{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T11:46:33Z","timestamp":1781264793428,"version":"3.54.1"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2015,10,13]],"date-time":"2015-10-13T00:00:00Z","timestamp":1444694400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Oral Invest"],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1007\/s00784-015-1622-1","type":"journal-article","created":{"date-parts":[[2015,10,13]],"date-time":"2015-10-13T19:15:41Z","timestamp":1444763741000},"page":"1347-1354","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["The association between hypodontia and dental development"],"prefix":"10.1007","volume":"20","author":[{"given":"Brunilda","family":"Dhamo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Strahinja","family":"Vucic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mette A. R.","family":"Kuijpers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent W. V.","family":"Jaddoe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Hofman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eppo B.","family":"Wolvius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edwin M.","family":"Ongkosuwito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,10,13]]},"reference":[{"issue":"2","key":"1622_CR1","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1046\/j.1365-263X.2003.00436.x","volume":"13","author":"R Silva Meza","year":"2003","unstructured":"Silva Meza R (2003) Radiographic assessment of congenitally missing teeth in orthodontic patients. Int J Paediatr Dent 13(2):112\u2013116","journal-title":"Int J Paediatr Dent"},{"key":"1622_CR2","first-page":"381","volume":"21","author":"JR Goodman","year":"1994","unstructured":"Goodman JR, Jones SP, Hobkirk JA, King PA (1994) Hypodonta 1: clinical features and the management of mild to moderate hypodontia. Dent Updat 21:381\u2013384","journal-title":"Dent Updat"},{"issue":"5","key":"1622_CR3","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/S0889-5406(95)70047-1","volume":"108","author":"B \u00d8gaard","year":"1995","unstructured":"\u00d8gaard B, Krogstad O (1995) Craniofacial structure and soft tissue profile in patients with severe hypodontia. Am J Orthod Dentofac Orthop 108(5):472\u2013477","journal-title":"Am J Orthod Dentofac Orthop"},{"issue":"4","key":"1622_CR4","first-page":"294","volume":"33","author":"PJ Dhanrajani","year":"2002","unstructured":"Dhanrajani PJ (2002) Hypodontia: etiology, clinical features, and management. Quintessence Int 33(4):294\u2013302","journal-title":"Quintessence Int"},{"issue":"2","key":"1622_CR5","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1179\/1465313312Y.0000000035","volume":"40","author":"S Kotecha","year":"2013","unstructured":"Kotecha S, Turner PJ, Dietrich T, Dhopatkar A (2013) The impact of tooth agenesis on oral health-related quality of life in children. J Orthod 40(2):122\u2013129. doi: 10.1179\/1465313312Y.0000000035","journal-title":"J Orthod"},{"issue":"6","key":"1622_CR6","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.ijom.2007.01.021","volume":"36","author":"N Worsaae","year":"2007","unstructured":"Worsaae N, Jensen BN, Holm B, Holsko J (2007) Treatment of severe hypodontia\u2013oligodontia\u2014an interdisciplinary concept. Int J Oral Maxillofac Surg 36(6):473\u2013480","journal-title":"Int J Oral Maxillofac Surg"},{"issue":"4","key":"1622_CR7","first-page":"278","volume":"20","author":"AD Guckes","year":"1998","unstructured":"Guckes AD, Roberts MW, McCarthy GR (1998) Pattern of permanent teeth present in individuals with ectodermal dysplasia and severe hypodontia suggests treatment with dental implants. Pediatr Dent 20(4):278\u2013280","journal-title":"Pediatr Dent"},{"issue":"3","key":"1622_CR8","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1111\/j.1600-0528.2004.00158.x","volume":"32","author":"BJ Polder","year":"2004","unstructured":"Polder BJ, Van\u2019t Hof MA, Van der Linden FPGM, Kuijpers-Jagtman AM (2004) A meta-analysis of the prevalence of dental agenesis of permanent teeth. Community Dent Oral Epidemiol 32(3):217\u2013226. doi: 10.1111\/j.1600-0528.2004.00158.x","journal-title":"Community Dent Oral Epidemiol"},{"issue":"1","key":"1622_CR9","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.jdsr.2008.12.001","volume":"45","author":"T Shimizu","year":"2009","unstructured":"Shimizu T, Maeda T (2009) Prevalence and genetic basis of tooth agenesis. Jpn Dent Sci Rev 45(1):52\u201358","journal-title":"Jpn Dent Sci Rev"},{"issue":"5","key":"1622_CR10","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1136\/jmedgenet-2012-100750","volume":"49","author":"M-J Boogaard van den","year":"2012","unstructured":"van den Boogaard M-J, Cr\u00e9ton M, Bronkhorst Y, van der Hout A, Hennekam E, Lindhout D, Cune M, van Amstel HKP (2012) Mutations in WNT10A are present in more than half of isolated hypodontia cases. J Med Genet 49(5):327\u2013331","journal-title":"J Med Genet"},{"issue":"6","key":"1622_CR11","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1097\/00005537-200206000-00005","volume":"112","author":"E Daniel","year":"2002","unstructured":"Daniel E, McCurdy EA, Shashi V, McGuirt WF (2002) Ectodermal dysplasia: otolaryngologic manifestations and management. Laryngoscope 112(6):962\u2013967. doi: 10.1097\/00005537-200206000-00005","journal-title":"Laryngoscope"},{"issue":"4","key":"1622_CR12","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1002\/ajmg.10654","volume":"112","author":"EL Johnson","year":"2002","unstructured":"Johnson EL, Roberts MW, Guckes AD, Bailey LTJ, Phillips CL, Wright JT (2002) Analysis of craniofacial development in children with hypohidrotic ectodermal dysplasia. Am J Med Genet 112(4):327\u2013334. doi: 10.1002\/ajmg.10654","journal-title":"Am J Med Genet"},{"issue":"2","key":"1622_CR13","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1111\/j.1754-4505.2001.tb00230.x","volume":"21","author":"AG Acerbi","year":"2001","unstructured":"Acerbi AG, de Freitas C, de Magalhaes MHCG (2001) Prevalence of numeric anomalies in the permanent dentition of patients with Down syndrome. Spec Care Dent 21(2):75\u201378. doi: 10.1111\/j.1754-4505.2001.tb00230.x","journal-title":"Spec Care Dent"},{"issue":"Suppl","key":"1622_CR14","first-page":"69","volume":"22","author":"SR Mestrovic","year":"1998","unstructured":"Mestrovic SR, Rajic Z, Papic JS (1998) Hypodontia in patients with Down\u2019s syndrome. Coll Antropol 22(Suppl):69\u201372","journal-title":"Coll Antropol"},{"issue":"12","key":"1622_CR15","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1177\/154405910308201215","volume":"82","author":"P Nieminen","year":"2003","unstructured":"Nieminen P, Kotilainen J, Aalto Y, Knuutila S, Pirinen S, Thesleff I (2003) MSX1 gene is deleted in Wolf-Hirschhorn syndrome patients with oligodontia. J Dent Res 82(12):1013\u20131017. doi: 10.1177\/154405910308201215","journal-title":"J Dent Res"},{"issue":"1","key":"1622_CR16","first-page":"3","volume":"5","author":"EJ Zabawski","year":"1999","unstructured":"Zabawski EJ, Cohen JB (1999) Hereditary hypodontia and onychorrhexis of the fingernails and toenail koilonychia: Witkop\u2019s tooth-and nail syndrome. Dermatol Online J 5(1):3","journal-title":"Dermatol Online J"},{"issue":"1","key":"1622_CR17","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1111\/j.1600-0722.2009.00698.x","volume":"118","author":"TN Bartzela","year":"2010","unstructured":"Bartzela TN, Carels CEL, Bronkhorst EM, R\u00f8nning E, Rizell S, Kuijpers-Jagtman AM (2010) Tooth agenesis patterns in bilateral cleft lip and palate. Eur J Oral Sci 118(1):47\u201352. doi: 10.1111\/j.1600-0722.2009.00698.x","journal-title":"Eur J Oral Sci"},{"issue":"4","key":"1622_CR18","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1111\/j.1600-0528.1987.tb00524.x","volume":"15","author":"PJ Davis","year":"1987","unstructured":"Davis PJ (1987) Hypodontia and hyperdontia of permanent teeth in Hong Kong schoolchildren. Community Dent Oral Epidemiol 15(4):218\u2013220","journal-title":"Community Dent Oral Epidemiol"},{"issue":"2","key":"1622_CR19","first-page":"113","volume":"34","author":"AC Medina","year":"2012","unstructured":"Medina AC (2012) Radiographic study of prevalence and distribution of hypodontia in a pediatric orthodontic population in Venezuela. Pediatr Dent 34(2):113\u2013116","journal-title":"Pediatr Dent"},{"issue":"5","key":"1622_CR20","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1111\/j.1600-0722.1993.tb01115.x","volume":"101","author":"B Aasheim","year":"1993","unstructured":"Aasheim B, \u00d6gaard B (1993) Hypodontia in 9\u2010year\u2010old Norwegians related to need of orthodontic treatment. Eur J Oral Sci 101(5):257\u2013260","journal-title":"Eur J Oral Sci"},{"issue":"3","key":"1622_CR21","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1016\/j.ajodo.2009.04.024","volume":"139","author":"E\u015e Tun\u00e7","year":"2011","unstructured":"Tun\u00e7 E\u015e, Bayrak \u015e, Koyut\u00fcrk AE (2011) Dental development in children with mild-to-moderate hypodontia. Am J Orthod Dentofac Orthop 139(3):334\u2013338. doi: 10.1016\/j.ajodo.2009.04.024","journal-title":"Am J Orthod Dentofac Orthop"},{"issue":"2","key":"1622_CR22","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.archoralbio.2005.06.004","volume":"51","author":"S Uslenghi","year":"2006","unstructured":"Uslenghi S, Liversidge HM, Wong FS (2006) A radiographic study of tooth development in hypodontia. Arch Oral Biol 51(2):129\u2013133. doi: 10.1016\/j.archoralbio.2005.06.004","journal-title":"Arch Oral Biol"},{"issue":"3","key":"1622_CR23","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.ajodo.2011.08.026","volume":"141","author":"EV Ruiz-Mealin","year":"2012","unstructured":"Ruiz-Mealin EV, Parekh S, Jones SP, Moles DR, Gill DS (2012) Radiographic study of delayed tooth development in patients with dental agenesis. Am J Orthod Dentofac Orthop 141(3):307\u2013314","journal-title":"Am J Orthod Dentofac Orthop"},{"key":"1622_CR24","first-page":"1","volume":"0","author":"Y Ben-Bassat","year":"2014","unstructured":"Ben-Bassat Y, Babadzhanov D, Brin I, Hazan-Molina H, Aizenbud D (2014) Maturation of teeth adjacent to dental agenesis site. Acta Odontol Scand 0:1\u20137","journal-title":"Acta Odontol Scand"},{"issue":"1","key":"1622_CR25","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/j.1365-3016.2003.00521.x","volume":"18","author":"A Hofman","year":"2004","unstructured":"Hofman A, Jaddoe VWV, Mackenbach JP, Moll HA, Snijders RFM, Steegers EAP, Verhulst FC, Witteman J, B\u00fcller HA (2004) Growth, development and health from early fetal life until young adulthood: the generation R study. Paediatr Perinat Epidemiol 18(1):61\u201372","journal-title":"Paediatr Perinat Epidemiol"},{"issue":"9","key":"1622_CR26","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1007\/s10654-012-9735-1","volume":"27","author":"VWV Jaddoe","year":"2012","unstructured":"Jaddoe VWV, van Duijn CM, Franco OH, van der Heijden AJ, van Iizendoorn MH, de Jongste JC, van der Lugt A, Mackenbach JP, Moll HA, Raat H (2012) The generation R study: design and cohort update 2012. Eur J Epidemiol 27(9):739\u2013756","journal-title":"Eur J Epidemiol"},{"issue":"12","key":"1622_CR27","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1007\/s10654-014-9980-6","volume":"29","author":"CJ Kruithof","year":"2015","unstructured":"Kruithof CJ, Kooijman MN, van Duijn CM, Franco OH, de Jongste JC, Klaver CCW, Mackenbach JP, Moll HA, Raat H, Rings EHHM, Rivadeneira F, Steegers EA, Tiemeier H, Uitterlinden AG, Verhulst FC, Wolvius EB, Hofman A, Jaddoe VWV (2015) The generation R study: biobank update 2015. Eur J Epidemiol 29(12):911\u2013927","journal-title":"Eur J Epidemiol"},{"key":"1622_CR28","volume-title":"A mixed-longitudinal, interdisciplinary study of growth and development","author":"B Prahl-Andersen","year":"1979","unstructured":"Prahl-Andersen B, Kowalski CJ, Heydendael PHJM (1979) A mixed-longitudinal, interdisciplinary study of growth and development. Academic, New York"},{"key":"1622_CR29","unstructured":"Demirjian A, Goldstein H, Tanner JM (1973) A new system of dental age assessment. Hum Biol:211\u2013227"},{"issue":"2","key":"1622_CR30","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1080\/000163500429280","volume":"58","author":"M Nystr\u00f6m","year":"2000","unstructured":"Nystr\u00f6m M, Aine L, Peck L, Haavikko K, Kataja M (2000) Dental maturity in Finns and the problem of missing teeth. Acta Odontol 58(2):49\u201356","journal-title":"Acta Odontol"},{"issue":"3","key":"1622_CR31","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1093\/ejo\/cji010","volume":"27","author":"IH Leurs","year":"2005","unstructured":"Leurs IH, Wattel E, Aartman IHA, Etty E, Prahl-Andersen B (2005) Dental age in Dutch children. Eur J Orthod 27(3):309\u2013314","journal-title":"Eur J Orthod"},{"issue":"2","key":"1622_CR32","first-page":"18","volume":"22","author":"N Chaillet","year":"2004","unstructured":"Chaillet N, Willems G (2004) Dental maturity in Belgian children using Demirjian\u2019s method and polynomial functions: new standard curves for forensic and clinical use. J Forensic Odontostomatol 22(2):18\u201327","journal-title":"J Forensic Odontostomatol"},{"issue":"2","key":"1622_CR33","first-page":"135","volume":"33","author":"HJ Keene","year":"1966","unstructured":"Keene HJ (1966) The relationship between maternal age and parity, birth weight and hypodontia in naval recruits. J Dent Child 33(2):135\u2013147","journal-title":"J Dent Child"},{"key":"1622_CR34","doi-asserted-by":"crossref","unstructured":"Sterne JAC, White IR, Carlin JB, Spratt M, Royston P, Kenward MG, Wood AM, Carpenter JR (2009) Multiple imputation for missing data in epidemiological and clinical research: potential and pitfalls. BMJ 338","DOI":"10.1136\/bmj.b2393"},{"issue":"3","key":"1622_CR35","first-page":"103","volume":"66","author":"K Haavikko","year":"1970","unstructured":"Haavikko K (1970) The formation and the alveolar and clinical eruption of the permanent teeth. An orthopantomographic study. Suomen Hammasl\u00e4\u00e4k\u00e4riseuran Toimituksia Finska Tandl\u00e4kars\u00e4llskapets F\u00f6rh 66(3):103","journal-title":"Suomen Hammasl\u00e4\u00e4k\u00e4riseuran Toimituksia Finska Tandl\u00e4kars\u00e4llskapets F\u00f6rh"},{"issue":"1","key":"1622_CR36","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.forsciint.2007.04.228","volume":"175","author":"ES Tunc","year":"2008","unstructured":"Tunc ES, Koyuturk AE (2008) Dental age assessment using Demirjian\u2019s method on northern Turkish children. Forensic Sci Int 175(1):23\u201326","journal-title":"Forensic Sci Int"},{"issue":"1","key":"1622_CR37","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1093\/ejo\/26.1.99","volume":"26","author":"N Mattheeuws","year":"2004","unstructured":"Mattheeuws N, Dermaut L, Martens G (2004) Has hypodontia increased in Caucasians during the 20th century? A meta-analysis. Eur J Orthod 26(1):99\u2013103","journal-title":"Eur J Orthod"},{"key":"1622_CR38","doi-asserted-by":"crossref","unstructured":"Smith JM (1978) Optimization theory in evolution. Ann Rev Ecol Syst:31\u201356","DOI":"10.1146\/annurev.es.09.110178.000335"},{"key":"1622_CR39","doi-asserted-by":"crossref","first-page":"S52","DOI":"10.1016\/j.archoralbio.2008.11.002","volume":"54","author":"N Parkin","year":"2009","unstructured":"Parkin N, Elcock C, Smith RN, Griffin RC, Brook AH (2009) The aetiology of hypodontia: the prevalence, severity and location of hypodontia within families. Arch Oral Biol 54:S52\u2013S56","journal-title":"Arch Oral Biol"},{"issue":"9","key":"1622_CR40","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1016\/j.archoralbio.2015.06.005","volume":"60","author":"B Kerekes-M\u00e1th\u00e9","year":"2015","unstructured":"Kerekes-M\u00e1th\u00e9 B, Brook AH, M\u00e1rtha K, Sz\u00e9kely M, Smith RN (2015) Mild hypodontia is associated with smaller tooth dimensions and cusp numbers than in controls. Arch Oral Biol 60(9):1442\u20131449","journal-title":"Arch Oral Biol"},{"issue":"7","key":"1622_CR41","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1177\/154405910808700715","volume":"87","author":"E Matalova","year":"2008","unstructured":"Matalova E, Fleischmannova J, Sharpe PT, Tucker AS (2008) Tooth agenesis: from molecular genetics to molecular dentistry. J Dent Res 87(7):617\u2013623","journal-title":"J Dent Res"},{"issue":"4","key":"1622_CR42","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1038\/bdj.2007.732","volume":"203","author":"MT Cobourne","year":"2007","unstructured":"Cobourne MT (2007) Familial human hypodontia\u2014is it all in the genes? Br Dent J 203(4):203\u2013208. doi: 10.1038\/bdj.2007.732","journal-title":"Br Dent J"}],"container-title":["Clinical Oral Investigations"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-015-1622-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00784-015-1622-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-015-1622-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,3,26]],"date-time":"2019-03-26T19:06:04Z","timestamp":1553627164000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00784-015-1622-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,13]]},"references-count":42,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["1622"],"URL":"https:\/\/doi.org\/10.1007\/s00784-015-1622-1","relation":{},"ISSN":["1432-6981","1436-3771"],"issn-type":[{"value":"1432-6981","type":"print"},{"value":"1436-3771","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,13]]}}}