{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:02:00Z","timestamp":1791820920895,"version":"4.3.4"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2015,8,13]],"date-time":"2015-08-13T00:00:00Z","timestamp":1439424000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Oral Invest"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1007\/s00784-015-1556-7","type":"journal-article","created":{"date-parts":[[2015,8,12]],"date-time":"2015-08-12T00:21:00Z","timestamp":1439338860000},"page":"675-683","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":101,"title":["Citrullination in the periodontium\u2014a possible link between periodontitis and rheumatoid arthritis"],"prefix":"10.1007","volume":"20","author":[{"given":"Oliver","family":"Laugisch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aneta","family":"Sroka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz","family":"Kantyka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Koziel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Neuhaus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton","family":"Sculean","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick J.","family":"Venables","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Potempa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burkhard","family":"M\u00f6ller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigrun","family":"Eick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,8,13]]},"reference":[{"key":"1556_CR1","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1111\/j.1600-051X.2011.01776.x","volume":"38","author":"RT Demmer","year":"2011","unstructured":"Demmer RT, Molitor JA, Jacobs Jr. DR, Michalowicz BS (2011) Periodontal disease, tooth loss and incident rheumatoid arthritis: results from the First National Health and Nutrition Examination Survey and its epidemiological follow-up study. J Clin Periodontol 38:998\u20131006","journal-title":"J Clin Periodontol"},{"key":"1556_CR2","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1136\/annrheumdis-2012-201593","volume":"72","author":"HH Chen","year":"2013","unstructured":"Chen HH, Huang N, Chen YM, Chen TJ, Chou P, Lee YL, Chou YJ, Lan JL, Lai KL, Lin CH, Chen DY (2013) Association between a history of periodontitis and the risk of rheumatoid arthritis: a nationwide, population-based, case-control study. Ann Rheum Dis 72:1206\u20131211","journal-title":"Ann Rheum Dis"},{"key":"1556_CR3","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s00296-011-2284-1","volume":"33","author":"R Joseph","year":"2013","unstructured":"Joseph R, Rajappan S, Nath SG, Paul BJ (2013) Association between chronic periodontitis and rheumatoid arthritis: a hospital-based case-control study. Rheumatol Int 33:103\u2013109","journal-title":"Rheumatol Int"},{"key":"1556_CR4","doi-asserted-by":"crossref","first-page":"67","DOI":"10.5051\/jpis.2012.42.3.67","volume":"42","author":"P Torkzaban","year":"2012","unstructured":"Torkzaban P, Hjiabadi T, Basiri Z, Poorolajal J (2012) Effect of rheumatoid arthritis on periodontitis: a historical cohort study. J Periodontal Implant Sci 42:67\u201372","journal-title":"J Periodontal Implant Sci"},{"key":"1556_CR5","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1902\/jop.2010.100058","volume":"81","author":"W Nesse","year":"2010","unstructured":"Nesse W, Dijkstra PU, Abbas F, Spijkervet FK, Stijger A, Tromp JA, van Dijk JL, Vissink A (2010) Increased prevalence of cardiovascular and autoimmune diseases in periodontitis patients: a cross-sectional study. J Periodontol 81:1622\u20131628","journal-title":"J Periodontol"},{"key":"1556_CR6","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1902\/jop.2013.120696","volume":"85","author":"T Kobayashi","year":"2014","unstructured":"Kobayashi T, Okada M, Ito S, Kobayashi D, Ishida K, Kojima A, Narita I, Murasawa A, Yoshie H (2014) Assessment of interleukin-6 receptor inhibition therapy on periodontal condition in patients with rheumatoid arthritis and chronic periodontitis. J Periodontol 85:57\u201367","journal-title":"J Periodontol"},{"key":"1556_CR7","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1111\/odi.12017","volume":"19","author":"K Erciyas","year":"2013","unstructured":"Erciyas K, Sezer U, Ustun K, Pehlivan Y, Kisacik B, Senyurt SZ, Tarakcioglu M, Onat AM (2013) Effects of periodontal therapy on disease activity and systemic inflammation in rheumatoid arthritis patients. Oral Dis 19:394\u2013400","journal-title":"Oral Dis"},{"key":"1556_CR8","doi-asserted-by":"crossref","first-page":"2607","DOI":"10.1007\/s00296-013-2781-5","volume":"33","author":"B Biyikoglu","year":"2013","unstructured":"Biyikoglu B, Buduneli N, Aksu K, Nalbantsoy A, Lappin DF, Evrenosoglu E, Kinane DF (2013) Periodontal therapy in chronic periodontitis lowers gingival crevicular fluid interleukin-1beta and DAS28 in rheumatoid arthritis patients. Rheumatol Int 33:2607\u20132616","journal-title":"Rheumatol Int"},{"issue":"Suppl 11","key":"1556_CR9","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1111\/j.1600-051X.2010.01669.x","volume":"38","author":"S Culshaw","year":"2011","unstructured":"Culshaw S, McInnes IB, Liew FY (2011) What can the periodontal community learn from the pathophysiology of rheumatoid arthritis? J Clin Periodontol 38(Suppl 11):106\u2013113","journal-title":"J Clin Periodontol"},{"key":"1556_CR10","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/nrrheum.2009.28","volume":"5","author":"P Pablo de","year":"2009","unstructured":"de Pablo P, Chapple IL, Buckley CD, Dietrich T (2009) Periodontitis in systemic rheumatic diseases. Nat Rev Rheumatol 5:218\u2013224","journal-title":"Nat Rev Rheumatol"},{"key":"1556_CR11","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.biopha.2006.09.002","volume":"60","author":"D Mewar","year":"2006","unstructured":"Mewar D, Wilson AG (2006) Autoantibodies in rheumatoid arthritis: a review. Biomed Pharmacother 60:648\u2013655","journal-title":"Biomed Pharmacother"},{"key":"1556_CR12","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/j.0105-2896.2009.00850.x","volume":"233","author":"N Wegner","year":"2010","unstructured":"Wegner N, Lundberg K, Kinloch A, Fisher B, Malmstrom V, Feldmann M, Venables PJ (2010) Autoimmunity to specific citrullinated proteins gives the first clues to the etiology of rheumatoid arthritis. Immunol Rev 233:34\u201354","journal-title":"Immunol Rev"},{"key":"1556_CR13","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.1002\/art.23618","volume":"58","author":"A Kinloch","year":"2008","unstructured":"Kinloch A, Lundberg K, Wait R, Wegner N, Lim NH, Zendman AJ, Saxne T, Malmstrom V, Venables PJ (2008) Synovial fluid is a site of citrullination of autoantigens in inflammatory arthritis. Arthritis Rheum 58:2287\u20132295","journal-title":"Arthritis Rheum"},{"key":"1556_CR14","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/nrmicro2873","volume":"10","author":"G Hajishengallis","year":"2012","unstructured":"Hajishengallis G, Darveau RP, Curtis MA (2012) The keystone-pathogen hypothesis. Nat Rev Microbiol 10:717\u2013725","journal-title":"Nat Rev Microbiol"},{"key":"1556_CR15","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/j.1600-0757.2010.00377.x","volume":"54","author":"Y Guo","year":"2010","unstructured":"Guo Y, Nguyen KA, Potempa J (2010) Dichotomy of gingipains action as virulence factors: from cleaving substrates with the precision of a surgeon\u2019s knife to a meat chopper-like brutal degradation of proteins. Periodontol 2000 54:15\u201344","journal-title":"Periodontol 2000"},{"key":"1556_CR16","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1034\/j.1600-0757.2000.2240108.x","volume":"24","author":"J Potempa","year":"2000","unstructured":"Potempa J, Banbula A, Travis J (2000) Role of bacterial proteinases in matrix destruction and modulation of host responses. Periodontol 2000 24:153\u2013192","journal-title":"Periodontol 2000"},{"key":"1556_CR17","doi-asserted-by":"crossref","first-page":"3248","DOI":"10.1128\/IAI.67.7.3248-3256.1999","volume":"67","author":"WT McGraw","year":"1999","unstructured":"McGraw WT, Potempa J, Farley D, Travis J (1999) Purification, characterization, and sequence analysis of a potential virulence factor from Porphyromonas gingivalis, peptidylarginine deiminase. Infect Immun 67:3248\u20133256","journal-title":"Infect Immun"},{"key":"1556_CR18","doi-asserted-by":"crossref","first-page":"11969","DOI":"10.1038\/srep11969","volume":"5","author":"T Goulas","year":"2015","unstructured":"Goulas T, Mizgalska D, Garcia-Ferrer I, Kantyka T, Guevara T, Szmigielski B, Sroka A, Millan C, Uson I, Veillard F, Potempa B, Mydel P, Sola M, Potempa J, Gomis-Ruth FX (2015) Structure and mechanism of a bacterial host-protein citrullinating virulence factor, Porphyromonas gingivalis peptidylarginine deiminase. Sci Rep 5:11969","journal-title":"Sci Rep"},{"key":"1556_CR19","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s10753-004-6641-z","volume":"28","author":"ED Rosenstein","year":"2004","unstructured":"Rosenstein ED, Greenwald RA, Kushner LJ, Weissmann G (2004) Hypothesis: the humoral immune response to oral bacteria provides a stimulus for the development of rheumatoid arthritis. Inflammation 28:311\u2013318","journal-title":"Inflammation"},{"key":"1556_CR20","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1902\/jop.2011.110020","volume":"82","author":"M Okada","year":"2011","unstructured":"Okada M, Kobayashi T, Ito S, Yokoyama T, Komatsu Y, Abe A, Murasawa A, Yoshie H (2011) Antibody responses to periodontopathic bacteria in relation to rheumatoid arthritis in Japanese adults. J Periodontol 82:1433\u20131441","journal-title":"J Periodontol"},{"key":"1556_CR21","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.intimp.2008.09.008","volume":"9","author":"TR Mikuls","year":"2009","unstructured":"Mikuls TR, Payne JB, Reinhardt RA, Thiele GM, Maziarz E, Cannella AC, Holers VM, Kuhn KA, O\u2019Dell JR (2009) Antibody responses to Porphyromonas gingivalis (P. gingivalis) in subjects with rheumatoid arthritis and periodontitis. Int Immunopharmacol 9:38\u201342","journal-title":"Int Immunopharmacol"},{"key":"1556_CR22","doi-asserted-by":"crossref","first-page":"2662","DOI":"10.1002\/art.27552","volume":"62","author":"N Wegner","year":"2010","unstructured":"Wegner N, Wait R, Sroka A, Eick S, Nguyen KA, Lundberg K, Kinloch A, Culshaw S, Potempa J, Venables PJ (2010) Peptidylarginine deiminase from Porphyromonas gingivalis citrullinates human fibrinogen and alpha-enolase: implications for autoimmunity in rheumatoid arthritis. Arthritis Rheum 62:2662\u20132672","journal-title":"Arthritis Rheum"},{"key":"1556_CR23","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1002\/art.27584","volume":"62","author":"D Aletaha","year":"2010","unstructured":"Aletaha D, Neogi T, Silman AJ, Funovits J, Felson DT, Bingham 3rd CO, Birnbaum NS, Burmester GR, Bykerk VP, Cohen MD, Combe B, Costenbader KH, Dougados M, Emery P, Ferraccioli G, Hazes JM, Hobbs K, Huizinga TW, Kavanaugh A, Kay J, Kvien TK, Laing T, Mease P, Menard HA, Moreland LW, Naden RL, Pincus T, Smolen JS, Stanislawska-Biernat E, Symmons D, Tak PP, Upchurch KS, Vencovsky J, Wolfe F, Hawker G (2010) 2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology\/European League Against Rheumatism collaborative initiative. Arthritis Rheum 62:2569\u20132581","journal-title":"Arthritis Rheum"},{"issue":"226-9","key":"1556_CR24","first-page":"231","volume":"124","author":"C Lo Frisco","year":"1993","unstructured":"Lo Frisco C, Cutler R, Bramson JB (1993) Periodontal screening and recording: perceptions and effects on practice. J Am Dent Assoc 124(226-9):231\u2013232","journal-title":"J Am Dent Assoc"},{"key":"1556_CR25","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1902\/jop.2011.100565","volume":"82","author":"A Guentsch","year":"2011","unstructured":"Guentsch A, Kramesberger M, Sroka A, Pfister W, Potempa J, Eick S (2011) Comparison of gingival crevicular fluid sampling methods in patients with severe chronic periodontitis. J Periodontol 82:1051\u20131060","journal-title":"J Periodontol"},{"key":"1556_CR26","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/j.1600-0765.2009.01224.x","volume":"45","author":"A Guentsch","year":"2010","unstructured":"Guentsch A, Ronnebeck M, Puklo M, Preshaw PM, Pfister W, Eick S (2010) Influence of serum on interaction of Porphyromonas gingivalis ATCC 33277 and Aggregatibacter actinomycetemcomitans Y4 with an epithelial cell line. J Periodontal Res 45:229\u2013238","journal-title":"J Periodontal Res"},{"key":"1556_CR27","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.diagmicrobio.2010.08.017","volume":"69","author":"S Eick","year":"2011","unstructured":"Eick S, Straube A, Guentsch A, Pfister W, Jentsch H (2011) Comparison of real-time polymerase chain reaction and DNA-strip technology in microbiological evaluation of periodontitis treatment. Diagn Microbiol Infect Dis 69:12\u201320","journal-title":"Diagn Microbiol Infect Dis"},{"key":"1556_CR28","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/0003-2697(80)90404-2","volume":"107","author":"TR Boyde","year":"1980","unstructured":"Boyde TR, Rahmatullah M (1980) Optimization of conditions for the colorimetric determination of citrulline, using diacetyl monoxime. Anal Biochem 107:424\u2013431","journal-title":"Anal Biochem"},{"key":"1556_CR29","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1136\/annrheumdis-2012-202701","volume":"73","author":"P Pablo de","year":"2014","unstructured":"de Pablo P, Dietrich T, Chapple IL, Milward M, Chowdhury M, Charles PJ, Buckley CD, Venables PJ (2014) The autoantibody repertoire in periodontitis: a role in the induction of autoimmunity to citrullinated proteins in rheumatoid arthritis? Ann Rheum Dis 73:580\u2013586","journal-title":"Ann Rheum Dis"},{"key":"1556_CR30","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1136\/annrheumdis-2012-202726","volume":"73","author":"AM Quirke","year":"2014","unstructured":"Quirke AM, Lugli EB, Wegner N, Hamilton BC, Charles P, Chowdhury M, Ytterberg AJ, Zubarev RA, Potempa J, Culshaw S, Guo Y, Fisher BA, Thiele G, Mikuls TR, Venables PJ (2014) Heightened immune response to autocitrullinated Porphyromonas gingivalis peptidylarginine deiminase: a potential mechanism for breaching immunologic tolerance in rheumatoid arthritis. Ann Rheum Dis 73:263\u2013269","journal-title":"Ann Rheum Dis"},{"key":"1556_CR31","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1902\/jop.2009.090309","volume":"81","author":"A Dissick","year":"2010","unstructured":"Dissick A, Redman RS, Jones M, Rangan BV, Reimold A, Griffiths GR, Mikuls TR, Amdur RL, Richards JS, Kerr GS (2010) Association of periodontitis with rheumatoid arthritis: a pilot study. J Periodontol 81:223\u2013230","journal-title":"J Periodontol"},{"issue":"Suppl 1","key":"1556_CR32","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/j.1600-0579.2010.00620.x","volume":"14","author":"J Konig","year":"2010","unstructured":"Konig J, Holtfreter B, Kocher T (2010) Periodontal health in Europe: future trends based on treatment needs and the provision of periodontal services\u2013position paper 1. Eur J Dent Educ 14(Suppl 1):4\u201324","journal-title":"Eur J Dent Educ"},{"key":"1556_CR33","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1358\/dnp.2009.22.9.1437962","volume":"22","author":"FJ Lopez-Longo","year":"2009","unstructured":"Lopez-Longo FJ, Sanchez-Ramon S, Carreno L (2009) The value of anti-cyclic citrullinated peptide antibodies in rheumatoid arthritis: do they imply new risk factors? Drug News Perspect 22:543\u2013548","journal-title":"Drug News Perspect"},{"key":"1556_CR34","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1111\/jre.12002","volume":"48","author":"GP Harvey","year":"2013","unstructured":"Harvey GP, Fitzsimmons TR, Dhamarpatni AA, Marchant C, Haynes DR, Bartold PM (2013) Expression of peptidylarginine deiminase-2 and -4, citrullinated proteins and anti-citrullinated protein antibodies in human gingiva. J Periodontal Res 48:252\u2013261","journal-title":"J Periodontal Res"},{"key":"1556_CR35","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1136\/annrheumdis-2011-200380","volume":"71","author":"D Potikuri","year":"2012","unstructured":"Potikuri D, Dannana KC, Kanchinadam S, Agrawal S, Kancharla A, Rajasekhar L, Pothuraju S, Gumdal N (2012) Periodontal disease is significantly higher in non-smoking treatment-naive rheumatoid arthritis patients: results from a case-control study. Ann Rheum Dis 71:1541\u20131544","journal-title":"Ann Rheum Dis"},{"key":"1556_CR36","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1002\/art.37911","volume":"65","author":"L Barra","year":"2013","unstructured":"Barra L, Scinocca M, Saunders S, Bhayana R, Rohekar S, Racape M, Coles R, Cairns E, Bell DA (2013) Anti-citrullinated protein antibodies in unaffected first-degree relatives of rheumatoid arthritis patients. Arthritis Rheum 65:1439\u20131447","journal-title":"Arthritis Rheum"},{"key":"1556_CR37","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1002\/art.38348","volume":"66","author":"TR Mikuls","year":"2014","unstructured":"Mikuls TR, Payne JB, Yu F, Thiele GM, Reynolds RJ, Cannon GW, Markt J, McGowan D, Kerr GS, Redman RS, Reimold A, Griffiths G, Beatty M, Gonzalez SM, Bergman DA, Hamilton 3rd BC, Erickson AR, Sokolove J, Robinson WH, Walker C, Chandad F, O\u2019Dell JR (2014) Periodontitis and Porphyromonas gingivalis in patients with rheumatoid arthritis. Arthritis Rheum 66:1090\u20131100","journal-title":"Arthritis Rheum"},{"key":"1556_CR38","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1002\/art.22817","volume":"56","author":"H Bang","year":"2007","unstructured":"Bang H, Egerer K, Gauliard A, Luthke K, Rudolph PE, Fredenhagen G, Berg W, Feist E, Burmester GR (2007) Mutation and citrullination modifies vimentin to a novel autoantigen for rheumatoid arthritis. Arthritis Rheum 56:2503\u20132511","journal-title":"Arthritis Rheum"},{"key":"1556_CR39","doi-asserted-by":"crossref","first-page":"3009","DOI":"10.1002\/art.23936","volume":"58","author":"K Lundberg","year":"2008","unstructured":"Lundberg K, Kinloch A, Fisher BA, Wegner N, Wait R, Charles P, Mikuls TR, Venables PJ (2008) Antibodies to citrullinated alpha-enolase peptide 1 are specific for rheumatoid arthritis and cross-react with bacterial enolase. Arthritis Rheum 58:3009\u20133019","journal-title":"Arthritis Rheum"},{"key":"1556_CR40","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1172\/JCI60975","volume":"122","author":"U Harre","year":"2012","unstructured":"Harre U, Georgess D, Bang H, Bozec A, Axmann R, Ossipova E, Jakobsson PJ, Baum W, Nimmerjahn F, Szarka E, Sarmay G, Krumbholz G, Neumann E, Toes R, Scherer HU, Catrina AI, Klareskog L, Jurdic P, Schett G (2012) Induction of osteoclastogenesis and bone loss by human autoantibodies against citrullinated vimentin. J Clin Invest 122:1791\u20131802","journal-title":"J Clin Invest"},{"key":"1556_CR41","doi-asserted-by":"crossref","first-page":"22s","DOI":"10.1083\/jcb.99.1.22s","volume":"99","author":"PM Steinert","year":"1984","unstructured":"Steinert PM, Jones JC, Goldman RD (1984) Intermediate filaments. J Cell Biol 99:22s\u201327s","journal-title":"J Cell Biol"},{"key":"1556_CR42","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.jsb.2011.11.017","volume":"177","author":"RD Goldman","year":"2012","unstructured":"Goldman RD, Cleland MM, Murthy SN, Mahammad S, Kuczmarski ER (2012) Inroads into the structure and function of intermediate filament networks. J Struct Biol 177:14\u201323","journal-title":"J Struct Biol"},{"key":"1556_CR43","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0003-9969(02)00164-4","volume":"48","author":"A Sculean","year":"2003","unstructured":"Sculean A, Berakdar M, Windisch P, Remberger K, Donos N, Brecx M (2003) Immunohistochemical investigation on the pattern of vimentin expression in regenerated and intact monkey and human periodontal ligament. Arch Oral Biol 48:77\u201386","journal-title":"Arch Oral Biol"},{"key":"1556_CR44","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1034\/j.1600-0714.2001.300308.x","volume":"30","author":"N Hunter","year":"2001","unstructured":"Hunter N, Nicholls B, Srivastava M, Chapple CC, Zoellner HF, Gibbins JR (2001) Reactive pocket epithelium in untreated chronic periodontal disease: possible derivation from developmental remnants of the enamel organ and root sheath. J Oral Pathol Med 30:178\u2013186","journal-title":"J Oral Pathol Med"},{"key":"1556_CR45","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1902\/jop.1981.52.4.181","volume":"52","author":"N Hidaka","year":"1981","unstructured":"Hidaka N, Maeda K, Kawakami C, Aono M, Okada H (1981) Fibrinolytic activity in periodontal disease. The relationship between fibrinolytic activity and severity of periodontal disease. J Periodontol 52:181\u2013186","journal-title":"J Periodontol"},{"key":"1556_CR46","doi-asserted-by":"crossref","first-page":"3083","DOI":"10.1002\/art.34539","volume":"64","author":"JU Scher","year":"2012","unstructured":"Scher JU, Ubeda C, Equinda M, Khanin R, Buischi Y, Viale A, Lipuma L, Attur M, Pillinger MH, Weissmann G, Littman DR, Pamer EG, Bretz WA, Abramson SB (2012) Periodontal disease and the oral microbiota in new-onset rheumatoid arthritis. Arthritis Rheum 64:3083\u20133094","journal-title":"Arthritis Rheum"},{"key":"1556_CR47","doi-asserted-by":"crossref","first-page":"R222","DOI":"10.1186\/ar4061","volume":"14","author":"MD Smit","year":"2012","unstructured":"Smit MD, Westra J, Vissink A, Doornbos-van der Meer B, Brouwer E, van Winkelhoff AJ (2012) Periodontitis in established rheumatoid arthritis patients: a cross-sectional clinical, microbiological and serological study. Arthritis Res Ther 14:R222","journal-title":"Arthritis Res Ther"},{"key":"1556_CR48","first-page":"2","volume":"7","author":"M Ogrendik","year":"2005","unstructured":"Ogrendik M, Kokino S, Ozdemir F, Bird PS, Hamlet S (2005) Serum antibodies to oral anaerobic bacteria in patients with rheumatoid arthritis. Med Gen Med 7:2","journal-title":"Med Gen Med"},{"key":"1556_CR49","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1177\/00220345010800010901","volume":"80","author":"A Yoshida","year":"2001","unstructured":"Yoshida A, Nakano Y, Yamashita Y, Oho T, Ito H, Kondo M, Ohishi M, Koga T (2001) Immunodominant region of Actinobacillus actinomycetemcomitans 40-kilodalton heat shock protein in patients with rheumatoid arthritis. J Dent Res 80:346\u2013350","journal-title":"J Dent Res"},{"key":"1556_CR50","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1111\/j.1600-051X.2012.01885.x","volume":"39","author":"W Nesse","year":"2012","unstructured":"Nesse W, Westra J, van der Wal JE, Abbas F, Nicholas AP, Vissink A, Brouwer E (2012) The periodontium of periodontitis patients contains citrullinated proteins which may play a role in ACPA (anti-citrullinated protein antibody) formation. J Clin Periodontol 39:599\u2013607","journal-title":"J Clin Periodontol"},{"key":"1556_CR51","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.anaerobe.2013.07.001","volume":"23","author":"SN Abdullah","year":"2013","unstructured":"Abdullah SN, Farmer EA, Spargo L, Logan R, Gully N (2013) Porphyromonas gingivalis peptidylarginine deiminase substrate specificity. Anaerobe 23:102\u2013108","journal-title":"Anaerobe"},{"key":"1556_CR52","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1128\/IAI.00830-12","volume":"81","author":"K Pyrc","year":"2013","unstructured":"Pyrc K, Milewska A, Kantyka T, Sroka A, Maresz K, Koziel J, Nguyen KA, Enghild JJ, Knudsen AD, Potempa J (2013) Inactivation of epidermal growth factor by Porphyromonas gingivalis as a potential mechanism for periodontal tissue damage. Infect Immun 81:55\u201364","journal-title":"Infect Immun"},{"key":"1556_CR53","doi-asserted-by":"crossref","first-page":"e1003627","DOI":"10.1371\/journal.ppat.1003627","volume":"9","author":"KJ Maresz","year":"2013","unstructured":"Maresz KJ, Hellvard A, Sroka A, Adamowicz K, Bielecka E, Koziel J, Gawron K, Mizgalska D, Marcinska KA, Benedyk M, Pyrc K, Quirke AM, Jonsson R, Alzabin S, Venables PJ, Nguyen KA, Mydel P, Potempa J (2013) Porphyromonas gingivalis facilitates the development and progression of destructive arthritis through its unique bacterial peptidylarginine deiminase (PAD). PLoS Pathog 9:e1003627","journal-title":"PLoS Pathog"},{"key":"1556_CR54","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1128\/IAI.64.2.660-664.1996","volume":"64","author":"PN Madianos","year":"1996","unstructured":"Madianos PN, Papapanou PN, Nannmark U, Dahlen G, Sandros J (1996) Porphyromonas gingivalis FDC381 multiplies and persists within human oral epithelial cells in vitro. Infect Immun 64:660\u2013664","journal-title":"Infect Immun"},{"key":"1556_CR55","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1111\/j.1399-302X.1993.tb00616.x","volume":"8","author":"H Hayashi","year":"1993","unstructured":"Hayashi H, Morioka M, Ichimiya S, Yamato K, Hinode D, Nagata A, Nakamura R (1993) Participation of an arginyl residue of insulin chain B in the inhibition of hemagglutination by Porphyromonas gingivalis. Oral Microbiol Immunol 8:386\u2013389","journal-title":"Oral Microbiol Immunol"}],"container-title":["Clinical Oral Investigations"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-015-1556-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00784-015-1556-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-015-1556-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,7]],"date-time":"2020-09-07T03:06:56Z","timestamp":1599448016000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00784-015-1556-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8,13]]},"references-count":55,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["1556"],"URL":"https:\/\/doi.org\/10.1007\/s00784-015-1556-7","relation":{},"ISSN":["1432-6981","1436-3771"],"issn-type":[{"value":"1432-6981","type":"print"},{"value":"1436-3771","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,13]]}}}