{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T01:37:24Z","timestamp":1785893844142,"version":"3.56.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2020,8,22]],"date-time":"2020-08-22T00:00:00Z","timestamp":1598054400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,8,22]],"date-time":"2020-08-22T00:00:00Z","timestamp":1598054400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Federal State of Mecklenburg\u2013West Pomerania, Germany"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Oral Invest"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Objectives<\/jats:title>\n                <jats:p>We aimed at investigating whether the interaction between the local inflammation, periodontitis, and obesity is independently associated with systemic inflammation.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>From the population-based Study of Health in Pomerania, 3366 participants, without (2366) and with (1000) obesity, were studied for the association of periodontitis, measured as probing depth (PD) and plaque together with body mass index (BMI) on C-reactive protein (CRP). Quantile regression was used to evaluate the association between periodontal, anthropometric, and inflammatory variables (outcomes).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The overall prevalence of obesity in this adult population was 31.4% in men and 28.1% in women. Both PD and plaque were positively associated with CRP, revealing an increasing impact across the CRP concentration distribution. Adjusting the regression of CRP or fibrinogen on PD for waist circumference attenuated but did not abolish the PD coefficients. Dental plaque was similarly associated with these interrelations. Association between PD and a dental plaque was different among participants with low-, medium-, or high-risk CRP concentrations.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Local and systemic sources of inflammation contribute to blood levels of inflammatory markers. The respective contributions depend on the relative rate in each of the inflammation-inducing risks and are dominated by adiposity.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Clinical relevance<\/jats:title>\n                <jats:p>Keeping systemic inflammation low in order to prevent age-related disease sequelae.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00784-020-03514-y","type":"journal-article","created":{"date-parts":[[2020,8,22]],"date-time":"2020-08-22T03:43:21Z","timestamp":1598067801000},"page":"2045-2053","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Competing interplay between systemic and periodontal inflammation: obesity overrides the impact of oral periphery"],"prefix":"10.1007","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0243-2435","authenticated-orcid":false,"given":"Peter","family":"Meisel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiane","family":"Pink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinay","family":"Pitchika","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Nauck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"V\u00f6lzke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Kocher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,8,22]]},"reference":[{"key":"3514_CR1","doi-asserted-by":"publisher","first-page":"1718","DOI":"10.1038\/oby.2011.291","volume":"20","author":"M Jimenez","year":"2012","unstructured":"Jimenez M, Hu FB, Marino M, Li Y, Joshipura KJ (2012) Prospective associations between measures of adiposity and periodontal disease. Obesity 20:1718\u20131725. https:\/\/doi.org\/10.1038\/oby.2011.291","journal-title":"Obesity"},{"key":"3514_CR2","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/j.pcad.2013.10.016","volume":"56","author":"M Bastien","year":"2014","unstructured":"Bastien M, Poirier P, Lemieux I, Despr\u00e9s JP (2014) Overview of epidemiology and contribution of obesity to cardiovascular disease. Prog Cardiovasc Dis 56:369\u2013381. https:\/\/doi.org\/10.1016\/j.pcad.2013.10.016","journal-title":"Prog Cardiovasc Dis"},{"key":"3514_CR3","doi-asserted-by":"publisher","first-page":"e381","DOI":"10.1111\/j.1467-789X.2010.00808.x","volume":"12","author":"J Suvan","year":"2011","unstructured":"Suvan J, D\u2019Aiuto F, Moles DR, Petrie A, Donos N (2011) Association between overweight\/obesity and periodontitis in adults. A systematic review. Obes Rev 12:e381\u2013e404. https:\/\/doi.org\/10.1111\/j.1467-789X.2010.00808.x","journal-title":"Obes Rev"},{"key":"3514_CR4","doi-asserted-by":"publisher","first-page":"777","DOI":"10.2169\/internalmedicine.9578-17","volume":"57","author":"N Aoyama","year":"2018","unstructured":"Aoyama N, Suzuki JI, Kobayas hi N, Hanatani T, Ashigaki N, Yoshida A, Shiheido Y, Sato H, Kumagai H et al (2018) Japanese cardiovascular disease patients with diabetes mellitus suffer increased tooth loss in comparison to those without diabetes mellitus -a cross-sectional study. Intern Med 57:777\u2013782. https:\/\/doi.org\/10.2169\/internalmedicine.9578-17","journal-title":"Intern Med"},{"key":"3514_CR5","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1016\/j.numecd.2019.03.010","volume":"29","author":"T Christen","year":"2019","unstructured":"Christen T, Trompet S, Rensen PCN, Willems van Dijk K, Lamb HJ, Jukema JW, Rosendaal FR, le Cessie S, de Mutsert R (2019) The role of inflammation in the association between overall and visceral and subclinical atherosclerosis. Nutr Metab Cardiovasc Dis 29:728\u2013735. https:\/\/doi.org\/10.1016\/j.numecd.2019.03.010","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"3514_CR6","doi-asserted-by":"publisher","first-page":"1776","DOI":"10.1002\/oby.21945","volume":"25","author":"S Gra\u00dfmann","year":"2017","unstructured":"Gra\u00dfmann S, Wirsching J, Eichelmann F, Aleksandrova K (2017) Association between peripheral adipokines and inflammation markers: a systematic review and meta-analysis. Obesity 25:1776\u20131785. https:\/\/doi.org\/10.1002\/oby.21945","journal-title":"Obesity"},{"key":"3514_CR7","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1111\/jcpe.13149","volume":"46","author":"K Torrungruang","year":"2019","unstructured":"Torrungruang K, Katudat D, Mahanonda R, Sritara P, Udomsak A (2019) Periodontitis is associated with elevated serum levels of cardiac biomarkers \u2013 soluble ST2 and C-reactive protein. J Clin Periodontol 46:809\u2013818. https:\/\/doi.org\/10.1111\/jcpe.13149","journal-title":"J Clin Periodontol"},{"key":"3514_CR8","doi-asserted-by":"publisher","first-page":"1708","DOI":"10.1902\/jop.2010.100321","volume":"81","author":"BW Chaffee","year":"2010","unstructured":"Chaffee BW, Weston SJ (2010) Association between chronic periodontal disease and obesity: a systematic review and meta-analysis. J Periodontol 81:1708\u20131724. https:\/\/doi.org\/10.1902\/jop.2010.100321","journal-title":"J Periodontol"},{"key":"3514_CR9","doi-asserted-by":"publisher","first-page":"4801418","DOI":"10.1155\/2016\/4801418","volume":"2016","author":"Z Akram","year":"2016","unstructured":"Akram Z, Abduljabbar T, Abu Hassan MI, Javed F, Vohra F (2016) Cytokine profile in chronic periodontitis patients with and without obesity. A systematic review and meta-analysis. Dis Markers 2016:4801418. https:\/\/doi.org\/10.1155\/2016\/4801418","journal-title":"Dis Markers"},{"key":"3514_CR10","first-page":"4","volume":"17","author":"JP Bastard","year":"2006","unstructured":"Bastard JP, Maachi M, Lagathu C, Kim MJ, Caron M, Vidal H, Capeau J, Feve B (2006) Recent advances in the relationship between obesity, inflammation, and insulin resistance. Eur Cytokine Netw 17:4\u201312","journal-title":"Eur Cytokine Netw"},{"key":"3514_CR11","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1111\/prd.12135","volume":"72","author":"JL Ebersole","year":"2016","unstructured":"Ebersole JL, Graves CL, Gonzalez OA, Dawson D, Morford LA, Huja PE, Hartsfield JK, Huja SS, Pandruvada S, Wallet SM (2016) Aging, inflammation, immunity and periodontal disease. Periodontology 2000 72:54\u201375. https:\/\/doi.org\/10.1111\/prd.12135","journal-title":"Periodontology 2000"},{"key":"3514_CR12","doi-asserted-by":"publisher","first-page":"e12991","DOI":"10.1111\/obr.12991","volume":"21","author":"BT Tam","year":"2010","unstructured":"Tam BT, Morais JA, Santosa S (2010) Obesity and ageing: two sides of the same coin. Obes Rev 21:e12991. https:\/\/doi.org\/10.1111\/obr.12991","journal-title":"Obes Rev"},{"key":"3514_CR13","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1159\/000345045","volume":"5","author":"P Marques-Vidal","year":"2012","unstructured":"Marques-Vidal P, Bochud M, Bastardot F, L\u00fcscher T, Ferrero F, Gaspoz JM, Paccaud F, Urwyler A, van K\u00e4nel R et al (2012) Association between inflammatory and obesity markers in a Swiss population-based sample (CoLaus Study). Obes Facts 5:734\u2013744. https:\/\/doi.org\/10.1159\/000345045","journal-title":"Obes Facts"},{"key":"3514_CR14","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.3945\/ajcn.2008.27030","volume":"89","author":"A Cartier","year":"2009","unstructured":"Cartier A, Cot\u00e9 M, Lemieux I, Perusse L, Tremblay A, Bouchard C, Despr\u00e9s JP (2009) Sex differences in inflammatory markers: what is the contribution of visceral adiposity? Am J Clin Nutr 89:1307\u20131314. https:\/\/doi.org\/10.3945\/ajcn.2008.27030","journal-title":"Am J Clin Nutr"},{"key":"3514_CR15","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1038\/oby.2011.218","volume":"20","author":"P Meisel","year":"2012","unstructured":"Meisel P, Wilke P, Biffar R, Holtfreter B, Wallaschofski H, Kocher T (2012) Total tooth loss and systemic correlates of inflammation: role of obesity. Obesity 20:644\u2013650. https:\/\/doi.org\/10.1038\/oby.2011.218","journal-title":"Obesity"},{"key":"3514_CR16","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1093\/ije\/dyp394","volume":"40","author":"H V\u00f6lzke","year":"2011","unstructured":"V\u00f6lzke H, Alte D, Schmidt CO, Radke D, Lorbeer R, Friedrich N, Aumann N, Lau K, Piontek M, Born G et al (2011) Cohort profile: the Study of Health in Pomerania. Int J Epidemiol 40:294\u2013307. https:\/\/doi.org\/10.1093\/ije\/dyp394","journal-title":"Int J Epidemiol"},{"key":"3514_CR17","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1007\/s13679-019-00359-9","volume":"8","author":"C Koliaki","year":"2019","unstructured":"Koliaki C, Liatis S, Dalamaga M, Kokkinos A (2019) Sarcopenic obesity: epidemiological evidence, pathophysiology, and therapeutic perspectives. Curr Obes Rep 8:458\u2013471. https:\/\/doi.org\/10.1007\/s13679-019-00359-9","journal-title":"Curr Obes Rep"},{"key":"3514_CR18","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1093\/pcmedi\/pbz007","volume":"2","author":"HG Hong","year":"2019","unstructured":"Hong HG, Christiani DC, Li Y (2019) Quantile regression for survival data in modern cancer research: expanding statistical tools for precision medicine. Precis Clin Med 2:90\u201399. https:\/\/doi.org\/10.1093\/pcmedi\/pbz007","journal-title":"Precis Clin Med"},{"key":"3514_CR19","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1080\/1354750X.2018.1501763","volume":"24","author":"X Bi","year":"2019","unstructured":"Bi X, Loo YT, Ponnalagu S, Henry CJ (2019) Obesity is an independent determinant of elevated C-reactive protein in healthy women but not men. Biomarkers 24:64\u201369. https:\/\/doi.org\/10.1080\/1354750X.2018.1501763","journal-title":"Biomarkers"},{"key":"3514_CR20","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1111\/j.1601-0825.2012.01940.x","volume":"18","author":"C Benguigui","year":"2012","unstructured":"Benguigui C, Bongard V, Ruidavets JB, Sixou M, Chamontin B, Ferri\u00e8res AJ (2012) Evaluation of oral health related to body mass index. Oral Dis 18:748\u2013755. https:\/\/doi.org\/10.1111\/j.1601-0825.2012.01940.x","journal-title":"Oral Dis"},{"key":"3514_CR21","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1038\/oby.2011.305","volume":"20","author":"CC Zeigler","year":"2012","unstructured":"Zeigler CC, Persson GR, Wondimu B, Marcus C, Sobko T, Mod\u00e9er T (2012) Microbiota in the oral subgingival biofilm is associated with obesity in adolescence. Obesity 20:157\u2013164. https:\/\/doi.org\/10.1038\/oby.2011.305","journal-title":"Obesity"},{"key":"3514_CR22","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1111\/jcpe.12634","volume":"43","author":"SS Maciel","year":"2016","unstructured":"Maciel SS, Feres M, Gon\u00e7alves TE, Zimmermann GS, Pereira da Silva HD, Figueiredo LC, Duarte PM (2016) Does obesity influence the subgingival microbiota composition inperiodontal health and disease? J Clin Periodontol 43:1003\u20131012. https:\/\/doi.org\/10.1111\/jcpe.12634","journal-title":"J Clin Periodontol"},{"issue":"5","key":"3514_CR23","doi-asserted-by":"publisher","first-page":"e00460-18","DOI":"10.1128\/mSphere.00460-18","volume":"3","author":"T Kato","year":"2018","unstructured":"Kato T, Yamazaki K, Nakajima M, Date Y, Kikuchi J, Hase K (2018) Oral administration of Porphyromonas gingivalis alters the gut microbiome and serum metabolome. mSphere 3(5):e00460-18. https:\/\/doi.org\/10.1128\/mSphere.00460-18","journal-title":"mSphere"},{"key":"3514_CR24","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1186\/s12903-015-0094-7","volume":"15","author":"HS Park","year":"2015","unstructured":"Park HS, Nam HS, Seo HS, Hwang SJ (2015) Change of periodontal inflammatory indicators through a 4-week weight control intervention including caloric restriction and exercise training in young Koreans: a pilot study. BMC Oral Health 15:109. https:\/\/doi.org\/10.1186\/s12903-015-0094-7","journal-title":"BMC Oral Health"},{"key":"3514_CR25","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1111\/prd.12239","volume":"78","author":"JE Suvan","year":"2018","unstructured":"Suvan JE, Finer N, D\u2019Aiuto F (2018) Periodontal complications with obesity. Periodontology 2000 78:98\u2013128. https:\/\/doi.org\/10.1111\/prd.12239","journal-title":"Periodontology 2000"},{"key":"3514_CR26","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1902\/jop.2017.170355","volume":"89","author":"L Virto","year":"2018","unstructured":"Virto L, Cano P, Jimenez-Ortega V, Fern\u00e1ndez-Mateos P, Gonz\u00e1lez J, Esquifino AI, Sanz M (2018) Obesity and periodontitis: an experimental study to evaluate periodontal and systemic effects of comorbidity. J Periodontol 89:176\u2013185. https:\/\/doi.org\/10.1902\/jop.2017.170355","journal-title":"J Periodontol"},{"key":"3514_CR27","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1007\/s00784-016-1817-0","volume":"21","author":"AB de Souza","year":"2017","unstructured":"de Souza AB, Okawa RT, Silva CO, Ara\u00fajo MG (2017) Short-term changes on C-reactive protein (CRP) levels after non-surgical periodontal treatment in systemically healthy individuals. Clin Oral Investig 21:477\u2013484. https:\/\/doi.org\/10.1007\/s00784-016-1817-0","journal-title":"Clin Oral Investig"},{"key":"3514_CR28","doi-asserted-by":"publisher","first-page":"1172","DOI":"10.1001\/archinte.163.10.1172","volume":"163","author":"GD Slade","year":"2003","unstructured":"Slade GD, Ghezzi EM, Heiss G, Beck JD, Riche E, Offenbacher S (2003) Relationship between periodontal disease and C-reactive protein among adults in the atherosclerosis risk in communities study. Arch Intern Med 163:1172\u20131179. https:\/\/doi.org\/10.1001\/archinte.163.10.1172","journal-title":"Arch Intern Med"},{"key":"3514_CR29","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.1007\/s40618-018-0872-6","volume":"41","author":"MI Maiorino","year":"2018","unstructured":"Maiorino MI, Bellastella G, Giugliano D, Esposito K (2018) From inflammation to sexual dysfunctions: a journey through diabetes, obesity, and metabolic syndrome. J Endocrinol Investig 41:1249\u20131258. https:\/\/doi.org\/10.1007\/s40618-018-0872-6","journal-title":"J Endocrinol Investig"},{"key":"3514_CR30","doi-asserted-by":"publisher","first-page":"2204","DOI":"10.2174\/1381612822666160216145107","volume":"22","author":"H Sasaki","year":"2016","unstructured":"Sasaki H, Hirai K, Martins CM, Furusho H, Battaglino R, Hashimoto K (2016) Interrelationship between periapical lesion and systemic metabolic disorders. Curr Pharm Des 22:2204\u20132215. https:\/\/doi.org\/10.2174\/1381612822666160216145107","journal-title":"Curr Pharm Des"},{"key":"3514_CR31","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1111\/jcpe.12473","volume":"42","author":"C Pink","year":"2015","unstructured":"Pink C, Kocher T, Meisel P, D\u00f6rr M, Markus MRP, Jablonowski L (2015) Longitudinal effects of systemic inflammation markers on periodontitis. J Clin Periodontol 42:988\u2013997. https:\/\/doi.org\/10.1111\/jcpe.12473","journal-title":"J Clin Periodontol"},{"key":"3514_CR32","doi-asserted-by":"publisher","first-page":"2235","DOI":"10.2337\/dc12-0072","volume":"35","author":"RT Demmer","year":"2012","unstructured":"Demmer RT, Squillaro A, Papapanou PN, Rosenbaum M, Friedewald WT, Jacobs DR, Desvarieux M (2012) Periodontal infection, systemic inflammation, and insulin resistance. Diabetes Care 35:2235\u20132242. https:\/\/doi.org\/10.2337\/dc12-0072","journal-title":"Diabetes Care"},{"key":"3514_CR33","doi-asserted-by":"publisher","first-page":"2000","DOI":"10.1007\/s10753-017-0640-3","volume":"40","author":"MA Leite","year":"2017","unstructured":"Leite MA, Morgenstern de Mattia T, Kakihata CMM, Bortolini BM, de Carli Rodrigues PH, Bertolini GRF, Brancalhao RMC, de Fatima Chasko Ribeiro L, Nassar CA, Nassar PO (2017) Experimental periodontitis in the potentialization of the effects of immobilism in the skeletal striated muscle. Inflammation 40:2000\u20132011. https:\/\/doi.org\/10.1007\/s10753-017-0640-3","journal-title":"Inflammation"},{"key":"3514_CR34","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1111\/jcpe.12531","volume":"43","author":"M Eremenko","year":"2016","unstructured":"Eremenko M, Pink C, Biffar R, Schmidt CO, Ittermann T, Kocher T, Meisel P (2016) Cross-sectional association between physical strength, obesity, periodontitis and number of teeth in a general population. J Clin Periodontol 43:401\u2013407. https:\/\/doi.org\/10.1111\/jcpe.12531","journal-title":"J Clin Periodontol"},{"key":"3514_CR35","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1111\/jcpe.13091","volume":"46","author":"J Kang","year":"2019","unstructured":"Kang J, Smith S, Pavitt S, Wu J (2019) Association between central obesity and tooth loss in the non-obese people: results from the continuous National Health and Nutrition Examination Survey (NHANES) 1999-2012. J Clin Periodontol 46:430\u2013437. https:\/\/doi.org\/10.1111\/jcpe.13091","journal-title":"J Clin Periodontol"},{"key":"3514_CR36","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.1002\/JPER.18-0733","volume":"90","author":"P Meisel","year":"2019","unstructured":"Meisel P, Eremenko M, Holtfreter B, V\u00f6lzke H, Kocher T (2019) The sex paradox in the interplay between periodontitis, obesity, and serum C-reactive protein: data from a general population. J Periodontol 90:1365\u20131373. https:\/\/doi.org\/10.1002\/JPER.18-0733","journal-title":"J Periodontol"},{"key":"3514_CR37","doi-asserted-by":"publisher","first-page":"1062","DOI":"10.1038\/oby.2008.627","volume":"17","author":"LE Beasley","year":"2009","unstructured":"Beasley LE, Koster A, Newman AB, Javaid MK, Ferrucci L, Kritchevsky SB, Kuller LH, Pahor M, Schaap LA, Visser M et al (2009) Inflammation and race and gender differences in computerized tomography-measured adipose depots. Obesity 17:1062\u20131069. https:\/\/doi.org\/10.1038\/oby.2008.627","journal-title":"Obesity"},{"key":"3514_CR38","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1186\/1471-2458-10-429","volume":"10","author":"MM Lai","year":"2010","unstructured":"Lai MM, Li CI, Kardia SL, Liu CS, Lin WY, Lee YD, Chang PC, Lin CC, Li TC (2010) Sex differences in the association of metabolic syndrome with high sensitivity C-reactive protein in a Taiwanese population. BMC Public Health 10:429. https:\/\/doi.org\/10.1186\/1471-2458-10-429","journal-title":"BMC Public Health"},{"key":"3514_CR39","doi-asserted-by":"publisher","first-page":"2099","DOI":"10.1210\/jc.2008-2260","volume":"94","author":"G Hu","year":"2009","unstructured":"Hu G, Jousilahti P, Tuomilehto J, Antikainen R, Sundvall J, Salomaa V (2009) Association of serum C-reactive protein level with sex-specific type 2 diabetes risk: a prospective Finnish study. J Clin Endocrinol Metab 94:2099\u20132105. https:\/\/doi.org\/10.1210\/jc.2008-2260","journal-title":"J Clin Endocrinol Metab"},{"key":"3514_CR40","doi-asserted-by":"publisher","unstructured":"Bennett JM, Reeves G, Billman GE, Sturmberg JP (2018) Inflammation \u2013 nature\u2019s way to efficiently respond to all types of challenges: implications for understanding and managing \u201cthe epidemic\u201d of chronic diseases. Front Med 5(613). https:\/\/doi.org\/10.3389\/fmed.2018.00316","DOI":"10.3389\/fmed.2018.00316"}],"updated-by":[{"DOI":"10.1007\/s00784-021-04033-0","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2021,6,23]],"date-time":"2021-06-23T00:00:00Z","timestamp":1624406400000}}],"container-title":["Clinical Oral Investigations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-020-03514-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00784-020-03514-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-020-03514-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,21]],"date-time":"2021-08-21T23:16:44Z","timestamp":1629587804000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00784-020-03514-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,22]]},"references-count":40,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["3514"],"URL":"https:\/\/doi.org\/10.1007\/s00784-020-03514-y","relation":{"correction":[{"id-type":"doi","id":"10.1007\/s00784-021-04033-0","asserted-by":"object"}]},"ISSN":["1432-6981","1436-3771"],"issn-type":[{"value":"1432-6981","type":"print"},{"value":"1436-3771","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,22]]},"assertion":[{"value":"2 July 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 August 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 August 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 June 2021","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s00784-021-04033-0","URL":"https:\/\/doi.org\/10.1007\/s00784-021-04033-0","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study involving human participants was in accordance with the ethical standards of the institutional ethics committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}