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However, it is unclear how <jats:italic>c-Fos<\/jats:italic> regulates orthodontic tooth movement (OTM) in vivo. The aim of this study was therefore to analyse OTM in transgenic mice with overexpression of <jats:italic>c-Fos<\/jats:italic>.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Materials and methods<\/jats:title>\n                <jats:p>We employed <jats:italic>c-Fos<\/jats:italic> transgenic mice (<jats:italic>c-Fos<\/jats:italic> tg) and wild-type littermates (WT) in a model of OTM induced by Nitinol tension springs that were bonded between the left first maxillary molars and the upper incisors. The unstimulated contralateral side served as an internal control. Mice were analysed by contact radiography, micro-computed tomography, decalcified histology and histochemistry.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Our analysis of the unstimulated side revealed that alveolar bone and root morphology were similar between c<jats:italic>-Fos<\/jats:italic> tg and control mice. However, we observed more osteoclasts in the alveolar bone of <jats:italic>c-Fos<\/jats:italic> tg mice as tartrate-resistant acid phosphatase (TRAP)-positive cells were increased by 40%. After 12 days of OTM, <jats:italic>c-Fos<\/jats:italic> tg mice exhibited 62% increased tooth movement as compared with WT mice. Despite the faster tooth movement, <jats:italic>c-Fos<\/jats:italic> tg and WT mice displayed the same amount of root resorption. Importantly, we did not observe orthodontically induced tissue necrosis (i.e. hyalinization) in <jats:italic>c-Fos<\/jats:italic> tg mice, while this was a common finding in WT mice.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Overexpression of c-Fos accelerates tooth movement without causing more root resorption.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Clinical relevance<\/jats:title>\n                <jats:p>Accelerated tooth movement must not result in more root resorption as higher tissue turnover may decrease the amount of mechanically induced tissue necrosis.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00784-020-03503-1","type":"journal-article","created":{"date-parts":[[2020,8,15]],"date-time":"2020-08-15T12:02:21Z","timestamp":1597492941000},"page":"593-601","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Role of c-Fos in orthodontic tooth movement: an in vivo study using transgenic mice"],"prefix":"10.1007","volume":"25","author":[{"given":"Maximilian G.","family":"Decker","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cita","family":"Nottmeier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Luther","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anke","family":"Baranowsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00e4rbel","family":"Kahl-Nieke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Amling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thorsten","family":"Schinke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Pierre","family":"David","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1093-1752","authenticated-orcid":false,"given":"Till","family":"Koehne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,8,15]]},"reference":[{"key":"3503_CR1","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1007\/s11914-018-0448-6","volume":"16","author":"GR Paul","year":"2018","unstructured":"Paul GR, Malhotra A, M\u00fcller R (2018) Mechanical stimuli in the local in vivo environment in bone: computational approaches linking organ-scale loads to cellular signals. 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