{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T19:24:55Z","timestamp":1772306695947,"version":"3.50.1"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2017,2,23]],"date-time":"2017-02-23T00:00:00Z","timestamp":1487808000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Department of Biotechnology (DBT), New Delhi","award":["BT\/PR4624\/MED\/30\/701\/2012"],"award-info":[{"award-number":["BT\/PR4624\/MED\/30\/701\/2012"]}]},{"name":"Departmental support of DBT Builder Programme","award":["BT\/PR9028\/INF\/22\/193\/2013"],"award-info":[{"award-number":["BT\/PR9028\/INF\/22\/193\/2013"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Oral Invest"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1007\/s00784-017-2074-6","type":"journal-article","created":{"date-parts":[[2017,2,23]],"date-time":"2017-02-23T07:00:01Z","timestamp":1487833201000},"page":"2721-2731","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["The elevated activation of NF\u03baB and AP-1 is correlated with differential regulation of Bcl-2 and associated with oral squamous cell carcinoma progression and resistance"],"prefix":"10.1007","volume":"21","author":[{"given":"Manzar","family":"Alam","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanushree","family":"Kashyap","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamdeo K.","family":"Pramanik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abhay K.","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siddavaram","family":"Nagini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajakishore","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,2,23]]},"reference":[{"key":"2074_CR1","doi-asserted-by":"publisher","first-page":"E359","DOI":"10.1002\/ijc.29210","volume":"136","author":"J Ferlay","year":"2015","unstructured":"Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray F (2015) Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer 136:E359\u2013E386. doi: 10.1002\/ijc.29210","journal-title":"Int J Cancer"},{"key":"2074_CR2","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1038\/ncponc0714","volume":"4","author":"TY Seiwert","year":"2007","unstructured":"Seiwert TY, Salama JK, Vokes EE (2007) The concurrent chemoradiation paradigm--general principles. Nat Clin Pract Oncol 4:86\u2013100. doi: 10.1038\/ncponc0714","journal-title":"Nat Clin Pract Oncol"},{"key":"2074_CR3","doi-asserted-by":"publisher","first-page":"e80998","DOI":"10.1371\/journal.pone.0080998 PONE-D-13-25926","volume":"8","author":"T Kiyoshima","year":"2013","unstructured":"Kiyoshima T, Yoshida H, Wada H, Nagata K, Fujiwara H, Kihara M, Hasegawa K, Someya H, Sakai H (2013) Chemoresistance to concanamycin A1 in human oral squamous cell carcinoma is attenuated by an HDAC inhibitor partly via suppression of bcl-2 expression. PLoS One 8:e80998. doi: 10.1371\/journal.pone.0080998 PONE-D-13-25926","journal-title":"PLoS One"},{"key":"2074_CR4","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.7744","author":"M Gilormini","year":"2016","unstructured":"Gilormini M, Malesys C, Armandy E, Manas P, Guy JB, Magne N, Rodriguez-Lafrasse C, Ardail D (2016) Preferential targeting of cancer stem cells in the radiosensitizing effect of ABT-737 on HNSCC. Oncotarget. doi: 10.18632\/oncotarget.7744","journal-title":"Oncotarget"},{"key":"2074_CR5","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1038\/348334a0","volume":"348","author":"D Hockenbery","year":"1990","unstructured":"Hockenbery D, Nunez G, Milliman C, Schreiber RD, Korsmeyer SJ (1990) Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature 348:334\u2013336. doi: 10.1038\/348334a0","journal-title":"Nature"},{"key":"2074_CR6","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1038\/369321a0","volume":"369","author":"XM Yin","year":"1994","unstructured":"Yin XM, Oltvai ZN, Korsmeyer SJ (1994) BH1 and BH2 domains of bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax. Nature 369:321\u2013323. doi: 10.1038\/369321a0","journal-title":"Nature"},{"key":"2074_CR7","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/j.1460-2075.1988.tb02791.x","volume":"7","author":"M Seto","year":"1988","unstructured":"Seto M, Jaeger U, Hockett RD, Graninger W, Bennett S, Goldman P, Korsmeyer SJ (1988) Alternative promoters and exons, somatic mutation and deregulation of the bcl-2-Ig fusion gene in lymphoma. EMBO J 7:123\u2013131","journal-title":"EMBO J"},{"key":"2074_CR8","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.oooo.2013.02.010","volume":"116","author":"GR Yedida","year":"2013","unstructured":"Yedida GR, Nagini S, Mishra R (2013) The importance of oncogenic transcription factors for oral cancer pathogenesis and treatment. Oral Surg Oral Med Oral Pathol Oral Radiol 116:179\u2013188. doi: 10.1016\/j.oooo.2013.02.010","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"2074_CR9","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S1368-8375(01)00056-2","volume":"38","author":"SR Timmons","year":"2002","unstructured":"Timmons SR, Nwankwo JO, Domann FE (2002) Acetaldehyde activates Jun\/AP-1 expression and DNA binding activity in human oral keratinocytes. Oral Oncol 38:281\u2013290","journal-title":"Oral Oncol"},{"key":"2074_CR10","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.archoralbio.2015.12.002","volume":"64","author":"LK Li","year":"2016","unstructured":"Li LK, Rola AS, Kaid FA, Ali AM, Alabsi AM (2016) Goniothalamin induces cell cycle arrest and apoptosis in H400 human oral squamous cell carcinoma: a caspase-dependent mitochondrial-mediated pathway with downregulation of NF-kappabeta. Arch Oral Biol 64:28\u201338. doi: 10.1016\/j.archoralbio.2015.12.002","journal-title":"Arch Oral Biol"},{"key":"2074_CR11","doi-asserted-by":"publisher","first-page":"E131","DOI":"10.1038\/ncb0502-e131 ncb0502-e131","volume":"4","author":"E Shaulian","year":"2002","unstructured":"Shaulian E, Karin M (2002) AP-1 as a regulator of cell life and death. Nat Cell Biol 4:E131\u2013E136. doi: 10.1038\/ncb0502-e131 ncb0502-e131","journal-title":"Nat Cell Biol"},{"key":"2074_CR12","doi-asserted-by":"publisher","first-page":"e0119402","DOI":"10.1371\/journal.pone.0119402 PONE-D-14-36651","volume":"10","author":"B Kreiseder","year":"2015","unstructured":"Kreiseder B, Holper-Schichl YM, Muellauer B, Jacobi N, Pretsch A, Schmid JA, de Martin R, Hundsberger H, Eger A, Wiesner C (2015) Alpha-catulin contributes to drug-resistance of melanoma by activating NF-kappaB and AP-1. PLoS One 10:e0119402. doi: 10.1371\/journal.pone.0119402 PONE-D-14-36651","journal-title":"PLoS One"},{"key":"2074_CR13","doi-asserted-by":"publisher","first-page":"1240","DOI":"10.1038\/cdd.2014.41","volume":"21","author":"W Bunjobpol","year":"2014","unstructured":"Bunjobpol W, Dulloo I, Igarashi K, Concin N, Matsuo K, Sabapathy K (2014) Suppression of acetylpolyamine oxidase by selected AP-1 members regulates DNp73 abundance: mechanistic insights for overcoming DNp73-mediated resistance to chemotherapeutic drugs. Cell Death Differ 21:1240\u20131249. doi: 10.1038\/cdd.2014.41","journal-title":"Cell Death Differ"},{"key":"2074_CR14","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/0092-8674(86)90346-6","volume":"46","author":"R Sen","year":"1986","unstructured":"Sen R, Baltimore D (1986) Multiple nuclear factors interact with the immunoglobulin enhancer sequences. Cell 46:705\u2013716","journal-title":"Cell"},{"key":"2074_CR15","doi-asserted-by":"publisher","first-page":"12637","DOI":"10.18632\/oncotarget.3703","volume":"6","author":"C Canino","year":"2015","unstructured":"Canino C, Luo Y, Marcato P, Blandino G, Pass HI, Cioce M (2015) A STAT3-NFkB\/DDIT3\/CEBPbeta axis modulates ALDH1A3 expression in chemoresistant cell subpopulations. Oncotarget 6:12637\u201312653. doi: 10.18632\/oncotarget.3703","journal-title":"Oncotarget"},{"key":"2074_CR16","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1146\/annurev.immunol.14.1.649","volume":"14","author":"AS Baldwin Jr","year":"1996","unstructured":"Baldwin AS Jr (1996) The NF-kappa B and I kappa B proteins: new discoveries and insights. Annu Rev Immunol 14:649\u2013683. doi: 10.1146\/annurev.immunol.14.1.649","journal-title":"Annu Rev Immunol"},{"key":"2074_CR17","doi-asserted-by":"crossref","first-page":"27339","DOI":"10.1074\/jbc.274.39.27339","volume":"274","author":"M Karin","year":"1999","unstructured":"Karin M (1999) The beginning of the end: IkappaB kinase (IKK) and NF-kappaB activation. J Biol Chem 274:27339\u201327342","journal-title":"J Biol Chem"},{"key":"2074_CR18","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1002\/ijc.24807","volume":"126","author":"A Mishra","year":"2010","unstructured":"Mishra A, Bharti AC, Saluja D, Das BC (2010) Transactivation and expression patterns of Jun and Fos\/AP-1 super-family proteins in human oral cancer. Int J Cancer 126:819\u2013829. doi: 10.1002\/ijc.24807","journal-title":"Int J Cancer"},{"key":"2074_CR19","doi-asserted-by":"crossref","first-page":"e6","DOI":"10.4317\/medoral.20570","volume":"21","author":"G Kamperos","year":"2016","unstructured":"Kamperos G, Nikitakis N, Sfakianou A, Avgoustidis D, Sklavounou-Andrikopoulou A (2016) Expression of NF-kappaB and IL-6 in oral precancerous and cancerous lesions: an immunohistochemical study. Med Oral Patol Oral Cir Bucal 21:e6\u201313","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"2074_CR20","doi-asserted-by":"publisher","first-page":"7342","DOI":"10.1038\/sj.onc.1204926","volume":"20","author":"SD Catz","year":"2001","unstructured":"Catz SD, Johnson JL (2001) Transcriptional regulation of bcl-2 by nuclear factor kappa B and its significance in prostate cancer. Oncogene 20:7342\u20137351. doi: 10.1038\/sj.onc.1204926","journal-title":"Oncogene"},{"key":"2074_CR21","doi-asserted-by":"publisher","unstructured":"Mishra R, Nagini S and Rana A (2015) Expression and inactivation of glycogen synthase kinase 3 alpha\/ beta and their association with the expression of cyclin D1 and p53 in oral squamous cell carcinoma progression. Mol Cancer 14:20. doi: 10.1186\/s12943-015-0300-x","DOI":"10.1186\/s12943-015-0300-x"},{"key":"2074_CR22","doi-asserted-by":"publisher","unstructured":"Weijers M, Snow GB, Bezemer DP, van dr Wal JE and van der Waal I (2004) The status of the deep surgical margins in tongue and floor of mouth squamous cell carcinoma and risk of local recurrence; an analysis of 68 patients. Int J Oral Maxillofac Surg 33:146\u2013149. doi: 10.1054\/ijom.2002.0469 S0901502702904698","DOI":"10.1054\/ijom.2002.0469%20S0901502702904698"},{"key":"2074_CR23","doi-asserted-by":"publisher","first-page":"2129","DOI":"10.1097\/00005537-200212000-00003","volume":"112","author":"CO Nathan","year":"2002","unstructured":"Nathan CO, Amirghahri N, Rice C, Abreo FW, Shi R, Stucker FJ (2002) Molecular analysis of surgical margins in head and neck squamous cell carcinoma patients. Laryngoscope 112:2129\u20132140. doi: 10.1097\/00005537-200212000-00003","journal-title":"Laryngoscope"},{"key":"2074_CR24","doi-asserted-by":"publisher","first-page":"16623","DOI":"10.18632\/oncotarget.3932","volume":"6","author":"S Maji","year":"2015","unstructured":"Maji S, Samal SK, Pattanaik L, Panda S, Quinn BA, Das SK, Sarkar D, Pellecchia M, Fisher PB, Dash R (2015) Mcl-1 is an important therapeutic target for oral squamous cell carcinomas. Oncotarget 6:16623\u201316637. doi: 10.18632\/oncotarget.3932","journal-title":"Oncotarget"},{"key":"2074_CR25","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1186\/1471-2407-10-392","volume":"10","author":"HK Kwon","year":"2010","unstructured":"Kwon HK, Hwang JS, So JS, Lee CG, Sahoo A, Ryu JH, Jeon WK, Ko BS, Im CR, Lee SH, Park ZY, Im SH (2010) Cinnamon extract induces tumor cell death through inhibition of NFkappaB and AP1. BMC Cancer 10:392. doi: 10.1186\/1471-2407-10-392","journal-title":"BMC Cancer"},{"key":"2074_CR26","doi-asserted-by":"publisher","first-page":"16811","DOI":"10.1038\/srep16811","volume":"5","author":"S Gupta","year":"2015","unstructured":"Gupta S, Kumar P, Kaur H, Sharma N, Saluja D, Bharti AC, Das BC (2015) Selective participation of c-Jun with Fra-2\/c-Fos promotes aggressive tumor phenotypes and poor prognosis in tongue cancer. Sci Rep 5:16811. doi: 10.1038\/srep16811","journal-title":"Sci Rep"},{"key":"2074_CR27","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0092-8674(00)00116-1","volume":"103","author":"RJ Davis","year":"2000","unstructured":"Davis RJ (2000) Signal transduction by the JNK group of MAP kinases. Cell 103:239\u2013252","journal-title":"Cell"},{"key":"2074_CR28","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1007\/s00795-013-0043-y","volume":"47","author":"ZL Li","year":"2014","unstructured":"Li ZL, Ueki K, Kumagai K, Araki R, Otsuki Y (2014) Regulation of bcl-2 transcription by estrogen receptor-alpha and c-Jun in human endometrium. Med Mol Morphol 47:43\u201353. doi: 10.1007\/s00795-013-0043-y","journal-title":"Med Mol Morphol"},{"key":"2074_CR29","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1177\/002215540305101204","volume":"51","author":"ZL Li","year":"2003","unstructured":"Li ZL, Abe H, Ueki K, Kumagai K, Araki R, Otsuki Y (2003) Identification of c-Jun as bcl-2 transcription factor in human uterine endometrium. J Histochem Cytochem 51:1601\u20131609","journal-title":"J Histochem Cytochem"},{"key":"2074_CR30","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/0092-8674(91)90241-P","volume":"64","author":"WJ Boyle","year":"1991","unstructured":"Boyle WJ, Smeal T, Defize LH, Angel P, Woodgett JR, Karin M, Hunter T (1991) Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity. Cell 64:573\u2013584","journal-title":"Cell"},{"key":"2074_CR31","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/0092-8674(92)90311-Y","volume":"70","author":"A Lin","year":"1992","unstructured":"Lin A, Frost J, Deng T, Smeal T, Al-Alawi N, Kikkawa U, Hunter T, Brenner D, Karin M (1992) Casein kinase II is a negative regulator of c-Jun DNA binding and AP-1 activity. Cell 70:777\u2013789","journal-title":"Cell"},{"key":"2074_CR32","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1186\/1476-4598-9-144","volume":"9","author":"R Mishra","year":"2010","unstructured":"Mishra R (2010) Glycogen synthase kinase 3 beta: can it be a target for oral cancer. Mol Cancer 9:144. doi: 10.1186\/1476-4598-9-144","journal-title":"Mol Cancer"},{"key":"2074_CR33","doi-asserted-by":"crossref","first-page":"23946","DOI":"10.1074\/jbc.273.37.23946","volume":"273","author":"D Moissac de","year":"1998","unstructured":"de Moissac D, Mustapha S, Greenberg AH, Kirshenbaum LA (1998) Bcl-2 activates the transcription factor NFkappaB through the degradation of the cytoplasmic inhibitor IkappaBalpha. J Biol Chem 273:23946\u201323951","journal-title":"J Biol Chem"},{"key":"2074_CR34","doi-asserted-by":"publisher","first-page":"7265","DOI":"10.1038\/sj.onc.1206933 1206933","volume":"22","author":"ZH Siddik","year":"2003","unstructured":"Siddik ZH (2003) Cisplatin: mode of cytotoxic action and molecular basis of resistance. Oncogene 22:7265\u20137279. doi: 10.1038\/sj.onc.1206933 1206933","journal-title":"Oncogene"},{"key":"2074_CR35","doi-asserted-by":"publisher","first-page":"1871","DOI":"10.1111\/j.1349-7006.2008.00914.x","volume":"99","author":"H Ishii","year":"2008","unstructured":"Ishii H, Iwatsuki M, Ieta K, Ohta D, Haraguchi N, Mimori K, Mori M (2008) Cancer stem cells and chemoradiation resistance. Cancer Sci 99:1871\u20131877. doi: 10.1111\/j.1349-7006.2008.00914.x","journal-title":"Cancer Sci"}],"container-title":["Clinical Oral Investigations"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00784-017-2074-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-017-2074-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-017-2074-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,18]],"date-time":"2019-09-18T20:46:44Z","timestamp":1568839604000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00784-017-2074-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,23]]},"references-count":35,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["2074"],"URL":"https:\/\/doi.org\/10.1007\/s00784-017-2074-6","relation":{},"ISSN":["1432-6981","1436-3771"],"issn-type":[{"value":"1432-6981","type":"print"},{"value":"1436-3771","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,23]]}}}