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All included studies were assessed for methodological quality and risk of bias.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>One hundred eighteen articles reporting on 160 PID patients were included for qualitative analysis. The majority (70%) were individual case reports. Clinical and radiographic manifestations of the periodontal disease included poor oral hygiene, generalised alveolar bone loss, severe gingival inflammation, increased pocket depths, tooth mobility and gingival recession. For most studies, the primary intervention was periodontal treatment in the form of scaling and root planing or dental extractions. Stabilisation of the periodontal condition varied between different PIDs. In severe congenital neutropenia (SCN), 61% of cases reported stabilisation of the periodontal condition, while for all other PIDs, \u2018stability\u2019 was reported in less than 43% of cases.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion<\/jats:title>\n<jats:p>The published literature suggests that patients with PIDs can present with severe periodontitis and that conventional treatment approaches have limited benefits.<\/jats:p>\n<\/jats:sec>","DOI":"10.1007\/s00784-019-03055-z","type":"journal-article","created":{"date-parts":[[2019,10,18]],"date-time":"2019-10-18T12:20:56Z","timestamp":1571401256000},"page":"1939-1951","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Periodontal status of children with primary immunodeficiencies: a systematic review"],"prefix":"10.1007","volume":"24","author":[{"given":"H.","family":"Halai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Somani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Donos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7750-5010","authenticated-orcid":false,"given":"Luigi","family":"Nibali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,10,18]]},"reference":[{"issue":"1","key":"3055_CR1","first-page":"16","volume":"20","author":"A Aghamohammadi","year":"2010","unstructured":"Aghamohammadi A, Moin M, Rezaei N (2010) History of primary immunodeficiency diseases in Iran. 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