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Also, these molecules have shown to interact with non-canonical nucleic acid structures, such as G-quadruplexes, and modulate oncogenic expression in cancer cells. Herein, we report the synthesis and characterisation of two metallo-phthalocyanines containing either zinc (<jats:bold>ZnPc<\/jats:bold>) or nickel (<jats:bold>NiPc<\/jats:bold>) in the central aromatic core and four alkyl ammonium lateral chains. The interaction of both molecules with G-quadruplex DNA was assessed by UV\u2013Vis, fluorescence and FRET melting experiments. Both molecules bind strongly to G-quadruplexes and stabilise these structures, being <jats:bold>NiPc<\/jats:bold> the most notable G-quadruplex stabiliser. In addition, the photosensitizing ability of both metal complexes was explored by the evaluation of the singlet oxygen generation and their photoactivation in cells. Only <jats:bold>ZnPc<\/jats:bold> showed a high singlet oxygen generation either by direct observation or by indirect evaluation using a DPBF dye. The cellular evaluation showed mainly cytoplasmic localization of <jats:bold>ZnPc<\/jats:bold> and a decrease of the IC<jats:sub>50<\/jats:sub> values of the cell viability of <jats:bold>ZnPc<\/jats:bold> upon light activation of two orders of magnitude.<\/jats:p>\n                <jats:p><jats:bold>Graphical abstract<\/jats:bold><\/jats:p>","DOI":"10.1007\/s00775-023-02003-3","type":"journal-article","created":{"date-parts":[[2023,7,14]],"date-time":"2023-07-14T18:02:21Z","timestamp":1689357741000},"page":"495-507","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Development and application of metallo-phthalocyanines as potent G-quadruplex DNA binders and photosensitizers"],"prefix":"10.1007","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1086-6660","authenticated-orcid":false,"given":"Ariadna","family":"Gil-Mart\u00ednez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adri\u00e1n","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1365-1323","authenticated-orcid":false,"given":"Cristina","family":"Galiana-Rosell\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7897-6888","authenticated-orcid":false,"given":"S\u00f2nia","family":"L\u00f3pez-Molina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3480-6793","authenticated-orcid":false,"given":"Javier","family":"Ortiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8835-2486","authenticated-orcid":false,"given":"\u00c1ngela","family":"Sastre-Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4601-6505","authenticated-orcid":false,"given":"Enrique","family":"Garc\u00eda-Espa\u00f1a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8994-1779","authenticated-orcid":false,"given":"Jorge","family":"Gonz\u00e1lez-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,7,14]]},"reference":[{"key":"2003_CR1","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1038\/nbt.1678","volume":"28","author":"TK Kelly","year":"2010","unstructured":"Kelly TK, De Carvalho DD, Jones PA (2010) Epigenetic modifications as therapeutic targets. 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