{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T15:49:57Z","timestamp":1760888997345},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2015,4,7]],"date-time":"2015-04-07T00:00:00Z","timestamp":1428364800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Oral Invest"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1007\/s00784-015-1460-1","type":"journal-article","created":{"date-parts":[[2015,4,6]],"date-time":"2015-04-06T01:24:01Z","timestamp":1428283441000},"page":"2337-2344","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["DNA methylation analysis of SOCS1, SOCS3, and LINE-1 in microdissected gingival tissue"],"prefix":"10.1007","volume":"19","author":[{"given":"Denise C.","family":"Andia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aline C.","family":"Planello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle","family":"Portinho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo A.","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristiane R.","family":"Salmon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enilson A.","family":"Sallum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco H. Nociti","family":"Junior","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana P.","family":"de Souza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,4,7]]},"reference":[{"key":"1460_CR1","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1902\/annals.1999.4.1.32","volume":"4","author":"TF Flemmig","year":"1999","unstructured":"Flemmig TF (1999) Periodontitis. Ann Periodontol 4:32\u201338","journal-title":"Ann Periodontol"},{"key":"1460_CR2","doi-asserted-by":"crossref","first-page":"207","DOI":"10.3109\/08977194.2012.687375","volume":"30","author":"JJ Babon","year":"2012","unstructured":"Babon JJ, Nicola NA (2012) The biology and mechanism of action of suppressor of cytokine signaling 3. Growth Factors 30:207\u2013219. doi: 10.3109\/08977194.2012.687375","journal-title":"Growth Factors"},{"key":"1460_CR3","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1172\/JCI16156","volume":"111","author":"PJ Egan","year":"2003","unstructured":"Egan PJ, Lawlor KE, Alexander WS, Wicks IP (2003) Suppressor of cytokine signaling-1 regulates acute inflammatory arthritis and T cell activation. J Clin Invest 111:915\u2013924. doi: 10.1172\/JCI200316156","journal-title":"J Clin Invest"},{"key":"1460_CR4","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.1002\/art.20302","volume":"50","author":"AS Hooge de","year":"2004","unstructured":"de Hooge AS, van de Loo FA, Koenders MI, Bennink MB, Arntz OJ, Kolbe T, van den Berg WB (2004) Local activation of STAT-1 and STAT-3 in the inflamed synovium during zymosan-induced arthritis: exacerbation of joint inflammation in STAT-1 gene-knockout mice. Arthritis Rheum 50:2014\u20132023. doi: 10.1002\/art.20302","journal-title":"Arthritis Rheum"},{"key":"1460_CR5","doi-asserted-by":"crossref","first-page":"R567","DOI":"10.1186\/ar1445","volume":"6","author":"J Yamana","year":"2004","unstructured":"Yamana J, Yamamura M, Okamoto A, Aita T, Iwahashi M, Sunahori K, Makino H (2004) Resistance to IL-10 inhibition of interferon gamma production and expression of suppressor of cytokine signaling 1 in CD4+ T cells from patients with rheumatoid arthritis. Arthritis Res Ther 6:R567\u2013R577. doi: 10.1186\/ar1445","journal-title":"Arthritis Res Ther"},{"key":"1460_CR6","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1096\/fj.05-5493fje","volume":"20","author":"H Qin","year":"2006","unstructured":"Qin H, Wilson CA, Lee SJ, Benveniste EM (2006) IFN-beta-induced SOCS-1 negatively regulates CD40 gene expression in macrophages and microglia. FASEB J 20:985\u2013987. doi: 10.1096\/fj.05-5493fje","journal-title":"FASEB J"},{"key":"1460_CR7","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1172\/JCI25660","volume":"116","author":"PK Wong","year":"2006","unstructured":"Wong PK, Egan PJ, Croker BA et al (2006) SOCS-3 negatively regulates innate and adaptive immune mechanisms in acute IL-1-dependent inflammatory arthritis. J Clin Invest 116:1571\u20131581. doi: 10.1172\/JCI25660","journal-title":"J Clin Invest"},{"key":"1460_CR8","doi-asserted-by":"crossref","first-page":"3202","DOI":"10.1002\/art.22915","volume":"56","author":"G Alsaleh","year":"2007","unstructured":"Alsaleh G, Messer L, Semaan N et al (2007) BAFF synthesis by rheumatoid synoviocytes is positively controlled by alpha5beta1 integrin stimulation and is negatively regulated by tumor necrosis factor alpha and Toll-like receptor ligands. Arthritis Rheum 56:3202\u20133214. doi: 10.1002\/art.22915","journal-title":"Arthritis Rheum"},{"key":"1460_CR9","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1093\/rheumatology\/kem198","volume":"46","author":"P Isom\u00e4ki","year":"2007","unstructured":"Isom\u00e4ki P, Alan\u00e4r\u00e4 T, Isohanni P et al (2007) The expression of SOCS is altered in rheumatoid arthritis. Rheumatology 46:1538\u20131546. doi: 10.1093\/rheumatology\/kem198","journal-title":"Rheumatology"},{"key":"1460_CR10","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1136\/ard.2011.154815","volume":"70","author":"S Veenbergen","year":"2011","unstructured":"Veenbergen S, Bennink MB, Affandi AJ et al (2011) A pivotal role for antigen-presenting cells overexpressing SOCS3 in controlling invariant NKT cell responses during collagen-induced arthritis. Ann Rheum Dis 70:2167\u20132175. doi: 10.1136\/ard.2011.154815","journal-title":"Ann Rheum Dis"},{"key":"1460_CR11","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1002\/art.37853","volume":"65","author":"A Lee","year":"2013","unstructured":"Lee A, Qiao Y, Grigoriev G et al (2013) Tumor necrosis factor \u03b1 induces sustained signaling and a prolonged and unremitting inflammatory response in rheumatoid arthritis synovial fibroblasts. Arthritis Rheum 65:928\u2013938. doi: 10.1002\/art.37853","journal-title":"Arthritis Rheum"},{"key":"1460_CR12","doi-asserted-by":"crossref","unstructured":"Larsson L, Castilho RM, Giannobile WV (2014) Epigenetics and its role in periodontal diseases\u2014a state-of-the-art review. J Periodontol 21:1\u201318. doi: 10.1902\/jop.2014.140559","DOI":"10.1902\/jop.2014.140559"},{"key":"1460_CR13","doi-asserted-by":"crossref","first-page":"5833","DOI":"10.4049\/jimmunol.164.11.5833","volume":"164","author":"H Saito","year":"2000","unstructured":"Saito H, Morita Y, Fujimoto M, Narazaki M, Naka T, Kishimoto T (2000) IFN regulatory factor-1-mediated transcriptional activation of mouse STAT-induced STAT inhibitor-1 gene promoter by IFN-gamma. J Immunol 164:5833\u20135843. doi: 10.4049\/jimmunol.164.11.5833","journal-title":"J Immunol"},{"key":"1460_CR14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1399-0039.2005.00532.x","volume":"67","author":"GM Davey","year":"2006","unstructured":"Davey GM, Heath WR, Starr R (2006) SOCS1: a potent and multifaceted regulator of cytokines and cell-mediated inflammation. Tissue Antigens 67:1\u20139. doi: 10.1111\/j.1399-0039.2005.00532.x","journal-title":"Tissue Antigens"},{"key":"1460_CR15","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1177\/0022034510378683","volume":"90","author":"D Bayarsaihan","year":"2011","unstructured":"Bayarsaihan D (2011) Epigenetic mechanisms in inflammation. J Dent Res 90:9\u201317. doi: 10.1177\/0022034510378683","journal-title":"J Dent Res"},{"key":"1460_CR16","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/nrg2732","volume":"11","author":"PW Laird","year":"2010","unstructured":"Laird PW (2010) Principles and challenges of genome wide DNA methylation analysis. Nat Rev Genet 11:191\u2013203. doi: 10.1038\/nrg2732","journal-title":"Nat Rev Genet"},{"key":"1460_CR17","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s13148-011-0032-8","volume":"2","author":"N Kitkumthorn","year":"2011","unstructured":"Kitkumthorn N, Mutirangura A (2011) Long interspersed nuclear element-1 hypomethylation in cancer: biology and clinical application. Clin Epigenet 2:315\u2013330. doi: 10.1007\/s13148-011-0032-8","journal-title":"Clin Epigenet"},{"key":"1460_CR18","doi-asserted-by":"crossref","first-page":"92","DOI":"10.4161\/epi.7.1.18815","volume":"7","author":"M Newman","year":"2012","unstructured":"Newman M, Blyth BJ, Hussey DJ, Jardine D, Sykes PJ, Ormsby RJ (2012) Sensitive quantitative analysis of murine LINE1 DNA methylation using high resolution melt analysis. Epigenetics 7:92\u2013105. doi: 10.4161\/epi.7.1.18815","journal-title":"Epigenetics"},{"key":"1460_CR19","first-page":"229","volume":"25","author":"J Ainamo","year":"1975","unstructured":"Ainamo J, Bay I (1975) Problems and proposals for recording gingivitis and plaque. Int Dent J 25:229\u2013235","journal-title":"Int Dent J"},{"key":"1460_CR20","first-page":"107","volume":"15","author":"HR M\u00fchlemann","year":"1971","unstructured":"M\u00fchlemann HR, Son S (1971) Gingival sulcus bleeding\u2014a leading symptom in initial gingivitis. Helv Odontol Acta 15:107\u2013113","journal-title":"Helv Odontol Acta"},{"key":"1460_CR21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1902\/annals.1999.4.1.1","volume":"4","author":"GC Armitage","year":"1999","unstructured":"Armitage GC (1999) Development of a classification system for periodontal diseases and conditions. Ann Periodontol 4:1\u20136","journal-title":"Ann Periodontol"},{"key":"1460_CR22","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1038\/nprot.2008.191","volume":"3","author":"TK Wojdacz","year":"2008","unstructured":"Wojdacz TK, Dobrovic A, Hansen LL (2008) Methylation-sensitive high-resolution melting. Nat Protoc 3:1903\u20131908. doi: 10.1038\/nprot.2008.191","journal-title":"Nat Protoc"},{"key":"1460_CR23","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/j.cca.2012.01.024","volume":"413","author":"N Kitkumthorn","year":"2012","unstructured":"Kitkumthorn N, Tuangsintanakul Time, Rattanatanyong P, Tiwawech D, Mutirangura A (2012) LINE-1 methylation in the peripheral blood mononuclear cells of cancer patients. Clin Chim Acta 413:869\u2013874. doi: 10.1016\/j.cca.2012.01.024","journal-title":"Clin Chim Acta"},{"key":"1460_CR24","doi-asserted-by":"crossref","first-page":"58","DOI":"10.3389\/fimmu.2014.00058","volume":"5","author":"B Carow","year":"2014","unstructured":"Carow B, Rottenberg ME (2014) Front Immunol 5:58. doi: 10.3389\/fimmu.2014.00058","journal-title":"Front Immunol"},{"key":"1460_CR25","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.smim.2013.12.004","volume":"26","author":"JJ Babon","year":"2014","unstructured":"Babon JJ, Varghese LN, Nicola NA (2014) Inhibition of IL-6 family cytokines by SOCS3. Semin Immunol 26:13\u201319. doi: 10.1016\/j.smim.2013.12.004","journal-title":"Semin Immunol"},{"key":"1460_CR26","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1177\/1753425913488429","volume":"20","author":"DD Lofrumento","year":"2014","unstructured":"Lofrumento DD, Nicolardi G, Cianciulli A et al (2014) Neuroprotective effects of resveratrol in an MPTP mouse model of Parkinson\u2019s-like disease: possible role of SOCS-1 in reducing pro-inflammatory responses. Innate Immun 20:249\u2013260. doi: 10.1177\/1753425913488429","journal-title":"Innate Immun"},{"key":"1460_CR27","author":"AS Collins","year":"2014","unstructured":"Collins AS, Ahmed S, Napoletano S et al (2014) Hepatitis C virus (HCV)-induced suppressor of cytokine signaling (SOCS) 3 regulates proinflammatory TNF-\u03b1 responses. J Leukoc Biol. doi: 10.1189\/jlb.2A1211-608RRRR","journal-title":"J Leukoc Biol"},{"key":"1460_CR28","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1016\/j.joen.2010.02.027","volume":"36","author":"A Fukushima","year":"2014","unstructured":"Fukushima A, Kajiya H, Izumi T, Shigeyama C, Okabe K, Anan H (2014) Pro-inflammatory cytokines induce suppressor of cytokine signaling-3 in human periodontal ligament cells. J Endod 36:1004\u20131008. doi: 10.1016\/j.joen.2010.02.027","journal-title":"J Endod"},{"key":"1460_CR29","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1016\/j.archoralbio.2011.03.022","volume":"56","author":"JA Souza de","year":"2011","unstructured":"de Souza JA, Nogueira AV, de Souza PP, Cirelli JA, Garlet GP, Rossa C Jr (2011) Expression of suppressor of cytokine signaling 1 and 3 in ligature-induced periodontitis in rats. Arch Oral Biol 56:1120\u20131128. doi: 10.1016\/j.archoralbio.2011.03.022","journal-title":"Arch Oral Biol"},{"key":"1460_CR30","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1111\/j.1600-0765.2006.00908.x","volume":"41","author":"GP Garlet","year":"2006","unstructured":"Garlet GP, Cardoso CR, Campanelli AP, Martins W Jr, Silva JS (2006) Expression of suppressors of cytokine signaling in diseased periodontal tissues: a stop signal for disease progression? J Periodontal Res 41:580\u2013584. doi: 10.1111\/j.1600-0765.2006.00908.x","journal-title":"J Periodontal Res"},{"key":"1460_CR31","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1016\/j.imbio.2011.01.006","volume":"216","author":"MB Viana","year":"2011","unstructured":"Viana MB, Cardoso FP, Diniz MG et al (2011) Methylation pattern of IFN-\u03b3 and IL-10 genes in periodontal tissues. Immunobiology 216:936\u2013941. doi: 10.1016\/j.imbio.2011.01.006","journal-title":"Immunobiology"},{"key":"1460_CR32","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/j.imbio.2012.12.001","volume":"218","author":"FA Stefani","year":"2013","unstructured":"Stefani FA, Viana MB, Dupim AC et al (2013) Expression, polymorphism and methylation pattern of interleukin-6 in periodontal tissues. Immunobiology 218:1012\u20131017. doi: 10.1016\/j.imbio.2012.12.001","journal-title":"Immunobiology"},{"key":"1460_CR33","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1902\/jop.2013.120294","volume":"84","author":"S Zhang","year":"2013","unstructured":"Zhang S, Barros SP, Moretti AJ et al (2013) Epigenetic regulation of TNFA expression in periodontal disease. J Periodontol 84:1606\u20131616. doi: 10.1902\/jop.2013.120294","journal-title":"J Periodontol"},{"key":"1460_CR34","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.archoralbio.2014.03.015","volume":"59","author":"NB Baptista","year":"2014","unstructured":"Baptista NB, Portinho D, Casarin RC et al (2014) DNA methylation levels of SOCS1 and LINE-1 in oral epithelial cells from aggressive periodontitis patients. Arch Oral Biol 59:670\u2013678. doi: 10.1016\/j.archoralbio.2014.03.015","journal-title":"Arch Oral Biol"},{"key":"1460_CR35","doi-asserted-by":"crossref","first-page":"e38","DOI":"10.1093\/nar\/gnh032","volume":"32","author":"AS Yang","year":"2004","unstructured":"Yang AS, Estecio MR, Doshi K, Kondo Y, Tajara EH, Issa JP (2004) A simple method for estimating global DNA methylation using bisulfite PCR of repetitive DNA elements. Nucleic Acids Res 32:e38. doi: 10.1093\/nar\/gnh032","journal-title":"Nucleic Acids Res"},{"key":"1460_CR36","doi-asserted-by":"crossref","unstructured":"Lange NE, Sordillo J, Tarantini L et al (2012) Alu and LINE-1 methylation and lung function in the normative ageing study. BMJ Open 2: doi: 10.1136\/bmjopen-2012-001231","DOI":"10.1136\/bmjopen-2012-001231"},{"key":"1460_CR37","doi-asserted-by":"crossref","first-page":"8841","DOI":"10.1038\/sj.onc.1208137","volume":"23","author":"K Chalitchagorn","year":"2004","unstructured":"Chalitchagorn K, Shuangshoti S, Hourpai N et al (2004) Distinctive pattern of LINE-1 methylation level in normal tissues and the association with carcinogenesis. Oncogene 23:8841\u20138846. doi: 10.1038\/sj.onc.1208137","journal-title":"Oncogene"},{"key":"1460_CR38","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1139\/o05-036","volume":"83","author":"MJ Hoffmann","year":"2005","unstructured":"Hoffmann MJ, Schulz WA (2005) Causes and consequences of DNA hypomethylation in human cancer. Biochem Cell Biol 83:296\u2013321. doi: 10.1139\/o05-036","journal-title":"Biochem Cell Biol"},{"key":"1460_CR39","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s00424-009-0730-7","volume":"459","author":"S Gravina","year":"2010","unstructured":"Gravina S, Vijg J (2010) Epigenetic factors in aging and longevity. Pflugers Arch 459:247\u2013258. doi: 10.1007\/s00424-009-0730-7","journal-title":"Pflugers Arch"},{"key":"1460_CR40","doi-asserted-by":"crossref","first-page":"e37009","DOI":"10.1371\/journal.pone.0037009","volume":"7","author":"M Patchsung","year":"2012","unstructured":"Patchsung M, Boonla C, Amnattrakul P, Dissayabutra T, Mutirangura A, Tosukhowong P (2012) Long interspersed nuclear element-1 hypomethylation and oxidative stress: correlation and bladder cancer diagnostic potential. PLoS One 7:e37009. doi: 10.1371\/journal.pone.0037009","journal-title":"PLoS One"}],"container-title":["Clinical Oral Investigations"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-015-1460-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00784-015-1460-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-015-1460-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,8]],"date-time":"2024-06-08T06:29:49Z","timestamp":1717828189000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00784-015-1460-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,7]]},"references-count":40,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["1460"],"URL":"https:\/\/doi.org\/10.1007\/s00784-015-1460-1","relation":{},"ISSN":["1432-6981","1436-3771"],"issn-type":[{"value":"1432-6981","type":"print"},{"value":"1436-3771","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,7]]}}}