{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:13:44Z","timestamp":1787062424355,"version":"build-2736575974"},"reference-count":68,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2018,2,16]],"date-time":"2018-02-16T00:00:00Z","timestamp":1518739200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"French Minister of Research","award":["Not applicable"],"award-info":[{"award-number":["Not applicable"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Oral Invest"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1007\/s00784-018-2385-2","type":"journal-article","created":{"date-parts":[[2018,2,16]],"date-time":"2018-02-16T13:04:55Z","timestamp":1518786295000},"page":"2997-3006","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Bone mineralization and vascularization in bisphosphonate-related osteonecrosis of the jaw: an experimental study in the rat"],"prefix":"10.1007","volume":"22","author":[{"given":"Jean-Daniel","family":"K\u00fcn-Darbois","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Libouban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Mabilleau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Pascaretti-Grizon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5886-9513","authenticated-orcid":false,"given":"Daniel","family":"Chappard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,2,16]]},"reference":[{"key":"2385_CR1","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.bone.2011.04.022","volume":"49","author":"RGG Russell","year":"2011","unstructured":"Russell RGG (2011) Bisphosphonates: the first 40 years. Bone 49:2\u201319","journal-title":"Bone"},{"key":"2385_CR2","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1007\/s00223-003-0042-4","volume":"74","author":"JT Harrington","year":"2004","unstructured":"Harrington JT, Ste-Marie LG, Brandi ML, Civitelli R, Fardellone P, Grauer A, Barton I, Boonen S (2004) Risedronate rapidly reduces the risk for nonvertebral fractures in women with postmenopausal osteoporosis. Calcif Tissue Int 74:129\u2013135","journal-title":"Calcif Tissue Int"},{"key":"2385_CR3","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1007\/PL00004171","volume":"9","author":"HA Pols","year":"1999","unstructured":"Pols HA, Felsenberg D, Hanley DA et al (1999) Multinational, placebo-controlled, randomized trial of the effects of alendronate on bone density and fracture risk in postmenopausal women with low bone mass: results of the FOSIT study. Fosamax International Trial Study Group. Osteoporos Int 9:461\u2013468","journal-title":"Osteoporos Int"},{"key":"2385_CR4","doi-asserted-by":"publisher","first-page":"123","DOI":"10.2174\/187152012799014986","volume":"12","author":"E Terpos","year":"2012","unstructured":"Terpos E (2012) Bisphosphonate anticancer activity in multiple myeloma. Anti Cancer Agents Med Chem 12:123\u2013128","journal-title":"Anti Cancer Agents Med Chem"},{"key":"2385_CR5","doi-asserted-by":"publisher","first-page":"1588","DOI":"10.1002\/cncr.23783","volume":"113","author":"P Musto","year":"2008","unstructured":"Musto P, Petrucci MT, Bringhen S et al (2008) A multicenter, randomized clinical trial comparing zoledronic acid versus observation in patients with asymptomatic myeloma. Cancer 113:1588\u20131595","journal-title":"Cancer"},{"key":"2385_CR6","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1016\/S0278-2391(03)00328-8","volume":"61","author":"J Wang","year":"2003","unstructured":"Wang J, Goodger NM, Pogrel MA (2003) Osteonecrosis of the jaws associated with cancer chemotherapy. J Oral Maxillofac Surg 61:1104\u20131107","journal-title":"J Oral Maxillofac Surg"},{"key":"2385_CR7","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1016\/S0278-2391(03)00720-1","volume":"61","author":"RE Marx","year":"2003","unstructured":"Marx RE (2003) Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic. J Oral Maxillofac Surg 61:1115\u20131117","journal-title":"J Oral Maxillofac Surg"},{"key":"2385_CR8","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1016\/j.mayocp.2013.01.002","volume":"88","author":"TD Rachner","year":"2013","unstructured":"Rachner TD, Platzbecker U, Felsenberg D, Hofbauer LC (2013) Osteonecrosis of the jaw after osteoporosis therapy with denosumab following long-term bisphosphonate therapy. Mayo Clin Proc 88:418\u2013419","journal-title":"Mayo Clin Proc"},{"key":"2385_CR9","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1308\/rcsfdj.2014.5.2.90","volume":"5","author":"S Ruggiero","year":"2014","unstructured":"Ruggiero S (2014) Osteonecrosis of the jaw: BRONJ and ARONJ. Fac Dent J 5:90\u201393","journal-title":"Fac Dent J"},{"key":"2385_CR10","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1111\/j.1747-4477.2009.00213.x","volume":"35","author":"Ruggiero SL, Dodson TB, Assael LA, Landesberg R, Marx RE, Mehrotra B, Task Force on Bisphosphonate-Related Osteonecrosis of the Jaws AAoOMS","year":"2009","unstructured":"Ruggiero SL, Dodson TB, Assael LA, Landesberg R, Marx RE, Mehrotra B, Task Force on Bisphosphonate-Related Osteonecrosis of the Jaws AAoOMS (2009) American Association of Oral and Maxillofacial Surgeons position paper on bisphosphonate-related osteonecrosis of the jaw - 2009 update. Aust Endodont J 35:119\u2013130","journal-title":"Aust Endodont J"},{"key":"2385_CR11","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1146\/annurev.med.60.063007.134350","volume":"60","author":"SL Ruggiero","year":"2009","unstructured":"Ruggiero SL, Mehrotra B (2009) Bisphosphonate-related osteonecrosis of the jaw: diagnosis, prevention, and management. Annu Rev Med 60:85\u201396","journal-title":"Annu Rev Med"},{"key":"2385_CR12","doi-asserted-by":"publisher","first-page":"5356","DOI":"10.1200\/JCO.2009.21.9584","volume":"27","author":"K Vahtsevanos","year":"2009","unstructured":"Vahtsevanos K, Kyrgidis A, Verrou E et al (2009) Longitudinal cohort study of risk factors in cancer patients of bisphosphonate-related osteonecrosis of the jaw. J Clin Oncol 27:5356\u20135362","journal-title":"J Clin Oncol"},{"key":"2385_CR13","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/1746-160X-6-11","volume":"6","author":"C Walter","year":"2010","unstructured":"Walter C, Al-Nawas B, Frickhofen N, Gamm H, Beck J, Reinsch L, Blum C, Grotz KA, Wagner W (2010) Prevalence of bisphosphonate associated osteonecrosis of the jaws in multiple myeloma patients. Head Face Med 6:11","journal-title":"Head Face Med"},{"key":"2385_CR14","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1007\/s00520-010-0882-1","volume":"18","author":"CA Migliorati","year":"2010","unstructured":"Migliorati CA, Woo SB, Hewson I, Barasch A, Elting LS, Spijkervet FK, Brennan MT (2010) A systematic review of bisphosphonate osteonecrosis (BON) in cancer. Supp Care Cancer 18:1099\u20131106","journal-title":"Supp Care Cancer"},{"key":"2385_CR15","doi-asserted-by":"publisher","first-page":"753","DOI":"10.7326\/0003-4819-144-10-200605160-00009","volume":"144","author":"SB Woo","year":"2006","unstructured":"Woo SB, Hellstein JW, Kalmar JR (2006) Narrative [corrected] review: bisphosphonates and osteonecrosis of the jaws. Ann Intern Med 144:753\u2013761","journal-title":"Ann Intern Med"},{"key":"2385_CR16","doi-asserted-by":"publisher","first-page":"2397","DOI":"10.1016\/j.joms.2007.08.003","volume":"65","author":"RE Marx","year":"2007","unstructured":"Marx RE, Cillo JE Jr, Ulloa JJ (2007) Oral bisphosphonate-induced osteonecrosis: risk factors, prediction of risk using serum CTX testing, prevention, and treatment. J Oral Maxillofac Surg 65:2397\u20132410","journal-title":"J Oral Maxillofac Surg"},{"key":"2385_CR17","doi-asserted-by":"publisher","first-page":"1567","DOI":"10.1016\/j.joms.2005.07.010","volume":"63","author":"RE Marx","year":"2005","unstructured":"Marx RE, Sawatari Y, Fortin M, Broumand V (2005) Bisphosphonate-induced exposed bone (osteonecrosis\/osteopetrosis) of the jaws: risk factors, recognition, prevention, and treatment. J Oral Maxillofac Surg 63:1567\u20131575","journal-title":"J Oral Maxillofac Surg"},{"key":"2385_CR18","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1016\/j.oraloncology.2007.11.012","volume":"44","author":"T Boonyapakorn","year":"2008","unstructured":"Boonyapakorn T, Schirmer I, Reichart PA, Sturm I, Massenkeil G (2008) Bisphosphonate-induced osteonecrosis of the jaws: prospective study of 80 patients with multiple myeloma and other malignancies. Oral Oncol 44:857\u2013869","journal-title":"Oral Oncol"},{"key":"2385_CR19","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.jdent.2012.12.008","volume":"41","author":"P Diz","year":"2013","unstructured":"Diz P, Scully C, Sanz M (2013) Dental implants in the medically compromised patient. J Dent 41:195\u2013206","journal-title":"J Dent"},{"key":"2385_CR20","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1111\/clr.12088","volume":"25","author":"T-G Kwon","year":"2014","unstructured":"Kwon T-G, Lee C-O, Park J-W, Choi S-Y, Rijal G, Shin H-I (2014) Osteonecrosis associated with dental implants in patients undergoing bisphosphonate treatment. Clin Oral Implants Res 25:632\u2013640","journal-title":"Clin Oral Implants Res"},{"key":"2385_CR21","doi-asserted-by":"publisher","first-page":"e38","DOI":"10.1111\/clr.12526","volume":"27","author":"J Ata-Ali","year":"2016","unstructured":"Ata-Ali J, Ata-Ali F, Pe\u00f1arrocha-Oltra D, Galindo-Moreno P (2016) What is the impact of bisphosphonate therapy upon dental implant survival? A systematic review and meta-analysis. Clin Oral Implants Res 27:e38\u2013e46","journal-title":"Clin Oral Implants Res"},{"key":"2385_CR22","doi-asserted-by":"publisher","first-page":"471035","DOI":"10.1155\/2014\/471035","volume":"2014","author":"L Rasmusson","year":"2014","unstructured":"Rasmusson L, Abtahi J (2014) Bisphosphonate associated osteonecrosis of the jaw: an update on pathophysiology, risk factors, and treatment. Int J Dent 2014:471035","journal-title":"Int J Dent"},{"issue":"Suppl 2","key":"2385_CR23","doi-asserted-by":"publisher","first-page":"e679","DOI":"10.1111\/cid.12307","volume":"17","author":"C Cardemil","year":"2015","unstructured":"Cardemil C, Thomsen P, Larsson Wexell C (2015) Jaw bone samples from bisphosphonate-treated patients: a pilot cohort study. Clin Implant Dent Relat Res 17(Suppl 2):e679\u2013e691","journal-title":"Clin Implant Dent Relat Res"},{"key":"2385_CR24","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1016\/j.jormas.2017.06.012","volume":"118","author":"PJ Voss","year":"2017","unstructured":"Voss PJ, Poxleitner P, Schmelzeisen R, Stricker A, Semper-Hogg W (2017) Update MRONJ and perspectives of its treatment. J Stomatol Oral Maxillofac Surg 118:232\u2013235","journal-title":"J Stomatol Oral Maxillofac Surg"},{"key":"2385_CR25","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1007\/s00784-013-1060-x","volume":"18","author":"AM Pabst","year":"2014","unstructured":"Pabst AM, Ziebart T, Ackermann M, Konerding MA, Walter C (2014) Bisphosphonates' antiangiogenic potency in the development of bisphosphonate-associated osteonecrosis of the jaws: influence on microvessel sprouting in an in vivo 3D Matrigel assay. Clin Oral Invest 18:1015\u20131022","journal-title":"Clin Oral Invest"},{"key":"2385_CR26","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1186\/1746-1596-7-78","volume":"7","author":"EB Petcu","year":"2012","unstructured":"Petcu EB, Ivanovski S, Wright RG, Slevin M, Miroiu RI, Brinzaniuc K (2012) Bisphosphonate-related osteonecrosis of jaw (BRONJ): an anti-angiogenic side-effect? Diagn Pathol 7:78","journal-title":"Diagn Pathol"},{"key":"2385_CR27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/2045-824X-5-1","volume":"5","author":"D Sharma","year":"2013","unstructured":"Sharma D, Ivanovski S, Slevin M, Hamlet S, Pop TS, Brinzaniuc K, Petcu EB, Miroiu RI (2013) Bisphosphonate-related osteonecrosis of jaw (BRONJ): diagnostic criteria and possible pathogenic mechanisms of an unexpected anti-angiogenic side effect. Vascular cell 5:1","journal-title":"Vascular cell"},{"key":"2385_CR28","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1016\/j.tripleo.2011.02.028","volume":"112","author":"F Wehrhan","year":"2011","unstructured":"Wehrhan F, Stockmann P, Nkenke E, Schlegel KA, Guentsch A, Wehrhan T, Neukam FW, Amann K (2011) Differential impairment of vascularization and angiogenesis in bisphosphonate-associated osteonecrosis of the jaw-related mucoperiosteal tissue. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 112:216\u2013221","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"2385_CR29","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.bone.2010.09.035","volume":"48","author":"V Stresing","year":"2011","unstructured":"Stresing V, Fournier PG, Bellahcene A, Benzaid I, Monkkonen H, Colombel M, Ebetino FH, Castronovo V, Clezardin P (2011) Nitrogen-containing bisphosphonates can inhibit angiogenesis in vivo without the involvement of farnesyl pyrophosphate synthase. Bone 48:259\u2013266","journal-title":"Bone"},{"key":"2385_CR30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.11005\/jbm.2015.22.1.1","volume":"22","author":"G-I Im","year":"2015","unstructured":"Im G-I, Jeong S-H (2015) Pathogenesis, management and prevention of atypical femoral fractures. J Bone Metab 22:1\u20138","journal-title":"J Bone Metab"},{"key":"2385_CR31","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1016\/j.bone.2007.04.196","volume":"41","author":"IR Reid","year":"2007","unstructured":"Reid IR, Bolland MJ, Grey AB (2007) Is bisphosphonate-associated osteonecrosis of the jaw caused by soft tissue toxicity? Bone 41:318\u2013320","journal-title":"Bone"},{"key":"2385_CR32","doi-asserted-by":"publisher","first-page":"31604","DOI":"10.1038\/srep31604","volume":"6","author":"G Russmueller","year":"2016","unstructured":"Russmueller G, Seemann R, Weiss K, Stadler V, Speiss M, Perisanidis C, Fuereder T, Willinger B, Sulzbacher I, Steininger C (2016) The association of medication-related osteonecrosis of the jaw with Actinomyces spp. infection. Sci Rep 6:31604","journal-title":"Sci Rep"},{"key":"2385_CR33","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1111\/odi.12067","volume":"19","author":"D Sharma","year":"2013","unstructured":"Sharma D, Hamlet S, Petcu E, Ivanovski S (2013) Animal models for bisphosphonate-related osteonecrosis of the jaws\u2014an appraisal. Oral Dis 19:747\u2013754","journal-title":"Oral Dis"},{"key":"2385_CR34","doi-asserted-by":"publisher","first-page":"e17196","DOI":"10.5812\/traumamon.17196","volume":"19","author":"F Sarkarat","year":"2014","unstructured":"Sarkarat F, Kalantar Motamedi MH, Jahanbani J, Sepehri D, Kahali R, Nematollahi Z (2014) Platelet-rich plasma in treatment of zoledronic acid-induced bisphosphonate-related osteonecrosis of the jaws. Trauma Mon 19:e17196","journal-title":"Trauma Mon"},{"key":"2385_CR35","doi-asserted-by":"publisher","first-page":"1481","DOI":"10.1016\/j.ijom.2013.06.011","volume":"42","author":"H Tsurushima","year":"2013","unstructured":"Tsurushima H, Kokuryo S, Sakaguchi O, Tanaka J, Tominaga K (2013) Bacterial promotion of bisphosphonate-induced osteonecrosis in Wistar rats. Int J Oral Maxillofac Surg 42:1481\u20131487","journal-title":"Int J Oral Maxillofac Surg"},{"issue":"1","key":"2385_CR36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/clr.12502","volume":"27","author":"Chun Lei Li","year":"2014","unstructured":"Li CL, Lu WW, Seneviratne CJ, Leung WK, Zwahlen RA, Zheng LW (2016) Role of periodontal disease in bisphosphonate-related osteonecrosis of the jaws in ovariectomized rats. Clin Oral Implants Res 27:1\u20136","journal-title":"Clinical Oral Implants Research"},{"key":"2385_CR37","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.1359\/jbmr.2003.18.6.1012","volume":"18","author":"O Akkus","year":"2003","unstructured":"Akkus O, Polyakova-Akkus A, Adar F, Schaffler MB (2003) Aging of microstructural compartments in human compact bone. J Bone Miner Res 18:1012\u20131019","journal-title":"J Bone Miner Res"},{"key":"2385_CR38","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/S8756-3282(98)00112-4","volume":"23","author":"P Roschger","year":"1998","unstructured":"Roschger P, Fratzl P, Eschberger J, Klaushofer K (1998) Validation of quantitative backscattered electron imaging for the measurement of mineral density distribution in human bone biopsies. Bone 23:319\u2013326","journal-title":"Bone"},{"key":"2385_CR39","first-page":"42","volume":"15","author":"G Mabilleau","year":"2015","unstructured":"Mabilleau G, Mieczkowska A, Libouban H, Simon Y, Audran M, Chappard D (2015) Comparison between quantitative X-ray imaging, dual energy X-ray absorptiometry and microCT in the assessment of bone mineral density in disuse-induced bone loss. J Musculoskel Neuronal Interact 15:42\u201352","journal-title":"J Musculoskel Neuronal Interact"},{"key":"2385_CR40","doi-asserted-by":"publisher","first-page":"e17336","DOI":"10.1371\/journal.pone.0017336","volume":"6","author":"H Nyangoga","year":"2011","unstructured":"Nyangoga H, Mercier P, Libouban H, Basle MF, Chappard D (2011) Three-dimensional characterization of the vascular bed in bone metastasis of the rat by microcomputed tomography (MicroCT). PLoSOne 6:e17336","journal-title":"PLoSOne"},{"key":"2385_CR41","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1016\/j.ijom.2013.02.007","volume":"42","author":"J Abtahi","year":"2013","unstructured":"Abtahi J, Agholme F, Aspenberg P (2013) Prevention of osteonecrosis of the jaw by mucoperiosteal coverage in a rat model. Int J Oral Maxillofac Surg 42:632\u2013636","journal-title":"Int J Oral Maxillofac Surg"},{"key":"2385_CR42","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1016\/j.bone.2012.04.020","volume":"51","author":"C Pautke","year":"2012","unstructured":"Pautke C, Kreutzer K, Weitz J, Knodler M, Munzel D, Wexel G, Otto S, Hapfelmeier A, Sturzenbaum S, Tischer T (2012) Bisphosphonate related osteonecrosis of the jaw: A minipig large animal model. Bone 51:592\u2013599","journal-title":"Bone"},{"key":"2385_CR43","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1563\/AAID-JOI-D-11-00057","volume":"38 Spec No","author":"KL Marino","year":"2012","unstructured":"Marino KL, Zakhary I, Abdelsayed RA, Carter JA, O'Neill JC, Khashaba RM, Elsalanty M, Stevens MR, Borke JL (2012) Development of a rat model of bisphosphonate-related osteonecrosis of the jaw (BRONJ). J Oral Implantol 38 Spec No:511\u2013518","journal-title":"J Oral Implantol"},{"key":"2385_CR44","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1111\/j.1600-0714.2011.01125.x","volume":"41","author":"J Abtahi","year":"2012","unstructured":"Abtahi J, Agholme F, Sandberg O, Aspenberg P (2012) Bisphosphonate-induced osteonecrosis of the jaw in a rat model arises first after the bone has become exposed. No primary necrosis in unexposed bone. J Oral Pathol Med 41:494\u2013499","journal-title":"J Oral Pathol Med"},{"key":"2385_CR45","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1111\/j.1600-0714.2009.00878.x","volume":"39","author":"M Biasotto","year":"2010","unstructured":"Biasotto M, Chiandussi S, Zacchigna S et al (2010) A novel animal model to study non-spontaneous bisphosphonates osteonecrosis of jaw. J Oral Pathol Med 39:390\u2013396","journal-title":"J Oral Pathol Med"},{"key":"2385_CR46","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1359\/jbmr.080205","volume":"23","author":"AO Hoff","year":"2008","unstructured":"Hoff AO, Toth BB, Altundag K et al (2008) Frequency and risk factors associated with osteonecrosis of the jaw in cancer patients treated with intravenous bisphosphonates. J Bone Miner Res 23:826\u2013836","journal-title":"J Bone Miner Res"},{"key":"2385_CR47","doi-asserted-by":"publisher","first-page":"2130","DOI":"10.1002\/jbmr.1669","volume":"27","author":"JI Aguirre","year":"2012","unstructured":"Aguirre JI, Akhter MP, Kimmel DB, Pingel JE, Williams A, Jorgensen M, Kesavalu L, Wronski TJ (2012) Oncologic doses of zoledronic acid induce osteonecrosis of the jaw-like lesions in rice rats (Oryzomys palustris) with periodontitis. J Bone Miner Res 27:2130\u20132143","journal-title":"J Bone Miner Res"},{"key":"2385_CR48","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1016\/j.joms.2006.10.061","volume":"65","author":"T Mavrokokki","year":"2007","unstructured":"Mavrokokki T, Cheng A, Stein B, Goss A (2007) Nature and frequency of bisphosphonate-associated osteonecrosis of the jaws in Australia. J Oral Maxillofac Surg 65:415\u2013423","journal-title":"J Oral Maxillofac Surg"},{"key":"2385_CR49","doi-asserted-by":"publisher","first-page":"8580","DOI":"10.1200\/JCO.2005.02.8670","volume":"23","author":"A Bamias","year":"2005","unstructured":"Bamias A, Kastritis E, Bamia C et al (2005) Osteonecrosis of the jaw in cancer after treatment with bisphosphonates: incidence and risk factors. J Clin Oncol 23:8580\u20138587","journal-title":"J Clin Oncol"},{"key":"2385_CR50","doi-asserted-by":"publisher","first-page":"1337","DOI":"10.1002\/jbmr.23","volume":"25","author":"A Hokugo","year":"2010","unstructured":"Hokugo A, Christensen R, Chung EM, Sung EC, Felsenfeld AL, Sayre JW, Garrett N, Adams JS, Nishimura I (2010) Increased prevalence of bisphosphonate-related osteonecrosis of the jaw with vitamin D deficiency in rats. J Bone Miner Res 25:1337\u20131349","journal-title":"J Bone Miner Res"},{"key":"2385_CR51","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1016\/j.bjoms.2016.05.025","volume":"54","author":"K Mitsimponas","year":"2016","unstructured":"Mitsimponas K, Moest T, Iliopoulos C, Rueger T, Mueller C, Lutz R, Shakib K, Neukam F, Schlegel K (2016) Search for a reliable model for bisphosphonate-related osteonecrosis of the jaw: establishment of a model in pigs and description of its histomorphometric characteristics. Br J Oral Maxillofac Surg 54:883\u2013888","journal-title":"Br J Oral Maxillofac Surg"},{"key":"2385_CR52","doi-asserted-by":"publisher","first-page":"20130144","DOI":"10.1259\/dmfr.20130144","volume":"43","author":"N Ersan","year":"2013","unstructured":"Ersan N, van Ruijven LJ, Bronckers AL, Olgac V, Ilguy D, Everts V (2013) Teriparatide and the treatment of bisphosphonate-related osteonecrosis of the jaw: a rat model. Dentomaxillofac Radiol 43:20130144","journal-title":"Dentomaxillofac Radiol"},{"key":"2385_CR53","doi-asserted-by":"publisher","first-page":"1871","DOI":"10.1002\/jbmr.379","volume":"26","author":"TL Aghaloo","year":"2011","unstructured":"Aghaloo TL, Kang B, Sung EC, Shoff M, Ronconi M, Gotcher JE, Bezouglaia O, Dry SM, Tetradis S (2011) Periodontal disease and bisphosphonates induce osteonecrosis of the jaws in the rat. J Bone Miner Res 26:1871\u20131882","journal-title":"J Bone Miner Res"},{"key":"2385_CR54","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1111\/iep.12133","volume":"96","author":"VN Pacheco","year":"2015","unstructured":"Pacheco VN, Langie R, Etges A, Ponzoni D, Puricelli E (2015) Nitrogen-containing bisphosphonate therapy: assessment of the alveolar bone structure in rats\u2014a blind randomized controlled trial. Int J Exp Pathol 96:255\u2013260","journal-title":"Int J Exp Pathol"},{"key":"2385_CR55","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1007\/s00198-007-0540-8","volume":"19","author":"RGG Russell","year":"2008","unstructured":"Russell RGG, Watts NB, Ebetino FH, Rogers MJ (2008) Mechanisms of action of bisphosphonates: similarities and differences and their potential influence on clinical efficacy. Osteoporos Int 19:733\u2013759","journal-title":"Osteoporos Int"},{"key":"2385_CR56","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1016\/j.bone.2010.07.018","volume":"47","author":"A Juillard","year":"2010","unstructured":"Juillard A, Falgayrac G, Cortet B, Vieillard M-H, Azaroual N, Hornez J-C, Penel G (2010) Molecular interactions between zoledronic acid and bone: an in vitro Raman microspectroscopic study. Bone 47:895\u2013904","journal-title":"Bone"},{"key":"2385_CR57","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.bone.2016.05.002","volume":"89","author":"C Olejnik","year":"2016","unstructured":"Olejnik C, Falgayrac G, During A, Cortet B, Penel G (2016) Doses effects of zoledronic acid on mineral apatite and collagen quality of newly-formed bone in the rat's calvaria defect. Bone 89:32\u201339","journal-title":"Bone"},{"key":"2385_CR58","doi-asserted-by":"publisher","first-page":"15812","DOI":"10.1021\/jp304472s","volume":"116","author":"E Boanini","year":"2012","unstructured":"Boanini E, Gazzano M, Bigi A (2012) Time course of zoledronate interaction with hydroxyapatite nanocrystals. J Phys Chem C 116:15812\u201315818","journal-title":"J Phys Chem C"},{"key":"2385_CR59","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1002\/jbmr.1780","volume":"28","author":"BM Misof","year":"2013","unstructured":"Misof BM, Roschger P, Gabriel D, Paschalis EP, Eriksen EF, Recker RR, Gasser JA, Klaushofer K (2013) Annual intravenous zoledronic acid for three years increased cancellous bone matrix mineralization beyond normal values in the HORIZON biopsy cohort. J Bone Miner Res 28:442\u2013448","journal-title":"J Bone Miner Res"},{"key":"2385_CR60","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1111\/odi.12587","volume":"23","author":"J Vermeer","year":"2017","unstructured":"Vermeer J, Renders G, Duin M, Jansen I, Bakker L, Kroon S, Vries T, Everts V (2017) Bone-site-specific responses to zoledronic acid. Oral Dis 23:126\u2013133","journal-title":"Oral Dis"},{"key":"2385_CR61","doi-asserted-by":"publisher","first-page":"1466","DOI":"10.1111\/clr.12492","volume":"26","author":"MHA Verzola","year":"2015","unstructured":"Verzola MHA, Frizzera F, de Oliveira GJPL, Pereira RMR, Rodrigues-Filho UP, Nonaka KO, Orrico SRP (2015) Effects of the long-term administration of alendronate on the mechanical properties of the basal bone and on osseointegration. Clin Oral Implants Res 26:1466\u20131475","journal-title":"Clin Oral Implants Res"},{"key":"2385_CR62","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1016\/0030-4220(52)90316-2","volume":"5","author":"RF Huebsch","year":"1952","unstructured":"Huebsch RF, Coleman RD, Frandsen AM, Becks H (1952) The healing process following molar extraction. I. Normal male rats (long-evans strain). Oral Surg Oral Med Oral Pathol 5:864\u2013876","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"2385_CR63","first-page":"6538","volume":"62","author":"P Fournier","year":"2002","unstructured":"Fournier P, Boissier S, Filleur S, Guglielmi J, Cabon F, Colombel M, Clezardin P (2002) Bisphosphonates inhibit angiogenesis in vitro and testosterone-stimulated vascular regrowth in the ventral prostate in castrated rats. Cancer Res 62:6538\u20136544","journal-title":"Cancer Res"},{"key":"2385_CR64","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1002\/ijc.24710","volume":"126","author":"X Tang","year":"2010","unstructured":"Tang X, Zhang Q, Shi S, Yen Y, Li X, Zhang Y, Zhou K, Le AD (2010) Bisphosphonates suppress insulin-like growth factor 1-induced angiogenesis via the HIF-1alpha\/VEGF signaling pathways in human breast cancer cells. Int J Cancer 126:90\u2013103","journal-title":"Int J Cancer"},{"key":"2385_CR65","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1159\/000313787","volume":"124","author":"A Allegra","year":"2010","unstructured":"Allegra A, Alonci A, Penna G et al (2010) Bisphosphonates induce apoptosis of circulating endothelial cells in multiple myeloma patients and in subjects with bisphosphonate-induced osteonecrosis of the jaws. Acta Haematol 124:79\u201385","journal-title":"Acta Haematol"},{"key":"2385_CR66","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1002\/hon.819","volume":"25","author":"A Allegra","year":"2007","unstructured":"Allegra A, Oteri G, Nastro E et al (2007) Patients with bisphosphonates-associated osteonecrosis of the jaw have reduced circulating endothelial cells. Hematol Oncol 25:164\u2013169","journal-title":"Hematol Oncol"},{"key":"2385_CR67","doi-asserted-by":"publisher","first-page":"280","DOI":"10.2353\/ajpath.2010.090592","volume":"177","author":"Y Bi","year":"2010","unstructured":"Bi Y, Gao Y, Ehirchiou D, Cao C, Kikuiri T, Le A, Shi S, Zhang L (2010) Bisphosphonates cause osteonecrosis of the jaw-like disease in mice. Am J Pathol 177:280\u2013290","journal-title":"Am J Pathol"},{"key":"2385_CR68","doi-asserted-by":"publisher","first-page":"192320","DOI":"10.1155\/2014\/192320","volume":"2014","author":"EA Sigua-Rodriguez","year":"2014","unstructured":"Sigua-Rodriguez EA, da Costa RR, de Brito AC, Alvarez-Pinzon N, de Albergaria-Barbosa JR (2014) Bisphosphonate-related osteonecrosis of the jaw: a review of the literature. Int J Dent 2014:192320","journal-title":"Int J Dent"}],"container-title":["Clinical Oral Investigations"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00784-018-2385-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-018-2385-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-018-2385-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T04:17:15Z","timestamp":1719807435000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00784-018-2385-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,16]]},"references-count":68,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["2385"],"URL":"https:\/\/doi.org\/10.1007\/s00784-018-2385-2","relation":{},"ISSN":["1432-6981","1436-3771"],"issn-type":[{"value":"1432-6981","type":"print"},{"value":"1436-3771","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,16]]},"assertion":[{"value":"12 April 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 February 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 February 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflicts of interest","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in the present study were in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki Declaration and its later amendments. This experimental protocol was approved by the local ethical committee of Angers University Hospital (France) and was done in accordance with the institutional guidelines of the French Ethical Committee (protocol number 2016-31).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}