{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T07:19:21Z","timestamp":1769152761181,"version":"3.49.0"},"reference-count":27,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:00:00Z","timestamp":1404172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Orthopaedic Science"],"published-print":{"date-parts":[[2014,7]]},"DOI":"10.1007\/s00776-014-0557-8","type":"journal-article","created":{"date-parts":[[2014,3,25]],"date-time":"2014-03-25T06:22:27Z","timestamp":1395728547000},"page":"646-656","source":"Crossref","is-referenced-by-count":18,"title":["Zoledronic acid in combination with alfacalcidol has additive effects on trabecular microarchitecture and mechanical properties in osteopenic ovariectomized rats"],"prefix":"10.1016","volume":"19","author":[{"given":"Deepak Kumar","family":"Khajuria","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rema","family":"Razdan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debiprosad Roy","family":"Mahapatra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1007\/s00776-014-0557-8_bb0010","first-page":"365","article-title":"Drugs for the management of osteoporosis: a review","volume":"51","author":"Khajuria","year":"2011","journal-title":"Rev Bras Reumatol"},{"key":"10.1007\/s00776-014-0557-8_bb0015","doi-asserted-by":"crossref","first-page":"2311","DOI":"10.2165\/00003495-200767160-00002","article-title":"Hormone therapy for the prevention of bone loss in menopausal women with osteopenia: is it a viable option?","volume":"67","author":"Hohenhaus","year":"2007","journal-title":"Drugs"},{"key":"10.1007\/s00776-014-0557-8_bb0020","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1056\/NEJMoa067312","article-title":"Cummings SR. Once-yearly zoledronic acid for treatment of postmenopausal osteoporosis","volume":"356","author":"Black","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1007\/s00776-014-0557-8_bb0025","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1359\/jbmr.2000.15.8.1467","article-title":"Protein geranylgeranylation is required for osteoclast formation, function, and survival: inhibition by bisphosphonates and GGTI-298","volume":"15","author":"Coxon","year":"2000","journal-title":"J Bone Miner Res"},{"key":"10.1007\/s00776-014-0557-8_bb0030","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1200\/JCO.1991.9.3.509","article-title":"Bone metastasis: patho-physiology and management policy","volume":"9","author":"Nielson","year":"1991","journal-title":"J Clin Oncol"},{"key":"10.1007\/s00776-014-0557-8_bb0035","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/S8756-3282(01)00412-4","article-title":"Visualization of bisphosphonate induced caspase-3 activity in apoptotic osteoclasts in vitro","volume":"28","author":"Benford","year":"2001","journal-title":"Bone"},{"key":"10.1007\/s00776-014-0557-8_bb0040","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1007\/s00776-013-0433-y","article-title":"Osteopro-tective effect of propranolol in ovariectomized rats: a comparison with zoledronic acid and alfacalcidol","volume":"18","author":"Khajuria","year":"2013","journal-title":"J Orthop Sci"},{"key":"10.1007\/s00776-014-0557-8_bb0045","first-page":"968","article-title":"Comparative evaluation of zoledronic acid, alfacalcidol, and propranolol in pharmacological correction of experimental osteoporosis","volume":"32","author":"Khajuria","year":"2013","journal-title":"Lat Am J Pharm"},{"key":"10.1007\/s00776-014-0557-8_bb0050","doi-asserted-by":"crossref","DOI":"10.3797\/scipharm.1310-06","article-title":"Prophylactic effects of propranolol versus standard therapy on a new model of disuse osteoporosis in rats","author":"Khajuria","year":"2014","journal-title":"Sci Pharm"},{"key":"10.1007\/s00776-014-0557-8_bb0055","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1007\/BF02409500","article-title":"Immobilization osteoporosis and active vitamin D: effect of active vitamin D analogs on the development of immobilization osteoporosis in rats","volume":"33","author":"Izawa","year":"1981","journal-title":"Calcif Tissue Int"},{"key":"10.1007\/s00776-014-0557-8_bb0060","first-page":"137-W","article-title":"Combination treatment in osteoporosis. Basic treatment plus specific osteoporosis medication","volume":"32","author":"Ringe","year":"2009","journal-title":"Med Monatsschr Pharm"},{"key":"10.1007\/s00776-014-0557-8_bb0065","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s00774-009-0148-5","article-title":"Effects of combination treatment with alendronate and vitamin K (2) on bone mineral density and strength in ovariectomized mice","volume":"28","author":"Sasaki","year":"2010","journal-title":"J Bone Miner Metab"},{"key":"10.1007\/s00776-014-0557-8_bb0070","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/j.bone.2012.02.005","article-title":"Combination therapy with alendronate and eldecalcitol has therapeutic advantages over monotherapy by improving bone strength","volume":"50","author":"Sakai","year":"2012","journal-title":"Bone"},{"key":"10.1007\/s00776-014-0557-8_bb0075","first-page":"174","article-title":"Combined therapies in osteoporosis: bisphosphonates and vitamin D-hormone analogs","volume":"7","author":"Schacht","year":"2007","journal-title":"J Musculoskelet Neuronal Interact"},{"key":"10.1007\/s00776-014-0557-8_bb0080","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1007\/s00296-006-0288-z","article-title":"Superiority of a combined treatment of alendronate and alfacalcidol compared to the combination of alendronate and plain vitamin D or alfacal-cidol alone in established postmenopausal or male osteoporosis(AAC-Trial)","volume":"27","author":"Ringe","year":"2007","journal-title":"Rheumatol Int"},{"key":"10.1007\/s00776-014-0557-8_bb0085","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1359\/jbmr.2002.17.8.1498","article-title":"Phipps R. Prevention of bone loss in ovari-ectomized rats by combined treatment with risedronate and 1 a,25-dihydroxyvitamin D3","volume":"17","author":"Erben","year":"2002","journal-title":"J Bone Miner Res"},{"key":"10.1007\/s00776-014-0557-8_bb0090","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1590\/S0482-50042012000300016","article-title":"Description of a new method of ovariectomy in female rats","volume":"52","author":"Khajuria","year":"2012","journal-title":"Rev Bras Reumatol"},{"key":"10.1007\/s00776-014-0557-8_bb0095","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1093\/clinchem\/47.1.74","article-title":"Tartrate-resistant acid phosphatase isoform 5b as serum marker for osteoclastic activity","volume":"47","author":"Janckila","year":"2001","journal-title":"Clin Chem"},{"issue":"13","key":"10.1007\/s00776-014-0557-8_bb0100","first-page":"9","article-title":"The role of bone turnover in the pathophysiology of osteoporosis","volume":"103","author":"Riis","year":"1996","journal-title":"Br J Obstet Gynaecol"},{"key":"10.1007\/s00776-014-0557-8_bb0105","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/BF01880414","article-title":"Screening procedure for women at risk of developing post menopausal osteoporosis","volume":"1","author":"Christiansen","year":"1990","journal-title":"Osteoporos Int"},{"key":"10.1007\/s00776-014-0557-8_bb0110","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1136\/bmj.303.6808.961","article-title":"Role of peak bone mass and bone loss in postmenopausal osteoporosis","volume":"303","author":"Hansen","year":"1991","journal-title":"Br Med J"},{"key":"10.1007\/s00776-014-0557-8_bb0115","first-page":"143","article-title":"Calcium status in premenopausal and postmenopausal women","volume":"22","author":"Qureshi","year":"2010","journal-title":"J Ayub Med Coll Abbottabad"},{"key":"10.1007\/s00776-014-0557-8_bb0120","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.jep.2010.12.013","article-title":"Goplakhrishna B. Anti-osteoporotic activity of aqueous-methanol extract of Berberis aristata in ovariectomized rats","volume":"134","author":"Yogesh","year":"2011","journal-title":"J Ethnopharmacol"},{"issue":"14","key":"10.1007\/s00776-014-0557-8_bb0125","first-page":"175","article-title":"Skeletal response of ovariecto-mized rats to low and high doses of 17b-estradiol","volume":"1991","author":"Kalu","year":"1991","journal-title":"Bone Miner"},{"issue":"2","key":"10.1007\/s00776-014-0557-8_bb0130","first-page":"210","article-title":"Evidence for a prospective anti-osteoporosis effect of black tea (Camellia sinensis) extract in a bilaterally ovariectomized rat model","volume":"13","author":"Das","year":"2004","journal-title":"Asia Pac J Clin Nutr"},{"key":"10.1007\/s00776-014-0557-8_bb0135","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1359\/jbmr.81005","article-title":"Prolonged treatments with antiresorptive agents and PTH have different effects on bone strength and the degree of mineralization in old estrogen-deficient osteoporotic rats","volume":"24","author":"Cheng","year":"2009","journal-title":"J Bone Miner Res"},{"key":"10.1007\/s00776-014-0557-8_bb0140","doi-asserted-by":"crossref","first-page":"96","DOI":"10.14310\/horm.2002.1226","article-title":"Bisphosphonate-associated adverse events","volume":"8","author":"Papapetrou","year":"2009","journal-title":"Hormones"}],"container-title":["Journal of Orthopaedic Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0949265815302402?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0949265815302402?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00776-014-0557-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,16]],"date-time":"2020-08-16T19:38:02Z","timestamp":1597606682000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0949265815302402"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7]]},"references-count":27,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["S0949265815302402"],"URL":"https:\/\/doi.org\/10.1007\/s00776-014-0557-8","relation":{},"ISSN":["0949-2658"],"issn-type":[{"value":"0949-2658","type":"print"}],"subject":[],"published":{"date-parts":[[2014,7]]}}}