{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T00:40:55Z","timestamp":1792975255394,"version":"4.5.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Oral Invest"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1007\/s00784-020-03552-6","type":"journal-article","created":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T18:45:46Z","timestamp":1598985946000},"page":"2297-2305","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Combination of etodolac and dexamethasone improves preemptive analgesia in third molar surgery: a randomized study"],"prefix":"10.1007","volume":"25","author":[{"given":"Guilherme Andr\u00e9 D.","family":"Ramires","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anderson Maikon","family":"de Souza Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo A. C.","family":"Momesso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T\u00e1rik Ocon B.","family":"Polo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William P. P.","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9fany","family":"Barbosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Paula F.","family":"Bassi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2249-3048","authenticated-orcid":false,"given":"Leonardo Perez","family":"Faverani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,9,1]]},"reference":[{"issue":"3","key":"3552_CR1","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/0304-3959(88)90286-2","volume":"33","author":"PD Wall","year":"1988","unstructured":"Wall PD (1988) The prevention of postoperative pain. Pain. 33(3):289\u2013290","journal-title":"Pain."},{"issue":"2","key":"3552_CR2","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1213\/00000539-199377020-00026","volume":"77","author":"CJ Woolf","year":"1993","unstructured":"Woolf CJ, Chong MS (1993) Preemptive analgesia--treating postoperative pain by preventing the establishment of central sensitization. Anesth Analg 77(2):362\u2013379","journal-title":"Anesth Analg"},{"issue":"9","key":"3552_CR3","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1016\/S0278-2391(03)00310-0","volume":"61","author":"RA Dionne","year":"2003","unstructured":"Dionne RA, Gordon SM, Rowan J, Kent A, Brahim JS (2003) Dexamethasone suppresses peripheral prostanoid levels without analgesia in a clinical model of acute inflammation. J Oral Maxillofac Surg 61(9):997\u20131003","journal-title":"J Oral Maxillofac Surg"},{"issue":"8","key":"3552_CR4","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1016\/j.ijom.2004.01.020","volume":"33","author":"KS Ong","year":"2004","unstructured":"Ong KS, Seymour RA, Chen FG, Ho VC (2004) Preoperative ketorolac has a preemptive effect for postoperative third molar surgical pain. Int J Oral Maxillofac Surg 33(8):771\u2013776","journal-title":"Int J Oral Maxillofac Surg"},{"issue":"4","key":"3552_CR5","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.1097\/00000542-200010000-00040","volume":"93","author":"I Kissin","year":"2000","unstructured":"Kissin I (2000) Preemptive analgesia. Anesthesiology. 93(4):1138\u20131143","journal-title":"Anesthesiology."},{"issue":"8","key":"3552_CR6","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1016\/j.ijom.2011.12.028","volume":"41","author":"L Aznar-Arasa","year":"2012","unstructured":"Aznar-Arasa L, Harutunian K, Figueiredo R, Valmaseda-Castellon E, Gay-Escoda C (2012) Effect of preoperative ibuprofen on pain and swelling after lower third molar removal: a randomized controlled trial. Int J Oral Maxillofac Surg 41(8):1005\u20131009","journal-title":"Int J Oral Maxillofac Surg"},{"issue":"8","key":"3552_CR7","doi-asserted-by":"publisher","first-page":"e346","DOI":"10.1016\/j.jcms.2012.01.018","volume":"40","author":"FA da Costa Araujo","year":"2012","unstructured":"da Costa Araujo FA, de Santana ST, de Morais HH, Laureano Filho JR, de Oliveira ESED, Vasconcellos RJ (2012) Comparative analysis of preemptive analgesic effect of tramadol chlorhydrate and nimesulide following third molar surgery. J Craniomaxillofac Surg 40(8):e346\u2013e349","journal-title":"J Craniomaxillofac Surg"},{"issue":"2","key":"3552_CR8","doi-asserted-by":"publisher","first-page":"e108","DOI":"10.1097\/SCS.0b013e318231e1d5","volume":"23","author":"RL Avelar","year":"2012","unstructured":"Avelar RL, Primo BT, Vogt BF, de Oliveira e Silva ED, Antunes AA, Magalhaes MT et al (2012) Effect of partially selective cyclooxygenase-2 inhibitor in the removal of third molars. J Craniofac Surg 23(2):e108\u2013e112","journal-title":"J Craniofac Surg"},{"issue":"3","key":"3552_CR9","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.curtheres.2005.06.007","volume":"66","author":"M Bocanegra","year":"2005","unstructured":"Bocanegra M, Seijas A, Gonz\u00e1lez YM (2005) Effectiveness and tolerability of once-daily nimesulide versus ibuprofen in pain management after surgical extraction of an impacted third molar: a 24-hour, double-blind, randomized, double-dummy, parallel-group study. Curr Ther Res 66(3):172\u2013180","journal-title":"Curr Ther Res"},{"issue":"1","key":"3552_CR10","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.tripleo.2011.05.027","volume":"114","author":"PA Trindade","year":"2012","unstructured":"Trindade PA, Giglio FP, Colombini-Ishikiriama BL, Calvo AM, Modena KC, Ribeiro DA et al (2012) Sublingual ketorolac and sublingual piroxicam are equally effective for postoperative pain, trismus, and swelling management in lower third molar removal. Oral Surg Oral Med Oral Pathol Oral Radiol 114(1):27\u201334","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"issue":"8","key":"3552_CR11","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1016\/j.jcms.2012.01.001","volume":"40","author":"JA de Sousa Santos","year":"2012","unstructured":"de Sousa Santos JA, da Silva LC, de Santana Santos T, Menezes Junior LR, de Assuncao Oliveira AC, Brandao JR (2012) Comparative study of tramadol combined with dexamethasone and diclofenac sodium in third-molar surgery. J Craniomaxillofac Surg 40(8):694\u2013700","journal-title":"J Craniomaxillofac Surg"},{"issue":"3","key":"3552_CR12","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1007\/s10006-012-0360-7","volume":"17","author":"HC Bauer","year":"2013","unstructured":"Bauer HC, Duarte FL, Horliana AC, Tortamano IP, Perez FE, Simone JL et al (2013) Assessment of preemptive analgesia with ibuprofen coadministered or not with dexamethasone in third molar surgery: a randomized double-blind controlled clinical trial. Oral Maxillofac Surg 17(3):165\u2013171","journal-title":"Oral Maxillofac Surg"},{"issue":"4","key":"3552_CR13","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1111\/j.1834-7819.2002.tb00546.x","volume":"47","author":"MB Comfort","year":"2002","unstructured":"Comfort MB, Tse AS, Tsang AC, McGrath C (2002) A study of the comparative efficacy of three common analgesics in the control of pain after third molar surgery under local anaesthesia. Aust Dent J 47(4):327\u2013330","journal-title":"Aust Dent J"},{"issue":"5","key":"3552_CR14","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1159\/000327658","volume":"20","author":"AM Tuzuner Oncul","year":"2011","unstructured":"Tuzuner Oncul AM, Yazicioglu D, Alanoglu Z, Demiralp S, Ozturk A, Ucok C (2011) Postoperative analgesia in impacted third molar surgery: the role of preoperative diclofenac sodium, paracetamol and lornoxicam. Med Princ Pract 20(5):470\u2013476","journal-title":"Med Princ Pract"},{"issue":"3","key":"3552_CR15","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1016\/j.pain.2010.12.012","volume":"152","author":"SE Daniels","year":"2011","unstructured":"Daniels SE, Goulder MA, Aspley S, Reader S (2011) A randomised, five-parallel-group, placebo-controlled trial comparing the efficacy and tolerability of analgesic combinations including a novel single-tablet combination of ibuprofen\/paracetamol for postoperative dental pain. Pain. 152(3):632\u2013642","journal-title":"Pain."},{"issue":"2","key":"3552_CR16","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1016\/j.clinthera.2012.01.004","volume":"34","author":"K Saito","year":"2012","unstructured":"Saito K, Kaneko A, Machii K, Ohta H, Ohkura M, Suzuki M (2012) Efficacy and safety of additional 200-mg dose of celecoxib in adult patients with postoperative pain following extraction of impacted third mandibular molar: a multicenter, randomized, double-blind, placebo-controlled, phase II study in Japan. Clin Ther 34(2):314\u2013328","journal-title":"Clin Ther"},{"issue":"2","key":"3552_CR17","first-page":"E129","volume":"13","author":"JR Laureano Filho","year":"2008","unstructured":"Laureano Filho JR, Maurette PE, Allais M, Cotinho M, Fernandes C (2008) Clinical comparative study of the effectiveness of two dosages of dexamethasone to control postoperative swelling, trismus and pain after the surgical extraction of mandibular impacted third molars. Med Oral Patol Oral Cir Bucal 13(2):E129\u2013E132","journal-title":"Med Oral Patol Oral Cir Bucal"},{"issue":"7","key":"3552_CR18","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1016\/j.ijom.2013.02.017","volume":"42","author":"P Mehra","year":"2013","unstructured":"Mehra P, Reebye U, Nadershah M, Cottrell D (2013) Efficacy of anti-inflammatory drugs in third molar surgery: a randomized clinical trial. Int J Oral Maxillofac Surg 42(7):835\u2013842","journal-title":"Int J Oral Maxillofac Surg"},{"issue":"2","key":"3552_CR19","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/j.ijom.2016.10.011","volume":"46","author":"JC Barbalho","year":"2017","unstructured":"Barbalho JC, Vasconcellos RJ, de Morais HH, Santos LA, Almeida RA, R\u00eabelo HL et al (2017) Effects of co-administered dexamethasone and nimesulide on pain, swelling, and trismus following third molar surgery: a randomized, triple-blind, controlled clinical trial. Int J Oral Maxillofac Surg 46(2):236\u2013242","journal-title":"Int J Oral Maxillofac Surg"},{"issue":"8","key":"3552_CR20","doi-asserted-by":"publisher","first-page":"1524","DOI":"10.1016\/j.joms.2016.04.003","volume":"74","author":"JC Silva de Oliveira","year":"2016","unstructured":"Silva de Oliveira JC, Grossi de Oliveira GA, Bassi AP (2016) Comparative assessment of the effect of ibuprofen and etodolac on edema, trismus, and pain in lower third molar surgery: a randomized clinical trial. J Oral Maxillofac Surg 74(8):1524\u20131530","journal-title":"J Oral Maxillofac Surg"},{"key":"3552_CR21","doi-asserted-by":"publisher","unstructured":"World Medical Association (2013) World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects. JAMA 310(20):2191\u20132194. https:\/\/doi.org\/10.1001\/jama.2013.281053","DOI":"10.1001\/jama.2013.281053"},{"issue":"1","key":"3552_CR22","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.joms.2017.06.012","volume":"76","author":"TC Lima","year":"2018","unstructured":"Lima TC, Bagordakis E, Falci SGM, Dos Santos CRR, Pinheiro MLP (2018) Pre-emptive effect of dexamethasone and diclofenac sodium associated with codeine on pain, swelling, and trismus after third molar surgery: a split-mouth, randomized, triple-blind, controlled clinical trial. J Oral Maxillofac Surg 76(1):60\u201366","journal-title":"J Oral Maxillofac Surg"},{"issue":"1","key":"3552_CR23","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/0304-3959(86)90228-9","volume":"27","author":"MP Jensen","year":"1986","unstructured":"Jensen MP, Karoly P, Braver S (1986) The measurement of clinical pain intensity: a comparison of six methods. Pain. 27(1):117\u2013126","journal-title":"Pain."},{"issue":"4","key":"3552_CR24","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1007\/s10006-011-0290-9","volume":"15","author":"AA Antunes","year":"2011","unstructured":"Antunes AA, Avelar RL, Martins Neto EC, Frota R, Dias E (2011) Effect of two routes of administration of dexamethasone on pain, edema, and trismus in impacted lower third molar surgery. Oral Maxillofac Surg 15(4):217\u2013223","journal-title":"Oral Maxillofac Surg"},{"issue":"6","key":"3552_CR25","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1016\/j.tripleo.2005.08.039","volume":"101","author":"S Lin","year":"2006","unstructured":"Lin S, Levin L, Emodi O, El-Naaj IA, Peled M (2006) Etodolac versus dexamethasone effect in reduction of postoperative symptoms following surgical endodontic treatment: a double-blind study. Oral Surg Oral Med Oral Pathol Oral Radiol Endodontol 101(6):814\u2013817","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endodontol"},{"issue":"3","key":"3552_CR26","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.ijom.2006.10.006","volume":"36","author":"A Markovic","year":"2007","unstructured":"Markovic A, Todorovic L (2007) Effectiveness of dexamethasone and low-power laser in minimizing oedema after third molar surgery: a clinical trial. Int J Oral Maxillofac Surg 36(3):226\u2013229","journal-title":"Int J Oral Maxillofac Surg"},{"issue":"3","key":"3552_CR27","first-page":"394","volume":"76","author":"HL da Silveira","year":"2006","unstructured":"da Silveira HL, Silveira HE (2006) Reproducibility of cephalometric measurements made by three radiology clinics. Angle Orthod 76(3):394\u2013399","journal-title":"Angle Orthod"},{"issue":"1","key":"3552_CR28","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.joms.2011.03.039","volume":"70","author":"MA Isiordia-Espinoza","year":"2012","unstructured":"Isiordia-Espinoza MA, S\u00e1nchez-Prieto M, Tob\u00edas-Az\u00faa F, Reyes-Garc\u00eda JG (2012) Pre-emptive analgesic effectiveness of meloxicam versus tramadol after mandibular third molar surgery: a pilot study. J Oral Maxillofac Surg 70(1):31\u201336","journal-title":"J Oral Maxillofac Surg"},{"issue":"1","key":"3552_CR29","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.oooo.2012.12.007","volume":"116","author":"R Warraich","year":"2013","unstructured":"Warraich R, Faisal M, Rana M, Shaheen A, Gellrich N-C, Rana M (2013) Evaluation of postoperative discomfort following third molar surgery using submucosal dexamethasone \u2013 a randomized observer blind prospective study. Oral Surg Oral Med Oral Pathol Oral Radiol 116(1):16\u201322","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"issue":"9","key":"3552_CR30","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1016\/j.joms.2003.11.014","volume":"62","author":"GD Slade","year":"2004","unstructured":"Slade GD, Foy SP, Shugars DA, Phillips C, White RP Jr (2004) The impact of third molar symptoms, pain, and swelling on oral health-related quality of life. J Oral Maxillofac Surg 62(9):1118\u20131124","journal-title":"J Oral Maxillofac Surg"},{"issue":"6","key":"3552_CR31","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1016\/j.ijom.2010.03.012","volume":"39","author":"SA De Menezes","year":"2010","unstructured":"De Menezes SA, Cury PR (2010) Efficacy of nimesulide versus meloxicam in the control of pain, swelling and trismus following extraction of impacted lower third molar. Int J Oral Maxillofac Surg 39(6):580\u2013584","journal-title":"Int J Oral Maxillofac Surg"},{"issue":"1","key":"3552_CR32","doi-asserted-by":"publisher","first-page":"e43","DOI":"10.1097\/SCS.0000000000003188","volume":"28","author":"AM Rocha-Neto","year":"2017","unstructured":"Rocha-Neto AM, Nogueira EF, Borba PM, Laureano-Filho JR, Vasconcelos BC (2017) Application of dexamethasone in the masseter muscle during the surgical removal of lower third molars. J Craniofac Surg 28(1):e43\u2013ee7","journal-title":"J Craniofac Surg"}],"container-title":["Clinical Oral Investigations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-020-03552-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00784-020-03552-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-020-03552-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T02:24:56Z","timestamp":1630463096000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00784-020-03552-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,1]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["3552"],"URL":"https:\/\/doi.org\/10.1007\/s00784-020-03552-6","relation":{},"ISSN":["1432-6981","1436-3771"],"issn-type":[{"value":"1432-6981","type":"print"},{"value":"1436-3771","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,1]]},"assertion":[{"value":"20 July 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 August 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 September 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee (#818.680) and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}