{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T22:01:42Z","timestamp":1768687302600,"version":"3.49.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2019,2,15]],"date-time":"2019-02-15T00:00:00Z","timestamp":1550188800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Oral Invest"],"published-print":{"date-parts":[[2019,11]]},"DOI":"10.1007\/s00784-019-02846-8","type":"journal-article","created":{"date-parts":[[2019,2,15]],"date-time":"2019-02-15T02:51:53Z","timestamp":1550199113000},"page":"4099-4105","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Relationship between periodontal inflammation and calcium channel blockers induced gingival overgrowth\u2014a cross-sectional study in a Japanese population"],"prefix":"10.1007","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4281-3216","authenticated-orcid":false,"given":"Shinji","family":"Matsuda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ai","family":"Okanobu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saki","family":"Hatano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikihito","family":"Kajiya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinya","family":"Sasaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuta","family":"Hamamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoyuki","family":"Iwata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhisa","family":"Ouhara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuhiro","family":"Takeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriyoshi","family":"Mizuno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsuyoshi","family":"Fujita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidemi","family":"Kurihara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,2,15]]},"reference":[{"issue":"3","key":"2846_CR1","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1177\/154411130401500305","volume":"15","author":"PC Trackman","year":"2004","unstructured":"Trackman PC, Kantarci A (2004) Connective tissue metabolism and gingival overgrowth. Crit Rev Oral Biol Med 15(3):165\u2013175","journal-title":"Crit Rev Oral Biol Med"},{"issue":"4","key":"2846_CR2","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1177\/0022034515571265","volume":"94","author":"PC Trackman","year":"2015","unstructured":"Trackman PC, Kantarci A (2015) Molecular and clinical aspects of drug-induced gingival overgrowth. J Dent Res 94(4):540\u2013546. \nhttps:\/\/doi.org\/10.1177\/0022034515571265","journal-title":"J Dent Res"},{"issue":"11","key":"2846_CR3","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.1902\/jop.1993.64.11.1098","volume":"64","author":"HE Pernu","year":"1993","unstructured":"Pernu HE, Pernu LM, Knuuttila ML (1993) Effect of periodontal treatment on gingival overgrowth among cyclosporine A-treated renal transplant recipients. J Periodontol 64(11):1098\u20131100. \nhttps:\/\/doi.org\/10.1902\/jop.1993.64.11.1098","journal-title":"J Periodontol"},{"issue":"11","key":"2846_CR4","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.1902\/jop.1997.68.11.1140","volume":"68","author":"A Khocht","year":"1997","unstructured":"Khocht A, Schneider LC (1997) Periodontal management of gingival overgrowth in the heart transplant patient: a case report. J Periodontol 68(11):1140\u20131146. \nhttps:\/\/doi.org\/10.1902\/jop.1997.68.11.1140","journal-title":"J Periodontol"},{"issue":"6","key":"2846_CR5","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1902\/jop.1998.69.6.729","volume":"69","author":"G Bader","year":"1998","unstructured":"Bader G, Lejeune S, Messner M (1998) Reduction of cyclosporine-induced gingival overgrowth following a change to tacrolimus. A case history involving a liver transplant patient. J Periodontol 69(6):729\u2013732. \nhttps:\/\/doi.org\/10.1902\/jop.1998.69.6.729","journal-title":"J Periodontol"},{"key":"2846_CR6","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.jim.2017.03.003","volume":"445","author":"A Okanobu","year":"2017","unstructured":"Okanobu A, Matsuda S, Kajiya M, Fujita T, Kittaka M, Shiba H, Kurihara H (2017) A novel gingival overgrowth mouse model induced by the combination of CsA and ligature-induced inflammation. J Immunol Methods 445:31\u201336. \nhttps:\/\/doi.org\/10.1016\/j.jim.2017.03.003","journal-title":"J Immunol Methods"},{"issue":"4","key":"2846_CR7","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1034\/j.1600-051x.2000.027004217.x","volume":"27","author":"RA Seymour","year":"2000","unstructured":"Seymour RA, Ellis JS, Thomason JM (2000) Risk factors for drug-induced gingival overgrowth. J Clin Periodontol 27(4):217\u2013223","journal-title":"J Clin Periodontol"},{"issue":"9","key":"2846_CR8","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1902\/jop.1997.68.9.900","volume":"68","author":"GL Pilatti","year":"1997","unstructured":"Pilatti GL, Sampaio JE (1997) The influence of chlorhexidine on the severity of cyclosporin A-induced gingival overgrowth. J Periodontol 68(9):900\u2013904. \nhttps:\/\/doi.org\/10.1902\/jop.1997.68.9.900","journal-title":"J Periodontol"},{"issue":"5","key":"2846_CR9","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1902\/jop.2001.72.5.605","volume":"72","author":"J Miranda","year":"2001","unstructured":"Miranda J, Brunet L, Roset P, Berini L, Farre M, Mendieta C (2001) Prevalence and risk of gingival enlargement in patients treated with nifedipine. J Periodontol 72(5):605\u2013611. \nhttps:\/\/doi.org\/10.1902\/jop.2001.72.5.605","journal-title":"J Periodontol"},{"issue":"9","key":"2846_CR10","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1046\/j.1365-2362.2001.00869.x","volume":"31","author":"L Brunet","year":"2001","unstructured":"Brunet L, Miranda J, Roset P, Berini L, Farre M, Mendieta C (2001) Prevalence and risk of gingival enlargement in patients treated with anticonvulsant drugs. Eur J Clin Investig 31(9):781\u2013788","journal-title":"Eur J Clin Investig"},{"issue":"5","key":"2846_CR11","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1111\/j.1365-2125.2005.02485.x","volume":"60","author":"P Meisel","year":"2005","unstructured":"Meisel P, Schwahn C, John U, Kroemer HK, Kocher T (2005) Calcium antagonists and deep gingival pockets in the population-based SHIP study. Br J Clin Pharmacol 60(5):552\u2013559. \nhttps:\/\/doi.org\/10.1111\/j.1365-2125.2005.02485.x","journal-title":"Br J Clin Pharmacol"},{"issue":"7","key":"2846_CR12","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1111\/jcpe.12426","volume":"42","author":"O Fardal","year":"2015","unstructured":"Fardal O, Lygre H (2015) Management of periodontal disease in patients using calcium channel blockers - gingival overgrowth, prescribed medications, treatment responses and added treatment costs. J Clin Periodontol 42(7):640\u2013646. \nhttps:\/\/doi.org\/10.1111\/jcpe.12426","journal-title":"J Clin Periodontol"},{"issue":"4","key":"2846_CR13","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1111\/j.1600-051X.1994.tb00314.x","volume":"21","author":"P Bullon","year":"1994","unstructured":"Bullon P, Machuca G, Martinez-Sahuquillo A, Rios JV, Rojas J, Lacalle JR (1994) Clinical assessment of gingival hyperplasia in patients treated with nifedipine. J Clin Periodontol 21(4):256\u2013259","journal-title":"J Clin Periodontol"},{"issue":"3","key":"2846_CR14","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1016\/S1079-2104(05)80223-9","volume":"79","author":"P Bullon","year":"1995","unstructured":"Bullon P, Machuca G, Martinez Sahuquillo A, Rojas J, Lacalle JR, Rios JV, Velasco E (1995) Clinical assessment of gingival size among patients treated with diltiazem. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 79(3):300\u2013304","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"issue":"6","key":"2846_CR15","first-page":"273","volume":"1","author":"C Neumann","year":"1996","unstructured":"Neumann C, Willershausen-Zonnchen B, Klug C, Darius H (1996) Clinical assessment of periodontal conditions in patients treated with nifedipine. Eur J Med Res 1(6):273\u2013279","journal-title":"Eur J Med Res"},{"issue":"6","key":"2846_CR16","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1902\/jop.1992.63.6.548","volume":"63","author":"HE Pernu","year":"1992","unstructured":"Pernu HE, Pernu LM, Huttunen KR, Nieminen PA, Knuuttila ML (1992) Gingival overgrowth among renal transplant recipients related to immunosuppressive medication and possible local background factors. J Periodontol 63(6):548\u2013553. \nhttps:\/\/doi.org\/10.1902\/jop.1992.63.6.548","journal-title":"J Periodontol"},{"issue":"1","key":"2846_CR17","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1111\/j.1600-051X.1993.tb01757.x","volume":"20","author":"JM Thomason","year":"1993","unstructured":"Thomason JM, Seymour RA, Rice N (1993) The prevalence and severity of cyclosporin and nifedipine-induced gingival overgrowth. J Clin Periodontol 20(1):37\u201340","journal-title":"J Clin Periodontol"},{"issue":"8","key":"2846_CR18","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1111\/j.1600-051X.2008.01249.x","volume":"35","author":"W Nesse","year":"2008","unstructured":"Nesse W, Abbas F, van der Ploeg I, Spijkervet FK, Dijkstra PU, Vissink A (2008) Periodontal inflamed surface area: quantifying inflammatory burden. J Clin Periodontol 35(8):668\u2013673. \nhttps:\/\/doi.org\/10.1111\/j.1600-051X.2008.01249.x","journal-title":"J Clin Periodontol"},{"issue":"12","key":"2846_CR19","doi-asserted-by":"publisher","first-page":"1381","DOI":"10.1177\/0022034516661142","volume":"95","author":"M Kuboniwa","year":"2016","unstructured":"Kuboniwa M, Sakanaka A, Hashino E, Bamba T, Fukusaki E, Amano A (2016) Prediction of periodontal inflammation via metabolic profiling of saliva. J Dent Res 95(12):1381\u20131386. \nhttps:\/\/doi.org\/10.1177\/0022034516661142","journal-title":"J Dent Res"},{"issue":"1","key":"2846_CR20","doi-asserted-by":"publisher","first-page":"e51","DOI":"10.1111\/odi.12264","volume":"21","author":"RS Brown","year":"2015","unstructured":"Brown RS, Arany PR (2015) Mechanism of drug-induced gingival overgrowth revisited: a unifying hypothesis. Oral Dis 21(1):e51\u2013e61. \nhttps:\/\/doi.org\/10.1111\/odi.12264","journal-title":"Oral Dis"},{"issue":"6","key":"2846_CR21","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1016\/0030-4220(72)90228-9","volume":"34","author":"AP Angelopoulos","year":"1972","unstructured":"Angelopoulos AP, Goaz PW (1972) Incidence of diphenylhydantoin gingival hyperplasia. Oral Surg Oral Med Oral Pathol 34(6):898\u2013906","journal-title":"Oral Surg Oral Med Oral Pathol"},{"issue":"5","key":"2846_CR22","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1902\/jop.1992.63.5.453","volume":"63","author":"CS Miller","year":"1992","unstructured":"Miller CS, Damm DD (1992) Incidence of verapamil-induced gingival hyperplasia in a dental population. J Periodontol 63(5):453\u2013456. \nhttps:\/\/doi.org\/10.1902\/jop.1992.63.5.453","journal-title":"J Periodontol"},{"issue":"1","key":"2846_CR23","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1902\/jop.1999.70.1.63","volume":"70","author":"JS Ellis","year":"1999","unstructured":"Ellis JS, Seymour RA, Steele JG, Robertson P, Butler TJ, Thomason JM (1999) Prevalence of gingival overgrowth induced by calcium channel blockers: a community-based study. J Periodontol 70(1):63\u201367. \nhttps:\/\/doi.org\/10.1902\/jop.1999.70.1.63","journal-title":"J Periodontol"},{"issue":"4","key":"2846_CR24","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1111\/j.1600-051X.1984.tb02214.x","volume":"11","author":"T Hassell","year":"1984","unstructured":"Hassell T, O'Donnell J, Pearlman J, Tesini D, Murphy T, Best H (1984) Phenytoin induced gingival overgrowth in institutionalized epileptics. J Clin Periodontol 11(4):242\u2013253","journal-title":"J Clin Periodontol"},{"issue":"10","key":"2846_CR25","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1177\/0022034512457373","volume":"91","author":"PI Eke","year":"2012","unstructured":"Eke PI, Dye BA, Wei L, Thornton-Evans GO, Genco RJ, Cdc Periodontal Disease Surveillance workgroup: James Beck GDRP (2012) Prevalence of periodontitis in adults in the United States: 2009 and 2010. J Dent Res 91(10):914\u2013920. \nhttps:\/\/doi.org\/10.1177\/0022034512457373","journal-title":"J Dent Res"},{"issue":"10","key":"2846_CR26","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.1902\/jop.2016.160013","volume":"87","author":"PI Eke","year":"2016","unstructured":"Eke PI, Wei L, Thornton-Evans GO, Borrell LN, Borgnakke WS, Dye B, Genco RJ (2016) Risk indicators for periodontitis in US adults: NHANES 2009 to 2012. J Periodontol 87(10):1174\u20131185. \nhttps:\/\/doi.org\/10.1902\/jop.2016.160013","journal-title":"J Periodontol"}],"container-title":["Clinical Oral Investigations"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00784-019-02846-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-019-02846-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-019-02846-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,3,3]],"date-time":"2020-03-03T08:36:52Z","timestamp":1583224612000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00784-019-02846-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,15]]},"references-count":26,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["2846"],"URL":"https:\/\/doi.org\/10.1007\/s00784-019-02846-8","relation":{},"ISSN":["1432-6981","1436-3771"],"issn-type":[{"value":"1432-6981","type":"print"},{"value":"1436-3771","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,15]]},"assertion":[{"value":"24 August 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 February 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 February 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the Ethical Committee for Epidemiological Research at Hiroshima University and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included in the study between November 1, 2015, and January 31, 2016.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}