{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T16:05:54Z","timestamp":1760889954076,"version":"3.37.3"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2019,11,15]],"date-time":"2019-11-15T00:00:00Z","timestamp":1573776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2019,11,15]],"date-time":"2019-11-15T00:00:00Z","timestamp":1573776000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Johannes Kepler University Linz"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Oral Invest"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n<jats:title>Objective<\/jats:title>\n<jats:p>To evaluate the clinical, functional and aesthetic outcomes for radial forearm free flap (RFFF) donor sites covered with amniotic membrane (AM).<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Material and methods<\/jats:title>\n<jats:p>The healing process of patients with RFFF donor sites covered with AM was prospectively followed for 1\u00a0year. Additionally at the 12-month evaluation, objective scoring systems were used to assess the aesthetic (Vancouver scar scale, VSS: range 1\u201313) and functional outcome (skin sensibility, hand\/wrist functionality [goniometer], grip strength [score 1\u2009=\u2009excellent, 5\u2009=\u2009poor]). By using a subjective rating system (score 1\u2009=\u2009excellent, 5\u2009=\u2009poor), the patient-reported aesthetic and functionality outcome was correlated with objective data analysis.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Twenty-one out of 23 patients were followed for 12\u00a0months (dropout: 2 patients at 3\u00a0months). In 17\/23 (73.9%) patients RFFF defect covered with AM showed an uneventful healing period (&lt;\u20093\u00a0months). Prolonged healing periods (&gt;\u20093\u00a0months &lt;\u20096) for 6 patients (26.1%) were attributed to wound infections (4\u00d7), seroma (1\u00d7) and inflammation (1\u00d7). At the 1-year evaluation, there was a significant (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) correlation between subjective (2.0\u2009\u00b1\u20090.71) and objective aesthetic scores (VVS 3.74\u2009\u00b1\u20092.18), and a successful grip strength (score 1.67\u2009\u00b1\u20090.86); however, thumb hyposensibility in 76.2% was seen. A high body mass index (BMI) was in conjunction with a negative (<jats:italic>p<\/jats:italic>\u2009=\u20090.012) and the use of antihypertensive medications provided positive effects (<jats:italic>p<\/jats:italic>\u2009=\u20090.041) on the aesthetic outcome.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusion<\/jats:title>\n<jats:p>RFFF donor site defects covered using AM show excellent clinical, aesthetic and functional outcome representing patient comorbidities (BMI, antihypertensive drugs) might affect the aesthetic outcome.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Clinical relevance<\/jats:title>\n<jats:p>In relation to the excellent outcomes found, the use of AM offers an alternative treatment procedure for RFFF defect covering.<\/jats:p>\n<\/jats:sec>","DOI":"10.1007\/s00784-019-03104-7","type":"journal-article","created":{"date-parts":[[2019,11,15]],"date-time":"2019-11-15T06:02:32Z","timestamp":1573797752000},"page":"2433-2443","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Use of amniotic membrane for radial forearm free flap donor site coverage: clinical, functional and cosmetic outcomes"],"prefix":"10.1007","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1998-5618","authenticated-orcid":false,"given":"Stefan","family":"Hunger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lukas","family":"Postl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raphael","family":"Stehrer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lukas","family":"Hingsammer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Krennmair","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Feistl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Malek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerald","family":"Krennmair","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,11,15]]},"reference":[{"key":"3104_CR1","unstructured":"Yang G, Chen B, Gao Y (1981) Forearm free skin flap tranplantation. 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