{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:56:06Z","timestamp":1787759766841,"version":"build-2784847793"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2020,5,16]],"date-time":"2020-05-16T00:00:00Z","timestamp":1589587200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,5,16]],"date-time":"2020-05-16T00:00:00Z","timestamp":1589587200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Implant B, NGT, Nazareth, Israel","award":["1"],"award-info":[{"award-number":["1"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Oral Invest"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1007\/s00784-020-03318-0","type":"journal-article","created":{"date-parts":[[2020,5,16]],"date-time":"2020-05-16T02:03:04Z","timestamp":1589594584000},"page":"4531-4539","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Peri-implant disease affects systemic complete blood count values\u2014an experimental in vivo study"],"prefix":"10.1007","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5755-7526","authenticated-orcid":false,"given":"Liat","family":"Chaushu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haim","family":"Tal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton","family":"Sculean","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blanca","family":"Fern\u00e1ndez-Tom\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gavriel","family":"Chaushu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,5,16]]},"reference":[{"issue":"Suppl 8","key":"3318_CR1","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1111\/j.1600-051X.2008.01274.x","volume":"35","author":"NU Zitzmann","year":"2008","unstructured":"Zitzmann NU, Berglundh T (2008) Definition and prevalence of peri-implant diseases. J Clin Periodontol 35(Suppl 8):286\u2013291. https:\/\/doi.org\/10.1111\/j.1600-051X.2008.01274.x","journal-title":"J Clin Periodontol"},{"issue":"1","key":"3318_CR2","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1111\/j.1600-0757.2012.00457.x","volume":"62","author":"RJ Genco","year":"2013","unstructured":"Genco RJ, Borgnakke WS (2013) Risk factors for periodontal disease. Periodontol 2000 62(1):59\u201394. https:\/\/doi.org\/10.1111\/j.1600-0757.2012.00457.x","journal-title":"Periodontol 2000"},{"issue":"1","key":"3318_CR3","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1177\/0022034516667484","volume":"96","author":"GE Salvi","year":"2017","unstructured":"Salvi GE, Cosgarea R, Sculean A (2017) Prevalence and mechanisms of peri-implant diseases. J Dent Res 96(1):31\u201337. https:\/\/doi.org\/10.1177\/0022034516667484","journal-title":"J Dent Res"},{"issue":"Suppl 11","key":"3318_CR4","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1111\/j.1600-051X.2010.01672.x","volume":"38","author":"T Berglundh","year":"2011","unstructured":"Berglundh T, Zitzmann NU, Donati M (2011) Are peri-implantitis lesions different from periodontitis lesions? J Clin Periodontol 38(Suppl 11):188\u2013202. https:\/\/doi.org\/10.1111\/j.1600-051X.2010.01672.x","journal-title":"J Clin Periodontol"},{"issue":"53","key":"3318_CR5","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1111\/j.1600-0757.2010.00348.x","volume":"2000","author":"LJ Heitz-Mayfield","year":"2010","unstructured":"Heitz-Mayfield LJ, Lang NP (2010) Comparative biology of chronic and aggressive periodontitis vs. peri-implantitis. Periodontol 2000(53):167\u2013181. https:\/\/doi.org\/10.1111\/j.1600-0757.2010.00348.x","journal-title":"Periodontol"},{"key":"3318_CR6","doi-asserted-by":"publisher","unstructured":"Liu Y, Liu Q, Li Z, Acharya A, Chen D, Chen Z, Mattheos N, Chen Z, Huang B (2019) Long non-coding RNA and mRNA expression profiles in peri-implantitis vs periodontitis. J Periodontal Res [Epub ahead of print]. https:\/\/doi.org\/10.1111\/jre.12718","DOI":"10.1111\/jre.12718"},{"issue":"3","key":"3318_CR7","doi-asserted-by":"publisher","first-page":"e289","DOI":"10.4317\/medoral.19563","volume":"19","author":"E Carramolino-Cu\u00e9llar","year":"2014","unstructured":"Carramolino-Cu\u00e9llar E, Tom\u00e1s I, Jim\u00e9nez-Soriano Y (2014) Relationship between the oral cavity and cardiovascular diseases and metabolic syndrome. Med Oral Patol Oral Cir Bucal 19(3):e289\u2013e294","journal-title":"Med Oral Patol Oral Cir Bucal"},{"issue":"1","key":"3318_CR8","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1111\/prd.12089","volume":"69","author":"SK Sonnenschein","year":"2015","unstructured":"Sonnenschein SK, Meyle J (2015) Local inflammatory reactions in patients with diabetes and periodontitis. Periodontol 2000 69(1):221\u2013254. https:\/\/doi.org\/10.1111\/prd.12089","journal-title":"Periodontol 2000"},{"issue":"1","key":"3318_CR9","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1111\/prd.12249","volume":"79","author":"A Falcao","year":"2019","unstructured":"Falcao A, Bull\u00f3n P (2019) A review of the influence of periodontal treatment in systemic diseases. Periodontol 79(1):117\u2013128. https:\/\/doi.org\/10.1111\/prd.12249","journal-title":"Periodontol"},{"issue":"11","key":"3318_CR10","doi-asserted-by":"publisher","first-page":"1750","DOI":"10.1902\/jop.2009.090209","volume":"80","author":"S Enhos","year":"2009","unstructured":"Enhos S, Duran I, Erdem S, Buyukbas S (2009) Relationship between iron-deficiency anemia and periodontal status in female patients. J Periodontol 80(11):1750\u20131755. https:\/\/doi.org\/10.1902\/jop.2009.090209","journal-title":"J Periodontol"},{"key":"3318_CR11","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1182\/asheducation-2015.1.14","volume":"2015","author":"PG Fraenkel","year":"2015","unstructured":"Fraenkel PG (2015) Understanding anemia of chronic disease. Hematol Am Soc Hematol Educ Program 2015:14\u201318. https:\/\/doi.org\/10.1182\/asheducation-2015.1.14","journal-title":"Hematol Am Soc Hematol Educ Program"},{"key":"3318_CR12","doi-asserted-by":"publisher","first-page":"1620","DOI":"10.3389\/fphys.2019.01620","volume":"10","author":"D Wu","year":"2020","unstructured":"Wu D, Lin Z, Zhang S, Cao F, Liang D, Zhou X (2020) Decreased hemoglobin concentration and iron metabolism disorder in periodontitis: systematic review and meta-analysis. Front Physiol 10:1620. https:\/\/doi.org\/10.3389\/fphys.2019.01620","journal-title":"Front Physiol"},{"issue":"11","key":"3318_CR13","doi-asserted-by":"publisher","first-page":"1252","DOI":"10.1002\/JPER.19-0124","volume":"90","author":"L Nibali","year":"2019","unstructured":"Nibali L, Darbar U, Rakmanee T, Donos N (2019) Anemia of inflammation associated with periodontitis: analysis of two clinical studies. J Periodontol 90(11):1252\u20131259. https:\/\/doi.org\/10.1002\/JPER.19-0124","journal-title":"J Periodontol"},{"issue":"4","key":"3318_CR14","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1189\/jlb.3VMR1014-468R","volume":"98","author":"G Hajishengallis","year":"2015","unstructured":"Hajishengallis G, Chavakis T, Hajishengallis E, Lambris JD (2015) Neutrophil homeostasis and inflammation: novel paradigms from studying periodontitis. J Leukoc Biol 98(4):539\u2013548. https:\/\/doi.org\/10.1189\/jlb.3VMR1014-468R","journal-title":"J Leukoc Biol"},{"issue":"2","key":"3318_CR15","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1111\/j.2041-1626.2010.00028.x","volume":"1","author":"V Naik","year":"2010","unstructured":"Naik V, Acharya A, Deshmukh VL, Shetty S, Shirhatti R (2010) Generalized, severe, chronic periodontitis is associated with anemia of chronic disease: a pilot study in urban, Indian males. J Investig Clin Dent 1(2):139\u2013143. https:\/\/doi.org\/10.1111\/j.2041-1626.2010.00028.x","journal-title":"J Investig Clin Dent"},{"issue":"1","key":"3318_CR16","doi-asserted-by":"publisher","first-page":"19","DOI":"10.4103\/0972-124X.128194","volume":"18","author":"MD Patel","year":"2014","unstructured":"Patel MD, Shakir QJ, Shetty A (2014) Interrelationship between chronic periodontitis and anemia: a 6-month follow-up study. J Indian Soc Periodontol 18(1):19\u201325. https:\/\/doi.org\/10.4103\/0972-124X.128194","journal-title":"J Indian Soc Periodontol"},{"issue":"3","key":"3318_CR17","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1055\/s-0039-1698963","volume":"6","author":"S Prakash","year":"2012","unstructured":"Prakash S, Dhingra K, Priya S (2012) Similar hematological and biochemical parameters among periodontitis and control group subjects. Eur J Dent 6(3):287\u2013294","journal-title":"Eur J Dent"},{"key":"3318_CR18","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.archoralbio.2018.10.024","volume":"97","author":"LFC Fran\u00e7a","year":"2019","unstructured":"Fran\u00e7a LFC, da Silva FRP, di Lenardo D, Alves EHP, Nascimento HMS, da Silva IAT et al (2019) Comparative analysis of blood parameters of the erythrocyte lineage between patients with chronic periodontitis and healthy patients: results obtained from a meta-analysis. Arch Oral Biol 97:144\u2013149. https:\/\/doi.org\/10.1016\/j.archoralbio.2018.10.024","journal-title":"Arch Oral Biol"},{"issue":"3","key":"3318_CR19","doi-asserted-by":"publisher","first-page":"e349","DOI":"10.4317\/medoral.20974","volume":"21","author":"FJ Silvestre","year":"2016","unstructured":"Silvestre FJ, Silvestre-Rangil J, Bag\u00e1n L, Bag\u00e1n JV (2016) Effect of nonsurgical periodontal treatment in patients with periodontitis and rheumatoid arthritis: a systematic review. Med Oral Patol Oral Cir Bucal 21(3):e349\u2013e354","journal-title":"Med Oral Patol Oral Cir Bucal"},{"issue":"2","key":"3318_CR20","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1124\/pr.114.009639","volume":"67","author":"S Siebert","year":"2015","unstructured":"Siebert S, Tsoukas A, Robertson J, McInnes I (2015) Cytokines as therapeutic targets in rheumatoid arthritis and other inflammatory diseases. Pharmacol Rev 67(2):280\u2013309. https:\/\/doi.org\/10.1124\/pr.114.009639","journal-title":"Pharmacol Rev"},{"issue":"12","key":"3318_CR21","doi-asserted-by":"publisher","first-page":"E492","DOI":"10.3390\/jcm7120492","volume":"7","author":"D Reinedahl","year":"2018","unstructured":"Reinedahl D, Chrcanovic B, Albrektsson T, Tengvall P, Wennerberg A (2018) Ligature-induced experimental peri-implantitis\u2014a systematic review. J Clin Med 7(12):E492. https:\/\/doi.org\/10.3390\/jcm7120492","journal-title":"J Clin Med"},{"key":"3318_CR22","doi-asserted-by":"publisher","first-page":"754857","DOI":"10.1155\/2011\/754857","volume":"2011","author":"HS Oz","year":"2011","unstructured":"Oz HS, Puleo DA (2011) Animal models for periodontal disease. J Biomed Biotechnol 2011:754857. https:\/\/doi.org\/10.1155\/2011\/754857","journal-title":"J Biomed Biotechnol"},{"key":"3318_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1600-051X.2011.01827.x","volume":"39","author":"T Berglundh","year":"2012","unstructured":"Berglundh T, Stavropoulos A (2012) Preclinical in vivo research in implant dentistry. Consensus of the eighth European workshop on periodontology. J Clin Periodontol 39:1\u20135. https:\/\/doi.org\/10.1111\/j.1600-051X.2011.01827.x","journal-title":"J Clin Periodontol"},{"key":"3318_CR24","doi-asserted-by":"publisher","first-page":"1190","DOI":"10.1016\/j.jcms.2017.05.025","volume":"45","author":"T Moest","year":"2017","unstructured":"Moest T, Wrede J, Schmitt CM, Stamp M, Neukam FW, Schlegel KA (2017) The influence of different abutment materials on tissue regeneration after surgical treatment of peri-implantitis\u2014a randomized controlled preclinical study. J Craniomaxillofac Surg 45:1190\u20131196. https:\/\/doi.org\/10.1016\/j.jcms.2017.05.025","journal-title":"J Craniomaxillofac Surg"},{"key":"3318_CR25","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1111\/clr.12067","volume":"24","author":"O Carcuac","year":"2013","unstructured":"Carcuac O, Abrahamsson I, Albouy JP, Linder E, Larsson L, Berglundh T (2013) Experimental periodontitis and peri-implantitis in dogs. Clin Oral Implants Res 24:363\u2013371. https:\/\/doi.org\/10.1111\/clr.12067","journal-title":"Clin Oral Implants Res"}],"container-title":["Clinical Oral Investigations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-020-03318-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00784-020-03318-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-020-03318-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,15]],"date-time":"2021-05-15T23:27:04Z","timestamp":1621121224000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00784-020-03318-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,16]]},"references-count":25,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["3318"],"URL":"https:\/\/doi.org\/10.1007\/s00784-020-03318-0","relation":{},"ISSN":["1432-6981","1436-3771"],"issn-type":[{"value":"1432-6981","type":"print"},{"value":"1436-3771","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,16]]},"assertion":[{"value":"24 February 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 April 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 May 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"Dr. Liat Chaushu is the founder of Implant B, Nazareth, Israel; Prof. Gavriel Chaushu and Prof. Haim Tal are on the scientific advisory board for Implant B, Nazareth, Israel; Dr. Blanca Fern\u00e1ndez-Tom\u00e9 and Prof. Anton Sculean report no conflicts of interest related to this study.Ethical approvalApproval number\u201420160927-3. The study procedures were reviewed and approved by the Ethical Committee of Animal Experimentation of Jesus Us\u00f3n Minimally Invasive Surgery Center (JUMISC) of Caceres, Spain, and authorized by the competent administration of the board of Extremadura, Spain, considering that the study is in accordance with the established in RD 53\/2013 of February 1, 2013 (Directive 2010\/63\/EU of the European Parliament and of the Council of September 22, 2010).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Not required. Animal study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}