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He might present indirect conflict of interest due to the persona fees for lecturing from Colgate, Dentium, Mozograu, Camlog and EMS.Author Elena Figuero declares that he has no conflict of interest with this research. She might present indirect conflict of interest due to the persona fees for lecturing from Colgate, Dentaid, Oral-B and Straumann.Author Bettina Alonso declares that he has no conflict of interest with this research Dentium, Mozograu, Camlog and EMS.Author Mariano Sanz declares that he has no conflict of interest with this research. He might present indirect conflict of interest due to the persona fees for lecturing from Dentaid, Oral-B, and Straumann; and due to grants (research contracts in university) from Dentsply and IMS outside the submitted work.Author David Herrera declares that he has no conflict of interest with this research. He might present indirect conflict of interest due to the personal fees for lecturing from Oral-B, Straumman, Klockner, Dexcel, Dentaid and Colgate; and due to grants from Kulzer outside the submitted work.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in the study participants were in accordance with the ethical standards of an institutional ethical committee (C.I. 15\/064, Comit\u00e9 de Ensayos Cl\u00ednicos del Hospital Cl\u00ednico de San Carlos, Madrid) and with the 1964 Helsinki declaration.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"All the included patients signed an informed consent which was previously approved by an institutional ethic committee.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}