{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T21:57:36Z","timestamp":1761947856787},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2013,2,8]],"date-time":"2013-02-08T00:00:00Z","timestamp":1360281600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Oral Invest"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1007\/s00784-013-0928-0","type":"journal-article","created":{"date-parts":[[2013,2,7]],"date-time":"2013-02-07T12:09:53Z","timestamp":1360238993000},"page":"2041-2048","source":"Crossref","is-referenced-by-count":29,"title":["Endotoxins potentiate COX-2 and RANKL expression in compressed PDL cells"],"prefix":"10.1007","volume":"17","author":[{"given":"Piero","family":"R\u00f6mer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josef","family":"K\u00f6stler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vasiliki","family":"Koretsi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Proff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,2,8]]},"reference":[{"key":"928_CR1","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1093\/ejo\/cjl001","volume":"28","author":"MC Meikle","year":"2006","unstructured":"Meikle MC (2006) The tissue, cellular, and molecular regulation of orthodontic tooth movement: 100\u00a0years after Carl Sandstedt. Eur J Orthod 28:221\u2013240","journal-title":"Eur J Orthod"},{"key":"928_CR2","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1471-2121-11-10","volume":"11","author":"N Ziegler","year":"2010","unstructured":"Ziegler N, Alonso A, Steinberg T, Woodnutt D, Kohl A, M\u00fcssig E et al (2010) Mechano-transduction in periodontal ligament cells identifies activated states of MAP-kinases p42\/44 and p38-stress kinase as a mechanism for MMP-13 expression. BMC Cell Biol 11:10","journal-title":"BMC Cell Biol"},{"key":"928_CR3","doi-asserted-by":"crossref","first-page":"592","DOI":"10.2319\/090310-519.1","volume":"81","author":"S Premaraj","year":"2011","unstructured":"Premaraj S, Souza I, Premaraj T (2011) Mechanical loading activates \u03b2-catenin signaling in periodontal ligament cells. Angle Orthod 81:592\u2013599","journal-title":"Angle Orthod"},{"key":"928_CR4","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1177\/154405910608500812","volume":"85","author":"M Yamaguchi","year":"2006","unstructured":"Yamaguchi M, Aihara N, Kojima T, Kasai K (2006) RANKL increase in compressed periodontal ligament cells from root resorption. J Dent Res 85:751\u2013756","journal-title":"J Dent Res"},{"key":"928_CR5","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s00784-009-0268-2","volume":"13","author":"P Proff","year":"2009","unstructured":"Proff P, R\u00f6mer P (2009) The molecular mechanism behind bone remodelling: a review. Clin Oral Investig 13:355\u2013362","journal-title":"Clin Oral Investig"},{"key":"928_CR6","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/j.1601-6343.2009.01444.x","volume":"12","author":"M Yamaguchi","year":"2009","unstructured":"Yamaguchi M (2009) RANK\/RANKL\/OPG during orthodontic tooth movement. Orthod Craniofac Res 12:113\u2013119","journal-title":"Orthod Craniofac Res"},{"key":"928_CR7","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1902\/jop.2004.75.12.1647","volume":"75","author":"S Tiranathanagul","year":"2004","unstructured":"Tiranathanagul S, Yongchaitrakul T, Pattamapun K, Pavasant P (2004) Actinobacillus actinomycetemcomitans lipopolysaccharide activates matrix metalloproteinase-2 and increases receptor activator of nuclear factor-kappaB ligand expression in human periodontal ligament cells. J Periodontol 75:1647\u20131654","journal-title":"J Periodontol"},{"key":"928_CR8","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1902\/jop.2010.100004","volume":"81","author":"Y Sun","year":"2010","unstructured":"Sun Y, Shu R, Li CL, Zhang MZ (2010) Gram-negative periodontal bacteria induce the activation of Toll-like receptors 2 and 4, and cytokine production in human periodontal ligament cells. J Periodontol 81:1488\u20131496","journal-title":"J Periodontol"},{"key":"928_CR9","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1111\/j.1600-051X.2007.01061.x","volume":"34","author":"N Bostanci","year":"2007","unstructured":"Bostanci N, Ilgenli T, Emingil G, Afacan B, Han B, T\u00f6z H et al (2007) Gingival crevicular fluid levels of RANKL and OPG in periodontal diseases: implications of their relative ratio. J Clin Periodontol 34:370\u2013376","journal-title":"J Clin Periodontol"},{"key":"928_CR10","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.archoralbio.2004.04.004","volume":"49","author":"M Miyauchi","year":"2004","unstructured":"Miyauchi M, Hiraoka M, Oka H, Sato S, Kudo Y, Ogawa I et al (2004) Immuno-localization of COX-1 and COX-2 in the rat molar periodontal tissue after topical application of lipopolysaccharide. Arch Oral Biol 49:739\u2013746","journal-title":"Arch Oral Biol"},{"key":"928_CR11","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1016\/j.cellsig.2006.04.003","volume":"18","author":"T Yucel-Lindberg","year":"2006","unstructured":"Yucel-Lindberg T, Olsson T, Kawakami T (2006) Signal pathways involved in the regulation of prostaglandin E synthase-1 in human gingival fibroblasts. Cell Signal 18:2131\u20132142","journal-title":"Cell Signal"},{"key":"928_CR12","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1902\/jop.2007.060257","volume":"78","author":"K Noguchi","year":"2007","unstructured":"Noguchi K, Miyauchi M, Oka H, Komaki M, Somerman MJ, Takata T (2007) Cyclooxygenase-2-dependent prostaglandin E(2) upregulates interleukin (IL)-1alpha-induced IL-6 generation in mouse cementoblasts. J Periodontol 78:135\u2013140","journal-title":"J Periodontol"},{"key":"928_CR13","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/0090-6980(76)90155-6","volume":"11","author":"TM ElAttar","year":"1976","unstructured":"ElAttar TM (1976) Prostaglandin E2 in human gingiva in health and disease and its stimulation by female sex steroids. Prostaglandins 11:331\u2013341","journal-title":"Prostaglandins"},{"key":"928_CR14","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1111\/j.1600-0765.1984.tb01305.x","volume":"19","author":"K Ohm","year":"1984","unstructured":"Ohm K, Albers HK, Lisboa BP (1984) Measurement of eight prostaglandins in human gingival and periodontal disease using high pressure liquid chromatography and radioimmunoassay. J Periodontal Res 19:501\u2013511","journal-title":"J Periodontal Res"},{"key":"928_CR15","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/j.1600-0757.2006.00170.x","volume":"43","author":"K Noguchi","year":"2007","unstructured":"Noguchi K, Ishikawa I (2007) The roles of cyclooxygenase-2 and prostaglandin E2 in periodontal disease. Periodontol 43:85\u2013101","journal-title":"Periodontol"},{"key":"928_CR16","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/j.1600-0765.1986.tb01443.x","volume":"21","author":"S Offenbacher","year":"1986","unstructured":"Offenbacher S, Odle BM, Van Dyke TE (1986) The use of crevicular fluid prostaglandin E2 levels as a predictor of periodontal attachment loss. J Periodontal Res 21:101\u2013112","journal-title":"J Periodontal Res"},{"key":"928_CR17","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1359\/jbmr.2002.17.2.210","volume":"17","author":"H Kanzaki","year":"2002","unstructured":"Kanzaki H, Chiba M, Shimizu Y, Mitani H (2002) Periodontal ligament cells under mechanical stress induce osteoclastogenesis by receptor activator of nuclear factor kappaB ligand up-regulation via prostaglandin E2 synthesis. J Bone Miner Res 17:210\u2013220","journal-title":"J Bone Miner Res"},{"key":"928_CR18","doi-asserted-by":"crossref","first-page":"4191","DOI":"10.1242\/jcs.00098","volume":"115","author":"Y Saito","year":"2002","unstructured":"Saito Y, Yoshizawa T, Takizawa F, Ikegame M, Ishibashi O, Okuda K, Hara K, Ishibashi K, Obinata M, Kawashima H (2002) A cell line with characteristics of the periodontal ligament fibroblasts is negatively regulated for mineralization and Runx2\/Cbfa1\/Osf2 activity, part of which can be overcome by bone morphogenetic protein-2. J Cell Sci 115:4191\u20134200","journal-title":"J Cell Sci"},{"key":"928_CR19","doi-asserted-by":"crossref","first-page":"701","DOI":"10.3892\/ijmm_00000516","volume":"26","author":"T Hasegawa","year":"2010","unstructured":"Hasegawa T, Chosa N, Asakawa T, Yoshimura Y, Ishisaki A, Tanaka M (2010) Establishment of immortalized human periodontal ligament cells derived from deciduous teeth. Int J Mol Med 26:701\u2013705","journal-title":"Int J Mol Med"},{"key":"928_CR20","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(\u2013delta delta C(T)) method. Methods 25:402\u2013408","journal-title":"Methods"},{"key":"928_CR21","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1007\/s00784-010-0456-0","volume":"15","author":"S Lossd\u00f6rfer","year":"2011","unstructured":"Lossd\u00f6rfer S, G\u00f6tz W, J\u00e4ger A (2011) PTH(1\u201334)-induced changes in RANKL and OPG expression by human PDL cells modify osteoclast biology in a co-culture model with RAW 264.7 cells. Clin Oral Investig 15:941\u2013952","journal-title":"Clin Oral Investig"},{"key":"928_CR22","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1177\/10.6.741","volume":"10","author":"T Barka","year":"1962","unstructured":"Barka T, Anderson PJ (1962) Histochemical methods for acid phosphatase using hexazonium pararosaniline as a coupler. J Histochem Cytochem 10:741\u2013752","journal-title":"J Histochem Cytochem"},{"key":"928_CR23","doi-asserted-by":"crossref","first-page":"521","DOI":"10.14219\/jada.archive.1999.0246","volume":"130","author":"NL Sanders","year":"1999","unstructured":"Sanders NL (1999) Evidence-based care in orthodontics and periodontics: a review of the literature. J Am Dent Assoc 130:521\u2013527","journal-title":"J Am Dent Assoc"},{"key":"928_CR24","doi-asserted-by":"crossref","first-page":"66","DOI":"10.4103\/0972-124X.65445","volume":"14","author":"A Dannan","year":"2010","unstructured":"Dannan A (2010) An update on periodontic-orthodontic interrelationships. J Indian Soc Periodontol 14:66\u201371","journal-title":"J Indian Soc Periodontol"},{"key":"928_CR25","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1006\/bmmb.1994.1068","volume":"53","author":"N Ogura","year":"1994","unstructured":"Ogura N, Shibata Y, Kamino Y, Matsuda U, Hayakawa M, Oikawa T et al (1994) Stimulation of interleukin-6 production of periodontal ligament cells by Porphyromonas endodontalis lipopolysaccharide. Biochem Med Metab Biol 53:130\u2013136","journal-title":"Biochem Med Metab Biol"},{"key":"928_CR26","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1111\/j.1600-0765.2006.00905.x","volume":"41","author":"T Yamamoto","year":"2006","unstructured":"Yamamoto T, Kita M, Oseko F, Nakamura T, Imanishi J, Kanamura N (2006) Cytokine production in human periodontal ligament cells stimulated with Porphyromonas gingivalis. J Periodontal Res 41:554\u2013559","journal-title":"J Periodontal Res"},{"key":"928_CR27","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/j.1600-0765.2009.01215.x","volume":"45","author":"SH Pi","year":"2010","unstructured":"Pi SH, Jeong GS, Oh HW, Kim YS, Pae HO, Chung HT et al (2010) Heme oxygenase-1 mediates nicotine- and lipopolysaccharide-induced expression of cyclooxygenase-2 and inducible nitric oxide synthase in human periodontal ligament cells. J Periodontal Res 45:177\u2013183","journal-title":"J Periodontal Res"},{"key":"928_CR28","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1902\/jop.2004.75.2.249","volume":"75","author":"J Nukaga","year":"2004","unstructured":"Nukaga J, Kobayashi M, Shinki T, Song H, Takada T, Takiguchi T et al (2004) Regulatory effects of interleukin-1beta and prostaglandin E2 on expression of receptor activator of nuclear factor-kappaB ligand in human periodontal ligament cells. J Periodontol 75:249\u2013259","journal-title":"J Periodontol"},{"key":"928_CR29","doi-asserted-by":"crossref","first-page":"150","DOI":"10.3109\/03008200903168484","volume":"51","author":"R Sanuki","year":"2010","unstructured":"Sanuki R, Shionome C, Kuwabara A, Mitsui N, Koyama Y, Suzuki N, Zhang F, Shimizu N, Maeno M (2010) Compressive force induces osteoclast differentiation via prostaglandin E2 production in MC3T3-E1 cells. Connect Tissue Res 51:150\u2013158","journal-title":"Connect Tissue Res"},{"key":"928_CR30","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.archoralbio.2010.09.017","volume":"56","author":"T Yamamoto","year":"2011","unstructured":"Yamamoto T, Kita M, Yamamoto K, Akamatsu Y, Oseko F, Kanamura N (2011) Mechanical stress enhances production of cytokines in human periodontal ligament cells induced by Porphyromonas gingivalis. Arch Oral Biol 56:251\u2013257","journal-title":"Arch Oral Biol"}],"container-title":["Clinical Oral Investigations"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-013-0928-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00784-013-0928-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-013-0928-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T06:34:22Z","timestamp":1559111662000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00784-013-0928-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2,8]]},"references-count":30,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["928"],"URL":"https:\/\/doi.org\/10.1007\/s00784-013-0928-0","relation":{},"ISSN":["1432-6981","1436-3771"],"issn-type":[{"value":"1432-6981","type":"print"},{"value":"1436-3771","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2,8]]}}}