{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:27:09Z","timestamp":1786980429372,"version":"build-2736575974"},"reference-count":59,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T00:00:00Z","timestamp":1704672000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T00:00:00Z","timestamp":1704672000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Discipline Construction Project of Guangdong Medical University","award":["4SG23004G"],"award-info":[{"award-number":["4SG23004G"]}]},{"name":"Medical Industry Innovation Project of Guangdong Medical University","award":["4SG22305P"],"award-info":[{"award-number":["4SG22305P"]}]},{"name":"Key Scientific Research Projects of Colleges and Universities in Guangdong Province","award":["2020ZDZX2031"],"award-info":[{"award-number":["2020ZDZX2031"]}]},{"name":"Dongguan Science and Technology of Social Development Program","award":["20211800905082"],"award-info":[{"award-number":["20211800905082"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Biol Inorg Chem"],"DOI":"10.1007\/s00775-023-02039-5","type":"journal-article","created":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T06:03:07Z","timestamp":1704693787000},"page":"265-278","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Lysosome-targeted ruthenium(II) complex encapsulated with pluronic\u00ae F-127 induces oncosis in A549 cells"],"prefix":"10.1007","volume":"29","author":[{"given":"Nanlian","family":"Pan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minying","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijun","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xide","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuling","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ciling","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zunnan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,1,8]]},"reference":[{"key":"2039_CR1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660","author":"H Sung","year":"2021","unstructured":"Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F (2021) Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. https:\/\/doi.org\/10.3322\/caac.21660","journal-title":"CA Cancer J Clin"},{"key":"2039_CR2","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1080\/14737140.2020.1760094","volume":"20","author":"N Giaj-Levra","year":"2022","unstructured":"Giaj-Levra N, Borghetti P, Bruni A, Ciammella P, Cuccia F, Fozza A, Franceschini D, Scotti V, Vagge S, Alongi F (2022) Current radiotherapy techniques in NSCLC: challenges and potential solutions. Expert Rev Anticancer 20:387\u2013402","journal-title":"Expert Rev Anticancer"},{"key":"2039_CR3","doi-asserted-by":"publisher","DOI":"10.1111\/imm.13562","author":"H Sadeghirad","year":"2022","unstructured":"Sadeghirad H, Bahrami T, Layeghi SM, Yousefi H, Rezaei M, Hosseini-Fard SR, Radfar P, Warkiani ME, O\u2019Byrne K, Kulasinghe A (2022) Immunotherapeutic targets in non-small cell lung cancer. Immunology. https:\/\/doi.org\/10.1111\/imm.13562","journal-title":"Immunology"},{"key":"2039_CR4","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1038\/s41571-021-00501-4","volume":"18","author":"JE Chaft","year":"2021","unstructured":"Chaft JE, Rimner A, Weder W, Azzoli CG, Kris MG, Cascone T (2021) Evolution of systemic therapy for stages I-III non-metastatic non-small-cell lung cancer. Nat Rev Clin Oncol 18:547\u2013557","journal-title":"Nat Rev Clin Oncol"},{"key":"2039_CR5","doi-asserted-by":"publisher","first-page":"1035217","DOI":"10.3389\/fphar.2022.1035217","volume":"13","author":"C Zhang","year":"2022","unstructured":"Zhang C, Kang T, Wang X, Song J, Zhang J, Li G (2022) Stimuli-responsive platinum and ruthenium complexes for lung cancer therapy. Front Pharmacol 13:1035217","journal-title":"Front Pharmacol"},{"key":"2039_CR6","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2019.102925","volume":"88","author":"S Ghosh","year":"2019","unstructured":"Ghosh S (2019) Cisplatin: the first metal based anticancer drug. Bioorg Chem 88:102925","journal-title":"Bioorg Chem"},{"key":"2039_CR7","doi-asserted-by":"publisher","first-page":"953","DOI":"10.2147\/IJN.S225038","volume":"15","author":"MH Zheng","year":"2020","unstructured":"Zheng MH, Bigdeli F, Gao LX, Wu DZ, Yan XW, Hu ML, Morsali A (2020) Synthesis, characterization and DNA binding investigations of a new binuclear Ag(I) complex and evaluation of its anticancer property. Int J Nanomed 15:953\u2013964","journal-title":"Int J Nanomed"},{"key":"2039_CR8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2021.111382","volume":"217","author":"M Kozsup","year":"2021","unstructured":"Kozsup M, Zhou X, Farkas E, B\u00e9nyei AC, Bonnet S, Patonay T, K\u00f3nya K, Bugly\u00f3 P (2021) Synthesis, characterization and cytotoxicity studies of co(III)-flavonolato complexes. J Inorg Biochem 217:111382","journal-title":"J Inorg Biochem"},{"key":"2039_CR9","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.01.047","volume":"112","author":"L Polloni","year":"2019","unstructured":"Polloni L, Seni Silva AC, Teixeira SC, Azevedo FVPV, Z\u00f3ia MAP, Silva MSD, Lima PMAP, Correia LIV, Almeida JDC, Silva CVD, Rodrigues \u00c1vila VM, Goulart LRF, Morelli S, Guerra W, Oliveira J\u00fanior RJ (2019) Action of copper(II) complex with \u03b2-diketone and 1,10-phenanthroline (CBP-01) on sarcoma cells and biological effects under cell death. Biomed Pharmacother 112:108586","journal-title":"Biomed Pharmacother"},{"key":"2039_CR10","doi-asserted-by":"publisher","first-page":"7317","DOI":"10.1039\/C7CS00356K","volume":"46","author":"A Notaro","year":"2017","unstructured":"Notaro A, Gasser G (2017) Monomeric and dimeric coordinatively saturated and substitutionally inert Ru(II) polypyridyl complexes as anticancer drug candidates. Chem Soc Rev 46:7317\u20137337","journal-title":"Chem Soc Rev"},{"key":"2039_CR11","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/j.ejmech.2017.06.038","volume":"138","author":"XD Song","year":"2017","unstructured":"Song XD, Kong X, He SF, Chen JX, Sun J, Chen BB, Zhao JW, Mao ZW (2017) Cyclometalated iridium(III)-guanidinium complexes as mitochondria-targeted anticancer agents. Eur J Med Chem 138:246\u2013254","journal-title":"Eur J Med Chem"},{"key":"2039_CR12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2021.113770","volume":"225","author":"J Mo","year":"2021","unstructured":"Mo J, Le Mai NP, Priefer R (2021) Evaluating the mechanisms of action and subcellular localization of ruthenium(II)-based photosensitizers. Eur J Med Chem 225:113770","journal-title":"Eur J Med Chem"},{"key":"2039_CR13","doi-asserted-by":"publisher","first-page":"2208","DOI":"10.1021\/acs.inorgchem.8b03447","volume":"58","author":"J Zhao","year":"2019","unstructured":"Zhao J, Li S, Wang X, Xu G, Gou S (2019) Dinuclear organoruthenium complexes exhibiting antiproliferative activity through DNA damage and a reactive-oxygen-species-mediated endoplasmic reticulum stress pathway. Inorg Chem 58:2208\u20132217","journal-title":"Inorg Chem"},{"key":"2039_CR14","doi-asserted-by":"publisher","first-page":"4260","DOI":"10.1021\/acs.molpharmaceut.9b00608","volume":"16","author":"R Ilmi","year":"2019","unstructured":"Ilmi R, Tseriotou E, Stylianou P, Christou YA, Georgiades SN (2019) A novel conjugate of bis[((4-bromophenyl)amino)quinazoline], a EGFR-TK Ligand, with a fluorescent Ru(II)-bipyridine complex exhibits specific subcellular localization in mitochondria. Mol Pharm 16:4260\u20134273","journal-title":"Mol Pharm"},{"key":"2039_CR15","doi-asserted-by":"publisher","first-page":"10498","DOI":"10.1021\/acs.inorgchem.8b01944","volume":"57","author":"Z Tian","year":"2018","unstructured":"Tian Z, Li J, Zhang S, Xu Z, Yang Y, Kong D, Zhang H, Ge X, Zhang J, Liu Z (2018) Lysosome-targeted chemotherapeutics: half-sandwich ruthenium(II) complexes that are selectively toxic to cancer cells. Inorg Chem 57:10498\u201310502","journal-title":"Inorg Chem"},{"key":"2039_CR16","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1038\/s41422-019-0164-5","volume":"29","author":"DL Tang","year":"2019","unstructured":"Tang DL, Kang R, Berghe TV, Vandenabeele P, Kroemer G (2019) The molecular machinery of regulated cell death. Cell Res 29:347\u2013364","journal-title":"Cell Res"},{"key":"2039_CR17","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.821855","volume":"10","author":"TM Holm","year":"2022","unstructured":"Holm TM, Yeo S, Turner KM, Guan JL (2022) Targeting autophagy in thyroid cancer: EMT, apoptosis, and cancer stem cells. Front Cell Dev Biol 10:821855","journal-title":"Front Cell Dev Biol"},{"key":"2039_CR18","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1038\/s41423-022-00905-x","volume":"19","author":"X Wei","year":"2022","unstructured":"Wei X, Xie F, Zhou X, Wu Y, Yan H, Liu T, Huang J, Wang F, Zhou F, Zhang L (2022) Role of pyroptosis in inflammation and cancer. Cell Mol Immunol 19:971\u2013992","journal-title":"Cell Mol Immunol"},{"key":"2039_CR19","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.920059","volume":"13","author":"C Zhang","year":"2022","unstructured":"Zhang C, Liu N (2022) Ferroptosis, necroptosis, and pyroptosis in the occurrence and development of ovarian cancer. Front Immunol 13:920059","journal-title":"Front Immunol"},{"key":"2039_CR20","first-page":"3","volume":"146","author":"G Majno","year":"1995","unstructured":"Majno G, Joris I (1995) Apoptosis, oncosis, and necrosis, an overview of cell death. Am J Pathol 146:3\u201315","journal-title":"Am J Pathol"},{"key":"2039_CR21","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1016\/j.yexmp.2012.09.018","volume":"93","author":"P Weerasinghe","year":"2012","unstructured":"Weerasinghe P, Buja LM (2012) Oncosis: an important non-apoptotic mode of cell death. Exp Mol Pathol 93:302\u2013308","journal-title":"Exp Mol Pathol"},{"key":"2039_CR22","doi-asserted-by":"publisher","first-page":"11823","DOI":"10.1021\/acs.inorgchem.0c01880","volume":"59","author":"H Yao","year":"2020","unstructured":"Yao H, Chen S, Deng Z, Tse MK, Matsuda Y, Zhu G (2020) BODI-Pt, a green-light-activatable and carboplatin-based platinum(IV) anticancer prodrug with enhanced activation and cytotoxicity. Inorg Chem 59:11823\u201311833","journal-title":"Inorg Chem"},{"key":"2039_CR23","doi-asserted-by":"publisher","first-page":"4362","DOI":"10.2174\/1381612825666190112162817","volume":"24","author":"C Faustino","year":"2018","unstructured":"Faustino C, Neto \u00cd, Fonte P, Macedo A (2018) Cytotoxicity and chemotherapeutic potential of natural rosin abietane diterpenoids and their synthetic derivatives. Curr Pharm Des 24:4362\u20134375","journal-title":"Curr Pharm Des"},{"key":"2039_CR24","doi-asserted-by":"publisher","first-page":"6290","DOI":"10.1073\/pnas.95.11.6290","volume":"95","author":"C Zhang","year":"1998","unstructured":"Zhang C, Xu Y, Gu J, Schlossman SF (1998) A cell surface receptor defined by a mAb mediates a unique type of cell death similar to oncosis. Proc Natl Acad Sci USA 95:6290\u20136295","journal-title":"Proc Natl Acad Sci USA"},{"key":"2039_CR25","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1146\/annurev.pharmtox.44.101802.121804","volume":"44","author":"X Liu","year":"2004","unstructured":"Liu X, Vleet TV, Schnellmann RG (2004) The role of calpain in oncotic cell death. Annu Rev Pharmacol Toxicol 44:349\u2013370","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"2039_CR26","doi-asserted-by":"publisher","first-page":"11865","DOI":"10.1002\/chem.201501675","volume":"21","author":"A Wragg","year":"2015","unstructured":"Wragg A, Gill MR, McKenzie L, Glover C, Mowll R, Weinstein JA, Su X, Smythe C, Thomas JA (2015) Serum albumin binding inhibits nuclear uptake of luminescent metal-complex-based DNA imaging probes. Chem Eur J 21:11865\u201311871","journal-title":"Chem Eur J"},{"key":"2039_CR27","doi-asserted-by":"publisher","first-page":"2925","DOI":"10.1021\/jacs.8b09999","volume":"141","author":"PJ Jarman","year":"2019","unstructured":"Jarman PJ, Noakes F, Fairbanks S, Smitten K, Griffiths IK, Saeed HK, Thomas JA, Smythe C (2019) Exploring the cytotoxicity, uptake, cellular response, and proteomics of mono-and dinuclear DNA light-switch complexes. J Am Chem Soc 141:2925\u20132937","journal-title":"J Am Chem Soc"},{"key":"2039_CR28","doi-asserted-by":"publisher","first-page":"420","DOI":"10.3390\/molecules23020420","volume":"23","author":"P \u0160tarha","year":"2018","unstructured":"\u0160tarha P, Tr\u00e1vn\u00ed\u010dek Z, Van\u010do J, Dvo\u0159\u00e1k Z (2018) Half-sandwich Ru(II) and Os(II) bathophenanthroline complexes containing a releasable dichloroacetato ligand. Molecules 23:420","journal-title":"Molecules"},{"key":"2039_CR29","doi-asserted-by":"publisher","first-page":"2197","DOI":"10.1039\/C8DT02236D","volume":"47","author":"J Pracharova","year":"2018","unstructured":"Pracharova J, Novohradsky V, Kostrhunova H, \u0160tarha P, Tr\u00e1vn\u00ed\u010dek Z, Kasparkova J, Brabec V (2018) Half-sandwich Os(II) and Ru(II) bathophenanthroline complexes: anticancer drug candidates with unusual potency and a cellular activity profile in highly invasive triple-negative breast cancer cells. Dalton Trans 47:2197\u201312208","journal-title":"Dalton Trans"},{"key":"2039_CR30","doi-asserted-by":"publisher","first-page":"18971","DOI":"10.1002\/chem.201803630","volume":"24","author":"Y Zheng","year":"2018","unstructured":"Zheng Y, Zhang DY, Zhang H, Cao JJ, Tan CP, Ji LN, Mao ZW (2018) Photodamaging of mitochondrial DNA to overcome cisplatin resistance by a RuII\u2013PtII bimetallic complex. Chem Eur J 24:18971\u201318980","journal-title":"Chem Eur J"},{"key":"2039_CR31","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2019.110976","volume":"205","author":"Y Li","year":"2020","unstructured":"Li Y, Wang KN, He L, Ji LN, Mao ZW (2020) Synthesis, photophysical and anticancer properties of mitochondria-targeted phosphorescent cyclometalated iridium(III) N-heterocyclic carbene complexes. J Inorg Biochem 205:110976","journal-title":"J Inorg Biochem"},{"key":"2039_CR32","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1021\/ja0677564","volume":"129","author":"CA Puckett","year":"2007","unstructured":"Puckett CA, Barton JK (2007) Methods to explore cellular uptake of ruthenium complexes. J Am Chem Soc 129:46\u201347","journal-title":"J Am Chem Soc"},{"key":"2039_CR33","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.jinorgbio.2018.01.003","volume":"180","author":"AF Tikum","year":"2018","unstructured":"Tikum AF, Jeon YJ, Lee JH, Park MH, Bae IY, Kim SH, Lee HJ, Kim J (2018) Cytotoxic and anticancer properties of new ruthenium polypyridyl complexes with different lipophilicities. J Inorg Biochem 180:204\u2013210","journal-title":"J Inorg Biochem"},{"key":"2039_CR34","doi-asserted-by":"publisher","first-page":"8890950","DOI":"10.1155\/2020\/8890950","volume":"2020","author":"JC Chen","year":"2020","unstructured":"Chen JC, Wang J, Deng YY, Wang T, Miao TF, Li CP, Cai XH, Liu Y, Henri J, Chen LM (2020) Ru(II) complexes bearing o, o-chelated ligands induced apoptosis in A549 cells through the mitochondrial apoptotic pathway. Bioinorg Chem Appl 2020:8890950","journal-title":"Bioinorg Chem Appl"},{"key":"2039_CR35","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.colsurfb.2006.10.038","volume":"55","author":"T Tsukagoshi","year":"2007","unstructured":"Tsukagoshi T, Kondo Y, Yoshino N (2007) Preparation of thin polymer films with drug release and protein adsorption resistance. Colloid Surf B 55:19\u201325","journal-title":"Colloid Surf B"},{"key":"2039_CR36","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/S0928-0987(00)00166-4","volume":"11","author":"VP Torchilin","year":"2000","unstructured":"Torchilin VP (2000) Drug targeting. Eur J Pharm Sci 11:81\u201391","journal-title":"Eur J Pharm Sci"},{"key":"2039_CR37","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1038\/nnano.2011.166","volume":"6","author":"H Cabral","year":"2011","unstructured":"Cabral H, Matsumoto Y, Mizuno K, Chen Q, Murakami M, Kimura M, Terada Y, Kano MR, Miyazono K, Uesaka M, Nishiyama N, Kataoka K (2011) Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size. Nat Nanotechnol 6:815\u2013823","journal-title":"Nat Nanotechnol"},{"key":"2039_CR38","doi-asserted-by":"publisher","first-page":"7044","DOI":"10.1039\/D0DT01412E","volume":"49","author":"Y Wen","year":"2020","unstructured":"Wen Y, Ouyang C, Li QW, Rees TW, Qiu KQ, Ji LN, Chao H (2020) Synthesis, characterization and anticancer mechanism studies of fluorinated cyclometalated ruthenium(II) complexes. Dalton Trans 49:7044\u20137052","journal-title":"Dalton Trans"},{"key":"2039_CR39","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.jinorgbio.2018.11.015","volume":"191","author":"L Xu","year":"2019","unstructured":"Xu L, Zhang PP, Fang XQ, Liu Y, Wang JQ, Zhou HZ, Chen ST, Chao H (2019) A ruthenium(II) complex containing a p-cresol group induces apoptosis in human cervical carcinoma cells through endoplasmic reticulum stress and reactive oxygen species production. J Inorg Biochem 191:126\u2013134","journal-title":"J Inorg Biochem"},{"key":"2039_CR40","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1590\/1519-6984.228437","volume":"81","author":"E Obeng","year":"2021","unstructured":"Obeng E (2021) Apoptosis (programmed cell death) and its signals\u2014a review. Braz J Biol 81:1133\u20131143","journal-title":"Braz J Biol"},{"key":"2039_CR41","first-page":"39","volume":"2","author":"G Yan","year":"2020","unstructured":"Yan G, Elbadawi M, Efferth T (2020) Multiple cell death modalities and their key features. World Acad Sci J 2:39\u201348","journal-title":"World Acad Sci J"},{"key":"2039_CR42","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1038\/nrm2312","volume":"9","author":"RC Taylor","year":"2008","unstructured":"Taylor RC, Cullen SP, Martin SJ (2008) Apoptosis: controlled demolition at the cellular level. Nat Rev Mol Cell Biol 9:231\u2013241","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2039_CR43","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1016\/j.ijbiomac.2021.09.101","volume":"191","author":"SR Kabir","year":"2021","unstructured":"Kabir SR, Islam J, Ahamed MS, Alam MT (2021) Asparagus racemosus and Geodorum densiflorum lectins induce apoptosis in cancer cells by altering proteins and genes expression. Int J Biol Macromol 191:646\u2013656","journal-title":"Int J Biol Macromol"},{"key":"2039_CR44","first-page":"8979904","volume":"2022","author":"Y Wang","year":"2022","unstructured":"Wang Y, Bao D, Dong Y, Wei X, Yu J, Niu C (2022) \u03b1-Lipoic acid-plus ameliorates endothelial injury by inhibiting the apoptosis pathway mediated by intralysosomal cathepsins in an in vivo and in vitro endothelial injury model. Oxid Med Cell Longev 2022:8979904","journal-title":"Oxid Med Cell Longev"},{"key":"2039_CR45","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1161\/01.ATV.18.2.177","volume":"18","author":"W Li","year":"1998","unstructured":"Li W, Yuan XM, Olsson AG, Brunk UT (1998) Uptake of oxidized LDL by macrophages results in partial lysosomal enzyme inactivation and relocation. Arterioscler Thromb Vasc Biol 18:177\u2013184","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2039_CR46","doi-asserted-by":"publisher","first-page":"1433","DOI":"10.3390\/antiox11081433","volume":"11","author":"SY Hsu","year":"2022","unstructured":"Hsu SY, Wen ZH, Shih PC, Kuo HM, Lin SC, Liu HT, Lee YH, Wang YJ, Chen WF, Chen NF (2022) Sinularin induces oxidative stress-mediated apoptosis and mitochondrial dysfunction, and inhibits angiogenesis in glioblastoma cells. Antioxidants (Basel) 11:1433","journal-title":"Antioxidants (Basel)"},{"key":"2039_CR47","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1016\/j.tcb.2020.03.002","volume":"30","author":"IS Harris","year":"2020","unstructured":"Harris IS, DeNicola GM (2020) The complex interplay between antioxidants and ROS in cancer. Trends Cell Biol 30:440\u2013451","journal-title":"Trends Cell Biol"},{"key":"2039_CR48","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2019.119280","volume":"216","author":"GG Yang","year":"2019","unstructured":"Yang GG, Zhou DJ, Pan ZY, Yang J, Zhang DY, Cao Q, Ji LN, Mao ZW (2019) Multifunctional low-temperature photothermal nanodrug with in vivo clearance, ROS-scavenging and anti-inflammatory abilities. Biomaterials 216:119280","journal-title":"Biomaterials"},{"key":"2039_CR49","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2020.114282","volume":"182","author":"T Rodrigues","year":"2020","unstructured":"Rodrigues T, Ferraz LS (2020) Therapeutic potential of targeting mitochondrial dynamics in cancer. Biochem Pharmacol 182:114282","journal-title":"Biochem Pharmacol"},{"key":"2039_CR50","doi-asserted-by":"publisher","first-page":"5637","DOI":"10.3390\/ijms23105637","volume":"23","author":"YS Cho","year":"2022","unstructured":"Cho YS (2022) Genipin, an inhibitor of UCP2 as a promising new anticancer agent: a review of the literature. Int J Mol Sci 23:5637","journal-title":"Int J Mol Sci"},{"key":"2039_CR51","volume":"2014","author":"G Zhang","year":"2014","unstructured":"Zhang G, Jiang C, Wang Z, Chen W, Gu W, Ding Y (2014) Dehydroabietic acid derivative QC2 induces oncosis in hepatocellular carcinoma cells. Biomed Res Int 2014:682197","journal-title":"Biomed Res Int"},{"key":"2039_CR52","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/S0021-9150(96)06037-6","volume":"130","author":"M Crisby","year":"1997","unstructured":"Crisby M, Kallin B, Thyberg J, Zhivotovsky B, Orrenius S, Kostulas V, Nilsson J (1997) Cell death in human atherosclerotic plaques involves both oncosis and apoptosis. Atherosclerosis 130:17\u201327","journal-title":"Atherosclerosis"},{"key":"2039_CR53","doi-asserted-by":"publisher","first-page":"9778","DOI":"10.1073\/pnas.171322898","volume":"98","author":"F Ma","year":"2001","unstructured":"Ma F, Zhang C, Prasad KV, Freeman GJ, Schlossman SF (2001) Molecular cloning of Porimin, a novel cell surface receptor mediating oncotic cell death. Proc Natl Acad Sci USA 98:9778\u20139783","journal-title":"Proc Natl Acad Sci USA"},{"key":"2039_CR54","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1021\/acs.inorgchem.9b03006","volume":"59","author":"Y Yang","year":"2020","unstructured":"Yang Y, Guo L, Ge X, Zhu T, Chen W, Zhou H, Zhao L, Liu Z (2020) The fluorine effect in zwitterionic half-sandwich iridium(III) anticancer complexes. Inorg Chem 59:748\u2013758","journal-title":"Inorg Chem"},{"key":"2039_CR55","doi-asserted-by":"publisher","first-page":"3111","DOI":"10.1016\/j.bmc.2009.03.009","volume":"17","author":"SW Chen","year":"2009","unstructured":"Chen SW, Xiang R, Liu J, Tian X (2009) Synthesis and biological evaluation of novel conjugates of podophyllotoxin and 5-FU as antineoplastic agents. Bioorg Med Chem 17:3111\u20133117","journal-title":"Bioorg Med Chem"},{"key":"2039_CR56","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2022.111729","volume":"229","author":"NL Pan","year":"2022","unstructured":"Pan NL, Liao JX, Huang MY, Zhang YQ, Chen JX, Zhang ZW, Yang ZX, Long XE, Wu XT, Sun J (2022) Lysosome-targeted ruthenium(II) complexes induce both apoptosis and autophagy in HeLa cells. J Inorg Biochem 229:111729","journal-title":"J Inorg Biochem"},{"key":"2039_CR57","doi-asserted-by":"publisher","first-page":"3334","DOI":"10.1021\/ic50190a006","volume":"17","author":"BP Sullivan","year":"1978","unstructured":"Sullivan BP, Salmon DJ, Meyer TJ (1978) Mixed phosphine 2,2\u2032-bipyridine complexes of ruthenium. Inorg Chem 17:3334\u20133341","journal-title":"Inorg Chem"},{"key":"2039_CR58","doi-asserted-by":"publisher","first-page":"5919","DOI":"10.1021\/ja00041a002","volume":"114","author":"RM Hartshorn","year":"1992","unstructured":"Hartshorn RM, Barton JK (1992) Novel dipyridophenazine complexes of ruthenium(II): exploring luminescent reporters of DNA. J Am Chem Soc 114:5919\u20135925","journal-title":"J Am Chem Soc"},{"key":"2039_CR59","doi-asserted-by":"publisher","first-page":"11711","DOI":"10.1021\/bi800856t","volume":"47","author":"CA Puckett","year":"2008","unstructured":"Puckett CA, Barton JK (2008) Mechanism of cellular uptake of a ruthenium polypyridyl complex. Biochemistry-US 47:11711\u201311716","journal-title":"Biochemistry-US"}],"container-title":["JBIC Journal of Biological Inorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00775-023-02039-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00775-023-02039-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00775-023-02039-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T23:35:41Z","timestamp":1715902541000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00775-023-02039-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,8]]},"references-count":59,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2024,3]]}},"alternative-id":["2039"],"URL":"https:\/\/doi.org\/10.1007\/s00775-023-02039-5","relation":{},"ISSN":["1432-1327"],"issn-type":[{"value":"1432-1327","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,8]]},"assertion":[{"value":"7 June 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 October 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 January 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing financial interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}