eleni","family":"Tziouri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Xanthopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria-Eirini","family":"Vlachou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Correia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna-Lisa","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin","family":"Th\u00fcne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonios","family":"Hatzidimitriou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inga","family":"Zerr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Schmitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodoros","family":"Sklaviadis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitra","family":"Hadjipavlou-Litina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7833-8744","authenticated-orcid":false,"given":"Dionysia","family":"Papagiannopoulou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,1,25]]},"reference":[{"key":"1986_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1126\/scitranslmed.3002369","volume":"3","author":"DM Holtzman","year":"2011","unstructured":"Holtzman DM, Morris JC, Goate AM (2011) Alzheimer\u2019s disease: the challenge of the second century. 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