{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T13:38:20Z","timestamp":1787578700004,"version":"build-2736575974"},"reference-count":63,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T00:00:00Z","timestamp":1539043200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"crossref","award":["DS"],"award-info":[{"award-number":["DS"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]},{"name":"CNPQ","award":["401058\/2016-6"],"award-info":[{"award-number":["401058\/2016-6"]}]},{"DOI":"10.13039\/501100004586","name":"FAPERJ","doi-asserted-by":"crossref","award":["E-26\/202.174\/2016"],"award-info":[{"award-number":["E-26\/202.174\/2016"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Oral Invest"],"published-print":{"date-parts":[[2018,11]]},"DOI":"10.1007\/s00784-018-2682-9","type":"journal-article","created":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T00:28:03Z","timestamp":1539044883000},"page":"2763-2785","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":66,"title":["Are dairy products containing probiotics beneficial for oral health? A systematic review and meta-analysis"],"prefix":"10.1007","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5782-1203","authenticated-orcid":false,"given":"Patricia","family":"Nadelman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcela Bara\u00fana","family":"Magno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Masterson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriano Gomes","family":"da Cruz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucianne Cople","family":"Maia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,10,9]]},"reference":[{"key":"2682_CR1","unstructured":"Food and Health Agricultural Organization of the United Nations and World Health Organization (2012) FAO\/WHO. Guideline for the evaluation of probiotics on food. Joint FAO\/WHO working group report on drafting guidelines for the evaluation of probiotics in food. 2012. Retrieved from: ftp:\/\/ftp.fao.org\/es\/esn\/food\/wgreport2.pdt . Assessed 2015 Jun 19"},{"key":"2682_CR2","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1111\/j.1600-0757.2008.00254.x","volume":"48","author":"W Teughels","year":"2008","unstructured":"Teughels W, Essche MV, Sliepen I, Quirynen M (2008) Probiotics and oral healthcare. Periodontology 2000 48:111\u2013147. https:\/\/doi.org\/10.1111\/j.1600-0757.2008.00254.x","journal-title":"Periodontology 2000"},{"key":"2682_CR3","doi-asserted-by":"publisher","unstructured":"Keller MK, Twetman S (2012) Acid production in dental plaque after exposure to probiotic bacteria. BMC Oral Health 12(44). https:\/\/doi.org\/10.1186\/1472-6831-12-44","DOI":"10.1186\/1472-6831-12-44"},{"issue":"8","key":"2682_CR4","first-page":"585","volume":"75","author":"L Bonifait","year":"2009","unstructured":"Bonifait L, Chandad F, Grenier D (2009) Probiotics for oral health: myth or reality? J Can Dent Assoc 75(8):585\u2013590","journal-title":"J Can Dent Assoc"},{"key":"2682_CR5","unstructured":"Hempel S, Newberry S, Ruelaz A, Wang Z, Miles JNV, Suttorp MJ, Johnsen B, Shanman R, Slusser W, Fu N, Smith A, Roth B, Polak J, Motala A, Perry T, Shakelle PG (2011) Safety of probiotics to reduce risk and prevent or treat disease. Evidence report\/technology assessment, number 200. AHRQ Publication No 11-E007"},{"issue":"6","key":"2682_CR6","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1080\/10408398.2012.733894","volume":"56","author":"AH Rad","year":"2016","unstructured":"Rad AH, Mehrabany EV, Alipoor B, Mehrabany LV (2016) The comparison of food and supplement as probiotic delivery vehicles. Crit Rev Food Sci Nutr 56(6):896\u2013909. https:\/\/doi.org\/10.1080\/10408398.2012.733894","journal-title":"Crit Rev Food Sci Nutr"},{"issue":"1","key":"2682_CR7","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1038\/sj.bdj.4801080a","volume":"191","author":"RS Levine","year":"2001","unstructured":"Levine RS (2001) Milk, flavoured milk products and caries. Br Dent J 191(1):20. https:\/\/doi.org\/10.1038\/sj.bdj.4801080a","journal-title":"Br Dent J"},{"issue":"8","key":"2682_CR8","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1016\/S0003-9969(01)00033-4","volume":"46","author":"S Petti","year":"2001","unstructured":"Petti S, Tarsitani G, D\u2019arca AS (2001) A randomized clinical trial of the effect of yoghurt on the human salivary microflora. Arch Oral Biol 46(8):705\u2013712. https:\/\/doi.org\/10.1016\/S0003-9969(01)00033-4","journal-title":"Arch Oral Biol"},{"issue":"3","key":"2682_CR9","doi-asserted-by":"publisher","first-page":"255","DOI":"10.3290\/j.qi.a33182","volume":"46","author":"I Laleman","year":"2015","unstructured":"Laleman I, Teughels W (2015) Probiotics in dental practice: a review. Quintessence Int 46(3):255\u2013264. https:\/\/doi.org\/10.3290\/j.qi.a33182","journal-title":"Quintessence Int"},{"issue":"7","key":"2682_CR10","doi-asserted-by":"publisher","first-page":"2530","DOI":"10.3390\/nu5072530","volume":"5","author":"MG Cagetti","year":"2013","unstructured":"Cagetti MG, Mastroberardino S, Milia E, Cocco F, Lingstr\u00f6m P, Campus G (2013) The use of probiotic strains in caries prevention: a systematic review. Nutrients 5(7):2530\u20132550. https:\/\/doi.org\/10.3390\/nu5072530","journal-title":"Nutrients"},{"key":"2682_CR11","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.jdent.2016.03.002","volume":"48","author":"D Gruner","year":"2016","unstructured":"Gruner D, Paris S, Schwendicke F (2016) Probiotics for managing caries and periodontitis: systematic review and meta-analysis. J Dent 48:16\u201325. https:\/\/doi.org\/10.1016\/j.jdent.2016.03.002","journal-title":"J Dent"},{"issue":"6","key":"2682_CR12","first-page":"329","volume":"22","author":"MD Stamatova","year":"2009","unstructured":"Stamatova MD, Meurman JH (2009) Probiotics: health benefits in the mouth. Am J Dent 22(6):329\u2013338","journal-title":"Am J Dent"},{"issue":"6","key":"2682_CR13","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.1007\/s00784-014-1228-z","volume":"18","author":"I Laleman","year":"2014","unstructured":"Laleman I, Detailleur V, Slot DE, Slomka V, Quirynen M, Teughels W (2014) Probiotics reduce mutans streptococci counts in humans: a systematic review and meta-analysis. Clin Oral Investig 18(6):1539\u20131552. https:\/\/doi.org\/10.1007\/s00784-014-1228-z","journal-title":"Clin Oral Investig"},{"issue":"1","key":"2682_CR14","first-page":"20","volume":"69","author":"K Pradeep","year":"2014","unstructured":"Pradeep K, Kuttappa MA, Prasana KR (2014) Probiotics and oral health: an update. SADJ 69(1):20\u201324","journal-title":"SADJ"},{"issue":"1","key":"2682_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1590\/1807-3107BOR-2015.vol29.0033","volume":"29","author":"CS Lodi","year":"2015","unstructured":"Lodi CS, Oliveira LV, BrighentI FL, Delbem ACB, Martinhon CCR (2015) Effects of probiotic fermented milk on biofilms, oral microbiota, and enamel. Braz Oral Res 29(1):1\u20137. https:\/\/doi.org\/10.1590\/1807-3107BOR-2015.vol29.0033","journal-title":"Braz Oral Res"},{"issue":"3","key":"2682_CR16","doi-asserted-by":"publisher","first-page":"e282","DOI":"10.4317\/medoral.21494","volume":"22","author":"M Semin\u00e1rio-Amez","year":"2017","unstructured":"Semin\u00e1rio-Amez M, L\u00f3pez JL, Devesa AE, Montero RA, Salas EJ (2017) Probiotics and oral health: a systematic review. Med Oral Patol Oral Cir Bucal 22(3):e282\u2013e288. https:\/\/doi.org\/10.4317\/medoral.21494","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"2682_CR17","doi-asserted-by":"publisher","first-page":"1006e1012","DOI":"10.1016\/j.jclinepi.2009.06.005","volume":"62","author":"D Moher","year":"2009","unstructured":"Moher D, Liberati A, Tetzlaff J, Altman DG, The PRISMA Group (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. J Clin Epidemiol 62:1006e1012","journal-title":"J Clin Epidemiol"},{"issue":"2","key":"2682_CR18","doi-asserted-by":"publisher","first-page":"117","DOI":"10.17796\/jcpd.37.2.h606137vj3826v61","volume":"37","author":"LC Maia","year":"2012","unstructured":"Maia LC, Antonio AG (2012) Systematic reviews in dental research. A guideline. J Clin Pediatr Dent 37(2):117\u2013124","journal-title":"J Clin Pediatr Dent"},{"key":"2682_CR19","volume-title":"Cochrane handbook for systematic reviews of interventions\u2014version 5.1.0 [updated March 2011]","year":"2011","unstructured":"Higgins JP, Green S (eds) (2011) Cochrane handbook for systematic reviews of interventions\u2014version 5.1.0 [updated March 2011]. The Cochrane Collaboration, Oxford Available from http:\/\/handbook.cochrane.org"},{"key":"2682_CR20","doi-asserted-by":"publisher","DOI":"10.1002\/9780470743386","volume-title":"Introduction to meta-analysis","author":"M Borenstein","year":"2009","unstructured":"Borenstein M, Hedges LV, Higgins JP, Rothstein HR (2009) Introduction to meta-analysis. Wiley, Hoboken ISBN: 978-0-470-05724-7"},{"issue":"11","key":"2682_CR21","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1016\/S0003-9969(02)00112-7","volume":"47","author":"AJ Ahola","year":"2002","unstructured":"Ahola AJ, Knuuttila HY, Suomalainen T, Poussa T, Ahlstrom A, Meurman JH, Korpela R (2002) Short-term consumption of probiotic-containing cheese and its effect on dental caries risk factors. Arch Oral Biol 47(11):799\u2013804","journal-title":"Arch Oral Biol"},{"key":"2682_CR22","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1159\/000325741","volume":"45","author":"NA Aminabadi","year":"2011","unstructured":"Aminabadi NA, Erfanparast L, Ebrahimi A, Oskouei SG (2011) Effect of chlorhexidine pretreatment on the stability of salivary lactobacilli probiotic in six- to twelve-year-old children: a randomized controlled trial. Caries Res 45:148\u2013154. https:\/\/doi.org\/10.1159\/000325741","journal-title":"Caries Res"},{"issue":"2","key":"2682_CR23","doi-asserted-by":"publisher","first-page":"ZC06","DOI":"10.7860\/JCDR\/2015\/10942.5532","volume":"9","author":"D Ashwin","year":"2015","unstructured":"Ashwin D, Ke V, Taranath M, Ramagoni NK, Nara A, Sarpangala M (2015) Effect of probiotic containing ice cream on salivary mutans streptococci (sms) levels in children of 6-12 years of age: a randomized controlled double blind study with six-months follow up. J Clin Diagn Res 9(2):ZC06\u2013ZC09. https:\/\/doi.org\/10.7860\/JCDR\/2015\/10942.5532","journal-title":"J Clin Diagn Res"},{"issue":"1","key":"2682_CR24","doi-asserted-by":"publisher","first-page":"31","DOI":"10.4103\/2231-0762.151970","volume":"5","author":"M Bhalla","year":"2015","unstructured":"Bhalla M, Ingle NA, Kaur N, Yadav P (2015) Mutans streptococci estimation in saliva before and after consumption of probiotic curd among school children. J Int Soc Prev Community Dent 5(1):31\u201334","journal-title":"J Int Soc Prev Community Dent"},{"key":"2682_CR25","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1080\/00016350510020070","volume":"63","author":"E Caglar","year":"2005","unstructured":"Caglar E, Sandalli N, Twetman S, Kavaloglu S, Ergeneli S, Selvi S (2005) Effect of yogurt with Bifidobacterium DN-173 010 on salivary mutans streptococci and lactobacilli in young adults. Ada Odontol Scand 63:317\u2013320. https:\/\/doi.org\/10.1080\/00016350510020070","journal-title":"Ada Odontol Scand"},{"key":"2682_CR26","doi-asserted-by":"publisher","first-page":"547","DOI":"10.4103\/0970-9290.123363","volume":"24","author":"A Chinnappa","year":"2013","unstructured":"Chinnappa A, Konde H, Konde S, Raj S, Beena JP (2013) Probiotics for future caries control: a short-term clinical study. Indian J Dent Res 24:547\u2013549","journal-title":"Indian J Dent Res"},{"issue":"3","key":"2682_CR27","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/S1991-7902(10)60021-9","volume":"5","author":"D Cogulu","year":"2010","unstructured":"Cogulu D, Topaloglu-Ak A, Caglar E, Sandalli N, Karagozlu C, Ersin N, Yerlikaya O (2010) Potential effects of a multistrain probiotic-kefir on salivary Streptococcus mutans and Lactobacillus spp. J Dent Sci 5(3):144\u2013149","journal-title":"J Dent Sci"},{"issue":"4","key":"2682_CR28","doi-asserted-by":"publisher","first-page":"257","DOI":"10.17796\/1053-4628-41.4.257","volume":"41","author":"E Ghasemi","year":"2017","unstructured":"Ghasemi E, Mazaheri R, Tahmourespour A (2017) Effect of probiotic yogurt and xylitol-containing chewing gums on salivary s mutans count. J Clin Pediatr Dent 41(4):257\u2013263. https:\/\/doi.org\/10.17796\/1053-4628-41.4.257","journal-title":"J Clin Pediatr Dent"},{"issue":"2","key":"2682_CR29","doi-asserted-by":"publisher","first-page":"214","DOI":"10.5005\/jp-journals-10024-1517","volume":"15","author":"M Ghasempour","year":"2014","unstructured":"Ghasempour M, Sefdgar SA, Moghadamnia AA, Ghadimi R, Gharekhani S, Shirkhani L (2014) Comparative study of kefir yogurt-drink and sodium fluoride mouth rinse on salivary mutans streptococci. J Contemp Dent Pract 15(2):214\u2013217. https:\/\/doi.org\/10.5005\/jp-journals-10024-1517","journal-title":"J Contemp Dent Pract"},{"issue":"2","key":"2682_CR30","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1177\/154405910708600204","volume":"86","author":"K Hatakka","year":"2007","unstructured":"Hatakka K, Ahola AJ, Yli-Knuuttila H, Richardson M, Poussa T, Meurman JH, Korpela R (2007) Probiotics reduce the prevalence of oral Candida in the elderly\u2014a randomized controlled trial. J Dent Res 86(2):125\u2013130. https:\/\/doi.org\/10.1177\/154405910708600204","journal-title":"J Dent Res"},{"issue":"1","key":"2682_CR31","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.ajodo.2013.02.023","volume":"144","author":"JE Jose","year":"2013","unstructured":"Jose JE, Padmanabhan S, Chitharanjan AB (2013) Systemic consumption of probiotic curd and use of probiotic toothpaste to reduce Streptococcus mutans in plaque around orthodontic brackets. Am J Orthod Dentofac Orthop 144(1):67\u201372. https:\/\/doi.org\/10.1016\/j.ajodo.2013.02.023","journal-title":"Am J Orthod Dentofac Orthop"},{"issue":"3","key":"2682_CR32","first-page":"151","volume":"37","author":"S Lassan","year":"2013","unstructured":"Lassan S, Rahbar M, Valaei N, Abbasi-Vardoogh S, Abbasi-Vargoogh M (2013) Effect of probiotic yoghurt on salivary Streptococcus mutans and Lactobacillus. J Fac Med 37(3):151\u2013157","journal-title":"J Fac Med"},{"issue":"4","key":"2682_CR33","doi-asserted-by":"publisher","first-page":"383","DOI":"10.3290\/j.ohpd.a19974","volume":"8","author":"MO Lexner","year":"2010","unstructured":"Lexner MO, Blomqvist S, Dahl\u00e9n G, Twetman S (2010) Microbiological profiles in saliva and supragingival plaque from caries-active adolescents before and after a short-term daily intake of milk supplemented with probiotic bacteria\u2014a pilot study. Oral Health Prev Dent 8(4):383\u2013388. https:\/\/doi.org\/10.3290\/j.ohpd.a19974","journal-title":"Oral Health Prev Dent"},{"key":"2682_CR34","first-page":"73","volume":"10","author":"P Moeny","year":"2013","unstructured":"Moeny P, Jamei N, Mohamadi M, Shafizadeh N, Valaei N, Rahbar M et al (2013) Effect of probiotic yoghurt produced in Iran on the salivary counts of Streptococcus mutans. J Res Dent Sci 10:73\u201382","journal-title":"J Res Dent Sci"},{"issue":"7","key":"2682_CR35","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1111\/odi.12669","volume":"23","author":"TY Miyazima","year":"2017","unstructured":"Miyazima TY, Ishikawa KH, Mayer MPA, Saad SMI, Nakamae AEM (2017) Cheese supplemented with probiotics reduces Candida levels in denture wearers\u2014RCT. Oral Dis 23(7):919\u2013925. https:\/\/doi.org\/10.1111\/odi.12669","journal-title":"Oral Dis"},{"issue":"1","key":"2682_CR36","first-page":"57","volume":"17","author":"S Mortazavi","year":"2012","unstructured":"Mortazavi S, Akhlaghi N (2012) Salivary Streptococcus mutans and Lactobacilli levels following probiotic cheese consumption in adults: a double blind randomized clinical trial. J Res Med Sci 17(1):57\u201366","journal-title":"J Res Med Sci"},{"key":"2682_CR37","doi-asserted-by":"publisher","first-page":"213","DOI":"10.3290\/j.ohpd.a32673","volume":"13","author":"R Nagarajappa","year":"2015","unstructured":"Nagarajappa R, Daryani H, Sharda AJ, Asawa K, Batra M, Sanadhya S, Ramesh G (2015) Effect of chocobar ice cream containing Bifidobacterium on salivary Streptococcus mutans and Lactobacilli: a randomized controlled trial. Oral Health Prev Dent 13:213\u2013218. https:\/\/doi.org\/10.3290\/j.ohpd.a32673","journal-title":"Oral Health Prev Dent"},{"key":"2682_CR38","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1159\/000047484","volume":"35","author":"L Nase","year":"2001","unstructured":"Nase L, Hatakka K, Savilahti E, Saxelin M, Ponka A, Poussa T, Korpela R, Meurman JH (2001) Effect of long-term consumption of a probiotic bacterium, Lactobacillus rhamnosus GG, in milk on dental caries and caries risk in children. Caries Res 35:421\u2013420","journal-title":"Caries Res"},{"issue":"2","key":"2682_CR39","first-page":"81","volume":"16","author":"A Nozari","year":"2015","unstructured":"Nozari A, Motamedifar M, Seifi N, Hatamizargaran Z, Ranjbar MA (2015) The effect of iranian customary used probiotic yogurt on the children\u2019s salivary cariogenic microflora. J Dent (Shiraz) 16(2):81\u201386","journal-title":"J Dent (Shiraz)"},{"key":"2682_CR40","doi-asserted-by":"publisher","first-page":"321","DOI":"10.3109\/00016357.2011.568962","volume":"69","author":"LG Petersson","year":"2011","unstructured":"Petersson LG, Magnusson K, Hakestam ULF, Baigi A, Twetman S (2011) Reversal of primary root caries lesions after daily intake of milk supplemented with fluoride and probiotic Lactobacillus in older adults. Acta Odontol Scand 69:321\u2013327. https:\/\/doi.org\/10.3109\/00016357.2011.568962","journal-title":"Acta Odontol Scand"},{"key":"2682_CR41","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1159\/000353467","volume":"48","author":"GS Pinto","year":"2014","unstructured":"Pinto GS, Cenci MS, Azevedo MS, Epifanio M, Jones MH (2014) Effect of yogurt containing Bifidobacterium animalis subsp. lactis DN-173010 probiotic on dental plaque and saliva in orthodontic patients. Caries Res 48:63\u201368. https:\/\/doi.org\/10.1159\/000353467","journal-title":"Caries Res"},{"issue":"3","key":"2682_CR42","first-page":"147","volume":"7","author":"H Poureslami","year":"2013","unstructured":"Poureslami H, Pishbin L, Eslaminejad Z, Moqadam FJ, Farokhi MR (2013) The effects of a dairy probiotic product, espar, on salivary calcium and mutans streptococci. J Dent Res Dent Clin Dent Prospects 7(3):147\u2013151","journal-title":"J Dent Res Dent Clin Dent Prospects"},{"issue":"4","key":"2682_CR43","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1038\/sj.bdj.2017.169","volume":"222","author":"G Rodriguez","year":"2016","unstructured":"Rodriguez G, Ruiz B, Faleiros S, Vistoso A, Marr\u00f3 ML, S\u00e1nchez J, Urz\u00faa I, Cabello R (2016) Probiotic compared with standard milk for high-caries children: a cluster randomized trial. Br Dent J 222(4):260. https:\/\/doi.org\/10.1038\/sj.bdj.2017.169","journal-title":"Br Dent J"},{"key":"2682_CR44","doi-asserted-by":"publisher","first-page":"3","DOI":"10.3238\/OPKZH.2013.0120-0126","volume":"35","author":"N Shakovetz","year":"2013","unstructured":"Shakovetz N, Borutta A, Kneist S (2013) Probiotica in caries prevention for preschool children. Oralprophylaxe & Kinderzahnheilkunde 35:3. https:\/\/doi.org\/10.3238\/OPKZH.2013.0120-0126","journal-title":"Oralprophylaxe & Kinderzahnheilkunde"},{"key":"2682_CR45","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1159\/000235581","volume":"43","author":"C Stecksen-Blicks","year":"2009","unstructured":"Stecksen-Blicks C, Sjostrom I, Twetman S (2009) Effect of long-term consumption of milk supplemented with probiotic lactobacilli and fluoride on dental caries and general health in preschool children: a cluster-rondomized study. Caries Res 43:374\u2013381. https:\/\/doi.org\/10.1159\/000235581","journal-title":"Caries Res"},{"issue":"2","key":"2682_CR46","doi-asserted-by":"publisher","first-page":"ZC13","DOI":"10.7860\/JCDR\/2016\/15530.7178","volume":"10","author":"S Srivastava","year":"2016","unstructured":"Srivastava S, Saha S, Kumari M, Mohd S (2016) Effect of probiotic curd on salivary pH and Streptococcus mutans: a double blind parallel randomized controlled trial. J Clin Diagn Res 10(2):ZC13\u2013ZC16. https:\/\/doi.org\/10.7860\/JCDR\/2016\/15530.7178","journal-title":"J Clin Diagn Res"},{"key":"2682_CR47","doi-asserted-by":"publisher","first-page":"850","DOI":"10.1111\/j.1600-051X.2009.01459.x","volume":"36","author":"B Staab","year":"2009","unstructured":"Staab B, Eick S, Knofler G, Jentsch H (2009) The influence of a probiotic milk drink on the development of gingivitis: a pilot study. J Clin Periodontol 36:850\u2013856. https:\/\/doi.org\/10.1111\/j.1600-051X.2009.01459.x","journal-title":"J Clin Periodontol"},{"key":"2682_CR48","doi-asserted-by":"publisher","first-page":"135","DOI":"10.4103\/0300-1652.104382","volume":"53","author":"R Sudhir","year":"2012","unstructured":"Sudhir R, Praveen P, Anantharaj A, Venkataraghavan K (2012) Assessment of the effect of probiotic curd consumption on salivary pH and Streptococcus mutans counts. Niger Med J 53:135\u2013139","journal-title":"Niger Med J"},{"issue":"1","key":"2682_CR49","doi-asserted-by":"publisher","first-page":"23","DOI":"10.17796\/jcpd.39.1.u433n8w245511781","volume":"39","author":"M Yadav","year":"2014","unstructured":"Yadav M, Poormina P, Roshan NM, Prachi N, Veena M, Neena IE (2014) Evaluation of probiotic milk on salivary mutans streptococci count: an in vivo microbiological study. J Clin Pediatr Dent 39(1):23\u201326","journal-title":"J Clin Pediatr Dent"},{"issue":"3","key":"2682_CR50","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1007\/s00784-013-1057-5","volume":"18","author":"R Teanpaisan","year":"2013","unstructured":"Teanpaisan R, Piwat S (2013) Lactobacillus paracasei SD1, a novel probiotic, reduces mutans streptococci in human volunteers: a randomized placebo-controlled trial. Clin Oral Investig 18(3):857\u2013862. https:\/\/doi.org\/10.1007\/s00784-013-1057-5","journal-title":"Clin Oral Investig"},{"issue":"4","key":"2682_CR51","doi-asserted-by":"publisher","first-page":"329","DOI":"10.17796\/jcpd.38.4.p608312353256684","volume":"38","author":"E Caglar","year":"2014","unstructured":"Caglar E (2014) Effect of Bifidobacterium bifidum containing yoghurt on dental plaque bacteria in children. J Clin Pediatr Dent 38(4):329\u2013332","journal-title":"J Clin Pediatr Dent"},{"issue":"5","key":"2682_CR52","first-page":"33","volume":"5","author":"RM Karuppaiah","year":"2013","unstructured":"Karuppaiah RM, Shankar S, Raj SK, Ramesh K, Prakash R, Kruthika M (2013) Evaluation of the efficacy of probiotics in plaque reduction and gingival health maintenance among school children\u2014a randomized control trial. J Int Oral Health 5(5):33\u201337","journal-title":"J Int Oral Health"},{"issue":"7","key":"2682_CR53","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.1007\/s00784-013-0990-7","volume":"17","author":"N Yanine","year":"2013","unstructured":"Yanine N, Araya I, Brignardello-Petersen R, Carrasco-Labra A, Gonzalez A, Preciado A (2013) Effects of probiotics in periodontal diseases: a systematic review. Clin Oral Investig 17(7):1627\u20131634","journal-title":"Clin Oral Investig"},{"key":"2682_CR54","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.archoralbio.2017.04.030","volume":"83","author":"R Ai","year":"2017","unstructured":"Ai R, Wei J, Ma D, Jiang L, Dan H, Zhou Y, Ji N, Zeng X, Chen Q (2017) A meta-analysis of randomized trials assessing the effects of probiotic preparations on oral candidiasis in the elderly. Arch Oral Biol 83:187\u2013192. https:\/\/doi.org\/10.1016\/j.archoralbio.2017.04.030","journal-title":"Arch Oral Biol"},{"key":"2682_CR55","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1159\/000439315","volume":"49","author":"CE Fern\u00e1ndez","year":"2015","unstructured":"Fern\u00e1ndez CE, Giacaman RA, Tenuta LM, Cury JA (2015) Effect of the probiotic Lactobacillus rhamnosus lb21 on the cariogenicity of Streptococcus mutans ua159 in a dual-species biofilm model. Caries Res 49:583\u2013590. https:\/\/doi.org\/10.1159\/000439315","journal-title":"Caries Res"},{"issue":"11","key":"2682_CR56","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1111\/j.1600-051X.2010.01665.x","volume":"38","author":"W Teughels","year":"2011","unstructured":"Teughels W, Loozen G, Quirynen M (2011) Do probiotics offer opportunities to manipulate the periodontal oral microbiota? J Clin Periodontol 38(11):159\u2013177. https:\/\/doi.org\/10.1111\/j.1600-051X.2010.01665.x","journal-title":"J Clin Periodontol"},{"issue":"7","key":"2682_CR57","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1016\/j.jdent.2015.02.017","volume":"43","author":"M Schroeder","year":"2015","unstructured":"Schroeder M, Reis A, Luque-Martinez I, Loguercio AD, Masterson D, Maia LC (2015) Effect of enamel bevel on retention of cervical composite resin restorations: a systematic review. J Dent 43(7):777\u2013788. https:\/\/doi.org\/10.1016\/j.jdent.2015.02.017","journal-title":"J Dent"},{"issue":"3","key":"2682_CR58","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1159\/000077753","volume":"38","author":"O Fejerskov","year":"2004","unstructured":"Fejerskov O (2004) Changing paradigms in concepts on dental caries: consequences for oral health care. Caries Res 38(3):182\u2013191. https:\/\/doi.org\/10.1159\/000077753","journal-title":"Caries Res"},{"issue":"3","key":"2682_CR59","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/j.dental.2015.12.002","volume":"32","author":"JA Cury","year":"2016","unstructured":"Cury JA, Oliveira BH, Santos APP, Tenuta LMA (2016) Are fluoride releasing dental materials clinically effective on caries control? Dent Mater 32(3):323\u2013333. https:\/\/doi.org\/10.1016\/j.dental.2015.12.002","journal-title":"Dent Mater"},{"issue":"9","key":"2682_CR60","doi-asserted-by":"publisher","first-page":"110S","DOI":"10.1177\/0022034515576052","volume":"94","author":"PW Caufield","year":"2015","unstructured":"Caufield PW, Sch\u00f6n CN, Saraithong P, Li Y, Argim\u00f3n S (2015) Oral Lactobacilli and dental caries. J Dent Res 94(9):110S\u2013118S. https:\/\/doi.org\/10.1177\/0022034515576052","journal-title":"J Dent Res"},{"key":"2682_CR61","doi-asserted-by":"crossref","unstructured":"Hoare A, Marsh PD, Diaz PL (2017) Ecological therapeutic opportunities for oral diseases. Microbiol Spectr 5(4)","DOI":"10.1128\/microbiolspec.BAD-0006-2016"},{"key":"2682_CR62","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1038\/sj.bdj.2016.865","volume":"221","author":"M Kilian","year":"2016","unstructured":"Kilian M, Chapple IL, Hannig M, Marsh PD, Meuric PD, Meuric V, Pedersen AM, Tonetti MS, Wade WG, Zaura E (2016) The oral microbiome\u2014an update for oral healthcare professionals. Br Dent J 221:657\u2013666. https:\/\/doi.org\/10.1038\/sj.bdj.2016.865","journal-title":"Br Dent J"},{"issue":"7","key":"2682_CR63","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1038\/ejcn.2011.45","volume":"65","author":"S Slawik","year":"2011","unstructured":"Slawik S, Staufenbie I, Schilke R, Nicksch S, Weinspach K, Stiesch M, Eberhard J (2011) Probiotics affect the clinical inflammatory parameters of experimental gingivitis in humans. Eur J Clin Nutr 65(7):857\u2013863. https:\/\/doi.org\/10.1038\/ejcn.2011.45","journal-title":"Eur J Clin Nutr"}],"container-title":["Clinical Oral Investigations"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00784-018-2682-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-018-2682-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-018-2682-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,3]],"date-time":"2022-09-03T16:23:13Z","timestamp":1662222193000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00784-018-2682-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,9]]},"references-count":63,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["2682"],"URL":"https:\/\/doi.org\/10.1007\/s00784-018-2682-9","relation":{},"ISSN":["1432-6981","1436-3771"],"issn-type":[{"value":"1432-6981","type":"print"},{"value":"1436-3771","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,9]]},"assertion":[{"value":"6 December 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 October 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 October 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"There is no conflict of interest for any of the authors that might introduce bias or affect their judgment.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This article does not contain any studies with human participants or animals performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"For this type of study, formal consent is not required.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}