{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T16:33:01Z","timestamp":1780590781824,"version":"3.54.1"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2020,7,4]],"date-time":"2020-07-04T00:00:00Z","timestamp":1593820800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,7,4]],"date-time":"2020-07-04T00:00:00Z","timestamp":1593820800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Singhealth Oral Health ACP","award":["BCR\/CY17\/12"],"award-info":[{"award-number":["BCR\/CY17\/12"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Oral Invest"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1007\/s00784-020-03439-6","type":"journal-article","created":{"date-parts":[[2020,7,4]],"date-time":"2020-07-04T16:02:26Z","timestamp":1593878546000},"page":"1327-1335","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Pulpal upregulation of connexin 43 during pulpitis"],"prefix":"10.1007","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9926-7922","authenticated-orcid":false,"given":"Wen Yi","family":"Lim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leigh Edward","family":"Madden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David Laurence","family":"Becker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,7,4]]},"reference":[{"issue":"3","key":"3439_CR1","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1111\/j.1600-0722.2010.00731.x","volume":"118","author":"L Bj\u00f8rndal","year":"2010","unstructured":"Bj\u00f8rndal L, Reit C, Bruun G et al (2010) Treatment of deep caries lesions in adults: randomized clinical trials comparing stepwise vs. direct complete excavation, and direct pulp capping vs. partial pulpotomy. Eur J Oral Sci 118(3):290\u2013297","journal-title":"Eur J Oral Sci"},{"issue":"3","key":"3439_CR2","first-page":"383","volume":"46","author":"NA Taha","year":"2018","unstructured":"Taha NA, Abdelkhader SZ (2018) Outcome of full pulpotomy using biodentine in adult patients with symptoms indicative of irreversible pulpitis. Int Endod J 46(3):383\u2013390","journal-title":"Int Endod J"},{"issue":"3","key":"3439_CR3","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/j.joen.2019.11.009","volume":"46","author":"SY Tan","year":"2020","unstructured":"Tan SY, Yu VSH, Lim KC, Tan BCK, Neo CLJ, Shen L, Messer HH (2020) Long-term pulpal and restorative outcomes of pulpotomy in mature permanent teeth. J Endod 46(3):383\u2013390","journal-title":"J Endod"},{"key":"3439_CR4","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1146\/annurev.bi.65.070196.002355","volume":"65","author":"A Goodenough Daniel","year":"1996","unstructured":"Goodenough Daniel A, Goliger JA, Paul DL (1996) Connexins, connexons, and intercellular communication. Annu Rev Biochem 65:475\u2013502","journal-title":"Annu Rev Biochem"},{"key":"3439_CR5","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.semcdb.2015.12.009","volume":"50","author":"DL Becker","year":"2016","unstructured":"Becker DL, Phillips AR, Duft BJ, Kim Y, Green CR (2016) Translating connexin biology into therapeutics. Semin Cell Dev Biol 50:49\u201358","journal-title":"Semin Cell Dev Biol"},{"issue":"6 I","key":"3439_CR6","doi-asserted-by":"publisher","first-page":"2621","DOI":"10.1083\/jcb.105.6.2621","volume":"105","author":"EC Beyer","year":"1987","unstructured":"Beyer EC, Paul DL, Goodenough DA (1987) Connexin43: a protein from rat heart homologous to a gap junction protein from liver. J Cell Biol 105(6 I):2621\u20132629","journal-title":"J Cell Biol"},{"key":"3439_CR7","first-page":"215","volume":"2005","author":"JC S\u00e1ez","year":"1711","unstructured":"S\u00e1ez JC, Retamal MA, Basilio D et al (1711) Connexin-based gap junction hemichannels: gating mechanisms. Biochim Biophys Acta - Biomembr 2005:215\u2013224","journal-title":"Biochim Biophys Acta - Biomembr"},{"issue":"1","key":"3439_CR8","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1038\/cdd.2008.138","volume":"16","author":"E Decrock","year":"2009","unstructured":"Decrock E, De Vuyst E, Vinken M et al (2009) Connexin 43 hemichannels contribute to the propagation of apoptotic cell death in a rat C6 glioma cell model. Cell Death Differ 16(1):151\u2013163","journal-title":"Cell Death Differ"},{"key":"3439_CR9","first-page":"100","volume":"18","author":"L Ebihara","year":"2003","unstructured":"Ebihara L (2003) New roles for connexons. News Physiol Sci 18:100\u2013103","journal-title":"News Physiol Sci"},{"key":"3439_CR10","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1083\/jcb.148.5.1063","volume":"148","author":"AP Quist","year":"2000","unstructured":"Quist AP, Rhee SK, Lin H, Lal R (2000) Physiological role of gap-junctional hemichannels: extracellular calcium-dependent isosmotic volume regulation. J Cell Biol 148:1063\u20131074","journal-title":"J Cell Biol"},{"key":"3439_CR11","first-page":"5274","volume":"53","author":"SM Freeman","year":"1993","unstructured":"Freeman SM (1993) Abboud Camille, Freeman Scott M., et al. The \u201cbystander effect\u201d: tumor regression when a fraction of the tumor mass is genetically modified. Cancer Res 53:5274\u20135283","journal-title":"Cancer Res"},{"key":"3439_CR12","doi-asserted-by":"crossref","unstructured":"Lin Jane HC, Weigel H, Cotrina ML et al (199) Gap-junction-mediated propagation and amplification of cell injury. Nat Neurosci 81(8):494\u2013500","DOI":"10.1038\/2210"},{"key":"3439_CR13","first-page":"985","volume":"995","author":"KAJ Fried","year":"1996","unstructured":"Fried KAJ, Mitsiadis TA, Guerrier A, Haegerstrand A, Meister B (1996) Combinatorial expression patterns of the connexins and regeneration of rat teeth. Int J Dev Biol 995:985\u2013995","journal-title":"Int J Dev Biol"},{"issue":"2\u20133","key":"3439_CR14","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1080\/03008200290000952","volume":"43","author":"I About","year":"2002","unstructured":"About I, Proust JP, Raffo S et al (2002) In vivo and in vitro expression of connexin 43 in human teeth. Connect Tissue Res 43(2\u20133):232\u2013237","journal-title":"Connect Tissue Res"},{"issue":"4","key":"3439_CR15","doi-asserted-by":"publisher","first-page":"1901","DOI":"10.2353\/ajpath.2010.100073","volume":"177","author":"RM Farahani","year":"2010","unstructured":"Farahani RM, Nguyen KA, Simonian M, Hunter N (2010) Adaptive calcified matrix response of dental pulp to bacterial invasion is associated with establishment of a network of glial fibrillary acidic protein+\/glutamine synthetase+ cells. Am J Pathol 177(4):1901\u20131914","journal-title":"Am J Pathol"},{"issue":"8","key":"3439_CR16","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1177\/0022034514539507","volume":"93","author":"E Couve","year":"2014","unstructured":"Couve E, Osorio R, Schmachtenberg O (2014) Reactionary dentinogenesis and neuroimmune response in dental caries. J Dent Res 93(8):788\u2013793","journal-title":"J Dent Res"},{"issue":"4","key":"3439_CR17","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1177\/0022034513478430","volume":"92","author":"H Ikeda","year":"2013","unstructured":"Ikeda H, Suda H (2013) Odontoblastic syncytium through electrical coupling in the human dental pulp. J Dent Res 92(4):371\u2013375","journal-title":"J Dent Res"},{"issue":"1","key":"3439_CR18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.yexcr.2015.09.008","volume":"338","author":"S Li","year":"2015","unstructured":"Li S, He H, Zhang G, Wang F, Zhang P, Tan Y (2015) Connexin43-containing gap junctions potentiate extracellular Ca2+\u2212induced odontoblastic differentiation of human dental pulp stem cells via Erk1\/2. Exp Cell Res 338(1):1\u20139","journal-title":"Exp Cell Res"},{"issue":"5","key":"3439_CR19","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1007\/s004290100166","volume":"203","author":"S Murakami","year":"2001","unstructured":"Murakami S, Muramatsu T, Shimono M (2001) Expression and localization of connexin 43 in rat incisor odontoblasts. Anat Embryol (Berl) 203(5):367\u2013374","journal-title":"Anat Embryol (Berl)"},{"issue":"3","key":"3439_CR20","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1007\/s10495-005-1875-2","volume":"10","author":"DV Krysko","year":"2005","unstructured":"Krysko DV, Leybaert L, Vandenabeele P, D\u2019Herde K (2005) Gap junctions and the propagation of cell survival and cell death signals. Apoptosis 10(3):459\u2013469","journal-title":"Apoptosis"},{"key":"3439_CR21","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1038\/nrm1150","volume":"4","author":"S Orrenius","year":"2003","unstructured":"Orrenius S, Zhivotovsky B, Nicotera P (2003) Regulation of cell death: the calcium-apoptosis link. Nat Rev Mol Cell Biol 4:552\u2013565","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"10","key":"3439_CR22","doi-asserted-by":"publisher","first-page":"3579","DOI":"10.1161\/01.CIR.96.10.3579","volume":"96","author":"D Garcia-Dorado","year":"1997","unstructured":"Garcia-Dorado D, Inserte J, Ruiz-Meana M et al (1997) Gap junction uncoupler heptanol prevents cell-to-cell progression of hypercontracture and limits necrosis during myocardial reperfusion. Circulation 96(10):3579\u20133586","journal-title":"Circulation"},{"issue":"3","key":"3439_CR23","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1016\/j.cardiores.2003.11.039","volume":"61","author":"D Garc\u00eda-Dorado","year":"2004","unstructured":"Garc\u00eda-Dorado D, Rodr\u00edguez-Sinovas A, Ruiz-Meana M (2004) Gap junction-mediated spread of cell injury and death during myocardial ischemia-reperfusion. Cardiovasc Res 61(3):386\u2013401","journal-title":"Cardiovasc Res"},{"issue":"RC114","key":"3439_CR24","first-page":"1","volume":"20","author":"HS Duffy","year":"2000","unstructured":"Duffy HS, John GR, Lee SC et al (2000) Reciprocal regulation of the junctional proteins claudin-1 and connexin43 by interleukin-1beta in primary human fetal astrocytes. J Neurosci 20(RC114):1\u20136","journal-title":"J Neurosci"},{"key":"3439_CR25","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1091\/mbc.e06-03-0182","volume":"18","author":"E De Vuyst","year":"2007","unstructured":"De Vuyst E, Decrock E, De Bock M et al (2007) Connexin hemichannels and gap junction channels are differentially influenced by lipopolysaccharide and basic fibroblast growth factor. Mol Biol Cell 18:34\u201346","journal-title":"Mol Biol Cell"},{"key":"3439_CR26","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1085\/jgp.200509397","volume":"27","author":"M Srinivas","year":"2006","unstructured":"Srinivas M, Calderon DP, Kronengold J, Verselis VK (2006) Regulation of connexin hemichannels by monovalent cations. J Gen Physiol 27:67\u201375","journal-title":"J Gen Physiol"},{"key":"3439_CR27","doi-asserted-by":"publisher","first-page":"355","DOI":"10.4248\/BR201304006","volume":"1","author":"MA Riquelme","year":"2013","unstructured":"Riquelme MA, Jiang JX (2013) Elevated intracellular Ca2+ signals by oxidative stress activate connexin 43 hemichannels in osteocytes. Bone Res 1:355\u2013361","journal-title":"Bone Res"},{"key":"3439_CR28","doi-asserted-by":"publisher","first-page":"1752","DOI":"10.1089\/ten.tea.2014.0651","volume":"21","author":"BW Calder","year":"2015","unstructured":"Calder BW, Matthew RJ, Bainbridge H et al (2015) Inhibition of connexin 43 hemichannel-mediated ATP release attenuates early Inflammation during the foreign body response. Tissue Eng - Part A 21:1752\u20131762","journal-title":"Tissue Eng - Part A"},{"key":"3439_CR29","first-page":"1","volume-title":"Advances in Protein Chemistry and Structural Biology","author":"Y Kim","year":"2016","unstructured":"Kim Y, Davidson JO, Gunn KC, Phillips AR et al (2016) Role of hemichannels in CNS inflammation and the inflammasome pathway. In: Rossen D (ed) Advances in Protein Chemistry and Structural Biology, vol 104. Academic Press Inc., San Diego, pp 1\u201337"},{"key":"3439_CR30","first-page":"197","volume":"2005","author":"M Chanson","year":"1711","unstructured":"Chanson M, Derouette JP, Roth I et al (1711) Gap junctional communication in tissue inflammation and repair. Biochim Biophys Acta - Biomembr 2005:197\u2013207","journal-title":"Biochim Biophys Acta - Biomembr"},{"issue":"1","key":"3439_CR31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-017-17765-5","volume":"8","author":"W Li","year":"2018","unstructured":"Li W, Bao G, Chen W et al (2018) Connexin 43 hemichannel as a novel mediator of sterile and infectious inflammatory diseases. Sci Rep 8(1):1\u20135","journal-title":"Sci Rep"},{"key":"3439_CR32","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1038\/s41418-018-0212-6","volume":"26","author":"D Frank","year":"2019","unstructured":"Frank D, Vince JE (2019) Pyroptosis versus necroptosis: similarities, differences, and crosstalk. Cell Death Differ 26:99\u2013114","journal-title":"Cell Death Differ"}],"container-title":["Clinical Oral Investigations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-020-03439-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00784-020-03439-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-020-03439-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,3]],"date-time":"2021-07-03T23:32:24Z","timestamp":1625355144000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00784-020-03439-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,4]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["3439"],"URL":"https:\/\/doi.org\/10.1007\/s00784-020-03439-6","relation":{},"ISSN":["1432-6981","1436-3771"],"issn-type":[{"value":"1432-6981","type":"print"},{"value":"1436-3771","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,4]]},"assertion":[{"value":"30 March 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 June 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 July 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by Singhealth CIRB2017\/2343 and informed consent was obtained from all patients. Animal ethics was received (NTU-IACUC\/A18035) for the animal experimentation involved in this study and was in accordance with the ARRIVE guidelines.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants in this study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}