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A tongue-enamel friction system mimicking xerostomic conditions was used to assess the relief and relief period expected from these substitutes under set circumstances.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Saliva Orthana spray, Biot\u00e8ne spray and Gum Hydral gel had an immediate effect on a SCF, increasing its structural softness. BioXtra gel, Biot\u00e8ne gel, Gum Hydral gel and Glandosane spray changed the S-SCF by increasing salivary protein adsorption, while others showed no sign of interaction. With respect to relief, only 2 out of the 16 saliva substitutes tested (Saliva Orthana spray and Gum Hydral gel) performed better than water. Overall, relief period correlated positively to structural softness change, whereas a positive correlation was seen between relief and mass adsorption.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>The majority of saliva substitutes did not adsorb on the SCF, thus did not enhance lubrication. Only saliva substitutes containing carrageenan, carboxymethylcellulose, pig gastric mucin, xanthan gum and carbomer performed better in enhancing oral lubrication.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Clinical relevance<\/jats:title>\n<jats:p>This objective assessment will help clinicians and patients make better choice of saliva substitutes. This study provides a scientific basis for future improvement in saliva substitutes.<\/jats:p>\n<\/jats:sec>","DOI":"10.1007\/s00784-020-03272-x","type":"journal-article","created":{"date-parts":[[2020,4,17]],"date-time":"2020-04-17T08:03:43Z","timestamp":1587110623000},"page":"4019-4030","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Dry mouth: saliva substitutes which adsorb and modify existing salivary condition films improve oral lubrication"],"prefix":"10.1007","volume":"24","author":[{"given":"Jeroen","family":"Vinke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans J.","family":"Kaper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjan","family":"Vissink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prashant K.","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,4,17]]},"reference":[{"key":"3272_CR1","unstructured":"United Nations, Department of Economic and Social Affairs, Population Division (2015) World population ageing. 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