{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T11:45:45Z","timestamp":1771328745628,"version":"3.50.1"},"reference-count":26,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2000,11,1]],"date-time":"2000-11-01T00:00:00Z","timestamp":973036800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Orthopaedic Science"],"published-print":{"date-parts":[[2000,11]]},"DOI":"10.1007\/s007760070008","type":"journal-article","created":{"date-parts":[[2003,2,12]],"date-time":"2003-02-12T18:05:56Z","timestamp":1045073156000},"page":"572-578","source":"Crossref","is-referenced-by-count":34,"title":["Activation of nuclear factor \u03baB at the onset of ossification of the spinal ligaments"],"prefix":"10.1016","volume":"5","author":[{"given":"Taiichi","family":"Kosaka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsuhiro","family":"Imakiire","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumio","family":"Mizuno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kengo","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1007\/s007760070008_bb0010","first-page":"67","article-title":"Involvement of NF-\u03baB associated proteins in FGF-mediated mesoderm induction","volume":"42","author":"Beck","year":"1998","journal-title":"Int J Devel Biol"},{"key":"10.1007\/s007760070008_bb0015","doi-asserted-by":"crossref","first-page":"5815","DOI":"10.4049\/jimmunol.158.12.5815","article-title":"A tandem GC box motif is necessary for lipopolysaccharide-induced transcription of the type II TNF receptor gene","volume":"158","author":"Bethea","year":"1997","journal-title":"J Immunol"},{"key":"10.1007\/s007760070008_bb0020","first-page":"1725","article-title":"Growth promoting peptides in osteoarthritis and diffuse idiopathic skeletal hyperostosis \u2014 insulin, insulin-like growth factor-I, growth hormone","volume":"21","author":"Denko","year":"1994","journal-title":"J Rheu-matol"},{"key":"10.1007\/s007760070008_bb0025","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1093\/nar\/11.5.1475","article-title":"Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalism nuclei","volume":"11","author":"Dignam","year":"1983","journal-title":"Nucleic Acids Res"},{"key":"10.1007\/s007760070008_bb0030","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1136\/ard.9.4.321","article-title":"Senile ankylosing hyperostosis of the spine","volume":"9","author":"Forestier","year":"1950","journal-title":"Ann Rheum Dis"},{"key":"10.1007\/s007760070008_bb0035","doi-asserted-by":"crossref","first-page":"17417","DOI":"10.1074\/jbc.271.29.17417","article-title":"Platelet-derived growth factor induction of the immediate-early gene MCP-1 is mediated by NF-\u03baB and a 90-kDa phosphoprotein coactivator","volume":"271","author":"Freter","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1007\/s007760070008_bb0040","doi-asserted-by":"crossref","first-page":"507","DOI":"10.2337\/diab.45.4.507","article-title":"Enhanced expression of platelet-derived growth factor-\u03b2 receptor by high glucose. Involvement of platelet-derived growth factor in diabetic angio-pathy","volume":"45","author":"Inaba","year":"1996","journal-title":"Diabetes"},{"key":"10.1007\/s007760070008_bb0045","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/8756-3282(93)90232-Y","article-title":"Characterization of cultured cells derived from ossification of the posterior longitudinal ligament of the spine","volume":"14","author":"Ishida","year":"1993","journal-title":"Bone"},{"key":"10.1007\/s007760070008_bb0050","first-page":"91","article-title":"Role of NF-\u03baB\/Rel transcription factors for the differentiation and function of osteoclasts","volume":"12","author":"Jimi","year":"1998","journal-title":"The Bone"},{"key":"10.1007\/s007760070008_bb0055","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/33429","article-title":"Role of Rel\/NF\u03baB transcription factors during the outgrowth of the vertebrate limb","volume":"392","author":"Kanegae","year":"1998","journal-title":"Nature"},{"key":"10.1007\/s007760070008_bb0060","first-page":"78","article-title":"Role of activation of NF\u03baB and diseases","volume":"27","author":"Kitajima","year":"1998","journal-title":"Clin Chem"},{"key":"10.1007\/s007760070008_bb0065","series-title":"Genetic analysis of OPLL Clin Orthop Surg","first-page":"33385","author":"Koga","year":"1998"},{"key":"10.1007\/s007760070008_bb0070","doi-asserted-by":"crossref","first-page":"583","DOI":"10.2337\/diabetes.47.4.583","article-title":"Evidence for involvement of the proteasome complex (26S) and NF\u03baB in IL-1-\u03b2 induced nitric oxide and prostaglandin production by rat islets and RINm5F cells","volume":"47","author":"Kwon","year":"1998","journal-title":"Diabetes"},{"key":"10.1007\/s007760070008_bb0075","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/0003-2697(80)90165-7","article-title":"A simple, rapid, and sensitive DNA assay procedure","volume":"102","author":"Labarca","year":"1980","journal-title":"Anal Biochem"},{"key":"10.1007\/s007760070008_bb0080","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1128\/MCB.18.1.110","article-title":"Transforming growth factor \u03b2 stimulates the human immunodeficiency virus 1 enhancer and requires NF-\u03baB activity","volume":"18","author":"Li","year":"1998","journal-title":"Mol Cell Biol"},{"key":"10.1007\/s007760070008_bb0085","doi-asserted-by":"crossref","first-page":"2361","DOI":"10.1161\/01.CIR.96.7.2361","article-title":"Platelet-derived growth factor-stimulated superoxide anion production modulates activation of transcription factor NF-\u03baB and expression of monocyte chemoattractant protein 1 in human aortic smooth muscle cells","volume":"96","author":"Marumo","year":"1997","journal-title":"Circulation"},{"key":"10.1007\/s007760070008_bb0090","doi-asserted-by":"crossref","first-page":"895","DOI":"10.2337\/diab.44.8.895","article-title":"Effect of a specific endothelin receptor A antagonist on mRNA levels for extracellular matrix components and growth factors in diabetic glomeruli","volume":"44","author":"Nakamura","year":"1995","journal-title":"Diabetes"},{"key":"10.1007\/s007760070008_bb0095","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1161\/01.ATV.18.8.1199","article-title":"Relation between plasma tumor necrosis factor-\u03b1 and insulin sensitivity in elderly men with non-insulin-dependent diabetes mellitus","volume":"18","author":"Nilsson","year":"1998","journal-title":"Arterioscler Thromb"},{"key":"10.1007\/s007760070008_bb00100","first-page":"1","article-title":"Redox control mechanism and NF-\u03baB activation","volume":"15","author":"Okamoto","year":"1997","journal-title":"Cyto-protection Biol"},{"key":"10.1007\/s007760070008_bb00105","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.2337\/diacare.19.10.1113","article-title":"Elevated plasma levels of transforming growth factor-\u03b21 in NIDDM","volume":"19","author":"Pfeiffer","year":"1996","journal-title":"Diabetes Care"},{"key":"10.1007\/s007760070008_bb00110","series-title":"The Ministry of Health and Welfare of Japan","first-page":"31","article-title":"The relationship of human serum and NF-\u03baB in the cells of HIV patients. Annual report of the special study group on HIV","author":"Renard","year":"1995"},{"key":"10.1007\/s007760070008_bb00115","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1148\/15.3.513","article-title":"Diffuse idiopathic skeletal hyperostosis (DISH). Forestier's disease with extraspinal manifestations","volume":"115","author":"Resnick","year":"1975","journal-title":"Radiology"},{"key":"10.1007\/s007760070008_bb00120","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1006\/bbrc.1998.8124","article-title":"TGF-\u03b2-activated kinase 1 stimulates NF-\u03baB activation by an NF-\u03baB-inducing kinase-independent mechanism","volume":"243","author":"Sakurai","year":"1998","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1007\/s007760070008_bb00125","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1006\/bbrc.1997.7206","article-title":"Glutathione regulation of tumor necrosis factor-\u03b1-induced NF-\u03baB activation in skeletal muscle-derived L6 cells","volume":"237","author":"Sen","year":"1997","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1007\/s007760070008_bb00130","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/BF00296345","article-title":"Elevation of alkaline phosphatase activity induced by parathyroid hormone in osteoblast-like cells from the spinal hyperostotic mouse TWY (twy\/twy)","volume":"56","author":"Terakado","year":"1995","journal-title":"Calcif Tissue Int"},{"key":"10.1007\/s007760070008_bb00135","first-page":"567","article-title":"Effect of cell growth factors on the cultured spinal ligament cells; a possible pathogenesis of OPLL","volume":"33","author":"Yamasaki","year":"1998","journal-title":"Clin Orthop Surg"}],"container-title":["Journal of Orthopaedic Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0949265815334163?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0949265815334163?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.springerlink.com\/index\/pdf\/10.1007\/s007760070008","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,7]],"date-time":"2024-01-07T08:51:59Z","timestamp":1704617519000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0949265815334163"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,11]]},"references-count":26,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2000,11]]}},"alternative-id":["S0949265815334163"],"URL":"https:\/\/doi.org\/10.1007\/s007760070008","relation":{},"ISSN":["0949-2658"],"issn-type":[{"value":"0949-2658","type":"print"}],"subject":[],"published":{"date-parts":[[2000,11]]}}}