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Postoperatively, the patients received either systemic antibiotics (i.e., 1\u00a0g of amoxicillin, twice daily for 7\u00a0days) (test) or no antibiotics (control). Clinical attachment level (CAL), probing depth (PD), and gingival recession (GR) were measured at baseline and at 1\u00a0year following regenerative surgery. The depth of the intrabony component (INTRA DD) and its width (INTRA DW) were measured during surgery and after 1\u00a0year at reentry. The depth (RxD) and width (RxW) of the intrabony defects were evaluated radiographically at baseline and at 1\u00a0year.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>No adverse events were observed in any of the two groups throughout the entire study period. In the test group, mean CAL changed from 8.7\u2009\u00b1\u20091.4\u00a0mm at baseline to 5.0\u2009\u00b1\u20091.7\u00a0mm at 1\u00a0year (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001), while PD decreased from 7.8\u2009\u00b1\u20091.5\u00a0mm at baseline to 4.0\u2009\u00b1\u20090.9\u00a0mm at 1\u00a0year (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). In the control group, mean CAL changed from 8.6\u2009\u00b1\u20091.9\u00a0mm to 5.9\u2009\u00b1\u20091.6\u00a0mm (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and mean PD improved from 7.4\u2009\u00b1\u20091.3\u00a0mm to 4.1\u2009\u00b1\u20091.3\u00a0mm (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Mean CAL gain measured 3.6\u2009\u00b1\u20091.6\u00a0mm in the test and 2.7\u2009\u00b1\u20091.6\u00a0mm in the control group, respectively. Defect fill (i.e., INTRA DD gain) at re-entry measured 3.7\u2009\u00b1\u20091.8\u00a0mm in the test and 2.7\u2009\u00b1\u20092.1\u00a0mm in the control group. A CAL gain of \u2265\u20093\u00a0mm was measured in 76% of the defects in the test group and in 40% of the defects in the control group, respectively. In both groups, all evaluated clinical and radiographic parameters improved statistically significantly compared with baseline, but no statistically significant differences were found between the two groups.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Within their limits, the present study has failed to show any substantial added clinical benefits following the postoperative administration of amoxicillin in conjunction with regenerative periodontal surgery using DBBM and GTR.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Clinical relevance<\/jats:title>\n                <jats:p>The post-surgically administration of systemic antibiotics does not seem to be necessary following regenerative periodontal surgery.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00784-020-03616-7","type":"journal-article","created":{"date-parts":[[2020,10,13]],"date-time":"2020-10-13T13:04:20Z","timestamp":1602594260000},"page":"2959-2968","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Effect of systemic antibiotics on the outcomes of regenerative periodontal surgery in intrabony defects: a randomized, controlled, clinical study"],"prefix":"10.1007","volume":"25","author":[{"given":"Ma\u0142gorzata","family":"Pietruska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Doli\u0144ska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Milewski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2836-5477","authenticated-orcid":false,"given":"Anton","family":"Sculean","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,10,13]]},"reference":[{"key":"3616_CR1","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1111\/prd.12086","volume":"68","author":"A Sculean","year":"2015","unstructured":"Sculean A, Nikolidakis D, Nikou G, Ivanovic A, Chapple ILC, Stavropoulos A (2015) Biomaterials for promoting periodontal regeneration in human intrabony defects: a systematic review. 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