{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T20:42:27Z","timestamp":1790023347783,"version":"4.0.1"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T00:00:00Z","timestamp":1588809600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T00:00:00Z","timestamp":1588809600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Medical University of Warsaw"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Oral Invest"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The aim of this study was to compare outcomes of the modified coronally advanced tunnel technique (MCAT) combined with subepithelial connective tissue graft (SCTG) with or without enamel matrix derivative (EMD), in the treatment of gingival recession types 1 and 2.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>A total of 20 patients with 150 multiple gingival recessions (GR) were included in the study. On one side, MCAT was combined with SCTG and EMD (tests), whereas MCAT with SCTG was applied on the contralateral side (controls). Clinical parameters were measured at baseline and 6\u00a0months after surgery. Visual analog scales (VAS) and questionnaires were used to assess patient-reported outcomes and the root coverage esthetic score (RES) for professional esthetic evaluation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      MCAT+SCTG+EMD was not superior with regard to root coverage. At 6\u00a0months, average root coverage (ARC) was 87.4% for SCTG+EMD-treated and 90.9% for SCTG-treated defects (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.4170). Complete root coverage (CRC) was observed in 86.7% (tests) and 85.3% (controls) of the cases (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.9872). Significantly less pain was reported using VAS (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0342) post-operatively in the SCTG+EMD group. Professional assessment of esthetic outcomes using RES showed a significant difference (9.25 versus 8.71,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0103) in favor of the test group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Both treatment modalities were equally effective in treatment of multiple GR and led to similar improvements in clinical parameters. However, the application of EMD as an adjunct resulted in less post-operative pain and better professionally assessed esthetic outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical relevance<\/jats:title>\n                    <jats:p>Patients\u2019 early morbidity and 6-month esthetic outcomes following GR coverage with MCAT might be influenced by means of EMD utilization.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00784-020-03312-6","type":"journal-article","created":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T06:02:54Z","timestamp":1588831374000},"page":"4475-4486","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Tunnel technique with enamel matrix derivative in addition to subepithelial connective tissue graft compared with connective tissue graft alone for the treatment of multiple gingival recessions: a randomized clinical trial"],"prefix":"10.1007","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3918-4332","authenticated-orcid":false,"given":"Bart\u0142omiej","family":"G\u00f3rski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata","family":"G\u00f3rska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Wysoki\u0144ska-Miszczuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz","family":"Kaczy\u0144ski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,5,7]]},"reference":[{"issue":"2","key":"3312_CR1","doi-asserted-by":"publisher","first-page":"220","DOI":"10.14219\/jada.archive.2003.0137","volume":"134","author":"MM Kassab","year":"2003","unstructured":"Kassab MM, Cohen RE (2003) The etiology and prevalence of gingival recession. J Am Dent Assoc 134(2):220\u2013225. https:\/\/doi.org\/10.14219\/jada.archive.2003.0137","journal-title":"J Am Dent Assoc"},{"issue":"Suppl 20","key":"3312_CR2","doi-asserted-by":"publisher","first-page":"S219","DOI":"10.1111\/jcpe.12951","volume":"45","author":"S Jepsen","year":"2017","unstructured":"Jepsen S, Caton JG, Albandar JM, Bissada NF, Bouchard P, Cortellini P, Demirel K, de Sanctis M, Ercoli C, Fan J, Geurs NC, Hughes FJ, Jin L, Kantarci A, Lalla E, Madianos PN, Matthews D, McGuire MK, Mills MP, Preshaw PM, Reynolds MA, Sculean A, Susin C, West NX, Yamazaki K (2017) Periodontal manifestations of systemic diseases and developmental and acquired conditions: consensus report of workgroup 3 of the 2017 World Workshop on the Classification of Periodontal and Per-Implant Diseases and Conditions. J Clin Periodontol 45(Suppl 20):S219\u2013S229. https:\/\/doi.org\/10.1111\/jcpe.12951","journal-title":"J Clin Periodontol"},{"issue":"7","key":"3312_CR3","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1111\/j.1600-051X.2011.01732.x","volume":"38","author":"F Cairo","year":"2011","unstructured":"Cairo F, Nieri M, Cincinelli S, Mervelt J, Pagliaro U (2011) The interproximal clinical attachment level to classify gingival recessions and predict root coverage outcomes: an explorative and reliability study. J Clin Periodontol 38(7):661\u2013666. https:\/\/doi.org\/10.1111\/j.1600-051X.2011.01732.x","journal-title":"J Clin Periodontol"},{"issue":"2","key":"3312_CR4","first-page":"8","volume":"5","author":"PD Miller","year":"1985","unstructured":"Miller PD (1985) A classification of marginal tissue recession. Int J Periodontics Rstorative Dent 5(2):8\u201313","journal-title":"Int J Periodontics Rstorative Dent"},{"issue":"2","key":"3312_CR5","first-page":"199","volume":"19","author":"I Zabalegui","year":"1999","unstructured":"Zabalegui I, Sicilia A, Cambra J, Gil J, Sanz M (1999) Treatment of multiple adjacent gingival recessions with the tunnel subepithelial connective tissue graft: a clinical report. Int J Periodontics Restorative Dent 19(2):199\u2013206","journal-title":"Int J Periodontics Restorative Dent"},{"issue":"1","key":"3312_CR6","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1902\/annals.2003.8.1.303","volume":"8","author":"TW Oates","year":"2003","unstructured":"Oates TW, Robinson M, Gunsolley JC (2003) Surgical therapies for treatment of gingival recession. A systematic review. Ann Periodontol 8(1):303\u2013320. https:\/\/doi.org\/10.1902\/annals.2003.8.1.303","journal-title":"Ann Periodontol"},{"issue":"5","key":"3312_CR7","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1111\/jcpe.12714","volume":"44","author":"MP Santamaria","year":"2017","unstructured":"Santamaria MP, Neves FLDS, Silveira CA, Mathias IF, Fernandes-Dias SB, Jardini MAN, Tatakis DN (2017) Connective tissue graft and tunnel or trapezoidal flap for the treatment of single maxillary gingival recessions: a randomized clinical trial. J Clin Periodontol 44(5):540\u2013547. https:\/\/doi.org\/10.1111\/jcpe.12714","journal-title":"J Clin Periodontol"},{"issue":"9","key":"3312_CR8","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1002\/JPER.18-0066","volume":"89","author":"L Tavelli","year":"2018","unstructured":"Tavelli L, Barootchi S, Nguyen TVN, Tattan M, Ravid\u00e0 A, Wang HL (2018) Efficacy of tunnel technique in the treatment of localized and multiple gingival recessions: a systematic review and meta-analysis. J Periodontol 89(9):1075\u20131090. https:\/\/doi.org\/10.1002\/JPER.18-0066","journal-title":"J Periodontol"},{"issue":"5","key":"3312_CR9","first-page":"457","volume":"27","author":"O Zuhr","year":"2007","unstructured":"Zuhr O, Fickl S, Wachtel H, Bolz W, H\u00fcrzeler MB (2007) Covering of gingival recessions with a modified microsurgical tunnel technique: case report. Int J Periodontics Restorative Dent 27(5):457\u2013463","journal-title":"Int J Periodontics Restorative Dent"},{"issue":"1","key":"3312_CR10","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1111\/j.1600-051X.2009.01492.x","volume":"37","author":"S Aroca","year":"2010","unstructured":"Aroca S, Keglevich T, Nikolidakis D, Gera I, Nagy K, Azzi R, Etienne D (2010) Treatment of class III multiple gingival recessions: a randomized-clinical trial. J Clin Periodontol 37(1):88\u201397. https:\/\/doi.org\/10.1111\/j.1600-051X.2009.01492.x","journal-title":"J Clin Periodontol"},{"issue":"8","key":"3312_CR11","doi-asserted-by":"publisher","first-page":"653","DOI":"10.3290\/j.qi.a36562","volume":"47","author":"A Sculean","year":"2016","unstructured":"Sculean A, Cosgarea R, St\u00e4hli A, Katsaros C, Arweiler NB, Miron RJ, Deppe H (2016) Treatment of multiple adjacent maxillary Miller class I, II, and III gingival recessions with the modified coronally advanced tunnel, enamel matrix derivative, and subepithelial connective tissue graft: a report of 12 cases. Quintessence Int 47(8):653\u2013659. https:\/\/doi.org\/10.3290\/j.qi.a36562","journal-title":"Quintessence Int"},{"issue":"2","key":"3312_CR12","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1007\/s00784-019-03008-6","volume":"24","author":"A St\u00e4hli","year":"2020","unstructured":"St\u00e4hli A, Imber JC, Raptis E, Salvi GE, Eick S, Sculean A (2020) Effect of enamel matrix derivative on wound healing following gingival recession coverage using the modified coronally advanced tunnel and subepithelial connective tissue graft: a randomised, controlled, clinical study. Clin Oral Investig 24(2):1043\u20131051. https:\/\/doi.org\/10.1007\/s00784-019-03008-6","journal-title":"Clin Oral Investig"},{"issue":"8","key":"3312_CR13","doi-asserted-by":"publisher","first-page":"1126","DOI":"10.1902\/jop.2003.74.8.1126","volume":"74","author":"MK McGuire","year":"2003","unstructured":"McGuire MK, Cochran DL (2003) Evaluation of human recession defects treated with coronally advanced flaps and either enamel matrix derivative or connective tissue. Part 2: histological evaluation. J Periodontol 74(8):1126\u20131135. https:\/\/doi.org\/10.1902\/jop.2003.74.8.1126","journal-title":"J Periodontol"},{"issue":"3","key":"3312_CR14","first-page":"269","volume":"20","author":"G Rasperini","year":"2000","unstructured":"Rasperini G, Silvestri M, Schenk RK, Nevins ML (2000) Clinical and histological evaluation of human gingival recession treated with a subepithelial connective tissue graft and enamel matrix derivative (Emdogain): a case report. Int J Periodontics Restorative Dent 20(3):269\u2013275","journal-title":"Int J Periodontics Restorative Dent"},{"issue":"5","key":"3312_CR15","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1111\/jre.12245","volume":"50","author":"RJ Miron","year":"2015","unstructured":"Miron RJ, Dard M, Weinreb M (2015) Enamel matrix derivative, inflammation and soft tissue wound healing. J Periodontal Res 50(5):555\u2013569. https:\/\/doi.org\/10.1111\/jre.12245","journal-title":"J Periodontal Res"},{"issue":"8","key":"3312_CR16","doi-asserted-by":"publisher","first-page":"3339","DOI":"10.1007\/s00784-018-2750-1","volume":"23","author":"Y Shirakata","year":"2018","unstructured":"Shirakata Y, Nakamura T, Shinohara Y, Nakamura-Hasegawa K, Hashiguchi C, Takeuchi N, Imafuji T, Sculean A, Noguchi K (2018) Split-mouth evaluation of connective tissue graft with or without enamel matrix derivative for the treatment of isolated gingival recession defects in dogs. Clin Oral Investig 23(8):3339\u20133349. https:\/\/doi.org\/10.1007\/s00784-018-2750-1","journal-title":"Clin Oral Investig"},{"issue":"5","key":"3312_CR17","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1902\/jop.2016.150567","volume":"87","author":"T Maymon-Gil","year":"2016","unstructured":"Maymon-Gil T, Weinberg E, Nemcovsky C, Weinreb M (2016) Enamel matrix derivative promotes healing of a surgical wound in the rat oral mucosa. J Periodontol 87(5):601\u2013609. https:\/\/doi.org\/10.1902\/jop.2016.150567","journal-title":"J Periodontol"},{"issue":"4","key":"3312_CR18","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1902\/jop.2009.080565","volume":"77","author":"F Cairo","year":"2009","unstructured":"Cairo F, Rotundo R, Miller PD, PiniPrato GP (2009) Root coverage esthetic score: a system to evaluate the esthetic outcome of the treatment of gingival recession through evaluation of clinical cases. J Periodontol 77(4):705\u2013710. https:\/\/doi.org\/10.1902\/jop.2009.080565","journal-title":"J Periodontol"},{"issue":"1","key":"3312_CR19","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1902\/jop.1972.43.1.38","volume":"43","author":"TJ O'Leary","year":"1972","unstructured":"O'Leary TJ, Drake RB, Naylor JE (1972) The plaque control record. J Periodontol 43(1):38\u201346","journal-title":"J Periodontol"},{"key":"3312_CR20","first-page":"229","volume":"25","author":"J Ainamo","year":"1975","unstructured":"Ainamo J, Bay I (1975) Problems and proposals for recording gingivitis and plaque. Int Dent J 25:229\u2013235","journal-title":"Int Dent J"},{"issue":"14","key":"3312_CR21","doi-asserted-by":"publisher","first-page":"1635","DOI":"10.1002\/(sici)1097-0258(19980730)17:14<1635::aid-sim881>3.0.co;2-k","volume":"17","author":"SA Julious","year":"1998","unstructured":"Julious SA, Campbell MJ (1998) Sample size calculations for paired or matched ordinal data. Stat Med 17(14):1635\u20131642. https:\/\/doi.org\/10.1002\/(sici)1097-0258(19980730)17:14<1635::aid-sim881>3.0.co;2-k","journal-title":"Stat Med"},{"issue":"80","key":"3312_CR22","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1111\/j.1600-051X.2010.01550.x","volume":"37","author":"G Zucchelli","year":"2010","unstructured":"Zucchelli G, Mele M, Stefanini M, Mazzotti C, Marzadori M, Montebugnoli L, de Sanctis M (2010) Patient morbidity and root coverage outcome after subepithelial connective tissue and de-epithelialized grafts: a comparative randomized controlled clinical trial. J Clin Periodontol 37(80):728\u2013738. https:\/\/doi.org\/10.1111\/j.1600-051X.2010.01550.x","journal-title":"J Clin Periodontol"},{"issue":"7","key":"3312_CR23","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1111\/jcpe.12112","volume":"40","author":"S Aroca","year":"2013","unstructured":"Aroca S, Molnar B, Windisch P, Gera I, Salvi GE, Nikolidakis S, Sculean A (2013) Treatment of multiple adjacent Millar class I and II gingival recessions with a modified coronally advanced tunnel (MCAT) technique and a collagen matrix or palatal connective tissue graft: a randomized, controlled clinical trial. J Clin Periodontol 40(7):713\u2013720. https:\/\/doi.org\/10.1111\/jcpe.12112","journal-title":"J Clin Periodontol"},{"issue":"1","key":"3312_CR24","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1111\/jcpe.13031","volume":"46","author":"M Pietruska","year":"2019","unstructured":"Pietruska M, Skurska A, Podlewski \u0141, Milewski R, Pietruski J (2019) Clinical evaluation of Miller I and II recessions treatment with the use of modified coronally advanced tunnel technique with either collagen matrix or subepithelial connective tissue graft: a randomized clinical study. J Clin Periodontol 46(1):86\u201395. https:\/\/doi.org\/10.1111\/jcpe.13031","journal-title":"J Clin Periodontol"},{"key":"3312_CR25","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1111\/jre.12715","volume":"55","author":"F Mercado","year":"2019","unstructured":"Mercado F, Hamlet S, Ivanovski S (2019) A 3-year prospective clinical and patient-centered trial on subepithelial connective tissue graft with or without enamel matrix derivative in class I-II Miller recessions. J Periodontol 55:296\u2013306. https:\/\/doi.org\/10.1111\/jre.12715","journal-title":"J Periodontol"},{"issue":"2","key":"3312_CR26","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1111\/jre.12199","volume":"50","author":"GL Cheng","year":"2015","unstructured":"Cheng GL, Fu E, Tu YK, Shen EC, Chiu HC, Huang RY, Yuh DY, Chiang CY (2015) Root coverage by coronally advanced flap with connective tissue graft and\/or enamel matrix derivative: a meta-analysis. J Periodontal Res 50(2):220\u2013230. https:\/\/doi.org\/10.1111\/jre.12199","journal-title":"J Periodontal Res"},{"issue":"1","key":"3312_CR27","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1034\/j.1600-051x.2002.290102.x","volume":"29","author":"JL Wennstr\u00f6m","year":"2002","unstructured":"Wennstr\u00f6m JL, Lindhe J (2002) Some effects of enamel matrix proteins on wound healing in the dento-gingival region. J Clin Periodontol 29(1):9\u201314","journal-title":"J Clin Periodontol"},{"issue":"1","key":"3312_CR28","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1007\/s00784-019-02941-w","volume":"24","author":"JH Lee","year":"2020","unstructured":"Lee JH, Park YS, Kim YT, Jeong SN (2020) Assessment of early discomfort and wound healing outcomes after periodontal surgery with and without enamel matrix derivative: an observational retrospective case-control study. Clin Oral Investig 24(1):229\u2013237. https:\/\/doi.org\/10.1007\/s00784-019-02941-w","journal-title":"Clin Oral Investig"},{"issue":"7","key":"3312_CR29","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1111\/jcpe.12114","volume":"40","author":"M Nieri","year":"2013","unstructured":"Nieri M, Pini Prato GP, Giani M, Magnani N, Pagliaro U, Rotundo R (2013) Patient perceptions of buccal gingival recessions and request for treatment. J Clin Periodontol 40(7):707\u2013712. https:\/\/doi.org\/10.1111\/jcpe.12114","journal-title":"J Clin Periodontol"},{"key":"3312_CR30","doi-asserted-by":"publisher","DOI":"10.1590\/1807-3107bor-2019.vol33.0006","volume":"33","author":"HS Aydinyurt","year":"2019","unstructured":"Aydinyurt HS, Tekin Y, Ertugrul AS (2019) The effect of enamel matrix derivatives on root coverage: a 12-month follow-up of a randomized clinical trial. Braz Oral Res 33:e006. https:\/\/doi.org\/10.1590\/1807-3107bor-2019.vol33.0006","journal-title":"Braz Oral Res"},{"issue":"Suppl 15","key":"3312_CR31","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1111\/jcpe.12185","volume":"41","author":"O Zuhr","year":"2014","unstructured":"Zuhr O, B\u00e4umer D, H\u00fcrzeler M (2014) The addition of soft tissue replacement grafts in plastic periodontal and implant surgery: critical elements in design and execution. J Clin Periodontol 41(Suppl 15):123\u2013142. https:\/\/doi.org\/10.1111\/jcpe.12185","journal-title":"J Clin Periodontol"},{"issue":"8","key":"3312_CR32","doi-asserted-by":"publisher","first-page":"2727","DOI":"10.1007\/s00784-018-2635-3","volume":"22","author":"S Barootchi","year":"2018","unstructured":"Barootchi S, Tavelli L, Ravid\u00e0 A, Wang CW, Wang HL (2018) Effect of EDTA root conditioning on the outcome of coronally advanced flap with connective tissue graft: a systematic review and meta-analysis. Clin Oral Investig 22(8):2727\u20132741. https:\/\/doi.org\/10.1007\/s00784-018-2635-3","journal-title":"Clin Oral Investig"},{"issue":"7","key":"3312_CR33","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1111\/jcpe.12923","volume":"45","author":"S Aroca","year":"2018","unstructured":"Aroca S, Antoine B, Clementini M, Renouard F, de Sanctis M (2018) Treatment of class III multiple gingival recessions: prognostic factors for achieving a complete root coverage. J Clin Periodontol 45(7):861\u2013868. https:\/\/doi.org\/10.1111\/jcpe.12923","journal-title":"J Clin Periodontol"},{"issue":"1","key":"3312_CR34","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1902\/jop.2009.080413","volume":"80","author":"S Kerner","year":"2009","unstructured":"Kerner S, Sarfati A, Katsahian S, Jaumet V, Micheau C, Mora F, Monnet-Corti V, Bouchard P (2009) Qualitative cosmetic evaluation after root-coverage procedures. J Periodontol 80(1):41\u201347. https:\/\/doi.org\/10.1902\/jop.2009.080413","journal-title":"J Periodontol"},{"issue":"28","key":"3312_CR35","doi-asserted-by":"publisher","first-page":"3470","DOI":"10.1002\/sim.3634","volume":"28","author":"E Lesaffre","year":"2009","unstructured":"Lesaffre E, Philstrom B, Needleman I, Worthington H (2009) The design and analysis of split-mouth studies: what statisticians and clinicians should know. Stat Med 28(28):3470\u20133482. https:\/\/doi.org\/10.1002\/sim.3634","journal-title":"Stat Med"}],"container-title":["Clinical Oral Investigations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-020-03312-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00784-020-03312-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-020-03312-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,6]],"date-time":"2021-05-06T20:06:03Z","timestamp":1620331563000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00784-020-03312-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,7]]},"references-count":35,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["3312"],"URL":"https:\/\/doi.org\/10.1007\/s00784-020-03312-6","relation":{},"ISSN":["1432-6981","1436-3771"],"issn-type":[{"value":"1432-6981","type":"print"},{"value":"1436-3771","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,7]]},"assertion":[{"value":"11 March 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 April 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 May 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. This study was reviewed and approved by the Bioethics Committee of Medical University of Warsaw, Poland (KB\/208\/2017).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}