{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T22:23:56Z","timestamp":1783117436539,"version":"3.54.6"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2017,10,6]],"date-time":"2017-10-06T00:00:00Z","timestamp":1507248000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Oral Invest"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1007\/s00784-017-2237-5","type":"journal-article","created":{"date-parts":[[2017,10,6]],"date-time":"2017-10-06T06:07:18Z","timestamp":1507270038000},"page":"1319-1325","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Diclofenac sodium gel therapy as an alternative to actinic cheilitis"],"prefix":"10.1007","volume":"22","author":[{"given":"Amanda Katarinny Goes","family":"Gonzaga","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patr\u00edcia Teixeira","family":"de Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9ricka Janine Dantas","family":"da Silveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e9lia Maria Guedes","family":"Queiroz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Miryam Costa","family":"de Medeiros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,10,6]]},"reference":[{"key":"2237_CR1","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.joms.2006.09.016","volume":"66","author":"AS Cavalcante","year":"2008","unstructured":"Cavalcante AS, Anbinder AL, Carvalho YR (2008) Actinic cheilitis: clinical and histological features. J Oral Maxillofac Surg 66:498\u2013503","journal-title":"J Oral Maxillofac Surg"},{"key":"2237_CR2","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1590\/S1807-59322010000400003","volume":"65","author":"K Pi\u00f1era-Marque","year":"2010","unstructured":"Pi\u00f1era-Marque K, Louren\u00e7o SV, Silva LF, Sotto MN, Carneiro PC (2010) Actinic lesions in fishermen\u2019s lower lip: clinical, cytopathological and histopathologic analysis. Clinics (Sao Paulo) 65:363\u2013367","journal-title":"Clinics (Sao Paulo)"},{"key":"2237_CR3","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1111\/j.1468-3083.2010.03777.x","volume":"25","author":"M Ulrich","year":"2010","unstructured":"Ulrich M, Gonz\u00e1lez S, Lange-Asschenfeldt B et al (2010) Non-invasive diagnosis and monitoring of actinic cheilitis with reflectance confocal microscopy. J Eur Acad Dermatol Venereol 25:276\u2013284","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"2237_CR4","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1111\/j.1601-0825.2012.01910.x","volume":"18","author":"EEL Souza De","year":"2012","unstructured":"De Souza EEL, Costa DC, da Silveira EJD, Lima KC et al (2012) Prevalence and factors associated to actinic cheilitis in beach workers. Oral Dis 18:575\u2013579","journal-title":"Oral Dis"},{"key":"2237_CR5","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1590\/abd1806-4841.20153848","volume":"90","author":"MLDS Lopes","year":"2015","unstructured":"Lopes MLDS, Silva J\u00fanior FL, Lima KC, Oliveira PT, da Silveira EJD (2015) Clinicopathological profile and management of 161 cases of actinic cheilitis. An Bras Dermatol 90:505\u2013512","journal-title":"An Bras Dermatol"},{"key":"2237_CR6","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/j.1834-7819.2010.01202.x","volume":"55","author":"NW Savage","year":"2010","unstructured":"Savage NW, McKay C, Faulker C (2010) Actinic cheilitis in dental practice. Aust Dent J 55:78\u201384","journal-title":"Aust Dent J"},{"key":"2237_CR7","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1590\/S0365-05962012000100013","volume":"87","author":"RA Vieira","year":"2011","unstructured":"Vieira RA, Minicucci EM, Marques ME, Marques AS (2011) Actinic cheilitis and squamous cell carcinoma of the lip: clinical, histopathological and imumunogenetic aspects. An Bras Dermatol 87:105\u2013114","journal-title":"An Bras Dermatol"},{"key":"2237_CR8","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1055\/s-0039-1698864","volume":"5","author":"NH Wood","year":"2011","unstructured":"Wood NH, Khammissa R, Meyerov R, Lemmer J, Feller L (2011) Actinic cheilitis: a case report and a review of the literature. Eur J Dent 5:101\u2013106","journal-title":"Eur J Dent"},{"key":"2237_CR9","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1111\/j.1600-0714.2007.00584.x","volume":"37","author":"S Warnakulasuriya","year":"2008","unstructured":"Warnakulasuriya S, Reibel J, Bouquot J, Dabelsteen E (2008) Oral epithelial dysplasia classification systems: predictive value, utility, weaknesses and scope for improvement. J Oral Pathol Med 37:127\u2013133","journal-title":"J Oral Pathol Med"},{"key":"2237_CR10","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1111\/j.1365-4632.2010.04802.x","volume":"50","author":"PR Martins-Filho","year":"2011","unstructured":"Martins-Filho PR, Da Silva LC, Piva MR (2011) The prevalence of actinic cheilitis in farmers in a semi-arid northeastern region of Brazil. Int J Dermatol 50:1109\u20131114","journal-title":"Int J Dermatol"},{"key":"2237_CR11","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1111\/j.1600-0560.2006.00668.x","volume":"34","author":"PR Cury","year":"2007","unstructured":"Cury PR, Furuse C, de Ara\u00fajo NS, de Ara\u00fajo VC (2007) Signal transducer and activator of transcription-3 expression and activation is dysregulated in actinic cheilitis. J Cutan Pathol 34:606\u2013611","journal-title":"J Cutan Pathol"},{"key":"2237_CR12","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1186\/1471-2407-10-685","volume":"10","author":"W Liu","year":"2010","unstructured":"Liu W, Wang YF, Zhou HW, Shi P, Zhou ZT, Tang GY (2010) Malignant transformation of oral leukoplakia: a retrospective cohort study of 218 Chinese patients. BMC Cancer 10:685","journal-title":"BMC Cancer"},{"key":"2237_CR13","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.1365-2133.2007.07863.x","volume":"156","author":"C Ulrich","year":"2007","unstructured":"Ulrich C, Forschner T, Ulrich M, Stockfleth E, Sterry W, Termeer C (2007) Management of actinic cheilitis using diclofenac 3% gel: a report of six cases. Br J Dermatol 156:43\u201346","journal-title":"Br J Dermatol"},{"key":"2237_CR14","first-page":"825","volume":"33","author":"C Berking","year":"2007","unstructured":"Berking C, Herzinger T, Flaig MJ, Brenner M, Borelli C, Degitz K (2007) The efficacy of photodynamic therapy in actinic cheilitis of the lower lip: a prospective study of 15 patients. Dermatol Surg 33:825\u2013830","journal-title":"Dermatol Surg"},{"key":"2237_CR15","first-page":"712","volume":"6","author":"CG Nelson","year":"2007","unstructured":"Nelson CG, Spencer J, Nelson CG Jr (2007) A single-arm, open-label efficacy and tolerability study of diclofenac sodium 3% gel for the treatment of actinic keratosis of the upper and lower lip. J Drugs Dermatol 6:712\u2013717","journal-title":"J Drugs Dermatol"},{"key":"2237_CR16","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1080\/14764170601110099","volume":"9","author":"A Orenstein","year":"2007","unstructured":"Orenstein A, Goldan O, Weissman O, Winkler E, Haik J (2007) A new modality in the treatment of actinic cheilitis using the Er:YAG laser. J Cosmet Laser Ther 9:23\u201325","journal-title":"J Cosmet Laser Ther"},{"key":"2237_CR17","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s00403-005-0601-9","volume":"297","author":"D Pirard","year":"2005","unstructured":"Pirard D, Vereecken P, M\u00e9lot C, Heenen M (2005) Three percent diclofenac in 2.5% hyaluronan gel in the treatment of actinic keratoses: a meta-analysis of the recent studies. Arch Dermatol Res 297:185\u2013189","journal-title":"Arch Dermatol Res"},{"key":"2237_CR18","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1590\/S1678-77572010000500018","volume":"18","author":"GS Lima","year":"2010","unstructured":"Lima GS, Silva GF, Gomes APN, Ara\u00fajo LMA, Salum FG (2010) Diclofenac in hyaluronic acid gel: an alternative treatment for actinic cheilitis. J Appl Oral Sci 18:533\u2013537","journal-title":"J Appl Oral Sci"},{"key":"2237_CR19","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1080\/09546630701818870","volume":"19","author":"O Kose","year":"2008","unstructured":"Kose O, Koc E, Erbil AH, Caliskan E, Kurumlu Z (2008) Comparison of the efficacy and tolerability of 3% diclofenac sodium gel and 5% imiquimod cream in the treatment of actinic keratosis. J Dermatol Treat 19:159\u2013163","journal-title":"J Dermatol Treat"},{"key":"2237_CR20","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1111\/j.1468-3083.2009.03399.x","volume":"24","author":"T Dirschka","year":"2010","unstructured":"Dirschka T, Bierhoff E, Pflugfelder A, Garbe C (2010) Topical 3.0% diclofenac in 2.5% hyaluronic acid gel induces regression of cancerous transformation in actinic keratoses. J Eur Acad Dermatol Venereol 24:258\u2013263","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"2237_CR21","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.ejps.2015.06.013","volume":"77","author":"T Haque","year":"2015","unstructured":"Haque T, Rahman KM, Thurston DE, Hadgraft J, Lane ME (2015) Topical therapies for skin cancer and actinic keratosis. Eur J Pharm Sci 77:279\u2013289","journal-title":"Eur J Pharm Sci"},{"key":"2237_CR22","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1111\/j.1365-4632.2010.04580.x","volume":"49","author":"AY Shah","year":"2010","unstructured":"Shah AY, Doherty SD, Rosen T (2010) Actinic cheilitis: a treatment review. Int J Dermatol 49:1225\u20131234","journal-title":"Int J Dermatol"},{"key":"2237_CR23","first-page":"1306","volume":"60","author":"JL Masferrer","year":"2000","unstructured":"Masferrer JL, Leahy KM, Koki AT et al (2000) Antiangiogenic and antitumor activities of cyclooxygenase-2 inhibitors. Cancer Res 60:1306\u20131311","journal-title":"Cancer Res"},{"key":"2237_CR24","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1002\/hed.21507","volume":"33","author":"JD Cha","year":"2011","unstructured":"Cha JD, Li S, Cha IH (2011) Association between expression of embryonic lethal abnormal vision-like protein HuR and cyclooxygenase-2 in oral squamous cell carcinoma. Head Neck 33:627\u2013637","journal-title":"Head Neck"},{"key":"2237_CR25","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.anndiagpath.2012.02.004","volume":"16","author":"H Nagatsuka","year":"2012","unstructured":"Nagatsuka H, Siar CH, Tsujigiwa H et al (2012) Heparanase and cyclooxygenase-2 gene and protein expressions during progression of oral epithelial dysplasia to carcinoma. Ann Diagn Pathol 16:354\u2013361","journal-title":"Ann Diagn Pathol"},{"key":"2237_CR26","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.4103\/0973-1482.138205","volume":"10","author":"M Seyedmajidi","year":"2014","unstructured":"Seyedmajidi M, Shafaee S, Siadati S, Khorasani M, Bijani A, Ghasemi N (2014) Cyclo-oxygenase-2 expression in oral squamous cell carcinoma. J Cancer Res Ther 10:1024\u20131029","journal-title":"J Cancer Res Ther"},{"key":"2237_CR27","first-page":"1","volume":"2014","author":"Z Wang","year":"2014","unstructured":"Wang Z, Liu J, Liu HB, Ye M, Zhang YF, Yang DS (2014) Abnormal COX2 protein expression may be correlated with poor prognosis in oral cancer: a meta-analysis. Biomed Res Int 2014:1\u20139","journal-title":"Biomed Res Int"},{"key":"2237_CR28","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1007\/s12253-015-9940-9","volume":"4","author":"AA Byatnal","year":"2015","unstructured":"Byatnal AA, Byatnal A, Sen S, Guddattu V, Solomon MC (2015) Cyclooxygenase-2\u2014an imperative prognostic biomarker in oral squamous cell carcinoma\u2014an immunohistochemical study. Pathol Oncol Res 4:1123\u20131131","journal-title":"Pathol Oncol Res"},{"key":"2237_CR29","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/nrc2069","volume":"7","author":"RT Dorsam","year":"2007","unstructured":"Dorsam RT, Gutkind JS (2007) G-protein-coupled receptors and cancer. Nat Rev Cancer 7:79\u201394","journal-title":"Nat Rev Cancer"},{"key":"2237_CR30","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/nature07205","volume":"454","author":"A Mantovani","year":"2008","unstructured":"Mantovani A, Allavena P, Sica A, Balkwill F (2008) Cancer-related inflammation. Nature 454:436\u2013444","journal-title":"Nature"},{"key":"2237_CR31","doi-asserted-by":"crossref","unstructured":"Trinchieri G (2011) Innate inflammation and cancer: is it time for cancer prevention? Med Rep F1000:3\u201311","DOI":"10.3410\/M3-11"},{"key":"2237_CR32","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.oraloncology.2008.05.019","volume":"45","author":"IG Rojas","year":"2009","unstructured":"Rojas IG, Mart\u00ednez A, Brethauer U et al (2009) Actinic cheilitis: epithelial expression of COX-2 and its association with mast cell tryptase and PAR-2. Oral Oncol 45:284\u2013290","journal-title":"Oral Oncol"},{"key":"2237_CR33","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1600-0714.2011.01057.x","volume":"41","author":"IG Rojas","year":"2012","unstructured":"Rojas IG, Boza YV, Spencer ML, Flores M, Mart\u00ednez A (2012) Increased fibroblast density in actinic cheilitis: association with tryptase-positive mast cells, actinic elastosis and epithelial p53 and COX-2 expression. J Oral Pathol Med 41:27\u201333","journal-title":"J Oral Pathol Med"},{"key":"2237_CR34","first-page":"1011","volume":"9","author":"A Maltusch","year":"2011","unstructured":"Maltusch A, R\u00f6wert-Huber J, Matthies C, Lange-Asschenfeldt S, Stockfleth E (2011) Modes of action of diclofenac 3%\/hyaluronic acid 2.5% in the treatment of actinic keratosis. J Dtsch Dermatol Ges 9:1011\u20131017","journal-title":"J Dtsch Dermatol Ges"},{"key":"2237_CR35","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1001\/archderm.1997.03890460061007","volume":"133","author":"JK Rivers","year":"1997","unstructured":"Rivers JK, DI ML (1997) An open study to assess the efficacy and safety of topical 3% diclofenac in a 2.5% hyaluronic acid gel for the treatment of actinic keratosis. Arch Dermatol 133:1239\u20131242","journal-title":"Arch Dermatol"},{"key":"2237_CR36","doi-asserted-by":"crossref","first-page":"346","DOI":"10.4103\/0378-6323.27749","volume":"75","author":"I Fariba","year":"2006","unstructured":"Fariba I, Ali A, Hossein SA, Atefeh S, Atarzadeh Behbahan AS (2006) Efficacy of 3% diclofenac gel for the treatment of actinic keratoses: a randomized, double-blind, placebo controlled study. Indian J Dermatol Venereol Leprol 75:346\u2013349","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"2237_CR37","first-page":"156","volume":"5","author":"SR Smith","year":"2006","unstructured":"Smith SR, Morhenn VB, Piacquadio DJ (2006) Bilateral comparison of the efficacy and tolerability of 3% diclofenac sodium gel and 5% 5-fluorouracil cream in the treatment of actinic keratoses of the face and scalp. J Drugs Dermatol 5:156\u2013159","journal-title":"J Drugs Dermatol"},{"key":"2237_CR38","first-page":"669","volume":"7","author":"JM Berlin","year":"2008","unstructured":"Berlin JM, Rigel DS (2008) Diclofenac sodium 3% gel in the treatment of actinic keratoses postcryosurgery. J Drugs Dermatol 7:669\u2013673","journal-title":"J Drugs Dermatol"},{"key":"2237_CR39","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0001-7310(09)73379-4","volume":"2","author":"M Ulrich","year":"2009","unstructured":"Ulrich M, Stockfleth E (2009) Field treatment of actinic keratoses\u2014focus on COX-2-inhibitors. Actas Dermosifiliogr 2:55\u201358","journal-title":"Actas Dermosifiliogr"}],"container-title":["Clinical Oral Investigations"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00784-017-2237-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-017-2237-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-017-2237-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,18]],"date-time":"2020-10-18T21:06:57Z","timestamp":1603055217000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00784-017-2237-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,6]]},"references-count":39,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["2237"],"URL":"https:\/\/doi.org\/10.1007\/s00784-017-2237-5","relation":{},"ISSN":["1432-6981","1436-3771"],"issn-type":[{"value":"1432-6981","type":"print"},{"value":"1436-3771","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,6]]}}}