{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:28:30Z","timestamp":1790195310157,"version":"4.1.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,5,17]],"date-time":"2019-05-17T00:00:00Z","timestamp":1558051200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,5,17]],"date-time":"2019-05-17T00:00:00Z","timestamp":1558051200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["2305\/2011"],"award-info":[{"award-number":["2305\/2011"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Oral Invest"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1007\/s00784-019-02927-8","type":"journal-article","created":{"date-parts":[[2019,5,17]],"date-time":"2019-05-17T08:09:20Z","timestamp":1558080560000},"page":"333-341","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Effects of a full-mouth disinfection protocol on the treatment of type-2 diabetic and non-diabetic subjects with mild-to-moderate periodontitis: one-year clinical outcomes"],"prefix":"10.1007","volume":"24","author":[{"given":"Mariana Linhares","family":"Almeida","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poliana Mendes","family":"Duarte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo Aleixo","family":"Figueira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana\u00edna Cavalcante","family":"Lemos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cintia Mirela Guimar\u00e3es","family":"Nobre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamires Szeremeske","family":"Miranda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5971-134X","authenticated-orcid":false,"given":"Bruno C\u00e9sar","family":"de Vasconcelos Gurgel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,5,17]]},"reference":[{"issue":"suppl 14","key":"2927_CR1","first-page":"113","volume":"40","author":"PM Preshaw","year":"2013","unstructured":"Preshaw PM, Lalla E (2013) A review of the evidence for pathogenic mechanisms that may link periodontitis and diabetes. J Clin Periodontol 40(suppl 14):113\u2013134","journal-title":"J Clin Periodontol"},{"issue":"2","key":"2927_CR2","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1111\/jcpe.12808","volume":"45","author":"M Sanz","year":"2018","unstructured":"Sanz M, Ceriello A, Buysschaert M, Chapple I, Demmer RT, Graziani F, Herrera D, Jepsen S, Lione L, Madianos P, Mathur M, Montanya E, Shapira L, Tonetti M, Vegh D (2018) Scientific evidence on the links between periodontal diseases and diabetes: consensus report and guidelines of the joint workshop on periodontal diseases and diabetes by the international diabetes federation and the European Federation of Periodontology. J Clin Periodontol 45(2):138\u2013149","journal-title":"J Clin Periodontol"},{"issue":"2","key":"2927_CR3","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1111\/jcpe.12837","volume":"45","author":"F Graziani","year":"2018","unstructured":"Graziani F, Gennai S, Solini A, Petrini M (2018) A systematic review and meta-analysis of epidemiologic observational evidence on the effect of periodontitis on diabetes an update of the EFP-AAP review. J Clin Periodontol 45(2):167\u2013187","journal-title":"J Clin Periodontol"},{"issue":"Suppl 1","key":"2927_CR4","first-page":"S1","volume":"89","author":"JG Caton","year":"2018","unstructured":"Caton JG, Armitage G, Berglundh T, Chapple ILC, Jepsen S, Kornman KS, Mealey BL, Papapanou PN, Sanz M, Tonetti MS (2018) A new classification scheme for periodontal and peri-implant diseases and conditions - introduction and key changes from the 1999 classification. J Periodontol 89(Suppl 1):S1\u2013S8","journal-title":"J Periodontol"},{"issue":"Suppl 8","key":"2927_CR5","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1111\/j.1600-051X.2008.01257.x","volume":"35","author":"NP Lang","year":"2008","unstructured":"Lang NP, Tan WC, Kr\u00e4henmann MA, Zwahlen M (2008) A systematic review of the effects of full-mouth debridement with and without antiseptics in patients with chronic periodontitis. J Clin Periodontol 35(Suppl 8):8\u201321","journal-title":"J Clin Periodontol"},{"issue":"2","key":"2927_CR6","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1159\/000345107","volume":"59","author":"S Knapp","year":"2013","unstructured":"Knapp S (2013) Diabetes and infection: is there a link?-a mini-review. Gerontology 59(2):99\u2013104","journal-title":"Gerontology"},{"issue":"3","key":"2927_CR7","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1111\/jcpe.12514","volume":"43","author":"AP Grellmann","year":"2016","unstructured":"Grellmann AP, Sfreddo CS, Maier J, Lenzi TL, Zanatta FB (2016) Systemic antimicrobials adjuvant to periodontal therapy in diabetic subjects: a meta-analysis. J Clin Periodontol 43(3):250\u2013260","journal-title":"J Clin Periodontol"},{"issue":"12","key":"2927_CR8","doi-asserted-by":"publisher","first-page":"1406","DOI":"10.1902\/jop.2016.160214","volume":"87","author":"ES Rovai","year":"2016","unstructured":"Rovai ES, Souto ML, Ganhito JA, Holzhausen M, Chambrone L, Pannuti CM (2016) Efficacy of local antimicrobials in the non-surgical treatment of patients with periodontitis and diabetes: a systematic review. J Periodontol 87(12):1406\u20131417","journal-title":"J Periodontol"},{"key":"2927_CR9","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.pdpdt.2016.11.008","volume":"17","author":"T Abduljabbar","year":"2017","unstructured":"Abduljabbar T, Vohra F, Javed F, Akram Z (2017) Antimicrobial photodynamic therapy adjuvant to non-surgical periodontal therapy in patients with diabetes mellitus: a meta-analysis. Photodiagn Photodyn Ther 17:138\u2013146","journal-title":"Photodiagn Photodyn Ther"},{"issue":"1","key":"2927_CR10","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1111\/j.1600-0765.2011.01403.x","volume":"47","author":"VR Santos","year":"2012","unstructured":"Santos VR, Ribeiro FV, Lima JA, Miranda TS, Feres M, Bastos MF, Duarte PM (2012) Partial- and full-mouth scaling and root planing in type 2 diabetic subjects: a 12-mo follow-up of clinical parameters and levels of cytokines and osteoclastogenesis-related factors. J Periodontal Res 47(1):45\u201354","journal-title":"J Periodontal Res"},{"issue":"2","key":"2927_CR11","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1111\/jcpe.12040","volume":"40","author":"VR Santos","year":"2013","unstructured":"Santos VR, Lima JA, Miranda TS, Gon\u00e7alves TED, Figueiredo LC, Faveri M, Duarte PM (2013) Full-mouth disinfection as a therapeutic protocol for type-2 diabetic subjects with chronic periodontitis: twelve-month clinical outcomes: a randomized controlled clinical trial. J Clin Periodontol 40(2):155\u2013162","journal-title":"J Clin Periodontol"},{"key":"2927_CR12","first-page":"61","volume":"8","author":"R Schara","year":"2006","unstructured":"Schara R, Medvescek M, Skaleric U (2006) Periodontal disease and diabetes metabolic control: a full-mouth disinfection approach. J Int Acad Periodontol 8:61\u201366","journal-title":"J Int Acad Periodontol"},{"issue":"2","key":"2927_CR13","first-page":"103","volume":"47","author":"S Srirangarajan","year":"2016","unstructured":"Srirangarajan S, Setty R, Satyanarayan A, Shetty S (2016) Effect of full-mouth disinfection on insulin sensitivity in type 2 diabetes patients with and without chronic periodontitis. Quintessence Int 47(2):103\u2013112","journal-title":"Quintessence Int"},{"issue":"4","key":"2927_CR14","doi-asserted-by":"publisher","first-page":"523","DOI":"10.2334\/josnusd.16-0163","volume":"58","author":"Z Ta\u015fdemir","year":"2016","unstructured":"Ta\u015fdemir Z, \u00d6zsar\u0131 Ta\u015fdemir F, Ko\u00e7yi\u011fit \u0130, Yaz\u0131c\u0131 C, G\u00fcrgan CA (2016) The clinical and systemic effects of periodontal treatment in diabetic and non-diabetic obese patients. J Oral Sci 58(4):523\u2013531","journal-title":"J Oral Sci"},{"key":"2927_CR15","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.1177\/00220345950740080501","volume":"74","author":"M Quirynen","year":"1995","unstructured":"Quirynen M, Bollen CM, Vandekerckhove BN, Dekeyser C, Papaioannou W, Eyssen H (1995) Full- vs. partial-mouth disinfection in the treatment of periodontal infections: short-term clinical and microbiological observations. J Dent Res 74:1459\u20131467","journal-title":"J Dent Res"},{"issue":"4","key":"2927_CR16","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1111\/jre.12326","volume":"51","author":"H Fang","year":"2015","unstructured":"Fang H, Han M, Li QL, Cao CY, Xia R, Zhang ZH (2015) Comparison of full-mouth disinfection and quadrant-wise scaling in the treatment of adult chronic periodontitis: a systematic review and meta-analysis. J Periodontal Res 51(4):417\u2013430","journal-title":"J Periodontal Res"},{"key":"2927_CR17","doi-asserted-by":"crossref","unstructured":"Eberhard J, Jepsen S, Jerv\u00f8e-Storm PM, Needleman I, Worthington HV (2015) Full-mouth treatment modalities (within 24 hours) for chronic periodontitis in adults. Cochrane Database Syst Rev (17, 4):CD004622","DOI":"10.1002\/14651858.CD004622.pub3"},{"issue":"8","key":"2927_CR18","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0182992","volume":"12","author":"D Belstr\u00f8m","year":"2017","unstructured":"Belstr\u00f8m D, Sembler-M\u00f8ller ML, Grande MA, Kirkby N, Cotton SL, Paster BJ, Holmstrup P (2017) Microbial profile comparisons of saliva, pooled and site-specific subgingival samples in periodontitis patients. PLoS One 12(8):e0182992. \nhttps:\/\/doi.org\/10.1371\/journal.pone.0182992","journal-title":"PLoS One"},{"key":"2927_CR19","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1111\/jcpe.12004","volume":"39","author":"M Feres","year":"2012","unstructured":"Feres M, Soares GMS, Mendes JAV, Silva MP, Faveri M, Teles R, Socransky SS, Figueiredo LC (2012) Metronidazole alone or with amoxicillin as adjuncts to non-surgical treatment of chronic periodontitis: a 1-year double-blinded, placebo-controlled, randomized clinical trial. J Clin Periodontol 39:1149\u20131158","journal-title":"J Clin Periodontol"},{"key":"2927_CR20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1902\/annals.1999.4.1.1","volume":"4","author":"GC Armitage","year":"1999","unstructured":"Armitage GC (1999) Development of a classification system for periodontal diseases and conditions. Ann Periodontol 4:1\u20136","journal-title":"Ann Periodontol"},{"key":"2927_CR21","doi-asserted-by":"publisher","first-page":"1449","DOI":"10.1902\/jop.2012.110664","volume":"83","author":"PI Eke","year":"2012","unstructured":"Eke PI, Page RC, Wei L, Thornton-Evans G, Genco RJ (2012) Update of the case definitions for population-based surveillance of periodontitis. J Periodontol 83:1449\u20131454","journal-title":"J Periodontol"},{"issue":"Suppl 1","key":"2927_CR22","doi-asserted-by":"publisher","first-page":"S61","DOI":"10.2337\/dc19-S006","volume":"42","author":"American Diabetes Association","year":"2019","unstructured":"American Diabetes Association (2019) 6. Glycemic targets: standards of medical Care in Diabetes-2019. Diabetes Care 42(Suppl 1):S61\u2013S70","journal-title":"Diabetes Care"},{"key":"2927_CR23","first-page":"229","volume":"25","author":"J Ainamo","year":"1975","unstructured":"Ainamo J, Bay I (1975) Problems and proposals for recording gingivitis and plaque. Int Dent J 25:229\u2013235","journal-title":"Int Dent J"},{"key":"2927_CR24","doi-asserted-by":"publisher","first-page":"1736","DOI":"10.1902\/jop.2003.74.12.1736","volume":"74","author":"MW Araujo","year":"2003","unstructured":"Araujo MW, Hovey KM, Benedek JR et al (2003) Reproducibility of probing depth measurement using a constant-force electronic probe: analysis of inter- and intraexaminer variability. J Periodontol 74:1736\u20131740","journal-title":"J Periodontol"},{"issue":"3","key":"2927_CR25","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1111\/j.1365-263X.2006.00813.x","volume":"17","author":"VT Sakai","year":"2007","unstructured":"Sakai VT, Campos MR, Machado MA, Lauris JR, Greene AS, Santos CF (2007) Prevalence of four putative periodontopathic bacteria in saliva of a group of Brazilian children with mixed dentition: 1-year longitudinal study. Int J Paediatr Dent 17(3):192\u2013199","journal-title":"Int J Paediatr Dent"},{"issue":"2","key":"2927_CR26","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1002\/cyto.a.10013","volume":"51","author":"J Dolezel","year":"2003","unstructured":"Dolezel J, Bartos J, Voglmayr H, Greilhuber J (2003) Nuclear DNA content and genome size of trout and human. Cytometry A 51(2):127\u2013128","journal-title":"Cytometry A"},{"key":"2927_CR27","doi-asserted-by":"publisher","first-page":"1326","DOI":"10.1111\/jcpe.12994","volume":"45","author":"PM Duarte","year":"2018","unstructured":"Duarte PM, Feres M, Yassine LLS, Soares GMS, Miranda TS, Faveri M, Retamal-Valdes B, Figueiredo LC (2018) Clinical and microbiological effects of scaling and root planing, metronidazole and amoxicillin in the treatment of diabetic and non-diabetic subjects with periodontitis: a cohort study. J Clin Periodontol 45:1326\u20131335. \nhttps:\/\/doi.org\/10.1111\/jcpe.12994","journal-title":"J Clin Periodontol"},{"issue":"6","key":"2927_CR28","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1016\/j.jdent.2015.03.007","volume":"43","author":"LM Spineli","year":"2015","unstructured":"Spineli LM, Fleming PS, Pandis N (2015) Addressing missing participant outcome data in dental clinical trials. J Dent 43(6):605\u2013618","journal-title":"J Dent"},{"issue":"7","key":"2927_CR29","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.1902\/jop.2008.070503","volume":"79","author":"GA da Cruz","year":"2008","unstructured":"da Cruz GA, de Toledo S, Sallum EA et al (2008) Clinical and laboratory evaluations of non-surgical periodontal treatment in subjects with diabetes mellitus. J Periodontol 79(7):1150\u20131157","journal-title":"J Periodontol"},{"issue":"9","key":"2927_CR30","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1111\/j.1600-051X.2008.01289.x","volume":"35","author":"D Gon\u00e7alves","year":"2008","unstructured":"Gon\u00e7alves D, Correa FO, Khalil NM, de Faria Oliveira OM, Orrico SR (2008) The effect of non-surgical periodontal therapy on peroxidase activity in diabetic patients: a case-control pilot study. J Clin Periodontol 35(9):799\u2013806","journal-title":"J Clin Periodontol"},{"issue":"11","key":"2927_CR31","doi-asserted-by":"publisher","first-page":"2143","DOI":"10.1902\/jop.2008.080132","volume":"79","author":"FO Correa","year":"2008","unstructured":"Correa FO, Gon\u00e7alves D, Figueredo CM, Gustafsson A, Orrico SR (2008) The short-term effectiveness of non-surgical treatment in reducing levels of interleukin-1beta and proteases in gingival crevicular fluid from patients with type 2 diabetes mellitus and chronic periodontitis. J Periodontol 79(11):2143\u20132150","journal-title":"J Periodontol"},{"key":"2927_CR32","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1034\/j.1600-051x.2000.027008578.x","volume":"27","author":"M Quirynen","year":"2000","unstructured":"Quirynen M, Mongardini C, de Soete M, Pauwels M, Coucke W, van Eldere J, van Steenberghe D (2000) The r\u00f4le of chlorhexidine in the one-stage full-mouth disinfection treatment of patients with advanced adult periodontitis. Long-term clinical and microbiological observations. J Clin Periodontol 27:578\u2013589","journal-title":"J Clin Periodontol"},{"key":"2927_CR33","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1111\/j.1600-051X.2008.01368.x","volume":"36","author":"K Swierkot","year":"2009","unstructured":"Swierkot K, Nonnenmacher CI, Mutters R, Flores-de-Jacoby L, Mengel R (2009) One-stage full-mouth disinfection versus quadrant and full-mouth root planing. J Clin Periodontol 36:240\u2013249","journal-title":"J Clin Periodontol"},{"issue":"12","key":"2927_CR34","doi-asserted-by":"publisher","first-page":"1340","DOI":"10.1902\/jop.2015.150227","volume":"86","author":"DC Fonseca","year":"2015","unstructured":"Fonseca DC, Cortelli JR, Cortelli SC, Miranda Cota LO, Machado Costa LC, Moreira Castro MV, Oliveira Azevedo AM, Costa FO (2015) Clinical and microbiologic evaluation of scaling and root Planing per quadrant and one-stage full-mouth disinfection associated with azithromycin or chlorhexidine: a clinical randomized controlled trial. J Periodontol 86(12):1340\u20131351","journal-title":"J Periodontol"},{"key":"2927_CR35","doi-asserted-by":"publisher","first-page":"385641","DOI":"10.1155\/2013\/385641","volume":"2013","author":"E Tsourdi","year":"2013","unstructured":"Tsourdi E, Barthel A, Rietzsch H, Reichel A, Bornstein SR (2013) Current aspects in the pathophysiology and treatment of chronic wounds in diabetes mellitus. Biomed Res Int 2013:385641. \nhttps:\/\/doi.org\/10.1155\/2013\/385641","journal-title":"Biomed Res Int"},{"issue":"1","key":"2927_CR36","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1111\/j.1600-051X.1998.tb02364.x","volume":"25","author":"CM Bollen","year":"1998","unstructured":"Bollen CM, Mongardini C, Papaioannou W, Van Steenberghe D, Quirynen M (1998) The effect of a one-stage full-mouth disinfection on different intra-oral niches. Clinical and microbiological observations. J Clin Periodontol 25(1):56\u201366","journal-title":"J Clin Periodontol"},{"issue":"6","key":"2927_CR37","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1902\/jop.1999.70.6.646","volume":"70","author":"M Quirynen","year":"1999","unstructured":"Quirynen M, Mongardini C, Pauwels M, Bollen CM, Van Eldere J, van Steenberghe D (1999) One stage full- versus partial-mouth disinfection in the treatment of chronic adult or generalized early-onset periodontitis. II Long-term impact on microbial load. J Periodontol 70(6):646\u2013656","journal-title":"J Periodontol"},{"key":"2927_CR38","doi-asserted-by":"publisher","first-page":"2643079","DOI":"10.1155\/2017\/2643079","volume":"2017","author":"N Al-Rawi","year":"2017","unstructured":"Al-Rawi N, Al-Marzooq F (2017) The relation between Periodontopathogenic bacterial levels and Resistin in the saliva of obese type 2 diabetic patients. J Diabetes Res 2017:2643079. \nhttps:\/\/doi.org\/10.1155\/2017\/2643079","journal-title":"J Diabetes Res"},{"issue":"4","key":"2927_CR39","doi-asserted-by":"publisher","first-page":"549","DOI":"10.2334\/josnusd.16-0722","volume":"59","author":"T Ogawa","year":"2017","unstructured":"Ogawa T, Honda-Ogawa M, Ikebe K, Notomi Y, Iwamoto Y, Shirobayashi I, Hata S, Kibi M, Masayasu S, Sasaki S, Kawabata S, Maeda Y (2017) Characterizations of oral microbiota in elderly nursing home residents with diabetes. J Oral Sci 59(4):549\u2013555","journal-title":"J Oral Sci"},{"issue":"3","key":"2927_CR40","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0170437","volume":"12","author":"JM Goodson","year":"2017","unstructured":"Goodson JM, Hartman ML, Shi P, Hasturk H, Yaskell T, Vargas J, Song X, Cugini M, Barake R, Alsmadi O, al-Mutawa S, Ariga J, Soparkar P, Behbehani J, Behbehani K (2017) The salivary microbiome is altered in the presence of a high salivary glucose concentration. PLoS One 12(3):e0170437. \nhttps:\/\/doi.org\/10.1371\/journal.pone.0170437","journal-title":"PLoS One"}],"container-title":["Clinical Oral Investigations"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-019-02927-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00784-019-02927-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-019-02927-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,15]],"date-time":"2020-05-15T23:42:35Z","timestamp":1589586155000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00784-019-02927-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,17]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["2927"],"URL":"https:\/\/doi.org\/10.1007\/s00784-019-02927-8","relation":{},"ISSN":["1432-6981","1436-3771"],"issn-type":[{"value":"1432-6981","type":"print"},{"value":"1436-3771","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,17]]},"assertion":[{"value":"16 August 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 April 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 May 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the Ethics Committee in Clinical Research of the Federal University of Rio Grande do Norte (CAAE: 0151.0.051.000-11) and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"For this type of study, informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}