{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T22:29:07Z","timestamp":1790720947045,"version":"4.1.0"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2018,11,3]],"date-time":"2018-11-03T00:00:00Z","timestamp":1541203200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Oral Invest"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1007\/s00784-018-2740-3","type":"journal-article","created":{"date-parts":[[2018,11,3]],"date-time":"2018-11-03T12:33:25Z","timestamp":1541248405000},"page":"3173-3182","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Antimicrobial photodynamic therapy as adjunct to non-surgical periodontal treatment in smokers: a randomized clinical trial"],"prefix":"10.1007","volume":"23","author":[{"given":"Mariana Sales","family":"de Melo Soares","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristine","family":"D\u2019Almeida Borges","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos","family":"de Mendon\u00e7a Invernici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiani Gai","family":"Frantz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciene Cristina","family":"de Figueiredo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9rgio Luis Scombatti","family":"de Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Mario","family":"Taba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel Reis","family":"Messora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Arthur Bel\u00e9m","family":"Novaes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,11,3]]},"reference":[{"key":"2740_CR1","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1111\/j.1600-0757.2012.00457.x","volume":"62","author":"RJ Genco","year":"2013","unstructured":"Genco RJ, Borgnakke WS (2013) Risk factors for periodontal disease. Periodontol 62:59\u201394. \n                    https:\/\/doi.org\/10.1111\/j.1600-0757.2012.00457.","journal-title":"Periodontol"},{"key":"2740_CR2","doi-asserted-by":"publisher","first-page":"1390","DOI":"10.1902\/jop.2014.130577","volume":"85","author":"J Zeng","year":"2014","unstructured":"Zeng J, Williams SM, Fletcher DJ, Cameron CM, Broadbent JM, Shearer DM, Thomson WM (2014) Re-examining the association between smoking and periodontitis in the Dunedin study with an enhanced analytical approach. J Periodontol 85:1390\u20131397. \n                    https:\/\/doi.org\/10.1902\/jop.2014.130577.","journal-title":"J Periodontol"},{"key":"2740_CR3","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1902\/jop.2004.75.2.196","volume":"75","author":"GK Johnson","year":"2004","unstructured":"Johnson GK, Hill M (2004) Cigarette smoking and the periodontal patient. J Periodontol 75:196\u2013209. \n                    https:\/\/doi.org\/10.1902\/jop.2004.75.2.196","journal-title":"J Periodontol"},{"key":"2740_CR4","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1111\/j.1600-0757.2006.00163.x","volume":"43","author":"MI Ryder","year":"2007","unstructured":"Ryder MI (2007) The influence of smoking on host responses in periodontal infections. Periodontol 43:267\u2013277. \n                    https:\/\/doi.org\/10.1111\/j.1600-0757.2006.00163.x","journal-title":"Periodontol"},{"key":"2740_CR5","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1034\/j.1600-051X.2003.00080.x","volume":"30","author":"U Velden van der","year":"2003","unstructured":"van der Velden U, Varoufaki A, Hutter JW, Xu L, Timmerman MF, van Winkelhoff AJ, Loos BG (2003) Effect of smoking and periodontal treatment on the subgingival microflora. J Clin Periodontol 30:603\u2013610","journal-title":"J Clin Periodontol"},{"key":"2740_CR6","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1111\/adj.12225","volume":"60","author":"M Feres","year":"2015","unstructured":"Feres M, Bernal M, Matarazzo F, Faveri M, Duarte PM, Figueiredo LC (2015) Subgingival bacterial recolonization after scaling and root planning in smokers with chronic periodontitis. Aust Dent J 60:225\u2013232. \n                    https:\/\/doi.org\/10.1111\/adj.12225","journal-title":"Aust Dent J"},{"key":"2740_CR7","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1111\/j.1600-051X.2005.00720.x","volume":"32","author":"LH Carvalho","year":"2005","unstructured":"Carvalho LH, D\u2019Avila GB, Leao A, Gon\u00e7alves C, Haffajee AD, Socransky SS, Feres M (2005) Scaling and root planning, systemic metronidazole and professional plaque removal in the treatment of chronic periodontitis in a Brazilian population II. Microbiological results. J Clin Periodontol 32:406\u2013411. \n                    https:\/\/doi.org\/10.1111\/j.1600-051X.2005.00720.","journal-title":"J Clin Periodontol"},{"key":"2740_CR8","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1034\/j.1600-051X.29.s3.8.x","volume":"29","author":"D Herrera","year":"2002","unstructured":"Herrera D, Sanz M, Jepsen S, Needleman I, Roldan SA (2002) Systematic review on the effect of systemic antimicrobials as an adjunct to scaling and root planning in periodontitis patients. J Clin Periodontol 29:136\u2013159","journal-title":"J Clin Periodontol"},{"key":"2740_CR9","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1902\/annals.2003.8.1.115","volume":"8","author":"AD Haffajee","year":"2003","unstructured":"Haffajee AD, Socransky SS, Gunsolley JC (2003) Systemic anti-infective periodontal therapy: a systematic review. Ann Periodontol 8:115\u2013181. \n                    https:\/\/doi.org\/10.1902\/annals.2003.8.1.115","journal-title":"Ann Periodontol"},{"key":"2740_CR10","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1111\/j.1600-051X.2008.01304.x","volume":"35","author":"F Matarazzo","year":"2008","unstructured":"Matarazzo F, Figueiredo LC, Cruz SE, Faveri M, Feres M (2008) Clinical and microbiological benefits of systemic metronidazole and amoxicillin in the treatment of smokers with chronic periodontitis: a randomized placebo-controlled study. J Clin Periodontol 35:885\u2013896. \n                    https:\/\/doi.org\/10.1111\/j.1600-051X.2008.01304.","journal-title":"J Clin Periodontol"},{"key":"2740_CR11","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1016\/S0011-8532(03)00039-9","volume":"47","author":"TJ Pallasch","year":"2003","unstructured":"Pallasch TJ (2003) Antibiotic resistance. Dent Clin N Am 47:623\u2013639","journal-title":"Dent Clin N Am"},{"key":"2740_CR12","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1902\/jop.2007.060494","volume":"78","author":"RR Oliveira de","year":"2007","unstructured":"de Oliveira RR, Schwartz-Filho HO, Novaes AB Jr, Taba M Jr (2007) Antimicrobial photodynamic therapy in the non-surgical treatment of aggressive periodontitis: a preliminary randomized controlled clinical study. J Periodontol 78:965\u2013973. \n                    https:\/\/doi.org\/10.1902\/jop.2007.060494","journal-title":"J Periodontol"},{"key":"2740_CR13","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1007\/s10103-011-0901-6","volume":"27","author":"AB Novaes Jr","year":"2012","unstructured":"Novaes AB Jr, Schwartz-Filho HO, de Oliveira RR, Feres M, Sato S, Figueiredo LC (2012) Antimicrobial photodynamic therapy in the non-surgical treatment of aggressive periodontitis: microbiological profile. Lasers Med Sci 27:389\u2013395. \n                    https:\/\/doi.org\/10.1007\/s10103-011-0901-6","journal-title":"Lasers Med Sci"},{"key":"2740_CR14","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1007\/s10103-013-1379-1","volume":"30","author":"AC Queiroz","year":"2015","unstructured":"Queiroz AC, Suaid FA, de Andrade PF, Oliveira FS, Novaes AB Jr, Taba M Jr, Palioto DB, Grisi MF, Souza SL (2015) Adjunctive effect of antimicrobial photodynamic therapy to nonsurgical periodontal treatment in smokers: a randomized clinical trial. Lasers Med Sci 30:617\u2013625. \n                    https:\/\/doi.org\/10.1007\/s10103-013-1379-1","journal-title":"Lasers Med Sci"},{"key":"2740_CR15","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.jphotobiol.2004.11.023","volume":"79","author":"P Meisel","year":"2005","unstructured":"Meisel P, Kocher T (2005) Photodynamic therapy for periodontal diseases: state of the art. J Photochem Photobiol B 79:159\u2013170. \n                    https:\/\/doi.org\/10.1016\/j.jphotobiol.2004.11.023","journal-title":"J Photochem Photobiol B"},{"key":"2740_CR16","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1111\/j.1600-051X.2008.01303.x","volume":"35","author":"A Braun","year":"2008","unstructured":"Braun A, Dehn C, Krause F, Jepsen S (2008) Short-term clinical effects of adjunctive antimicrobial photodynamic therapy in periodontal treatment: a randomized clinical trial. J Clin Periodontol 35:877\u2013884","journal-title":"J Clin Periodontol"},{"key":"2740_CR17","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1111\/jcpe.12249","volume":"41","author":"CS Betsy","year":"2014","unstructured":"Betsy CS, Prasanth KV, Baiju J, Prasanthila N, Subhash (2014) Efficacy ofantimicrobial photodynamic therapy in the management of chronicperiodontitis: a randomized controlled clinical trial. J Clin Periodontol 41:573\u2013581","journal-title":"J Clin Periodontol"},{"key":"2740_CR18","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1902\/jop.2009.070465","volume":"80","author":"RR Oliveira de","year":"2009","unstructured":"de Oliveira RR, Schwartz-Filho HO, Novaes AB Jr, Garlet GP, de Souza RF, Taba M Jr, Scombatti SLS, Ribeiro FJ (2009) Antimicrobial photodynamic therapy in the non-surgical treatment of aggressive periodontitis: cytokine profile in gingival crevicular fluid, preliminary results. J Periodontol 80:98\u2013105. \n                    https:\/\/doi.org\/10.1902\/jop.2009.070465","journal-title":"J Periodontol"},{"key":"2740_CR19","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1590\/1678-7757201302366","volume":"21","author":"ML Balata","year":"2013","unstructured":"Balata ML, de Andrade LP, Santos DB, Cavalcanti AN, Tunes Uda R, Ribeiro EP, Bittencourt S (2013) Photodynamic therapy associated with full-mouth ultrasonic debridement in the treatment of severe chronic periodontitis: a randomized controlled clinical trial. J Appl Oral Sci 21:208\u2013214. \n                    https:\/\/doi.org\/10.1590\/1678-7757201302366","journal-title":"J Appl Oral Sci"},{"key":"2740_CR20","doi-asserted-by":"publisher","first-page":"1647","DOI":"10.1007\/s10103-014-1632-2","volume":"30","author":"M Petelin","year":"2014","unstructured":"Petelin M, Perkic K, Seme K, Ga\u0161pirc B (2014) Effect of repeated adjunctive antimicrobial photodynamic therapy on subgingival periodontal pathogens in the treatment of chronic periodontitis. Lasers Med Sci 30:1647\u20131656. \n                    https:\/\/doi.org\/10.1007\/s10103-014-1632-2","journal-title":"Lasers Med Sci"},{"key":"2740_CR21","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1902\/jop.2014.140392","volume":"86","author":"AL Moreira","year":"2015","unstructured":"Moreira AL, Novaes AB Jr, Grisi MF, Taba M Jr, Souza SL, Palioto DB, de Oliveira PG, Casati MZ, Casarin RC, Messora MR (2015) Antimicrobial photodynamic therapy as an adjunct to non-surgical treatment of aggressive periodontitis: a split-mouth randomized controlled trial. J Periodontol 86:376\u2013386. \n                    https:\/\/doi.org\/10.1902\/jop.2014.140392","journal-title":"J Periodontol"},{"key":"2740_CR22","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1902\/jop.2012.120096","volume":"84","author":"A Dilsiz","year":"2013","unstructured":"Dilsiz A, Canakci V, Aydin T (2013) Clinical effects of potassium-titanyl-phosphate laser and photodynamic therapy on outcomes of treatment of chronic periodontitis: a randomized controlled clinical trial. J Periodontol 84:278\u2013286. \n                    https:\/\/doi.org\/10.1902\/jop.2012.120096","journal-title":"J Periodontol"},{"key":"2740_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1902\/annals.1999.4.1.1","volume":"4","author":"GC Armitage","year":"1999","unstructured":"Armitage GC (1999) Development of a classification system for periodontal diseases and conditions. Ann Periodontol 4:1\u20136. \n                    https:\/\/doi.org\/10.1902\/annals.1999.4.1.1.","journal-title":"Ann Periodontol"},{"key":"2740_CR24","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1902\/jop.1972.43.1.38","volume":"43","author":"TJ O'Leary","year":"1972","unstructured":"O'Leary TJ, Drake RB, Naylor JE (1972) The plaque control record. J Periodontol 43:38. \n                    https:\/\/doi.org\/10.1902\/jop.1972.43.1.38","journal-title":"J Periodontol"},{"key":"2740_CR25","first-page":"149","volume":"80","author":"J Ainamo","year":"1976","unstructured":"Ainamo J, Bay I (1976) Periodontal indexes for and in practice. Tandlaegebladet 80:149\u2013152","journal-title":"Tandlaegebladet"},{"issue":"1","key":"2740_CR26","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/s40729-016-0058-y","volume":"2","author":"C Tirachaimongkol","year":"2016","unstructured":"Tirachaimongkol C, Pothacharoen P, Reichart PA, Khongkhunthian P (2016) Relation between the stability of dental implants and two biological markers during the healing period: a prospective clinical study. Int J Implant Dent 2(1):27","journal-title":"Int J Implant Dent"},{"key":"2740_CR27","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1111\/j.1600-051X.1998.tb02419.x","volume":"25","author":"SS Socransky","year":"1998","unstructured":"Socransky SS, Haffajee AD, Cugini MA, Smith C, Kent RL Jr (1998) Microbial complexes in subgingival plaque. J Clin Periodontol 25:134\u2013144","journal-title":"J Clin Periodontol"},{"key":"2740_CR28","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1111\/j.1600-051X.1991.tb00070.x","volume":"8","author":"SS Socransky","year":"1991","unstructured":"Socransky SS, Haffajee AD, Smith C, Dibart S (1991) Relation of counts of microbial species to clinical status at the sampled site. J Clin Periodontol 8:766\u2013775","journal-title":"J Clin Periodontol"},{"key":"2740_CR29","first-page":"1183","volume":"32","author":"MS Al-Zahrani","year":"2011","unstructured":"Al-Zahrani MS, Austah ON (2011) Photodynamic therapy as an adjunctive to scaling and root planing in treatment of chronic periodontitis in smokers. Saudi Med J 32:1183\u20131188","journal-title":"Saudi Med J"},{"issue":"28","key":"2740_CR30","doi-asserted-by":"publisher","first-page":"3470","DOI":"10.1002\/sim.3634","volume":"28","author":"E Lesaffre","year":"2009","unstructured":"Lesaffre E, Philstrom B, Needleman I, Worthington H (2009) The design and analysis of split-mouth studies: what statisticians and clinicians should know. Stat Med 28(28):3470\u20133482","journal-title":"Stat Med"},{"issue":"6","key":"2740_CR31","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1034\/j.1600-051x.2001.028006499.x","volume":"28","author":"M Quirynen","year":"2001","unstructured":"Quirynen M, De Soete M, Dierickx K, van Steenberghe D (2001) The intra-oral translocation of periodontopathogens jeopardises the outcome of periodontal therapy. A review of the literature. J Clin Periodontol 28(6):499\u2013507","journal-title":"J Clin Periodontol"},{"key":"2740_CR32","doi-asserted-by":"publisher","first-page":"S61","DOI":"10.1089\/pho.2009.2622","volume":"28","author":"CN Street","year":"2010","unstructured":"Street CN, Pedigo LA, Loebel NG (2010) Energy dose parameters affect antimicrobial photodynamic therapy-mediated eradication of periopathogenic biofilm and planktonic cultures. Photomed Laser Surg 28:S61\u2013S66. \n                    https:\/\/doi.org\/10.1089\/pho.2009.2622.","journal-title":"Photomed Laser Surg"},{"key":"2740_CR33","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.pdpdt.2016.09.004","volume":"16","author":"Z Akram","year":"2016","unstructured":"Akram Z, Abduljabbar T, Sauro S, Daood U (2016) Effect of photodynamic therapy and laser alone as adjunct to scaling and root planing on gingival crevicular fluid inflammatory proteins in periodontal disease: a systematic review. Photodiagn Photodyn Ther 16:142\u2013153. \n                    https:\/\/doi.org\/10.1016\/j.pdpdt.2016.09.004","journal-title":"Photodiagn Photodyn Ther"},{"key":"2740_CR34","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1111\/j.1600-051X.2009.01508.x","volume":"37","author":"G Matuliene","year":"2010","unstructured":"Matuliene G, Studer R, Lang NP, Schmidlin K, Pjetursson BE, Salvi GE, Br\u00e4gger U, Zwahlen M (2010) Significance of periodontal risk assessment in the recurrence of periodontitis and tooth loss. J Clin Periodontol 37:191\u2013199. \n                    https:\/\/doi.org\/10.1111\/j.1600-051X.2009.01508.x","journal-title":"J Clin Periodontol"},{"key":"2740_CR35","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1111\/j.1600-051X.2008.01245.x","volume":"35","author":"G Matuliene","year":"2008","unstructured":"Matuliene G, Pjetursson BE, Salvi GE, Schmidlin K, Br\u00e4gger U, Zwahlen M, Lang NP (2008) Influence of residual pockets on progression of periodontitis and tooth loss: results after 11 years of maintenance. J Clin Periodontol 35:685\u2013695. \n                    https:\/\/doi.org\/10.1111\/j.1600-051X.2008.01245.x","journal-title":"J Clin Periodontol"},{"key":"2740_CR36","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.pdpdt.2017.01.183","volume":"18","author":"D Xue","year":"2017","unstructured":"Xue D, Tang L, Bai Y, Ding Q, Wang P, Zhao Y (2017) Clinical efficacy of photodynamic therapy adjunctive to scaling and root planning in the treatment of chronic periodontitis: a systematic review and meta-analysis. Photodiagn Photodyn Ther 18:119\u2013127. \n                    https:\/\/doi.org\/10.1016\/j.pdpdt.2017.01.183","journal-title":"Photodiagn Photodyn Ther"},{"key":"2740_CR37","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1111\/jcpe.12498","volume":"43","author":"UD Ramos","year":"2016","unstructured":"Ramos UD, Ayub LG, Reino DM, Grisi MF, Taba M Jr, Souza SL, Palioto DB, Novaes AB Jr (2016) Antimicrobial photodynamic therapy as an alternative to systemic antibiotics: results from a double-blind, randomized, placebo-controlled, clinical study on type 2 diabetics. J Clin Periodontol 43:147\u2013155. \n                    https:\/\/doi.org\/10.1111\/jcpe.12498","journal-title":"J Clin Periodontol"},{"key":"2740_CR38","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1034\/j.1600-051x.2001.028005377.x","volume":"28","author":"AD Haffajee","year":"2001","unstructured":"Haffajee AD, Socransky SS (2001) Relationship of cigarette smoking to the subgingival microbiota. J Clin Periodontol 28:377\u2013388","journal-title":"J Clin Periodontol"},{"key":"2740_CR39","doi-asserted-by":"publisher","first-page":"917","DOI":"10.2217\/fmb.12.71","volume":"7","author":"PS Kumar","year":"2012","unstructured":"Kumar PS (2012) Smoking and the subgingival ecosystem: a pathogen-enriched community. Future Microbiol 7:917\u2013919. \n                    https:\/\/doi.org\/10.2217\/fmb.12.71","journal-title":"Future Microbiol"},{"key":"2740_CR40","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1111\/j.1600-051X.1998.tb02368.x","volume":"25","author":"L Bostr\u00f6m","year":"1998","unstructured":"Bostr\u00f6m L, Linder LE, Bergstr\u00f6m J (1998) Clinical expression of TNF-alpha in smoking-associated periodontal disease. J Clin Periodontol 25:767\u2013777","journal-title":"J Clin Periodontol"},{"key":"2740_CR41","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1016\/j.archoralbio.2012.11.009","volume":"58","author":"A Akpinar","year":"2013","unstructured":"Akpinar A, Toker H, Ozdemir H, Bostanci V, Aydin H (2013) The effects of non-surgical periodontal therapy on oxidant and anti-oxidant status in smokers with chronic periodontitis. Arch Oral Biol 58:717\u2013723. \n                    https:\/\/doi.org\/10.1016\/j.archoralbio.2012.11.009","journal-title":"Arch Oral Biol"},{"key":"2740_CR42","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.jphotobiol.2014.10.017","volume":"141","author":"AC Queiroz","year":"2014","unstructured":"Queiroz AC, Suaid FA, de Andrade PF, Novaes AB Jr, Taba M Jr, Palioto DB, Grisi MF, Souza SL (2014) Antimicrobial photodynamic therapy associated to nonsurgical periodontal treatment in smokers: microbiological results. J Photochem Photobiol B 141:170\u2013175. \n                    https:\/\/doi.org\/10.1016\/j.jphotobiol.2014.10.017","journal-title":"J Photochem Photobiol B"},{"key":"2740_CR43","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1177\/0022034511421200","volume":"91","author":"J Lee","year":"2012","unstructured":"Lee J, Taneja V, Vassallo R (2012) Cigarette smoking and inflammation: cellular and molecular mechanisms. J Dent Res 91:142\u2013149. \n                    https:\/\/doi.org\/10.1177\/0022034511421200","journal-title":"J Dent Res"},{"key":"2740_CR44","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1111\/prd.12063","volume":"67","author":"FH Nociti Jr","year":"2015","unstructured":"Nociti FH Jr, Casati MZ, Duarte PM (2015) Current perspective of the impact of smoking on the progression and treatment of periodontitis. Periodontol 67:187\u2013210. \n                    https:\/\/doi.org\/10.1111\/prd.12063","journal-title":"Periodontol"},{"key":"2740_CR45","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1111\/j.1600-0757.2012.00456.x","volume":"64","author":"A Johannsen","year":"2014","unstructured":"Johannsen A, Susin C, Gustafsson A (2014) Smoking and inflammation: evidence for a synergistic role in chronic disease. Periodontol 64:111\u2013126. \n                    https:\/\/doi.org\/10.1111\/j.1600-0757.2012.00456.x","journal-title":"Periodontol"},{"key":"2740_CR46","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1034\/j.1600-051X.2003.300107.x","volume":"30","author":"A Rawlinson","year":"2003","unstructured":"Rawlinson A, Grummitt JM, Walsh TF, Ian Douglas CW (2003) Interleukin 1 and receptor antagonist levels in gingival crevicular fluid in heavy smokers versus non-smokers. J Clin Periodontol 30:42\u201348","journal-title":"J Clin Periodontol"},{"key":"2740_CR47","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1111\/j.1600-051X.2010.01684.x","volume":"38","author":"KD Tymkiw","year":"2011","unstructured":"Tymkiw KD, Thunell DH, Johnson GK, Joly S, Burnell KK, Cavanaugh JE, Brogden KA, Guthmiller JM (2011) Influence of smoking on gingival crevicular fluid cytokines in severe chronic periodontitis. J Clin Periodontol 38:219\u2013228. \n                    https:\/\/doi.org\/10.1111\/j.1600-051X.2010.01684.x","journal-title":"J Clin Periodontol"},{"key":"2740_CR48","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1034\/j.1600-051X.2003.300201.x","volume":"30","author":"C Giannopoulou","year":"2003","unstructured":"Giannopoulou C, Kamma JJ, Mombelli A (2003) Effect of inflammation, smoking and stress on gingival crevicular fluid cytokine level. J Clin Periodontol 30:145\u2013153","journal-title":"J Clin Periodontol"},{"issue":"31","key":"2740_CR49","doi-asserted-by":"publisher","first-page":"e67","DOI":"10.1590\/1807-3107BOR-2017.vol31.0067.","volume":"3","author":"NZ Assem","year":"2017","unstructured":"Assem NZ, Alves MLF, Lopes AB, Gualberto EC Jr, Garcia VG, Theodoro LH (2017) Antibiotic therapy as an adjunct to scaling and root planning in smokers: a systematic review and meta-analysis. Braz Oral Res 3(31):e67. \n                    https:\/\/doi.org\/10.1590\/1807-3107BOR-2017.vol31.0067.","journal-title":"Braz Oral Res"},{"key":"2740_CR50","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1902\/jop.2013.130278","volume":"85","author":"M Faveri","year":"2014","unstructured":"Faveri M, Rebello A, de Oliveira DR Borges I Jr, Duarte PM, Figueiredo LC, Feres M (2014) Clinical and microbiologic effects of adjunctive metronidazole plus amoxicillin in the treatment of generalized chronic periodontitis: smokers versus non-smokers. J Periodontol 85:581\u2013591. \n                    https:\/\/doi.org\/10.1902\/jop.2013.130278","journal-title":"J Periodontol"},{"key":"2740_CR51","doi-asserted-by":"publisher","first-page":"1320","DOI":"10.1902\/jop.2016.160268","volume":"87","author":"L Chambrone","year":"2016","unstructured":"Chambrone L, Vargas M, Arboleda S, Serna M, Guerrero M, de Sousa J, Lafaurie GI (2016) Efficacy of local and systemic antimicrobials in the non-surgical treatment of smokers with chronic periodontitis: a systematic review. J Periodontol 87:1320\u20131332. \n                    https:\/\/doi.org\/10.1902\/jop.2016.160268","journal-title":"J Periodontol"}],"container-title":["Clinical Oral Investigations"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-018-2740-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00784-018-2740-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-018-2740-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,18]],"date-time":"2020-02-18T02:13:03Z","timestamp":1581991983000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00784-018-2740-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,3]]},"references-count":51,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["2740"],"URL":"https:\/\/doi.org\/10.1007\/s00784-018-2740-3","relation":{},"ISSN":["1432-6981","1436-3771"],"issn-type":[{"value":"1432-6981","type":"print"},{"value":"1436-3771","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,3]]},"assertion":[{"value":"2 August 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 October 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 November 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}