{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T08:13:02Z","timestamp":1783671182558,"version":"3.55.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2020,6,4]],"date-time":"2020-06-04T00:00:00Z","timestamp":1591228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,6,4]],"date-time":"2020-06-04T00:00:00Z","timestamp":1591228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"University Medical Center Utrecht"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Oral Invest"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Objectives<\/jats:title>\n                <jats:p>Clinicians agree that children with isolated cleft lip have fewer cleft-associated problems than children with cleft lip and palate. Unfortunately, for isolated cleft lip children, the risk of cleft-associated problems is unknown and maybe underestimated. Often, these children do not get the required follow-up by a multidisciplinary team and thereby not the known benefits in supporting their development. This study examines the incidence of cleft-related speech problems and ear problems in children with isolated cleft lip.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Materials and methods<\/jats:title>\n                <jats:p>A prospective study was performed on all children born with an isolated cleft lip and treated at the Wilhelmina Children\u2019s Hospital in Utrecht between January 2007 and April 2014. Data were collected for sex, date of birth, genetics, cleft lip type, date of cleft lip repair, type of repair, speech\/language problems, and ear problems.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>This study included 75 patients (59% male). The mean age of the children at the moment of speech examination was 32.5\u00a0months (SD 6.1). Eighteen of the 75 children (24%) needed speech and language therapy; however, only one child (1.3%) had a cleft-related speech problem. Sixteen of the 75 patients (21%) reported a history of one or more episodes of acute otitis media (AOM)\/otitis media with effusion (OME) during the first 6\u00a0years.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion\/clinical relevance<\/jats:title>\n                <jats:p>This is the first prospective study analyzing the incidence of cleft-related speech problems in children with an isolated cleft lip. These children do not have a higher risk of cleft-related speech problems or AOM\/OME when compared to the general population. However, children with an isolated cleft do have a higher incidence of speech therapy.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00784-020-03367-5","type":"journal-article","created":{"date-parts":[[2020,6,4]],"date-time":"2020-06-04T11:02:41Z","timestamp":1591268561000},"page":"823-831","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Incidence of cleft-related speech problems in children with an isolated cleft lip"],"prefix":"10.1007","volume":"25","author":[{"given":"B. J. A.","family":"Smarius","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Haverkamp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"de Wilde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"van Wijck-Warnaar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. B.","family":"Mink van der Molen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. C.","family":"Breugem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,6,4]]},"reference":[{"key":"3367_CR1","first-page":"1058","volume":"138","author":"MP Van Den Berg","year":"1994","unstructured":"Van Den Berg MP, Hage JJ, Kortekaas RTJ, Bloem JJAM (1994) Schisis, een voortdurend probleem voor de pati\u00ebnt? Ned Tijdschr Geneeskd 138:1058\u20131061","journal-title":"Ned Tijdschr Geneeskd"},{"issue":"2","key":"3367_CR2","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1097\/00006534-199608000-00005","volume":"98","author":"RJ Rohrich","year":"1996","unstructured":"Rohrich RJ, Rowsell AR, Johns DF, Drury MA, Grieg G, Watson DJ, Godfrey AM, Poole MD (1996) Timing of hard palatal closure: a critical long-term analysis. Plast Reconstr Surg 98(2):236\u2013246","journal-title":"Plast Reconstr Surg"},{"key":"3367_CR3","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1016\/S0165-5876(03)00098-3","volume":"67","author":"P Sheahan","year":"2003","unstructured":"Sheahan P, Miller I, Sheahan JN, Earley MJ, Blayney AW (2003) Incidence and outcome of middle ear disease in cleft lip and\/or cleft palate. Int J Pediatr Otorhinolaryngol 67:785\u2013793","journal-title":"Int J Pediatr Otorhinolaryngol"},{"key":"3367_CR4","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1597\/05-185","volume":"44","author":"AG Masarei","year":"2007","unstructured":"Masarei AG, Sell D, Habel A, Mars M, Sommerlad BC, Wade A (2007) The nature of feeding in infants with unrepaired cleft lip and\/or palate compared with healthy noncleft infants. Cleft Palate Craniofac J 44:321\u2013328","journal-title":"Cleft Palate Craniofac J"},{"key":"3367_CR5","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1597\/06-207.1","volume":"45","author":"LD Vallino","year":"2008","unstructured":"Vallino LD, Zuker R, Napoli JA (2008) A study of speech, language, hearing, and dentition in children with cleft lip only. Cleft Palate\u2013Craniofacial J 45:485\u2013494","journal-title":"Cleft Palate\u2013Craniofacial J"},{"issue":"suppl","key":"3367_CR6","doi-asserted-by":"publisher","first-page":"9","DOI":"10.4103\/0970-0358.57182","volume":"42","author":"P Mossey","year":"2009","unstructured":"Mossey P, Little J (2009) Addressing the challenges of cleft lip and palate research in India. Indian J Plast Surg 42(suppl):9\u201318","journal-title":"Indian J Plast Surg"},{"issue":"1","key":"3367_CR7","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1597\/09-217","volume":"48","author":"IPDTOC Working Group","year":"2011","unstructured":"IPDTOC Working Group (2011 Jan) Prevalence at birth of cleft lip with or without cleft palate: data from the International Perinatal Database of Typical Oral Clefts (IPDTOC). Cleft Palate Craniofac J 48(1):66\u201381","journal-title":"Cleft Palate Craniofac J"},{"key":"3367_CR8","first-page":"93","volume":"9","author":"CD Bluestone","year":"1972","unstructured":"Bluestone CD, Wittel RA, Paradise JL (1972) Roentgenographic evaluation of Eustachian tube function in infants with cleft and normal palates. Cleft Palate J 9:93\u2013100","journal-title":"Cleft Palate J."},{"key":"3367_CR9","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1093\/infdis\/162.3.685","volume":"162","author":"DW Teele","year":"1990","unstructured":"Teele DW, Klein JO, Chase G, Menyuk P, Rosner BA, Greater Boston Otitis Media Study Group (1990) Otitis media in infancy and intellectual ability, school achievement, speech, and language at age 7 years. J Infect Dis 162:685\u2013694","journal-title":"J Infect Dis"},{"issue":"6","key":"3367_CR10","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1016\/j.bjps.2010.10.018","volume":"64","author":"JD Deelder","year":"2011","unstructured":"Deelder JD, Breugem CC, de Vries IA, de Bruin M, van der Molen AB M, van der Horst CM (2011 Jun) Is an isolated cleft lip an isolated anomaly? J Plast Reconstr Aesthet Surg 64(6):754\u2013758","journal-title":"J Plast Reconstr Aesthet Surg"},{"key":"3367_CR11","doi-asserted-by":"publisher","unstructured":"Spruijt NE, Widdershoven JC, Breugem CC, Speleman L, Homveld IL, Kon M, van der Molen AB M (2012) Velopharyngeal dysfunction and 22q11.2 deletion syndrome: a longitudinal study of functional outcome and preoperative prognostic factors. Cleft Palate Craniofac J 49(4):447\u2013455. https:\/\/doi.org\/10.1597\/10-049","DOI":"10.1597\/10-049"},{"issue":"5","key":"3367_CR12","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1016\/j.ijporl.2011.01.035","volume":"75","author":"P van der Heijden","year":"2011","unstructured":"van der Heijden P, Hobbel HH, van der Laan BF, Korsten-Meijer AG, Goorhuis-Brouwer SM (2011) Nasometry cooperation in children 4-6 years of age. Int J Pediatr Otorhinolaryngol 75(5):627\u2013630","journal-title":"Int J Pediatr Otorhinolaryngol"},{"key":"3367_CR13","first-page":"2014","volume":"16","author":"RP Venekamp","year":"2014","unstructured":"Venekamp RP, Damoiseaux RA, Schilder AG (2014) Acute otitis media in children. BMJ Clin Evid 16:2014","journal-title":"BMJ Clin Evid."},{"issue":"1","key":"3367_CR14","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1097\/01.PRS.0000169693.87591.9B","volume":"116","author":"DM Fisher","year":"2005","unstructured":"Fisher DM (2005) Unilateral cleft lip repair: an anatomical subunit approximation technique. Plast Reconstr Surg 116(1):61\u201371","journal-title":"Plast Reconstr Surg"},{"issue":"2","key":"3367_CR15","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1097\/00006534-195202000-00005","volume":"9","author":"CW Tennison","year":"1952","unstructured":"Tennison CW (1952) The repair of the unilateral cleft lip by the stencil method. Plast Reconstr Surg (1946) 9(2):115\u2013120","journal-title":"Plast Reconstr Surg (1946)"},{"issue":"2","key":"3367_CR16","doi-asserted-by":"publisher","first-page":"326e","DOI":"10.1097\/PRS.0000000000003535","volume":"140","author":"DC Kim","year":"2017","unstructured":"Kim DC, Mulliken JB (2017) Direct anthropometry of repaired bilateral complete cleft lip: a long-term assessment. Plast Reconstr Surg 140(2):326e\u2013332e","journal-title":"Plast Reconstr Surg"},{"key":"3367_CR17","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1597\/06-205.1","volume":"45","author":"YS Phua","year":"2008","unstructured":"Phua YS, de Chalain T (2008) Incidence of oronasal fistulae and velopharyngeal insufficiency after cleft palate repair: an audit of 211 children born between 1990 and 2004. Cleft Palate Craniofac J 45:172\u2013178","journal-title":"Cleft Palate Craniofac J"},{"key":"3367_CR18","doi-asserted-by":"crossref","unstructured":"Losken HW, van Aalst JA, Teotia SS, Dean SB, Hultman S, Uhrich KS (2011) Achieving low cleft palate fistula rates: surgical results and techniques. Cleft Palate Craniofac J 48:312\u2013320","DOI":"10.1597\/08-288"},{"key":"3367_CR19","unstructured":"\u00a0Tenenbaum M, Fowler E, Finazzo C, Grames LM, Kane A. Prevalence of speech and language disorders in patients with isolated cleft lip. Presented at the Annual Meeting of the American Cleft Palate-Craniofacial Association; April 2006; Vancouver, British Columbia"},{"key":"3367_CR20","doi-asserted-by":"crossref","unstructured":"Witt PD, Wahlen JC, Marsh JL, Grames LM, Pilgram TK (1998) The effect of surgeon experience on velopharyngeal functional outcome following palatoplasty: is there a learning curve? Plast Reconstr Surg 102(5):1375\u20131384","DOI":"10.1097\/00006534-199810000-00009"},{"key":"3367_CR21","unstructured":"Bicknell S, McFadden LR, Curran JB (2002 Dec) Frequency of pharyngoplasty after primary repair of cleft palate. J Can Dent Assoc 68(11):688\u2013692"},{"key":"3367_CR22","doi-asserted-by":"crossref","unstructured":"Mahoney MH, Swan MC, Fisher DM (2013) Prospective analysis of presurgical risk factors for outcomes in primary palatoplasty. Plast Reconstr Surg 132(1):165\u2013171","DOI":"10.1097\/PRS.0b013e3182910acb"},{"key":"3367_CR23","doi-asserted-by":"crossref","unstructured":"Stevenson J, Richman N (1976 Aug) The prevalence of language delay in a population of three-year-old children and its association with general retardation. Dev Med Child Neurol 18(4):431\u2013441","DOI":"10.1111\/j.1469-8749.1976.tb03682.x"},{"key":"3367_CR24","doi-asserted-by":"crossref","unstructured":"Silva PA (1980) The prevalence, stability and significance of developmental language delay in preschool children. Dev Med Child Neurol 22:768\u2013777","DOI":"10.1111\/j.1469-8749.1980.tb03743.x"},{"key":"3367_CR25","unstructured":"National Institute of Deafness and Other Communication Disorders (NIDCD). Statistics on voice, speech, and language. Available at:\u00a0http:\/\/www.nidcd.nih.gov\/health\/statistics\/vs1.asp. Accessed 5 June 2007"},{"key":"3367_CR26","doi-asserted-by":"crossref","unstructured":"Law J, Boyle J, Harris F, Harkness A, Nye C (2000) Prevalence and natural history of primary speech and language delay: findings from a systematic review of the literature. Int J Lang Com Dis 35:165\u2013188","DOI":"10.1080\/136828200247133"},{"key":"3367_CR27","doi-asserted-by":"crossref","unstructured":"Hannus S, Kauppila T, Launonen K (2009) Increasing prevalence of specific language impairment (SLI) in primary healthcare of a Finnish town, 1989-99. Int J Lang Commun Disord 44(1):79\u201397","DOI":"10.1080\/13682820801903310"},{"key":"3367_CR28","unstructured":"Riski JE, DeLong E (1984) Articulation development in children with cleft lip\/palate. Cleft Palate J 21:57\u201364"},{"key":"3367_CR29","unstructured":"Kono D, Young L, Hotmann B (1981) The association of submucous cleft palate and clefting of the primary palate. Cleft Palate J 18:207\u2013209"},{"key":"3367_CR30","doi-asserted-by":"crossref","unstructured":"Gosain AK, Conley SF, Santoro TD, Denny AD (1999) A prospective evaluation of the prevalence of submucous cleft palate in patients with isolated cleftlip versus controls. Plast Reconstr Surg 103(7):1857\u20131863","DOI":"10.1097\/00006534-199906000-00007"},{"key":"3367_CR31","doi-asserted-by":"crossref","unstructured":"Ruegg TA, Cooper ME, Leslie EJ, Ford MD, Wehby GL, Deleyiannis FWB, Czeizel AE, Hecht JT, Marazita ML, Weinberg SM (2017 Mar) Ear infection in isolated cleft lip: etiological implications. Cleft Palate Craniofac J 54(2):189\u2013192","DOI":"10.1597\/15-010"},{"key":"3367_CR32","unstructured":"Williamson I (2011) Otitis media with effusion in children. BMJ Clin Evid 2011:0502"},{"key":"3367_CR33","doi-asserted-by":"crossref","unstructured":"Hak E, Rovers MM, Kuyvenhoven MM, Schellevis FG, Verheij TJ (2006) Incidence of GP-diagnosed respiratory tract infections according to age, gender and high-risk co-morbidity: the Second Dutch National Survey of General Practice. Fam Pract 23:291\u2013294","DOI":"10.1093\/fampra\/cmi121"},{"key":"3367_CR34","doi-asserted-by":"crossref","unstructured":"Gribben B, Salkeld LJ, Hoare S, Jones HF (2012) The incidence of acute otitis media in New Zealand children under five years of age in the primary care setting. J Prim Health Care 4:205\u2013212","DOI":"10.1071\/HC12205"},{"key":"3367_CR35","doi-asserted-by":"crossref","unstructured":"Marchisio P, Cantarutti L, Sturkenboom M, Girotto S, Picelli G, Dona D, Scamarcia A, Villa M, Giaquinto C, Pedianet (2012) Burden of acute otitis media in primary care pediatrics in Italy: a secondary data analysis from the Pedianet database. BMC Pediatr 12:185","DOI":"10.1186\/1471-2431-12-185"},{"key":"3367_CR36","doi-asserted-by":"crossref","unstructured":"Liese JG, Silfverdal SA, Giaquinto C et al (2014) Incidence and clinical presentation of acute otitis media in children aged <6 years in European medical practices. Epidemiol Infect 142:1778\u20131782","DOI":"10.1017\/S0950268813002744"},{"key":"3367_CR37","doi-asserted-by":"crossref","unstructured":"de Hoog MLA, Fortanier AC, Smit HA et al (2016) Impact of early-onset acute otitis media on multiple recurrences and associated health care use. J Pediatr 177:286\u2013291.e1","DOI":"10.1016\/j.jpeds.2016.06.066"},{"key":"3367_CR38","doi-asserted-by":"crossref","unstructured":"Lohmander A, Olsson M (2004) Methodology for perceptual assessment of speech in patients with cleft palate: a critical review of the literature. Cleft Palate Craniofac J 41:64\u201370","DOI":"10.1597\/02-136"}],"container-title":["Clinical Oral Investigations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-020-03367-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00784-020-03367-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-020-03367-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,3]],"date-time":"2021-06-03T23:57:46Z","timestamp":1622764666000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00784-020-03367-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,4]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["3367"],"URL":"https:\/\/doi.org\/10.1007\/s00784-020-03367-5","relation":{},"ISSN":["1432-6981","1436-3771"],"issn-type":[{"value":"1432-6981","type":"print"},{"value":"1436-3771","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,4]]},"assertion":[{"value":"25 March 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 May 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 June 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"Author BS declares that he has no conflict of interest.Author SH declares that he has no conflict of interest.Author HW declares that he has no conflict of interest.Author AW declares that he has no conflict of interest.Author AM declares that he has no conflict of interest.Author CB declares that he has no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This article does not contain any studies with human participants or animals performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"For this type of study, formal consent is not required.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}