{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T12:20:54Z","timestamp":1768566054753,"version":"3.49.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2009,7,14]],"date-time":"2009-07-14T00:00:00Z","timestamp":1247529600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Oral Invest"],"published-print":{"date-parts":[[2010,2]]},"DOI":"10.1007\/s00784-009-0312-2","type":"journal-article","created":{"date-parts":[[2009,7,13]],"date-time":"2009-07-13T08:59:55Z","timestamp":1247475595000},"page":"51-58","source":"Crossref","is-referenced-by-count":50,"title":["Expression profile and synthesis of different collagen types I, II, III, and V of human gingival fibroblasts, osteoblasts, and SaOS-2 cells after bisphosphonate treatment"],"prefix":"10.1007","volume":"14","author":[{"given":"Maciej J. K.","family":"Simon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Niehoff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernhard","family":"Kimmig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f6rg","family":"Wiltfang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yahya","family":"A\u00e7il","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2009,7,14]]},"reference":[{"key":"312_CR1","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1056\/NEJM199612123352401","volume":"335","author":"GN Hortobagyi","year":"1996","unstructured":"Hortobagyi GN, Theriault RL, Porter L, Blayney D, Lipton A, Sinoff C, Wheeler H, Simeone JF, Seaman J, Knight RD, Heffernan M, Reitsma DJ, Kennedy I, Allan SG, Mellars K (1996) Efficacy of pamidronate in reducing skeletal complications in patients with breast cancer and lytic bone metastases. N Engl J Med 335:1785\u20131791","journal-title":"N Engl J Med"},{"key":"312_CR2","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1053\/ctrv.2000.0210","volume":"27","author":"RE Coleman","year":"2001","unstructured":"Coleman RE (2001) Metastatic bone disease: clinical features, pathophysiology, and treatment strategies. Cancer Treat Rev 27:165\u2013176","journal-title":"Cancer Treat Rev"},{"key":"312_CR3","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1172\/JCI0215952","volume":"110","author":"F Rauch","year":"2002","unstructured":"Rauch F, Travers R, Plotkin H, Glorieux FH (2002) The effects of intravenous pamidronate on the bone tissue of children and adolescent with osteogenesis imperfecta. J Clin Invest 110:1293\u20131299","journal-title":"J Clin Invest"},{"key":"312_CR4","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1093\/jnci\/94.19.1458","volume":"94","author":"F Saad","year":"2002","unstructured":"Saad F, Gleason DM, Murray R, Tchekmedyian S, Venner P, Lacombe L, Chen JL, Vinholes JJ, Goas JA, Chen B (2002) A randomized, placebo controlled trial of zoledronic acid in patients with hormone-refractory metastatic prostate carcinoma. J Natl Cancer Inst 94:1458\u20131468","journal-title":"J Natl Cancer Inst"},{"key":"312_CR5","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1093\/jnci\/djh141","volume":"96","author":"F Saad","year":"2004","unstructured":"Saad F, Gleason DM, Murray R, Tchekmedyian S, Venner P, Lacombe L, Chin JL, Vinholes JJ, Goas JA, Zheng M (2004) Long-term efficacy of zoledronic acid for the prevention of skeletal complications in patients with metastatic hormone-refractory prostate cancer. J Natl Cancer Inst 96:879\u2013882","journal-title":"J Natl Cancer Inst"},{"key":"312_CR6","first-page":"1351","volume":"15","author":"D Santini","year":"2006","unstructured":"Santini D, Vincenzi B, Hannon RA, Brown JE, Dicuonzo G, Angeletti S, La Cesa A, Coleman RE, Tonini G, Budillon A, Caraglia M, Ingunn H (2006) Changes in bone resorption and vascular endothelial growth factor after a single zoledronic acid infusion in cancer patients with bone metastases from solid tumours. Oncol Rep 15:1351\u20131357","journal-title":"Oncol Rep"},{"key":"312_CR7","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1097\/00001622-200211000-00004","volume":"14","author":"JR Green","year":"2002","unstructured":"Green JR (2002) Bisphosphonates in cancer therapy. Curr Opin Oncol 14:609\u2013615","journal-title":"Curr Opin Oncol"},{"key":"312_CR8","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1210\/edrv.19.1.0325","volume":"19","author":"H Fleisch","year":"1998","unstructured":"Fleisch H (1998) Bisphosphonates: mechanism of action. Endocr Rev 19:80\u2013100","journal-title":"Endocr Rev"},{"key":"312_CR9","first-page":"417","volume":"182","author":"PM Purcell","year":"2005","unstructured":"Purcell PM, Boyd IW (2005) Bisphosphonates and osteonecrosis of the jaw. MJA 182:417\u2013418","journal-title":"MJA"},{"key":"312_CR10","doi-asserted-by":"crossref","first-page":"111","DOI":"10.3816\/CLM.2008.n.013","volume":"8","author":"AM Cafro","year":"2008","unstructured":"Cafro AM (2008) Osteonecrosis of the jaw in patients with multiple myeloma treated with bisphosphonates: definition and management of the risk related to zoledronic acid. Clin Lymphoma Myeloma 8:111\u2013116","journal-title":"Clin Lymphoma Myeloma"},{"key":"312_CR11","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/S0278-2391(03)00720-1","volume":"61","author":"RE Marx","year":"2003","unstructured":"Marx RE (2003) Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic. J Oral Maxillofac Surg 61:1115\u20131118","journal-title":"J Oral Maxillofac Surg"},{"key":"312_CR12","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.joms.2004.02.004","volume":"62","author":"SL Ruggiero","year":"2004","unstructured":"Ruggiero SL, Mehrotra B, Rosenberg TJ, Engroff SL (2004) Osteonecrosis of the jaws associated with the use of bisphosphonates: a review of 63 cases. J Oral Maxillofac Surg 62:527\u2013534","journal-title":"J Oral Maxillofac Surg"},{"key":"312_CR13","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1016\/j.joms.2005.07.010","volume":"63","author":"RE Marx","year":"2005","unstructured":"Marx RE, Sawatari Y, Fortin M, Broumand V (2005) Bisphosphonate-induced exposed bone (osteonecrosis\/osteopetrosis) of the jaws: risk factors, recognition, prevention, and treatment. J Oral Maxillofac Surg 63:1567\u20131575","journal-title":"J Oral Maxillofac Surg"},{"issue":"2","key":"312_CR14","first-page":"111","volume":"71","author":"MD Melo","year":"2005","unstructured":"Melo MD, Obeid G (2005) Osteonecrosis of the maxilla in a patient with a history of bisphosphonate therapy. J Can Dent Assoc 71(2):111\u2013113","journal-title":"J Can Dent Assoc"},{"key":"312_CR15","first-page":"836","volume":"23","author":"AO Hoff","year":"2008","unstructured":"Hoff AO, Toth BB, Altundag K, Johnson MM, Warnecke CL, Hu M, Nooka A et al (2008) J Bone Miner Res 23:836\u2013836","journal-title":"J Bone Miner Res"},{"key":"312_CR16","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1111\/j.1600-051X.2005.00842.x","volume":"32","author":"F Ficarra","year":"2005","unstructured":"Ficarra F, Beninati F, Rubio I, Vannucchi A, Longo G, Tonelli P, Pini Prato G (2005) Osteonecrosis of the jaws in periodontal patients with a history of bisphosphonates treatment. J Clin Periodontol 32:1123\u20131128","journal-title":"J Clin Periodontol"},{"key":"312_CR17","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.tripleo.2006.06.057","volume":"103","author":"JY Choi","year":"2007","unstructured":"Choi JY, Kim HJ, Lee YC, Cho BU, Seong HS, Cho M, Kim SG (2007) Inhibition of bone healing by pamidronate in calvarial bone defects. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 103:321\u2013328","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"312_CR18","doi-asserted-by":"crossref","first-page":"6222","DOI":"10.1158\/1078-0432.CCR-06-0843","volume":"12","author":"AJ Roelfs","year":"2006","unstructured":"Roelfs AJ, Thompson K, Gordon S, Rogers MJ (2006) Molecular mechanisms of action of bisphosphonates: current status. Clin Cancer Res 12:6222\u20136230","journal-title":"Clin Cancer Res"},{"issue":"4","key":"312_CR19","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1002\/1097-4636(20000915)51:4<703::AID-JBM19>3.0.CO;2-A","volume":"51","author":"Y Acil","year":"2000","unstructured":"Acil Y, Terheyden H, Dunsche A, Fleiner B, Jepsen S (2000) Three-dimensional cultivation of human osteoblast-like cells on highly porous natural bone mineral. JBMR 51(4):703\u2013710","journal-title":"JBMR"},{"key":"312_CR20","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1002\/jcb.10197","volume":"86","author":"Y Acil","year":"2002","unstructured":"Acil Y, Springer IN, Broek V, Terheyden H, Jepsen S (2002) Effects of bone morphogenetic protein-7 stimulation on osteoblasts cultured on different biomaterials. J Cell Biochem 86:90\u201398","journal-title":"J Cell Biochem"},{"key":"312_CR21","first-page":"89","volume":"8","author":"Y Acil","year":"1999","unstructured":"Acil Y, Schilde K, Terheyden H, Jepsen S (1999) Biokompatibilit\u00e4t von sechs verschiedenen Knochenersatzmaterialien in der Osteoblastenzellkultur. Osteologie 8:89\u201390","journal-title":"Osteologie"},{"key":"312_CR22","first-page":"1261","volume":"17","author":"B Ramaswamy","year":"2003","unstructured":"Ramaswamy B, Shapiro CL (2003) Bisphosphonates in the prevention and treatment of bone metastasis. Oncology 17:1261\u20131270","journal-title":"Oncology"},{"key":"312_CR23","doi-asserted-by":"crossref","first-page":"063","DOI":"10.5005\/jcdp-9-1-63","volume":"1","author":"SKS Kumar","year":"2008","unstructured":"Kumar SKS, Meru MC, Sedghizadeh PP (2008) Osteonecrosis of the jaws secondary to bisphosphonate therapy: a case serious. J Contemp Dent Pract 1:063\u2013069","journal-title":"J Contemp Dent Pract"},{"key":"312_CR24","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1210\/endo.137.6.8641182","volume":"137","author":"C Vitt\u00e9","year":"1996","unstructured":"Vitt\u00e9 C, Fleisch H, Guenther HL (1996) Bisphosphonates induce osteoblasts to secrete an inhibitor of osteoclast-mediated resorption. Endocrinology 137:2324\u20132333","journal-title":"Endocrinology"},{"key":"312_CR25","first-page":"2893","volume":"9","author":"D Santini","year":"2003","unstructured":"Santini D, Vincenzi B, Dicuonzo G, Avvisati G, Massacesi C, Battistoni F, Gavasci M, Rocci L, Triindelli MC, Altomare V, Tocchini M, Bonsignori M, Tonini G (2003) Zoledronic acid induces significant and long-lasting modifications of circulating angiogenic factors in cancer patients. Clin Cancer Res 9:2893\u20132897","journal-title":"Clin Cancer Res"},{"key":"312_CR26","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/1471-2407-6-49","volume":"6","author":"MT Valenti","year":"2006","unstructured":"Valenti MT, Bertoldo F, Carbonare LD, Azzarello G, Zenari S, Zanatta M, Balducci E, Vinante O, Lo Cascio V (2006) The effect of bisphosphonates on gene expression: GAPDH as a housekeeping or a new target gene? BMC Cancer 6:49","journal-title":"BMC Cancer"},{"key":"312_CR27","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1042\/BJ20040380","volume":"384","author":"M Chaplet","year":"2004","unstructured":"Chaplet M, Detry C, Deroanne C, Fisher LW, Castronovo V, Bellahcene A (2004) Zoledronic acid up-regulates bone sialoprotein expression in osteoblastic cells through Rho GTPase inhibition. Biochemical J 384:591\u2013598","journal-title":"Biochemical J"},{"key":"312_CR28","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.4049\/jimmunol.174.4.1801","volume":"174","author":"K Takagi","year":"2005","unstructured":"Takagi K, Takagi M, Kanangat S, Warrington KJ, Shigemitsu H, Postlethwaite AE (2005) Modulation of TNF-alpha gene expression by IFN-gamma and pamidronate in murine macrophages: regulation by STAT1-dependent pathways. J Immunol 174:1801\u20131810","journal-title":"J Immunol"},{"key":"312_CR29","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1359\/jbmr.2003.18.1.78","volume":"18","author":"L Gomez-Garcia","year":"2003","unstructured":"Gomez-Garcia L, Esbrit P, Carreno L, Sabando P, Garcia-Flores M, Martinez ME (2003) Alendronate interacts with the inhibitory effect of 1, 25 (OH)2D3 on parathyroid hormone-related protein expression in human osteoblastic cells. J Bone Miner Res 18:78\u201387","journal-title":"J Bone Miner Res"},{"key":"312_CR30","first-page":"1658","volume":"136","author":"CA Migliorati","year":"2005","unstructured":"Migliorati CA, Casiglia J, Epstein J, Jacobsen PL, Siegel MA, Woo SB (2005) Managing the care of patients with bisphosphonate-associated osteonecrosis. JADA 136:1658\u20131668","journal-title":"JADA"},{"key":"312_CR31","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.joms.2007.11.035","volume":"66","author":"PP Sedghizadeh","year":"2008","unstructured":"Sedghizadeh PP, Kumar SK, Gorur A, Schaudinn C, Shuler CF, Costerton JW (2008) Identification of microbial biofilms in osteonecrosis of the jaws secondary to bisphosphonate therapy. J Oral Maxillofac Surg 66:767\u2013775","journal-title":"J Oral Maxillofac Surg"},{"key":"312_CR32","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.joms.2008.01.026","volume":"66","author":"R Landesberg","year":"2008","unstructured":"Landesberg R, Cozin M, Cremers S, Woo V, Kousteni S, Sinha S, Garrett-Sinha LA, Raghavan S (2008) Inhibition of oral mucosal cell wound healing by bisphosphonates. J Oral Maxillofac Surg 66:839\u2013847","journal-title":"J Oral Maxillofac Surg"},{"key":"312_CR33","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1016\/j.joms.2008.11.015","volume":"67","author":"TS Lazarovici","year":"2009","unstructured":"Lazarovici TS, Yahalom R, Teicher S, Elad S, Hardan I, Yarom N (2009) Bisphosphonate-related osteonecrosis of the jaws: a single-center study of 101 patients. J Oral Maxillofac Surg 67:850\u2013855","journal-title":"J Oral Maxillofac Surg"}],"container-title":["Clinical Oral Investigations"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-009-0312-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00784-009-0312-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-009-0312-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,20]],"date-time":"2020-05-20T14:16:13Z","timestamp":1589984173000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00784-009-0312-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7,14]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,2]]}},"alternative-id":["312"],"URL":"https:\/\/doi.org\/10.1007\/s00784-009-0312-2","relation":{},"ISSN":["1432-6981","1436-3771"],"issn-type":[{"value":"1432-6981","type":"print"},{"value":"1436-3771","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,7,14]]}}}