{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T16:36:44Z","timestamp":1780072604160,"version":"3.54.0"},"reference-count":70,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2015,6,12]],"date-time":"2015-06-12T00:00:00Z","timestamp":1434067200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Oral Invest"],"published-print":{"date-parts":[[2015,11]]},"DOI":"10.1007\/s00784-015-1499-z","type":"journal-article","created":{"date-parts":[[2015,6,11]],"date-time":"2015-06-11T07:05:49Z","timestamp":1434006349000},"page":"1763-1775","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Non-surgical periodontal therapy supplemented with systemically administered azithromycin: a systematic review of RCTs"],"prefix":"10.1007","volume":"19","author":[{"given":"Sabrina L.","family":"Buset","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola U.","family":"Zitzmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Weiger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clemens","family":"Walter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,6,12]]},"reference":[{"key":"1499_CR1","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1902\/annals.2003.8.1.115","volume":"8","author":"AD Haffajee","year":"2003","unstructured":"Haffajee AD, Socransky SS, Gunsolley JC (2003) Systemic anti-infective periodontal therapy. A systematic review. Ann Periodontol 8:115\u2013181","journal-title":"Ann Periodontol"},{"key":"1499_CR2","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/j.1600-051X.2008.01260.x","volume":"35","author":"D Herrera","year":"2008","unstructured":"Herrera D, Alonso B, Leon R, Roldan S, Sanz M (2008) Antimicrobial therapy in periodontitis: the use of systemic antimicrobials against the subgingival biofilm. J Clin Periodontol 35:45\u201366","journal-title":"J Clin Periodontol"},{"key":"1499_CR3","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/S1532-3382(12)70013-1","volume":"12","author":"D Herrera","year":"2012","unstructured":"Herrera D, Matesanz P, Bascones-Martinez A, Sanz M (2012) Local and systemic antimicrobial therapy in periodontics. J Evid Based Dent Pract 12:50\u201360","journal-title":"J Evid Based Dent Pract"},{"key":"1499_CR4","author":"JA Keestra","year":"2014","unstructured":"Keestra JA, Grosjean I, Coucke W, Quirynen M, Teughels W (2014) Non-surgical periodontal therapy with systemic antibiotics in patients with untreated aggressive periodontitis: a systematic review and meta-analysis. J Periodontal Res. doi: 10.1111\/jre.12252","journal-title":"J Periodontal Res"},{"key":"1499_CR5","author":"JA Keestra","year":"2014","unstructured":"Keestra JA, Grosjean I, Coucke W, Quirynen M, Teughels W (2014) Non-surgical periodontal therapy with systemic antibiotics in patients with untreated chronic periodontitis: a systematic review and meta-analysis. J Periodontal Res. doi: 10.1111\/jre.12221","journal-title":"J Periodontal Res"},{"key":"1499_CR6","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1902\/jop.2013.120733","volume":"85","author":"M Astasov-Frauenhoffer","year":"2014","unstructured":"Astasov-Frauenhoffer M, Braissant O, Hauser-Gerspach I, Weiger R, Walter C, Zitzmann NU, Waltimo T (2014) Microcalorimetric determination of the effects of amoxicillin, metronidazole, and their combination on in vitro biofilm. J Periodontol 85:349\u2013357","journal-title":"J Periodontol"},{"key":"1499_CR7","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.archoralbio.2014.03.007","volume":"59","author":"EM Kulik Kunz","year":"2014","unstructured":"Kulik Kunz EM, Lenkeit K, Waltimo T, Weiger R, Walter C (2014) Combinatorial effects of amoxicillin and metronidazole on selected periodontal bacteria and whole plaque samples. Arch Oral Biol 59:608\u2013615","journal-title":"Arch Oral Biol"},{"key":"1499_CR8","first-page":"11","volume":"13","author":"C Walter","year":"2011","unstructured":"Walter C, Kulik EM, Weiger R, Zitzmann NU, Waltimo T (2011) Additive or synergistic antimicrobial effects of amoxicillin and metronidazole on whole plaque samples: a preliminary report. J Int Acad Periodontol 13:11\u201316","journal-title":"J Int Acad Periodontol"},{"key":"1499_CR9","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/j.1600-051X.1994.tb00287.x","volume":"21","author":"MJ Pavicic","year":"1994","unstructured":"Pavicic MJ, van Winkelhoff AJ, Douque NH, Steures RW, de Graaff J (1994) Microbiological and clinical effects of metronidazole and amoxicillin in Actinobacillus actinomycetemcomitans-associated periodontitis. A 2-year evaluation. J Clin Periodontol 21:107\u2013112","journal-title":"J Clin Periodontol"},{"key":"1499_CR10","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1093\/jac\/34.6.1047","volume":"34","author":"MJ Pavicic","year":"1994","unstructured":"Pavicic MJ, van Winkelhoff AJ, Pavicic-Temming YA, de Graaff J (1994) Amoxycillin causes an enhanced uptake of metronidazole in Actinobacillus actinomycetemcomitans: a mechanism of synergy. J Antimicrob Chemother 34:1047\u20131050","journal-title":"J Antimicrob Chemother"},{"key":"1499_CR11","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1111\/j.1600-051X.2005.00814.x","volume":"32","author":"A Guerrero","year":"2005","unstructured":"Guerrero A, Griffiths GS, Nibali L, Suvan J, Moles DR, Laurell L, Tonetti MS (2005) Adjunctive benefits of systemic amoxicillin and metronidazole in non-surgical treatment of generalized aggressive periodontitis: a randomized placebo-controlled clinical trial. J Clin Periodontol 32:1096\u20131107","journal-title":"J Clin Periodontol"},{"key":"1499_CR12","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1111\/j.1600-051X.2007.01122.x","volume":"34","author":"D Kaner","year":"2007","unstructured":"Kaner D, Bernimoulin JP, Hopfenmuller W, Kleber BM, Friedmann A (2007) Controlled-delivery chlorhexidine chip versus amoxicillin\/metronidazole as adjunctive antimicrobial therapy for generalized aggressive periodontitis: a randomized controlled clinical trial. J Clin Periodontol 34:880\u2013891","journal-title":"J Clin Periodontol"},{"key":"1499_CR13","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1902\/jop.2011.110333","volume":"83","author":"AS Rodrigues","year":"2012","unstructured":"Rodrigues AS, Lourencao DS, Lima Neto LG, Pannuti CM, Hirata RD, Hirata MH, Lotufo RF, De Micheli G (2012) Clinical and microbiologic evaluation, by real-time polymerase chain reaction, of non-surgical treatment of aggressive periodontitis associated with amoxicillin and metronidazole. J Periodontol 83:744\u2013752","journal-title":"J Periodontol"},{"key":"1499_CR14","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1111\/j.1600-051X.2006.00905.x","volume":"33","author":"C Xajigeorgiou","year":"2006","unstructured":"Xajigeorgiou C, Sakellari D, Slini T, Baka A, Konstantinidis A (2006) Clinical and microbiological effects of different antimicrobials on generalized aggressive periodontitis. J Clin Periodontol 33:254\u2013264","journal-title":"J Clin Periodontol"},{"key":"1499_CR15","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1902\/jop.2009.090390","volume":"81","author":"N Cionca","year":"2010","unstructured":"Cionca N, Giannopoulou C, Ugolotti G, Mombelli A (2010) Microbiologic testing and outcomes of full-mouth scaling and root planing with or without amoxicillin\/metronidazole in chronic periodontitis. J Periodontol 81:15\u201323","journal-title":"J Periodontol"},{"key":"1499_CR16","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1111\/jcpe.12004","volume":"39","author":"M Feres","year":"2012","unstructured":"Feres M, Soares GM, Mendes JA, Silva MP, Faveri M, Teles R, Socransky SS, Figueiredo LC (2012) Metronidazole alone or with amoxicillin as adjuncts to non-surgical treatment of chronic periodontitis: a 1-year double-blinded, placebo-controlled, randomized clinical trial. J Clin Periodontol 39:1149\u20131158","journal-title":"J Clin Periodontol"},{"key":"1499_CR17","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jebdp.2012.09.007","volume":"12","author":"JM Albandar","year":"2012","unstructured":"Albandar JM (2012) Adjunctive antibiotics with nonsurgical periodontal therapy improve the clinical outcome of chronic periodontitis in current smokers. J Evid Based Dent Pract 12:63\u201366","journal-title":"J Evid Based Dent Pract"},{"key":"1499_CR18","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1111\/j.1600-051X.2008.01304.x","volume":"35","author":"F Matarazzo","year":"2008","unstructured":"Matarazzo F, Figueiredo LC, Cruz SE, Faveri M, Feres M (2008) Clinical and microbiological benefits of systemic metronidazole and amoxicillin in the treatment of smokers with chronic periodontitis: a randomized placebo-controlled study. J Clin Periodontol 35:885\u2013896","journal-title":"J Clin Periodontol"},{"key":"1499_CR19","first-page":"E54","volume":"35","author":"JC Schmidt","year":"2013","unstructured":"Schmidt JC, Walter C, Rischewski JR, Weiger R (2013) Treatment of periodontitis as a manifestation of neutropenia with or without systemic antibiotics: a systematic review. Pediatr Dent 35:E54\u201363","journal-title":"Pediatr Dent"},{"key":"1499_CR20","first-page":"861","volume":"123","author":"C Walter","year":"2013","unstructured":"Walter C, Buset S, Thillainathan L, Weiger R, Zitzmann NU (2013) Evaluation of periodontal therapy in undergraduate courses of the University of Basle. A retrospective study. Schweiz Monatsschr Zahnmed 123:861\u2013877","journal-title":"Schweiz Monatsschr Zahnmed"},{"key":"1499_CR21","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/j.1600-0757.2010.00356.x","volume":"55","author":"A Mombelli","year":"2011","unstructured":"Mombelli A, Cionca N, Almaghlouth A (2011) Does adjunctive antimicrobial therapy reduce the perceived need for periodontal surgery? Periodontol 2000 55:205\u2013216","journal-title":"Periodontol 2000"},{"key":"1499_CR22","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1111\/j.1600-051X.1989.tb01626.x","volume":"16","author":"AJ Winkelhoff van","year":"1989","unstructured":"van Winkelhoff AJ, Rodenburg JP, Goene RJ, Abbas F, Winkel EG, de Graaff J (1989) Metronidazole plus amoxycillin in the treatment of Actinobacillus actinomycetemcomitans associated periodontitis. J Clin Periodontol 16:128\u2013131","journal-title":"J Clin Periodontol"},{"key":"1499_CR23","first-page":"344","volume":"23","author":"J Cosgarea","year":"2014","unstructured":"Cosgarea J, Juncar R, Tristiu R, Arweiler N, Heumann C, Lascu L, Sculean A (2014) Nicht \u2013 chirurgische parodontale Therapie mit adjunktiver Gabe von Amoxicillin und Metronidazol f\u00fcr unterschiedliche Zeitabst\u00e4nde in Patienten mit schwerer chronischer Parodontitis. Parodontologie 23:344\u2013345","journal-title":"Parodontologie"},{"key":"1499_CR24","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1902\/jop.2007.060354","volume":"78","author":"RM Moreira","year":"2007","unstructured":"Moreira RM, Feres-Filho EJ (2007) Comparison between full-mouth scaling and root planing and quadrant-wise basic therapy of aggressive periodontitis: 6-month clinical results. J Periodontol 78:1683\u20131688","journal-title":"J Periodontol"},{"key":"1499_CR25","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1111\/jcpe.12052","volume":"40","author":"MX Silva-Senem","year":"2013","unstructured":"Silva-Senem MX, Heller D, Varela VM, Torres MC, Feres-Filho EJ, Colombo AP (2013) Clinical and microbiological effects of systemic antimicrobials combined to an anti-infective mechanical debridement for the management of aggressive periodontitis: a 12-month randomized controlled trial. J Clin Periodontol 40:242\u2013251","journal-title":"J Clin Periodontol"},{"key":"1499_CR26","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1111\/j.1600-051X.2006.00957.x","volume":"33","author":"NJ Lopez","year":"2006","unstructured":"Lopez NJ, Socransky SS, Da Silva I, Japlit MR, Haffajee AD (2006) Effects of metronidazole plus amoxicillin as the only therapy on the microbiological and clinical parameters of untreated chronic periodontitis. J Clin Periodontol 33:648\u2013660","journal-title":"J Clin Periodontol"},{"key":"1499_CR27","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1111\/j.1600-051X.2005.00807.x","volume":"32","author":"A Mombelli","year":"2005","unstructured":"Mombelli A (2005) Antimicrobial profiles of periodontal pathogens and systemic antimicrobial therapy. J Clin Periodontol 32:891\u2013892","journal-title":"J Clin Periodontol"},{"key":"1499_CR28","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1111\/j.1600-051X.2005.00782.x","volume":"32","author":"AJ Winkelhoff van","year":"2005","unstructured":"van Winkelhoff AJ, Herrera D, Oteo A, Sanz M (2005) Antimicrobial profiles of periodontal pathogens isolated from periodontitis patients in The Netherlands and Spain. J Clin Periodontol 32:893\u2013898","journal-title":"J Clin Periodontol"},{"key":"1499_CR29","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1111\/j.1600-051X.2006.01019.x","volume":"33","author":"C Walter","year":"2006","unstructured":"Walter C, Weiger R (2006) Antibiotics as the only therapy of untreated chronic periodontitis: a critical commentary. J Clin Periodontol 33:938\u2013939, author reply 940-1","journal-title":"J Clin Periodontol"},{"key":"1499_CR30","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1902\/jop.2014.130291","volume":"85","author":"TE Rams","year":"2014","unstructured":"Rams TE, Feik D, Mortensen JE, Degener JE, van Winkelhoff AJ (2014) Antibiotic susceptibility of periodontal Streptococcus constellatus and Streptococcus intermedius clinical isolates. J Periodontol 85:1792\u20131798","journal-title":"J Periodontol"},{"key":"1499_CR31","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1056\/NEJMoa1003833","volume":"366","author":"WA Ray","year":"2012","unstructured":"Ray WA, Murray KT, Hall K, Arbogast PG, Stein CM (2012) Azithromycin and the risk of cardiovascular death. N Engl J Med 366:1881\u20131890","journal-title":"N Engl J Med"},{"key":"1499_CR32","unstructured":"WHO (2014) Antibiotic resistance: global report on surveillance. ISBN: 978 92 4 156474 8"},{"key":"1499_CR33","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1902\/jop.2012.110625","volume":"83","author":"F Sgolastra","year":"2012","unstructured":"Sgolastra F, Gatto R, Petrucci A, Monaco A (2012) Effectiveness of systemic amoxicillin\/metronidazole as adjunctive therapy to scaling and root planing in the treatment of chronic periodontitis: a systematic review and meta-analysis. J Periodontol 83:1257\u20131269","journal-title":"J Periodontol"},{"key":"1499_CR34","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1111\/j.1600-051X.2007.01130.x","volume":"34","author":"A Guerrero","year":"2007","unstructured":"Guerrero A, Echeverria JJ, Tonetti MS (2007) Incomplete adherence to an adjunctive systemic antibiotic regimen decreases clinical outcomes in generalized aggressive periodontitis patients: a pilot retrospective study. J Clin Periodontol 34:897\u2013902","journal-title":"J Clin Periodontol"},{"key":"1499_CR35","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1093\/jac\/dkn472","volume":"63","author":"C Llor","year":"2009","unstructured":"Llor C, Sierra N, Hernandez S, Moragas A, Hernandez M, Bayona C, Miravitlles M (2009) The higher the number of daily doses of antibiotic treatment in lower respiratory tract infection the worse the compliance. J Antimicrob Chemother 63:396\u2013399","journal-title":"J Antimicrob Chemother"},{"key":"1499_CR36","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.ejphar.2013.02.044","volume":"705","author":"FW Muniz","year":"2013","unstructured":"Muniz FW, de Oliveira CC, de Sousa arvalho CR, Moreira MM, de Moraes ME, Martins RS (2013) Azithromycin: a new concept in adjuvant treatment of periodontitis. Eur J Pharmacol 705:135\u2013139","journal-title":"Eur J Pharmacol"},{"key":"1499_CR37","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s10787-012-0165-1","volume":"21","author":"PM Bartold","year":"2013","unstructured":"Bartold PM, du Bois AH, Gannon S, Haynes DR, Hirsch RS (2013) Antibacterial and immunomodulatory properties of azithromycin treatment implications for periodontitis. Inflammopharmacology 21:321\u2013238","journal-title":"Inflammopharmacology"},{"key":"1499_CR38","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/S0924-8579(01)00430-7","volume":"18","author":"WL Hand","year":"2001","unstructured":"Hand WL, Hand DL (2001) Characteristics and mechanisms of azithromycin accumulation and efflux in human polymorphonuclear leukocytes. Int J Antimicrob Agents 18:419\u2013425","journal-title":"Int J Antimicrob Agents"},{"key":"1499_CR39","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1007\/BF01975835","volume":"10","author":"PJ McDonald","year":"1991","unstructured":"McDonald PJ, Pruul H (1991) Phagocyte uptake and transport of azithromycin. Eur J Clin Microbiol Infect Dis 10:828\u2013833","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"1499_CR40","first-page":"356","volume":"32","author":"A Wildfeuer","year":"1994","unstructured":"Wildfeuer A, Laufen H, Zimmermann T (1994) Distribution of orally administered azithromycin in various blood compartments. Int J Clin Pharmacol Ther 32:356\u2013360","journal-title":"Int J Clin Pharmacol Ther"},{"key":"1499_CR41","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.jclinepi.2009.06.006","volume":"62","author":"A Liberati","year":"2009","unstructured":"Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gotzsche PC, Ioannidis JP, Clarke M, Devereaux PJ, Kleijnen J, Moher D (2009) The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. J Clin Epidemiol 62:e1\u201334","journal-title":"J Clin Epidemiol"},{"key":"1499_CR42","unstructured":"Moher D, Liberati A, Tetzlaff J, Altman DG, The PRISMA Group (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med 6(6): e1000097. doi: 10.1371\/journal.pmed1000097 ."},{"key":"1499_CR43","doi-asserted-by":"crossref","first-page":"40S","DOI":"10.1016\/0002-9343(91)90401-I","volume":"91","author":"S Hopkins","year":"1991","unstructured":"Hopkins S (1991) Clinical toleration and safety of azithromycin. Am J Med 91:40S\u201345S","journal-title":"Am J Med"},{"key":"1499_CR44","author":"MA Martinez","year":"2014","unstructured":"Martinez MA, Vuppalanchi R, Fontana RJ, Stolz A, Kleiner DE, Hayashi PH, Gu J, Hoofnagle JH, Chalasani N (2014) Clinical and histologic features of azithromycin-induced liver injury. Clin Gastroenterol Hepatol. doi: 10.1016\/j.cgh.2014.07.054","journal-title":"Clin Gastroenterol Hepatol"},{"key":"1499_CR45","doi-asserted-by":"crossref","first-page":"d5928","DOI":"10.1136\/bmj.d5928","volume":"343","author":"JP Higgins","year":"2011","unstructured":"Higgins JP, Altman DG, Gotzsche PC, Juni P, Moher D, Oxman AD, Savovic J, Schulz KF, Weeks L, Sterne JA (2011) The Cochrane Collaboration\u2019s tool for assessing risk of bias in randomised trials. BMJ 343:d5928","journal-title":"BMJ"},{"issue":"Suppl 12","key":"1499_CR46","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1111\/j.1600-051X.2011.01832.x","volume":"39","author":"F Graziani","year":"2012","unstructured":"Graziani F, Figuero E, Herrera D (2012) Systematic review of quality of reporting, outcome measurements and methods to study efficacy of preventive and therapeutic approaches to peri-implant diseases. J Clin Periodontol 39(Suppl 12):224\u2013244","journal-title":"J Clin Periodontol"},{"key":"1499_CR47","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1111\/j.1600-051X.2008.01254.x","volume":"35","author":"AN Haas","year":"2008","unstructured":"Haas AN, de Castro GD, Moreno T, Susin C, Albandar JM, Oppermann RV, Rosing CK (2008) Azithromycin as an adjunctive treatment of aggressive periodontitis: 12-months randomized clinical trial. J Clin Periodontol 35:696\u2013704","journal-title":"J Clin Periodontol"},{"key":"1499_CR48","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1111\/j.1600-051X.2006.01040.x","volume":"34","author":"AD Haffajee","year":"2007","unstructured":"Haffajee AD, Torresyap G, Socransky SS (2007) Clinical changes following four different periodontal therapies for the treatment of chronic periodontitis: 1-year results. J Clin Periodontol 34:243\u2013253","journal-title":"J Clin Periodontol"},{"key":"1499_CR49","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1902\/jop.2009.090067","volume":"80","author":"A Yashima","year":"2009","unstructured":"Yashima A, Gomi K, Maeda N, Arai T (2009) One-stage full-mouth versus partial-mouth scaling and root planing during the effective half-life of systemically administered azithromycin. J Periodontol 80:1406\u20131413","journal-title":"J Periodontol"},{"key":"1499_CR50","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1111\/j.1600-051X.2010.01607.x","volume":"37","author":"A Oteo","year":"2010","unstructured":"Oteo A, Herrera D, Figuero E, O\u2019Connor A, Gonzalez I, Sanz M (2010) Azithromycin as an adjunct to scaling and root planing in the treatment of Porphyromonas gingivalis-associated periodontitis: a pilot study. J Clin Periodontol 37:1005\u20131015","journal-title":"J Clin Periodontol"},{"key":"1499_CR51","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1902\/jop.2005.76.3.426","volume":"76","author":"P Mascarenhas","year":"2005","unstructured":"Mascarenhas P, Gapski R, Al-Shammari K, Hill R, Soehren S, Fenno JC, Giannobile WV, Wang HL (2005) Clinical response of azithromycin as an adjunct to non-surgical periodontal therapy in smokers. J Periodontol 76:426\u2013436","journal-title":"J Periodontol"},{"key":"1499_CR52","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1111\/j.1600-0765.2012.01488.x","volume":"47","author":"G Emingil","year":"2012","unstructured":"Emingil G, Han B, Ozdemir G, Tervahartiala T, Vural C, Atilla G, Baylas H, Sorsa T (2012) Effect of azithromycin, as an adjunct to nonsurgical periodontal treatment, on microbiological parameters and gingival crevicular fluid biomarkers in generalized aggressive periodontitis. J Periodontal Res 47:729\u2013739","journal-title":"J Periodontal Res"},{"key":"1499_CR53","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1902\/jop.2007.060247","volume":"78","author":"K Gomi","year":"2007","unstructured":"Gomi K, Yashima A, Nagano T, Kanazashi M, Maeda N, Arai T (2007) Effects of full-mouth scaling and root planing in conjunction with systemically administered azithromycin. J Periodontol 78:422\u2013429","journal-title":"J Periodontol"},{"key":"1499_CR54","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1902\/jop.2012.110519","volume":"83","author":"B Han","year":"2012","unstructured":"Han B, Emingil G, Ozdemir G, Tervahartiala T, Vural C, Atilla G, Baylas H, Sorsa T (2012) Azithromycin as an adjunctive treatment of generalized severe chronic periodontitis: clinical, microbiologic, and biochemical parameters. J Periodontol 83:1480\u20131491","journal-title":"J Periodontol"},{"key":"1499_CR55","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1111\/j.1600-051X.2011.01766.x","volume":"38","author":"E Sampaio","year":"2011","unstructured":"Sampaio E, Rocha M, Figueiredo LC, Faveri M, Duarte PM, Gomes Lira EA, Feres M (2011) Clinical and microbiological effects of azithromycin in the treatment of generalized chronic periodontitis: a randomized placebo-controlled clinical trial. J Clin Periodontol 38:838\u2013846","journal-title":"J Clin Periodontol"},{"key":"1499_CR56","doi-asserted-by":"crossref","DOI":"10.1038\/sj.bdj.2008.874","volume":"205","author":"M Farman","year":"2008","unstructured":"Farman M, Joshi RI (2008) Full-mouth treatment versus quadrant root surface debridement in the treatment of chronic periodontitis: a systematic review. Br Dent J 205, E18, discussion 496-497","journal-title":"Br Dent J"},{"key":"1499_CR57","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/sj.ebd.6400631","volume":"10","author":"DC Matthews","year":"2009","unstructured":"Matthews DC (2009) No difference between full-mouth and quadrant-wise treatment of chronic periodontitis. Evid Based Dent 10:17","journal-title":"Evid Based Dent"},{"key":"1499_CR58","doi-asserted-by":"crossref","first-page":"25","DOI":"10.2165\/00002018-199920010-00004","volume":"20","author":"N Principi","year":"1999","unstructured":"Principi N, Esposito S (1999) Comparative tolerability of erythromycin and newer macrolide antibacterials in paediatric patients. Drug Saf 20:25\u201341","journal-title":"Drug Saf"},{"key":"1499_CR59","first-page":"318","volume":"7","author":"ZS Almalki","year":"2014","unstructured":"Almalki ZS, Guo JJ (2014) Cardiovascular events and safety outcomes associated with azithromycin therapy: a meta-analysis of randomized controlled trials. Am Health Drug Benefits 7:318\u2013328","journal-title":"Am Health Drug Benefits"},{"issue":"Suppl E","key":"1499_CR60","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/jac\/31.suppl_E.1","volume":"31","author":"G Panteix","year":"1993","unstructured":"Panteix G, Guillaumond B, Harf R, Desbos A, Sapin V, Leclercq M, Perrin-Fayolle M (1993) In-vitro concentration of azithromycin in human phagocytic cells. J Antimicrob Chemother 31(Suppl E):1\u20134","journal-title":"J Antimicrob Chemother"},{"key":"1499_CR61","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1128\/AAC.40.3.825","volume":"40","author":"S Jaruratanasirikul","year":"1996","unstructured":"Jaruratanasirikul S, Hortiwakul R, Tantisarasart T, Phuenpathom N, Tussanasunthornwong S (1996) Distribution of azithromycin into brain tissue, cerebrospinal fluid, and aqueous humor of the eye. Antimicrob Agents Chemother 40:825\u2013826","journal-title":"Antimicrob Agents Chemother"},{"key":"1499_CR62","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1902\/jop.2007.060246","volume":"78","author":"K Gomi","year":"2007","unstructured":"Gomi K, Yashima A, Iino F, Kanazashi M, Nagano T, Shibukawa N, Ohshima T, Maeda N, Arai T (2007) Drug concentration in inflamed periodontal tissues after systemically administered azithromycin. J Periodontol 78:918\u2013923","journal-title":"J Periodontol"},{"key":"1499_CR63","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1902\/jop.1997.68.12.1206","volume":"68","author":"T Malizia","year":"1997","unstructured":"Malizia T, Tejada MR, Ghelardi E, Senesi S, Gabriele M, Giuca MR, Blandizzi C, Danesi R, Campa M, Del Tacca M (1997) Periodontal tissue disposition of azithromycin. J Periodontol 68:1206\u20131209","journal-title":"J Periodontol"},{"key":"1499_CR64","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1111\/j.1600-051X.1989.tb02326.x","volume":"16","author":"B Loos","year":"1989","unstructured":"Loos B, Nylund K, Claffey N, Egelberg J (1989) Clinical effects of root debridement in molar and non-molar teeth. A 2-year follow-up. J Clin Periodontol 16:498\u2013504","journal-title":"J Clin Periodontol"},{"key":"1499_CR65","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/j.1600-051X.1987.tb00972.x","volume":"14","author":"P Nordland","year":"1987","unstructured":"Nordland P, Garrett S, Kiger R, Vanooteghem R, Hutchens LH, Egelberg J (1987) The effect of plaque control and root debridement in molar teeth. J Clin Periodontol 14:231\u2013236","journal-title":"J Clin Periodontol"},{"key":"1499_CR66","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s00784-010-0431-9","volume":"15","author":"C Walter","year":"2011","unstructured":"Walter C, Weiger R, Zitzmann NU (2011) Periodontal surgery in furcation-involved maxillary molars revisited\u2014an introduction of guidelines for comprehensive treatment. Clin Oral Investig 15:9\u201320","journal-title":"Clin Oral Investig"},{"key":"1499_CR67","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1111\/j.1600-051X.2008.01245.x","volume":"35","author":"G Matuliene","year":"2008","unstructured":"Matuliene G, Pjetursson BE, Salvi GE, Schmidlin K, Bragger U, Zwahlen M, Lang NP (2008) Influence of residual pockets on progression of periodontitis and tooth loss: results after 11 years of maintenance. J Clin Periodontol 35:685\u2013695","journal-title":"J Clin Periodontol"},{"key":"1499_CR68","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/j.1600-051X.1984.tb01309.x","volume":"11","author":"A Badersten","year":"1984","unstructured":"Badersten A, Nilveus R, Egelberg J (1984) Effect of nonsurgical periodontal therapy. II. Severely advanced periodontitis. J Clin Periodontol 11:63\u201376","journal-title":"J Clin Periodontol"},{"key":"1499_CR69","first-page":"7","volume":"60","author":"S Warnakulasuriya","year":"2010","unstructured":"Warnakulasuriya S, Dietrich T, Bornstein MM, Casals Peidro E, Preshaw PM, Walter C, Wennstrom JL, Bergstrom J (2010) Oral health risks of tobacco use and effects of cessation. Int Dent J 60:7\u201330","journal-title":"Int Dent J"},{"issue":"Suppl 14","key":"1499_CR70","first-page":"S195","volume":"40","author":"BS Michalowicz","year":"2013","unstructured":"Michalowicz BS, Gustafsson A, Thumbigere-Math V, Buhlin K (2013) The effects of periodontal treatment on pregnancy outcomes. J Clin Periodontol 40(Suppl 14):S195\u2013208","journal-title":"J Clin Periodontol"}],"container-title":["Clinical Oral Investigations"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-015-1499-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00784-015-1499-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-015-1499-z","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,26]],"date-time":"2019-08-26T13:37:21Z","timestamp":1566826641000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00784-015-1499-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,12]]},"references-count":70,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["1499"],"URL":"https:\/\/doi.org\/10.1007\/s00784-015-1499-z","relation":{},"ISSN":["1432-6981","1436-3771"],"issn-type":[{"value":"1432-6981","type":"print"},{"value":"1436-3771","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,12]]}}}