{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T22:46:04Z","timestamp":1778107564870,"version":"3.51.4"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T00:00:00Z","timestamp":1602633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T00:00:00Z","timestamp":1602633600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Oral Invest"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1007\/s00784-020-03632-7","type":"journal-article","created":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T19:02:56Z","timestamp":1602702176000},"page":"3087-3093","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Does inflammatory dental disease affect the development of medication-related osteonecrosis of the jaw in patients using high-dose bone-modifying agents?"],"prefix":"10.1007","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0929-4047","authenticated-orcid":false,"given":"Nobuhiro","family":"Ueda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chie","family":"Nakashima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kumiko","family":"Aoki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroko","family":"Shimotsuji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiko","family":"Nakaue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hajime","family":"Yoshioka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Kurokawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichiro","family":"Imai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadaaki","family":"Kirita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,10,14]]},"reference":[{"key":"3632_CR1","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.4161\/cbt.5.9.3305","volume":"5","author":"JR Berenson","year":"2006","unstructured":"Berenson JR, Rajdev L, Broder M (2006) Treatment strategies for skeletal complications of cancer. Cancer Biol Ther 5:1074\u20131077. https:\/\/doi.org\/10.4161\/cbt.5.9.3305","journal-title":"Cancer Biol Ther"},{"key":"3632_CR2","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1016\/S0140-6736(10)62344-6","volume":"377","author":"K Fizazi","year":"2011","unstructured":"Fizazi K, Carducci M, Smith M, Dami\u00e3o R, Brown J, Karsh L, Milecki P, Shore N, Rader M, Wang H, Jiang Q (2011) Denosumab versus zoledronic acid for treatment of bone metastases in men with castration-resistant prostate cancer: a randomised, double-blind study. Lancet 377:813\u2013822. https:\/\/doi.org\/10.1016\/S0140-6736(10)62344-6","journal-title":"Lancet"},{"key":"3632_CR3","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1016\/s0278-2391(03)00720-1","volume":"61","author":"RE Marx","year":"2003","unstructured":"Marx RE (2003) Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic. J Oral Maxillofac Surg 61:1115\u20131117. https:\/\/doi.org\/10.1016\/s0278-2391(03)00720-1","journal-title":"J Oral Maxillofac Surg"},{"key":"3632_CR4","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1200\/JOP.2006.2.1.7","volume":"2","author":"S Ruggiero","year":"2006","unstructured":"Ruggiero S, Gralow J, Marx RE, Hoff AO, Schubert MM, Huryn JM, Toth B, Damato K, Valero V (2006) Practical guidelines for the prevention, diagnosis, and treatment of osteonecrosis of the jaw in patients with cancer. J Oncol Pract 2:7\u201314. https:\/\/doi.org\/10.1200\/JOP.2006.2.1.7","journal-title":"J Oncol Pract"},{"key":"3632_CR5","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1007\/s00774-010-0162-7","volume":"28","author":"T Yoneda","year":"2010","unstructured":"Yoneda T, Hagino H, Sugimoto T, Ohta H, Takahashi S, Soen S, Taguchi A, Toyosawa S, Nagata T, Urade M (2010) Bisphosphonate-related osteonecrosis of the jaw: position paper from the Allied Task Force Committee of Japanese Society for Bone and Mineral Research, Japan Osteoporosis Society, Japanese Society of Periodontology, Japanese Society for Oral and Maxillofacial Radiology and Japanese Society of Oral and Maxillofacial Surgeons. J Bone Miner Metab 28:365\u2013383. https:\/\/doi.org\/10.1007\/s00774-010-0162-7","journal-title":"J Bone Miner Metab"},{"key":"3632_CR6","doi-asserted-by":"publisher","first-page":"1938","DOI":"10.1016\/j.joms.2014.04.031","volume":"72","author":"SL Ruggiero","year":"2014","unstructured":"Ruggiero SL, Dodson TB, Fantasia J, Goodday R, Aghaloo T, Mehrotra B, O\u2019Ryan F (2014) American Association of Oral and Maxillofacial Surgeons position paper on medication-related osteonecrosis of the jaw\u20142014 update. J Oral Maxillofac Surg 72:1938\u20131956. https:\/\/doi.org\/10.1016\/j.joms.2014.04.031","journal-title":"J Oral Maxillofac Surg"},{"key":"3632_CR7","doi-asserted-by":"publisher","first-page":"2270","DOI":"10.1200\/JCO.19.01186","volume":"37","author":"N Yarom","year":"2019","unstructured":"Yarom N, Shapiro CL, Peterson DE, Van Poznak CH, Bohlke K, Ruggiero SL, Migliorati CA, Khan A, Morrison A, Anderson H, Murphy BA, Alston-Johnson D, Mendes RA, Beadle BM, Jensen SB, Saunders DP (2019) Medication-related osteonecrosis of the jaw: MASCC\/ISOO\/ASCO Clinical Practice Guideline. J Clin Oncol 37:2270\u20132290. https:\/\/doi.org\/10.1200\/JCO.19.01186","journal-title":"J Clin Oncol"},{"key":"3632_CR8","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.jcms.2007.06.008","volume":"36","author":"MH Abu-Id","year":"2008","unstructured":"Abu-Id MH, Warnke PH, Gottschalk J, Springer I, Wiltfang J, Acil Y, Russo PA, Kreusch TJ (2008) \u201cBis-phossy jaws\u201d\u2014High and low risk factors for bisphosphonate-induced osteonecrosis of the jaw. Craniomaxillofac Surg 36:95\u2013103. https:\/\/doi.org\/10.1016\/j.jcms.2007.06.008","journal-title":"Craniomaxillofac Surg"},{"key":"3632_CR9","doi-asserted-by":"publisher","first-page":"4634","DOI":"10.1200\/JCO.2008.16.2768","volume":"26","author":"A Kyrgidis","year":"2008","unstructured":"Kyrgidis A, Vahtsevanos K, Koloutsos G, Andreadis C, Boukovinas I, Teleioudis Z, Patrikidou A, Triaridis S (2008) Bisphosphonate-related osteonecrosis of the jaws: a case-control study of risk factors in breast cancer patients. J Clin Oncol 26:4634\u20134638. https:\/\/doi.org\/10.1200\/JCO.2008.16.2768","journal-title":"J Clin Oncol"},{"key":"3632_CR10","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1177\/0022034510397196","volume":"130","author":"A Barasch","year":"2013","unstructured":"Barasch A, Cunha-Cruz J, Curro FA, Hujoel P, Sung AH, Vena D, Voinea-Griffin AE, Beadnell S, Craig RG, DeRouen T, Desaranayake A, Gilbert A, Gilbert GH, Goldberg K, Hauley R, Hashimoto M, Holmes J, Latzke B, Leroux B, Lindblad A, Richman J, Safford M, Ship J, Thompson VP, Williams OD, CONDOR Collaborative Group, Wanrong Y (2013) Risk factors for osteonecrosis of the jaws: a case-control study from the CONDOR Dental PBRN. Tex Dent J 130:299\u2013307. https:\/\/doi.org\/10.1177\/0022034510397196","journal-title":"Tex Dent J"},{"key":"3632_CR11","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1016\/j.jcms.2015.03.039","volume":"43","author":"S Otto","year":"2015","unstructured":"Otto S, Tr\u00f6ltzsch M, Jambrovic V, Panya S, Probst F, Ristow O, Ehrenfeld M, Pautke C (2015) Tooth extraction in patients receiving oral or intravenous bisphosphonate administration: a trigger for BRONJ development? J Craniomaxillofac Surg 43:847\u2013854. https:\/\/doi.org\/10.1016\/j.jcms.2015.03.039","journal-title":"J Craniomaxillofac Surg"},{"key":"3632_CR12","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1902\/jop.2009.080454","volume":"80","author":"G Avila","year":"2009","unstructured":"Avila G, Galindo-Moreno P, Soehren S, Misch CE, Morelli T, Wang HL (2009) A novel decision-making process for tooth retention or extraction. J Periodontol 80:476\u2013591. https:\/\/doi.org\/10.1902\/jop.2009.080454","journal-title":"J Periodontol"},{"key":"3632_CR13","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/s12903-020-1014-z","volume":"20","author":"J Lee","year":"2020","unstructured":"Lee J, Kang S, Jung HI, Kim S, Karabucak B, Kim E (2020) Dentists' clinical decision-making about teeth with apical periodontitis using a variable-controlled survey model in South Korea. BMC Oral Health 20:23. https:\/\/doi.org\/10.1186\/s12903-020-1014-z","journal-title":"BMC Oral Health"},{"key":"3632_CR14","doi-asserted-by":"publisher","first-page":"e0201343","DOI":"10.1371\/journal.pone.0201343","volume":"13","author":"S Soutome","year":"2018","unstructured":"Soutome S, Hayashida S, Funahara M, Sakamoto Y, Kojima Y, Yanamoto S, Umeda M (2018) Factors affecting development of medication-related osteonecrosis of the jaw in cancer patients receiving high-dose bisphosphonate or denosumab therapy: is tooth extraction a risk factor? PLoS One 13:e0201343. https:\/\/doi.org\/10.1371\/journal.pone.0201343","journal-title":"PLoS One"},{"key":"3632_CR15","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.1016\/j.ijom.2012.06.020","volume":"41","author":"T Yamazaki","year":"2012","unstructured":"Yamazaki T, Yamori M, Ishizaki T, Asai K, Goto K, Takahashi K, Nakayama T, Bessho K (2012) Increased incidence of osteonecrosis of the jaw after tooth extraction in patients treated with bisphosphonates: a cohort study. Int J Oral Maxillofac Surg 41:1397\u20131403. https:\/\/doi.org\/10.1016\/j.ijom.2012.06.020","journal-title":"Int J Oral Maxillofac Surg"},{"key":"3632_CR16","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1093\/annonc\/mdr435","volume":"23","author":"F Saad","year":"2012","unstructured":"Saad F, Brown JE, Van Poznak C, Ibrahim T, Stemmer SM, Stopeck AT, Diel IJ, Takahashi S, Shore N, Henry DH, Barrios CH, Facon T, Senecal F, Fizazi K, Zhou L, Daniels A, Carri\u00e8re P, Dansey R (2012) Incidence, risk factors, and outcomes of osteonecrosis of the jaw: integrated analysis from three blinded active-controlled phase III trials in cancer patients with bone metastases. Ann Oncol 23:1341\u20131347. https:\/\/doi.org\/10.1093\/annonc\/mdr435","journal-title":"Ann Oncol"},{"key":"3632_CR17","doi-asserted-by":"publisher","first-page":"1360","DOI":"10.1016\/j.joms.2013.02.016","volume":"71","author":"C Tsao","year":"2013","unstructured":"Tsao C, Darby I, Ebeling PR, Walsh K, O\u2019Brien-Simpson N, Reynolds E, Borromeo G (2013) Oral health risk factors for bisphosphonate-associated jaw osteonecrosis. J Oral Maxillofac Surg 71:1360\u20131366. https:\/\/doi.org\/10.1016\/j.joms.2013.02.016","journal-title":"J Oral Maxillofac Surg"},{"key":"3632_CR18","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1016\/j.amjmed.2010.04.033","volume":"123","author":"S Fedele","year":"2010","unstructured":"Fedele S, Porter SR, D\u2019Aiuto F, Aljohani S, Vescovi P, Manfredi M, Arduino PG, Broccoletti R, Musciotto A, Di Fede O, Lazarovici TS, Campisi G, Yarom N (2010) Nonexposed variant of bisphosphonate-associated osteonecrosis of the jaw: a case series. Am J Med 123:1060\u20131064. https:\/\/doi.org\/10.1016\/j.amjmed.2010.04.033","journal-title":"Am J Med"},{"key":"3632_CR19","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1016\/j.joms.2008.01.038","volume":"66","author":"MR Allen","year":"2008","unstructured":"Allen MR, Burr DB (2008) Mandible matrix necrosis in beagle dogs after 3 years of daily bisphosphonate treatment. J Oral Maxillofac Surg 66:987\u2013994. https:\/\/doi.org\/10.1016\/j.joms.2008.01.038","journal-title":"J Oral Maxillofac Surg"},{"key":"3632_CR20","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1002\/ar.a.20396","volume":"288","author":"SS Huja","year":"2006","unstructured":"Huja SS, Fernandez SA, Hill KJ, Li Y (2006) Remodeling dynamics in the alveolar process in skeletally mature dogs. Anat Rec A Discov Mol Cell Evol Biol 288:1243\u20131249. https:\/\/doi.org\/10.1002\/ar.a.20396","journal-title":"Anat Rec A Discov Mol Cell Evol Biol"},{"key":"3632_CR21","first-page":"845","volume":"19","author":"DE Tow","year":"1978","unstructured":"Tow DE, Garcia DA, Jansons D, Sullivan TM, Niederman R (1978) Bone scan in dental diseases. J Nucl Med 19:845\u2013847","journal-title":"J Nucl Med"},{"key":"3632_CR22","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1097\/00003072-197912000-00005","volume":"4","author":"KP Lyons","year":"1979","unstructured":"Lyons KP, Jensen JL (1979) Dental lesions causing abnormalities on skeletal scintigraphy. Clin Nucl Med 4:509\u2013512","journal-title":"Clin Nucl Med"},{"key":"3632_CR23","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1016\/0030-4220(89)90243-0","volume":"68","author":"EJ Strittmatter","year":"1989","unstructured":"Strittmatter EJ, Keller DL, LaBounty GL, Lewis DM, Graham GD (1989) The relationship between radionuclide bone scans and dental examinations. Oral Surg Oral Med Oral Pathol 68:576\u2013581. https:\/\/doi.org\/10.1016\/0030-4220(89)90243-0","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"3632_CR24","doi-asserted-by":"publisher","first-page":"1381","DOI":"10.1002\/j.0022-0337.2002.66.12.tb03612.x","volume":"66","author":"RI Ferreira","year":"2002","unstructured":"Ferreira RI, de Almeida SM, Boscolo FN, Santos AO, Camargo EE (2002) Bone scintigraphy as an adjunct for the diagnosis of oral diseases. J Dent Educ 66:1381\u20131387","journal-title":"J Dent Educ"},{"key":"3632_CR25","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1097\/00006231-200403000-00015","volume":"25","author":"JA Arias","year":"2004","unstructured":"Arias JA, Pardo C, Olmos A, Cuadrado ML, Ruibal A (2004) Dental diseases and radionuclide imaging of the jaws. Nucl Med Commun 25:305\u2013310. https:\/\/doi.org\/10.1097\/00006231-200403000-00015","journal-title":"Nucl Med Commun"},{"key":"3632_CR26","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1097\/00008505-199500440-00002","volume":"4","author":"LP Garetto","year":"1995","unstructured":"Garetto LP, Chen J, Parr JA, Roberts WE (1995) Remodeling dynamics of bone supporting rigidly fixed titanium implants: a histomorphometric comparison in four species including humans. Implant Dent 4:235\u2013243. https:\/\/doi.org\/10.1097\/00008505-199500440-00002","journal-title":"Implant Dent"}],"container-title":["Clinical Oral Investigations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-020-03632-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00784-020-03632-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-020-03632-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,14]],"date-time":"2021-10-14T01:46:38Z","timestamp":1634175998000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00784-020-03632-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,14]]},"references-count":26,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["3632"],"URL":"https:\/\/doi.org\/10.1007\/s00784-020-03632-7","relation":{},"ISSN":["1432-6981","1436-3771"],"issn-type":[{"value":"1432-6981","type":"print"},{"value":"1436-3771","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,14]]},"assertion":[{"value":"27 May 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 October 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 October 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"All procedures performed in this study, which involved human participants, were in accordance with the ethical standards of the institutional review board of Nara Medical University Hospital (Receipt No. 2184) and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"For this type of study, formal consent is not required.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}