{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:59:06Z","timestamp":1790812746607,"version":"4.1.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T00:00:00Z","timestamp":1588896000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T00:00:00Z","timestamp":1588896000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Oral Invest"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1007\/s00784-020-03310-8","type":"journal-article","created":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T10:02:58Z","timestamp":1588932178000},"page":"4455-4461","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Correlation of molecular biomarker concentrations between synovial fluid and saliva of the patients with temporomandibular disorders"],"prefix":"10.1007","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1492-6897","authenticated-orcid":false,"given":"Deniz","family":"Yaman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cansu","family":"Alpaslan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcl\u00e7in","family":"Akca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emre","family":"Avc\u0131","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,5,8]]},"reference":[{"key":"3310_CR1","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1016\/S0022-3913(97)70145-8","volume":"77","author":"C McNeill","year":"1997","unstructured":"McNeill C (1997) Management of temporomandibular disorders: concepts and controversies. J Prosthet Dent 77:510\u2013522","journal-title":"J Prosthet Dent"},{"key":"3310_CR2","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1054\/bjom.2001.0634","volume":"39","author":"T Mizui","year":"2001","unstructured":"Mizui T, Ishimaru JI, Miyamoto K, Kurita K (2001) Matrix metalloproteinase-2 in synovial lavage fluid of patients with disorders of the temporomandibular joint. Br J Oral Maxillofac Surg 39:310\u2013314","journal-title":"Br J Oral Maxillofac Surg"},{"key":"3310_CR3","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1038\/260808a0","volume":"260","author":"A Maroudas","year":"1976","unstructured":"Maroudas A (1976) Balance between swelling pressure and collagen tension in normal and degenerate cartilage. Nature 260:808\u2013809","journal-title":"Nature"},{"key":"3310_CR4","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0307-742X(21)00330-1","volume":"7","author":"FN Ghadially","year":"1981","unstructured":"Ghadially FN (1981) Structure and function of articular-cartilage. Clin Rheum Dis 7:3\u201328","journal-title":"Clin Rheum Dis"},{"key":"3310_CR5","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/S0278-2391(97)90438-9","volume":"55","author":"E Kubota","year":"1997","unstructured":"Kubota E, Imamura H, Kubota T, Shibata T, Murakami KI (1997) Interleukin 1\u03b2 and stromelysin (MMP3) activity of synovial fluid as possible markers of osteoarthritis in the temporomandibular joint. J Oral Maxillofac Surg 55:20\u201327","journal-title":"J Oral Maxillofac Surg"},{"key":"3310_CR6","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/S0901-5027(98)80072-6","volume":"27","author":"G Zardeneta","year":"1998","unstructured":"Zardeneta G, Milan SB, Lee T, Schmits JP (1998) Detection and preliminary characterization of matrix metalloproteinase activity in temporomandibular joint lavage fluid. J Oral Maxillofac Surg 27:397\u2013403","journal-title":"J Oral Maxillofac Surg"},{"key":"3310_CR7","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/0168-9525(90)90126-Q","volume":"6","author":"LM Matrisian","year":"1990","unstructured":"Matrisian LM (1990) Metalloproteinases and their inhibitors in matrix remodeling. Trends Genet 6:121\u2013125","journal-title":"Trends Genet"},{"key":"3310_CR8","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1002\/art.1780340902","volume":"34","author":"CE Brinckerhoff","year":"1991","unstructured":"Brinckerhoff CE (1991) Joint destruction in arthritis: Metalloproteinases the spotlight. Arthritis Rheumatol 34:1073\u20131075","journal-title":"Arthritis Rheumatol"},{"key":"3310_CR9","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1097\/BOR.0b013e32835a9381","volume":"25","author":"M Attur","year":"2013","unstructured":"Attur M, Krasnokutsky-Samuels S, Samuels J, Abramson SB (2013) Prognostic biomarkers in osteoarthritis. Curr Opin Rheumatol 25:136\u2013144","journal-title":"Curr Opin Rheumatol"},{"key":"3310_CR10","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.joms.2013.08.022","volume":"72","author":"LM Vos","year":"2014","unstructured":"Vos LM, Kuijer R, Huddleston Slater JJ, Bulstra SK, Stegenga B (2014) Inflammation is more distinct in temporomandibular joint osteoarthritis compared to the knee joint. J Oral Maxillofac Surg 72:35\u201340","journal-title":"J Oral Maxillofac Surg"},{"key":"3310_CR11","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1067\/moe.2002.124106","volume":"94","author":"M Nishimura","year":"2002","unstructured":"Nishimura M, Segami N, Kaneyama K, Suzuki T, Miyamaru M (2002) Relationships between pain-related mediators and both synovitis and joint pain in patients with internal derangements and osteoarthritis of the temporomandibular joint. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 94:328\u2013332","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"3310_CR12","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1111\/joor.12480","volume":"44","author":"M Ernberg","year":"2017","unstructured":"Ernberg M (2017) The role of molecular pain biomarkers in temporomandibular joint internal derangement. J Oral Rehabil 44:481\u2013491","journal-title":"J Oral Rehabil"},{"key":"3310_CR13","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1111\/j.1601-0825.2004.01038.x","volume":"10","author":"T Sorsa","year":"2004","unstructured":"Sorsa T, Tjaderhane L, Salo T (2004) Matrix metalloproteinases (MMPs) in oral diseases. Oral Dis 10:311\u2013318","journal-title":"Oral Dis"},{"key":"3310_CR14","doi-asserted-by":"publisher","first-page":"2151","DOI":"10.1002\/art.20313","volume":"50","author":"N Buisson-Legendre","year":"2004","unstructured":"Buisson-Legendre N, Smith S, March L, Jackson C (2004) Elevation of activated protein C in synovial joints in rheumatoid arthritis and its correlation with matrix metalloproteinase 2. Arthritis Rheumatol 50:2151\u20132156","journal-title":"Arthritis Rheumatol"},{"key":"3310_CR15","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1002\/art.33450","volume":"64","author":"M Puliti","year":"2012","unstructured":"Puliti M, Momi S, Falcinelli E, Gresele P, Fetal B (2012) Contribution of matrix metalloproteinase 2 to joint destruction in group B streptococcus-induced murine arthritis. Arthritis Rheumatol 64:1089\u20131097","journal-title":"Arthritis Rheumatol"},{"key":"3310_CR16","doi-asserted-by":"publisher","first-page":"1762","DOI":"10.1016\/j.bbrc.2009.12.150","volume":"391","author":"J Kaur","year":"2010","unstructured":"Kaur J, Adya R, Tan BK, Chen J, Randeva HS (2010) Identification of chemerin receptor (ChemR23) in human endothelial cells: chemerin induced endothelial angiogenesis. Biochem Biophys Res Commun 391:1762\u20131768","journal-title":"Biochem Biophys Res Commun"},{"key":"3310_CR17","doi-asserted-by":"publisher","first-page":"23982","DOI":"10.1074\/jbc.M111.220491","volume":"286","author":"S Muruganandan","year":"2011","unstructured":"Muruganandan S, Parlee SD, Rourke JL, Ernst MC, Goralski KB, Sinal CJ (2011) Chemerin, a novel peroxisome proliferator-activated receptor gamma (PPAR gamma) target gene that promotes mesenchymal stem cell adipogenesis. J Biol Chem 286:23982\u201323995","journal-title":"J Biol Chem"},{"key":"3310_CR18","doi-asserted-by":"publisher","first-page":"1998","DOI":"10.1210\/en.2009-1098","volume":"151","author":"MC Ernst","year":"2010","unstructured":"Ernst MC, Issa M, Goralski KB, Sinal CJ (2010) Chemerin exacerbates glucose intolerance in mouse models of obesity and diabetes. Endocrinology 151:1998\u20132007","journal-title":"Endocrinology"},{"key":"3310_CR19","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1111\/aji.12405","volume":"74","author":"CH Jin","year":"2015","unstructured":"Jin CH, Yi KW, Ha YR, Shin JH, Park HT, Kim T, Hur JY (2015) Chemerin expression in the peritoneal fluid, serum, and ovarian endometrioma of women with endometriosis. Am J Reprod Immunol 74:379\u2013386","journal-title":"Am J Reprod Immunol"},{"key":"3310_CR20","doi-asserted-by":"publisher","first-page":"12181","DOI":"10.1111\/jicd.12181","volume":"8","author":"K Patnaik","year":"2017","unstructured":"Patnaik K, Pradeep AR, Nagpal K, Karvekar S, Singh P, Raju A (2017) Human chemerin correlation in gingival crevicular fluid and tear fluid as markers of inflammation in chronic periodontitis and type-2 diabetes mellitus. J Investig Clin Dent 8:12181\u201312188","journal-title":"J Investig Clin Dent"},{"key":"3310_CR21","doi-asserted-by":"crossref","unstructured":"Eisinger K, Bauer S, Schaffler A, Walter R, Neumann E, Buechler C, M\u00fcller- Ladner U, Frommer KW (2012) Chemerin induces CCL2 and TLR4 in synovial fibroblasts of patients with rheumatoid arthritis and osteoarthritis. Exp Mol Patho 92:90\u201396","DOI":"10.1016\/j.yexmp.2011.10.006"},{"key":"3310_CR22","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1186\/ar3215","volume":"12","author":"V Berg","year":"2010","unstructured":"Berg V, Sveinbj\u00f6rnsson B, Bendiksen S, Brox J, Meknas K, Figenschau Y (2010) Human articular chondrocytes express ChemR23 and chemerin; ChemR23 promotes inflammatory signalling upon binding the ligand chemerin 21-157. Arthritis Res Ther 12:228","journal-title":"Arthritis Res Ther"},{"key":"3310_CR23","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1136\/ard.2010.132399","volume":"70","author":"J Conde","year":"2011","unstructured":"Conde J, Gomez R, Bianco G, Scotece M, Lear P, Dieguez C, Gomez-Reino J, Lago F, Gualillo O (2011) Expanding the adipokine network in cartilage: identification and regulation of novel factors in human and murine chondrocytes. Ann Rheum Dis 70:551\u2013559","journal-title":"Ann Rheum Dis"},{"key":"3310_CR24","doi-asserted-by":"publisher","first-page":"2223","DOI":"10.1016\/j.bmc.2007.01.011","volume":"15","author":"RP Verma","year":"2007","unstructured":"Verma RP, Hansch C (2007) Matrix metalloproteinases (MMPs): chemical-biological functions and (Q) SARs. Bioorg Med Chem 15:2223\u20132268","journal-title":"Bioorg Med Chem"},{"key":"3310_CR25","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1002\/prca.200800140","volume":"3","author":"W Yan","year":"2009","unstructured":"Yan W, Apweiler R, Balgley BM, Boontheung P, Bundy JL, Cargile BJ, Cole S, Fang X, Gonzalez-Begne M, Griffin TJ (2009) Systematic comparison of the human saliva and plasma proteomes. Proteomics Clin Appl 3:116\u2013134","journal-title":"Proteomics Clin Appl"},{"key":"3310_CR26","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1177\/0022034519865187","volume":"98","author":"B Shoukri","year":"2019","unstructured":"Shoukri B, Prieto JC, Ruellas A, Yatabe M, Sugai J, Styner M, Zhu H, Huang C, Paniagua B, Aronovich S, Ashman L, Benavides E, de Dumast P, Ribera NT, Mirabel C, Michoud L, Allohaibi Z, Loshida M, Bittencourt L, Fattori L, Gomes LR, Cevidanes L (2019) Minimally invasive approach for diagnosing TMJ osteoarthritis. J Dent Res 98:1103\u20131111","journal-title":"J Dent Res"},{"key":"3310_CR27","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/1471-2350-11-40","volume":"11","author":"H Manso","year":"2010","unstructured":"Manso H, Krug T, Sobral J, Albergaria I, Gaspar G, Ferro JM, Oliveira SA, Vicente AM (2010) Variants of the matrix Metalloproteinase-2 but not the matrix Metalloproteinase-9 genes significantly influence functional outcome after stroke. BMC Med Genet 11:40","journal-title":"BMC Med Genet"},{"key":"3310_CR28","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.jneuroim.2007.11.001","volume":"193","author":"EA Milward","year":"2008","unstructured":"Milward EA, Kim KJ, Szklarczyk A, Nguyen T, Melli G, Nayak M, Deshpande D, Fitzsimmons C, Hoke A, Kerr D, Griffin JW, Calabresi PA, Conant K (2008) Cleavage of myelin associated glycoprotein by matrix metalloproteinase. J Neuroimmunol 193:140\u2013148","journal-title":"J Neuroimmunol"},{"key":"3310_CR29","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.jad.2016.03.068","volume":"205","author":"K Bobi\u0144ska","year":"2016","unstructured":"Bobi\u0144ska K, Szemraj J, Czarny P, Ga\u0142ecki P (2016) Role of MMP-2, MMP-7, MMP-9 and TIMP-2 in the development of recurrent depressive disorder. J Affect Disord 205:119\u2013129","journal-title":"J Affect Disord"},{"key":"3310_CR30","doi-asserted-by":"crossref","unstructured":"Rafni E, Yanwirasti Y, Darwin E, Rikmasari R (2017) The difference of matrix metalloproteinase-9 level in saliva between myofascial pain and disc displacement of temporomandibular joint disorders. Padjadjaran Journal of Dentistry 29","DOI":"10.24198\/pjd.vol29no2.13613"},{"key":"3310_CR31","first-page":"13393","volume":"8","author":"J Ma","year":"2015","unstructured":"Ma J, Niu DS, Wan NJ, Qin Y, Guo CJ (2015) Elevated chemerin levels in synovial fluid and synovial membrane from patients with knee osteoarthritis. Int J Clin Exp Pathol 8:13393\u201313398","journal-title":"Int J Clin Exp Pathol"},{"key":"3310_CR32","doi-asserted-by":"publisher","first-page":"2577","DOI":"10.1007\/s00264-014-2416-9","volume":"38","author":"S Bas","year":"2014","unstructured":"Bas S, Finckh A, Puskas GJ, Suva D, Hoffmeyer P, Gabay C, L\u00fcbbeke A (2014) Adipokines correlate with pain in lower limb osteoarthritis: different associations in hip and knee. Int Orthop 38:2577\u20132583","journal-title":"Int Orthop"},{"issue":"1","key":"3310_CR33","doi-asserted-by":"publisher","first-page":"16","DOI":"10.3109\/1354750X.2011.634028","volume":"17","author":"K Huang","year":"2012","unstructured":"Huang K, Du G, Li L, Liang H, Zhang B (2012) Association of chemerin levels in synovial fluid with the severity of knee osteoarthritis. Biomarkers 17(1):16\u201320","journal-title":"Biomarkers"},{"key":"3310_CR34","doi-asserted-by":"publisher","first-page":"1431","DOI":"10.1007\/s10067-009-1242-8","volume":"28","author":"JH Ku","year":"2009","unstructured":"Ku JH, Lee CK, Joo BS, An BM, Choi SH, Wang TH, Cho HL (2009) Correlation of synovial fluid leptin concentrations with the severity of osteoarthritis. J Clin Rheumatol 28:1431\u20131435","journal-title":"J Clin Rheumatol"},{"key":"3310_CR35","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1002\/acr.21922","volume":"65","author":"CA Karvonen-Gutierrez","year":"2013","unstructured":"Karvonen-Gutierrez CA, Harlow SD, Mancuso P, Jacobson J, Mendes de Leon CF, Nan B (2013) Association of leptin levels with radiographic knee osteoarthritis among a cohort of midlife women. Arthritis Care Res 65:936\u2013944","journal-title":"Arthritis Care Res"},{"key":"3310_CR36","doi-asserted-by":"publisher","first-page":"171","DOI":"10.2337\/dc09-1351","volume":"33","author":"D Pfau","year":"2010","unstructured":"Pfau D, Bachmann A, L\u00f6ssner U, Kratzsch J, Bl\u00fcher M, Stumvoll M, Fasshauer M (2010) Serum levels of the adipokine chemerin in relation to renal function. Diabetes Care 33:171\u2013173","journal-title":"Diabetes Care"},{"key":"3310_CR37","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.1111\/jre.12476","volume":"52","author":"HFR Jentsch","year":"2017","unstructured":"Jentsch HFR, Arnold N, Richter V, Deschner J, Kantyka T, Eick S (2017) Salivary, gingival crevicular fluid and serum levels of ghrelin and chemerin in patients with periodontitis and overweight. J Periodontal Res 52:1050\u20131057","journal-title":"J Periodontal Res"},{"key":"3310_CR38","doi-asserted-by":"publisher","first-page":"6153","DOI":"10.1074\/jbc.M109.088708","volume":"285","author":"K Ohashi","year":"2010","unstructured":"Ohashi K, Parker JL, Ouchi N, Higuchi A, Vita JA, Gokce N, Pedersen AA, Kalthoff C, Tullin S, Sams A, Summer R, Walsh K (2010) Adiponectin promotes macrophage polarization toward an anti-inflammatory phenotype. J Biol Chem 285:6153\u20136160","journal-title":"J Biol Chem"},{"key":"3310_CR39","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1084\/jem.20030382","volume":"198","author":"V Wittamer","year":"2003","unstructured":"Wittamer V, Franssen JD, Vulcano M, Mirjolet JF, Le Poul E, Migeotte I, Brezillon S, Tyldesley R, Blanpain C, Detheux M, Mantovani A, Sozzani S, Vassart G, Parmentier M, Communi D (2003) Specific recruitment of antigen-presenting cells by chemerin, a novel processed ligand from human inflammatory fluids. J Exp Med 198:977\u2013985","journal-title":"J Exp Med"},{"key":"3310_CR40","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.jcms.2014.10.017","volume":"43","author":"O G\u00fcven","year":"2015","unstructured":"G\u00fcven O, Tekin U, Salmano\u011flu B, Kaymak E (2015) Tumor necrosis factor- alpha levels in the synovial fluid of patients with temporomandibular joint internal derangement. J Craniomaxillofac Surg 43:102\u2013105","journal-title":"J Craniomaxillofac Surg"}],"container-title":["Clinical Oral Investigations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-020-03310-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00784-020-03310-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-020-03310-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,23]],"date-time":"2022-10-23T09:09:16Z","timestamp":1666516156000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00784-020-03310-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,8]]},"references-count":40,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["3310"],"URL":"https:\/\/doi.org\/10.1007\/s00784-020-03310-8","relation":{},"ISSN":["1432-6981","1436-3771"],"issn-type":[{"value":"1432-6981","type":"print"},{"value":"1436-3771","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,8]]},"assertion":[{"value":"22 January 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 April 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 May 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants (parents) included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}