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Statistical significance level was 0.05.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>A total of 56 participants in OMJ (<jats:italic>N<\/jats:italic>\u00a0=\u200930) and GC (<jats:italic>N<\/jats:italic>\u00a0=\u200926) groups completed the study. OMJ significantly increased saliva pH (<jats:italic>p<\/jats:italic>\u00a0=\u20090.042) and BC (<jats:italic>p<\/jats:italic>\u00a0=\u20090.013) after 1-month use, while GC only improved saliva pH (<jats:italic>p<\/jats:italic>\u00a0=\u20090.027). Both interventions tended to increase SSFR but only GC had a significant increase at 2\u00a0months (<jats:italic>p<\/jats:italic>\u00a0=\u20090.015). GC and OMJ significantly decreased the number of <jats:italic>Candida<\/jats:italic> species at 1 and 2\u00a0months, respectively. Both groups tended to reduce <jats:italic>Candida<\/jats:italic> counts but not significant.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Both OMJ and GC saliva gels could improve saliva pH and decrease the number of <jats:italic>Candida<\/jats:italic> species. OMJ is superior to GC in its buffering capacity, while GC may better improve salivary flow rate. Long-term and large-scale study is warranted to test the efficacy of artificial saliva in oral health improvement.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Clinical relevance<\/jats:title>\n                <jats:p>OMJ and GC gel could decrease the number of <jats:italic>Candida<\/jats:italic> species and improve saliva properties in post-radiation xerostomic patients.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Trial registration number<\/jats:title>\n                <jats:p><jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/clinicaltrials.gov\">Clinicaltrials.gov<\/jats:ext-link> NCT03035825. Date of registration: 25th January 2017.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00784-020-03484-1","type":"journal-article","created":{"date-parts":[[2020,8,10]],"date-time":"2020-08-10T18:03:55Z","timestamp":1597082635000},"page":"1815-1827","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Efficacy of gel-based artificial saliva on Candida colonization and saliva properties in xerostomic post-radiotherapy head and neck cancer patients: a randomized controlled trial"],"prefix":"10.1007","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6673-8831","authenticated-orcid":false,"given":"Aroonwan","family":"Lam-ubol","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oranart","family":"Matangkasombut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dunyaporn","family":"Trachootham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Supanat","family":"Tarapan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanthana","family":"Sattabanasuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sineepat","family":"Talungchit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wannaporn","family":"Paemuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tawaree","family":"Phonyiam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orapin","family":"Chokchaitam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"On-ong","family":"Mungkung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,8,10]]},"reference":[{"issue":"9","key":"3484_CR1","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1002\/hed.20045","volume":"26","author":"MS Chambers","year":"2004","unstructured":"Chambers MS, Garden AS, Kies MS, Martin JW (2004) Radiation-induced xerostomia in patients with head and neck cancer: pathogenesis, impact on quality of life, and management. 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