{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:54:36Z","timestamp":1792803276194,"version":"4.5.0"},"reference-count":59,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2021,1,6]],"date-time":"2021-01-06T00:00:00Z","timestamp":1609891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,1,6]],"date-time":"2021-01-06T00:00:00Z","timestamp":1609891200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Oral Invest"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1007\/s00784-020-03707-5","type":"journal-article","created":{"date-parts":[[2021,5,20]],"date-time":"2021-05-20T09:17:45Z","timestamp":1621502265000},"page":"3775-3787","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Tailored 70S30C Bioactive glass induces severe inflammation as pulpotomy agent in primary teeth: an interim analysis of a randomised controlled trial"],"prefix":"10.1007","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5464-1968","authenticated-orcid":false,"given":"Yasmine","family":"Elhamouly","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3147-0032","authenticated-orcid":false,"given":"Rania M.","family":"El Backly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1897-1986","authenticated-orcid":false,"given":"Dalia M.","family":"Talaat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1126-5963","authenticated-orcid":false,"given":"Samia S.","family":"Omar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4989-6584","authenticated-orcid":false,"given":"Maha","family":"El Tantawi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4126-9909","authenticated-orcid":false,"given":"Karin M. L.","family":"Dowidar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,1,6]]},"reference":[{"key":"3707_CR1","doi-asserted-by":"publisher","first-page":"1967","DOI":"10.1007\/s00784-018-2616-6","volume":"23","author":"JE Stringhini","year":"2019","unstructured":"Stringhini JE, Dos Santos MGC, Oliveira LB, Mercad\u00e9 M (2019) MTA and biodentine for primary teeth pulpotomy: a systematic review and meta-analysis of clinical trials. Clin Oral Investig 23:1967\u20131976. https:\/\/doi.org\/10.1007\/s00784-018-2616-6","journal-title":"Clin Oral Investig"},{"key":"3707_CR2","doi-asserted-by":"publisher","first-page":"51","DOI":"10.9790\/0853-1245157","volume":"12","author":"V Arora","year":"2013","unstructured":"Arora V, Nikhil V, Namrata S, Arora P (2013) Bioactive dentin replacement. IOSR J Dent Med Sci 12:51\u201357. https:\/\/doi.org\/10.9790\/0853-1245157","journal-title":"IOSR J Dent Med Sci"},{"key":"3707_CR3","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1111\/j.1365-2591.2011.01995.x","volume":"45","author":"P Laurent","year":"2012","unstructured":"Laurent P, Camps J, About I (2012) BiodentineTM induces TGF-\u03b21 release from human pulp cells and early dental pulp mineralization. Int Endod J 45:439\u2013448. https:\/\/doi.org\/10.1111\/j.1365-2591.2011.01995.x","journal-title":"Int Endod J"},{"key":"3707_CR4","doi-asserted-by":"publisher","first-page":"1639","DOI":"10.1007\/s00784-015-1656-4","volume":"20","author":"C Cuadros-Fern\u00e1ndez","year":"2016","unstructured":"Cuadros-Fern\u00e1ndez C, Lorente Rodr\u00edguez AI, S\u00e1ez-Mart\u00ednez S, Garc\u00eda-Binimelis J, About I, Mercad\u00e9 M (2016) Short-term treatment outcome of pulpotomies in primary molars using mineral trioxide aggregate and Biodentine: a randomized clinical trial. Clin Oral Investig 20:1639\u20131645. https:\/\/doi.org\/10.1007\/s00784-015-1656-4","journal-title":"Clin Oral Investig"},{"key":"3707_CR5","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1111\/iej.12619","volume":"50","author":"S Rajasekharan","year":"2017","unstructured":"Rajasekharan S, Martens LC, Vandenbulcke J, Jacquet W, Bottenberg P, Cauwels RGEC (2017) Efficacy of three different pulpotomy agents in primary molars: a randomized control trial. Int Endod J 50:215\u2013228. https:\/\/doi.org\/10.1111\/iej.12619","journal-title":"Int Endod J"},{"key":"3707_CR6","doi-asserted-by":"publisher","first-page":"457","DOI":"10.4103\/0976-237X.194116","volume":"7","author":"N Grewal","year":"2016","unstructured":"Grewal N, Salhan R, Kaur N, Patel H (2016) Comparative evaluation of calcium silicate-based dentin substitute (Biodentine \u00ae ) and calcium hydroxide (pulpdent) in the formation of reactive dentin bridge in regenerative pulpotomy of vital primary teeth: triple blind, randomized clinical trial. Contemp Clin Dent 7:457. https:\/\/doi.org\/10.4103\/0976-237X.194116","journal-title":"Contemp Clin Dent"},{"key":"3707_CR7","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1177\/0022034511405326","volume":"23","author":"KM Galler","year":"2011","unstructured":"Galler KM, D\u2019Souza RN, Hartgerink JD, Schmalz G (2011) Scaffolds for dental pulp tissue engineering. Adv Dent Res 23:333\u2013339. https:\/\/doi.org\/10.1177\/0022034511405326","journal-title":"Adv Dent Res"},{"key":"3707_CR8","doi-asserted-by":"publisher","first-page":"964","DOI":"10.1016\/j.biomaterials.2005.07.017","volume":"27","author":"JR Jones","year":"2006","unstructured":"Jones JR, Ehrenfried LM, Hench LL (2006) Optimising bioactive glass scaffolds for bone tissue engineering. Biomaterials 27:964\u2013973. https:\/\/doi.org\/10.1016\/j.biomaterials.2005.07.017","journal-title":"Biomaterials"},{"key":"3707_CR9","doi-asserted-by":"publisher","first-page":"332","DOI":"10.4103\/0976-237x.188552","volume":"7","author":"R Haghgoo","year":"2016","unstructured":"Haghgoo R, Ahmadvand M (2016) Evaluation of pulpal response of deciduous teeth after direct pulp capping with bioactive glass and mineral trioxide aggregate. Contemp Clin Dent 7:332\u2013335. https:\/\/doi.org\/10.4103\/0976-237x.188552","journal-title":"Contemp Clin Dent"},{"key":"3707_CR10","doi-asserted-by":"publisher","first-page":"1647","DOI":"10.1016\/j.joen.2017.03.011","volume":"43","author":"Y Long","year":"2017","unstructured":"Long Y, Liu S, Zhu L, Liang Q, Chen X, Dong Y (2017) Evaluation of pulp response to novel bioactive glass pulp capping materials. J Endod 43:1647\u20131650. https:\/\/doi.org\/10.1016\/j.joen.2017.03.011","journal-title":"J Endod"},{"key":"3707_CR11","unstructured":"Abdel Naby SM (2007) A comparative study of the pulpal response to mineral trioxide aggregate versus bioactive glass as pulpotomy agents in primary teeth. Dissertation, University of Alexandria"},{"key":"3707_CR12","doi-asserted-by":"publisher","first-page":"9169","DOI":"10.1016\/j.actbio.2013.07.014","volume":"9","author":"S Midha","year":"2013","unstructured":"Midha S, Kim TB, Van Den Bergh W, Lee PD, Jones JR, Mitchell CA (2013) Preconditioned 70S30C bioactive glass foams promote osteogenesis in vivo. Acta Biomater 9:9169\u20139182. https:\/\/doi.org\/10.1016\/j.actbio.2013.07.014","journal-title":"Acta Biomater"},{"key":"3707_CR13","doi-asserted-by":"publisher","first-page":"1632","DOI":"10.1089\/ten.tea.2012.0585","volume":"19","author":"S Wang","year":"2013","unstructured":"Wang S, Kowal TJ, Marei MK, Falk MM, Jain H (2013) Nanoporosity significantly enhances the biological performance of engineered glass tissue scaffolds. Tissue Eng A 19:1632\u20131640. https:\/\/doi.org\/10.1089\/ten.tea.2012.0585","journal-title":"Tissue Eng A"},{"key":"3707_CR14","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1177\/2380084416660672","volume":"1","author":"N El Shazley","year":"2016","unstructured":"El Shazley N, Hamdy A, El-Eneen HA, El Backly RM, Saad MM, Essam W, Moussa H, El Tantawi M, Jain H, Marei MK (2016) Bioglass in alveolar bone regeneration in orthodontic patients. JDR Clin Transl Res 1:244\u2013255. https:\/\/doi.org\/10.1177\/2380084416660672","journal-title":"JDR Clin Transl Res"},{"key":"3707_CR15","doi-asserted-by":"publisher","first-page":"2792","DOI":"10.1016\/j.actbio.2014.02.013","volume":"10","author":"S Wang","year":"2014","unstructured":"Wang S, Gao X, Gong W, Zhang Z, Chen X, Dong Y (2014) Odontogenic differentiation and dentin formation of dental pulp cells under nanobioactive glass induction. Acta Biomater 10:2792\u20132803. https:\/\/doi.org\/10.1016\/j.actbio.2014.02.013","journal-title":"Acta Biomater"},{"key":"3707_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2017\/2495282","volume":"2017","author":"SK Jun","year":"2017","unstructured":"Jun SK, Lee JH, Lee HH (2017) The biomineralization of a bioactive glass-incorporated light-curable pulp capping material using human dental pulp stem cells. Biomed Res Int 2017:1\u20139. https:\/\/doi.org\/10.1155\/2017\/2495282","journal-title":"Biomed Res Int"},{"key":"3707_CR17","doi-asserted-by":"publisher","first-page":"290","DOI":"10.11648\/j.ijmsa.20170606.14","volume":"6","author":"J Alsenan","year":"2017","unstructured":"Alsenan J, Chou L (2017) Effect of silicon and calcium on human dental pulp cell cultures. Int J Mater Sci Appl 6:290. https:\/\/doi.org\/10.11648\/j.ijmsa.20170606.14","journal-title":"Int J Mater Sci Appl"},{"key":"3707_CR18","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1002\/jbm.b.33532","volume":"105","author":"TCC Lopez","year":"2017","unstructured":"Lopez TCC, Diniz IMA, Ferreira LS, Marchi J, Borges R, de Cara SPHM, D\u2019Almeida-Couto R, Marques MM (2017) Bioactive glass plus laser phototherapy as promise candidates for dentine hypersensitivity treatment. J Biomed Mater Res B Appl Biomater 105:107\u2013116. https:\/\/doi.org\/10.1002\/jbm.b.33532","journal-title":"J Biomed Mater Res B Appl Biomater"},{"key":"3707_CR19","doi-asserted-by":"publisher","first-page":"2644","DOI":"10.1016\/j.actbio.2011.03.009","volume":"7","author":"C Wu","year":"2011","unstructured":"Wu C, Luo Y, Cuniberti G, Xiao Y, Gelinsky M (2011) Three-dimensional printing of hierarchical and tough mesoporous bioactive glass scaffolds with a controllable pore architecture, excellent mechanical strength and mineralization ability. Acta Biomater 7:2644\u20132650. https:\/\/doi.org\/10.1016\/j.actbio.2011.03.009","journal-title":"Acta Biomater"},{"key":"3707_CR20","doi-asserted-by":"publisher","first-page":"347649","DOI":"10.1155\/2015\/347649","volume":"2015","author":"M Goldberg","year":"2015","unstructured":"Goldberg M, Njeh A, Uzunoglu E (2015) Is pulp inflammation a prerequisite for pulp healing and regeneration? Mediat Inflamm 2015:347649\u2013347611. https:\/\/doi.org\/10.1155\/2015\/347649","journal-title":"Mediat Inflamm"},{"key":"3707_CR21","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1111\/iej.12030","volume":"46","author":"M ElSalhy","year":"2013","unstructured":"ElSalhy M, Azizieh F, Raghupathy R (2013) Cytokines as diagnostic markers of pulpal inflammation. Int Endod J 46:573\u2013580. https:\/\/doi.org\/10.1111\/iej.12030","journal-title":"Int Endod J"},{"key":"3707_CR22","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1177\/08959374010150011201","volume":"15","author":"H Magloire","year":"2001","unstructured":"Magloire H, Romeas A, Melin M, Couble ML, Bleicher F, Farges JC (2001) Molecular regulation of odontoblast activity under dentin injury. Adv Dent Res 15:46\u201350. https:\/\/doi.org\/10.1177\/08959374010150011201","journal-title":"Adv Dent Res"},{"key":"3707_CR23","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1046\/j.1600-9657.2003.00204.x","volume":"19","author":"N Salako","year":"2003","unstructured":"Salako N, Joseph B, Ritwik P, Salonen J, John P, Junaid TA (2003) Comparison of bioactive glass, mineral trioxide aggregate, ferric sulfate, and formocresol as pulpotomy agents in rat molar. Dent Traumatol 19:314\u2013320. https:\/\/doi.org\/10.1046\/j.1600-9657.2003.00204.x","journal-title":"Dent Traumatol"},{"key":"3707_CR24","first-page":"155","volume":"4","author":"R Haghgoo","year":"2007","unstructured":"Haghgoo R, Naderi NJ (2007) Comparison of calcium hydroxide and bioactive glass after direct pulp capping in primary teeth. J Front Dent 4:155\u2013159","journal-title":"J Front Dent"},{"key":"3707_CR25","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.1007\/s10856-011-4297-4","volume":"22","author":"S Wang","year":"2011","unstructured":"Wang S, Falk MM, Rashad A, Saad MM, Marques AC, Almeida RM, Marei MK, Jain H (2011) Evaluation of 3D nano\u2013macro porous bioactive glass scaffold for hard tissue engineering. J Mater Sci Mater Med 22:1195\u20131203. https:\/\/doi.org\/10.1007\/s10856-011-4297-4","journal-title":"J Mater Sci Mater Med"},{"key":"3707_CR26","doi-asserted-by":"publisher","first-page":"1636","DOI":"10.1111\/bcp.13280","volume":"83","author":"TA Althunian","year":"2017","unstructured":"Althunian TA, De Boer A, Groenwold RHH, Klungel OH (2017) Defining the noninferiority margin and analysing noninferiority: an overview. Br J Clin Pharmacol 83:1636\u20131642. https:\/\/doi.org\/10.1111\/bcp.13280","journal-title":"Br J Clin Pharmacol"},{"key":"3707_CR27","doi-asserted-by":"publisher","first-page":"276","DOI":"10.5395\/rde.2015.40.4.276","volume":"40","author":"B Kusum","year":"2015","unstructured":"Kusum B, Rakesh K, Richa K (2015) Clinical and radiographical evaluation of mineral trioxide aggregate, biodentine and propolis as pulpotomy medicaments in primary teeth. Restor Dent Endod 40:276\u2013285. https:\/\/doi.org\/10.5395\/rde.2015.40.4.276","journal-title":"Restor Dent Endod"},{"key":"3707_CR28","doi-asserted-by":"publisher","first-page":"571","DOI":"10.3290\/j.qi.a36095","volume":"47","author":"OA El Meligy","year":"2016","unstructured":"El Meligy OA, Allazzam S, Alamoudi NM (2016) Comparison between biodentine and formocresol for pulpotomy of primary teeth: a randomized clinical trial. Quintessence Int (Berl) 47:571\u2013580. https:\/\/doi.org\/10.3290\/j.qi.a36095","journal-title":"Quintessence Int (Berl)"},{"key":"3707_CR29","first-page":"325","volume":"39","author":"American Academy of Pediatric Dentistry","year":"2014","unstructured":"American Academy of Pediatric Dentistry (2014) Pulp therapy for primary and immature permanent teeth. Reference Manual 39:325\u2013333","journal-title":"Reference Manual"},{"key":"3707_CR30","first-page":"302","volume":"26","author":"HA Agamy","year":"2004","unstructured":"Agamy HA, Bakry NS, Mounir MMF, Avery DR (2004) Comparison of mineral trioxide aggregate and formocresol as pulp-capping agents in pulpotomized primary teeth. Pediatr Dent 26:302\u2013309","journal-title":"Pediatr Dent"},{"key":"3707_CR31","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/1471-2288-4-26","volume":"4","author":"M Saghaei","year":"2004","unstructured":"Saghaei M (2004) Random allocation software for parallel group randomized trials. BMC Med Res Methodol 4:26. https:\/\/doi.org\/10.1186\/1471-2288-4-26","journal-title":"BMC Med Res Methodol"},{"key":"3707_CR32","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1177\/154405910508401210","volume":"84","author":"KC Huth","year":"2005","unstructured":"Huth KC, Paschos E, Hajek-Al-Khatar N, Hollweck R, Crispin A, Hickel R, Folwaczny M (2005) Effectiveness of 4 pulpotomy techniques\u2014randomized controlled trial. J Dent Res 84:1144\u20131148. https:\/\/doi.org\/10.1177\/154405910508401210","journal-title":"J Dent Res"},{"key":"3707_CR33","doi-asserted-by":"publisher","unstructured":"McHugh ML (2012) Interrater reliability: the kappa statistic. Biochem Med. https:\/\/doi.org\/10.11613\/bm.2012.031","DOI":"10.11613\/bm.2012.031"},{"key":"3707_CR34","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/1741-7015-8-18","volume":"8","author":"KF Schulz","year":"2010","unstructured":"Schulz KF, Altman DG, Moher D (2010) CONSORT 2010 statement: updated guidelines for reporting parallel group randomised trials. BMC Med 8:18. https:\/\/doi.org\/10.1186\/1741-7015-8-18","journal-title":"BMC Med"},{"key":"3707_CR35","first-page":"202E","volume":"34","author":"A Shayegan","year":"2012","unstructured":"Shayegan A, Jurysta C, Atash R, Petein M, Vanden AA (2012) Biodentine used as a pulp-capping agent in primary pig teeth. Pediatr Dent 34:202E\u2013208E","journal-title":"Pediatr Dent"},{"key":"3707_CR36","doi-asserted-by":"publisher","first-page":"145","DOI":"10.2334\/josnusd.57.145","volume":"57","author":"Y Ozdemir","year":"2015","unstructured":"Ozdemir Y, Kutukculer N, Topaloglu-Ak A, Kose T, Eronat C (2015) Comparative evaluation of pro-inflammatory cytokine levels in pulpotomized primary molars. J Oral Sci 57:145\u2013150. https:\/\/doi.org\/10.2334\/josnusd.57.145","journal-title":"J Oral Sci"},{"key":"3707_CR37","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1016\/S0188-4409(02)00396-X","volume":"33","author":"S Pezelj-Ribaric","year":"2002","unstructured":"Pezelj-Ribaric S, Anic I, Brekalo I, Miletic I, Hasan M, Simunovic-Soskic M (2002) Detection of tumor necrosis factor \u03b1 in Normal and inflamed human dental pulps. Arch Med Res 33:482\u2013484. https:\/\/doi.org\/10.1016\/S0188-4409(02)00396-X","journal-title":"Arch Med Res"},{"key":"3707_CR38","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1515\/bglass-2017-0009","volume":"3","author":"S Gholami","year":"2017","unstructured":"Gholami S, Labbaf S, Houreh AB, Ting HK, Jones JR, Esfahani MHN (2017) Long term effects of bioactive glass particulates on dental pulp stem cells in vitro. Biomed Glas 3:96\u2013103. https:\/\/doi.org\/10.1515\/bglass-2017-0009","journal-title":"Biomed Glas"},{"key":"3707_CR39","first-page":"38","volume":"35","author":"E Uzuno\u011flu","year":"2011","unstructured":"Uzuno\u011flu E, Y\u0131lmaz Z, Evren \u00dclker A, Kalayc\u0131 S, Karahan S (2011) Determination of pH and calcium ion realease provided by different calcium hyroxide pastes. Clin Dent Res 35:38\u201342","journal-title":"Clin Dent Res"},{"key":"3707_CR40","first-page":"1","volume":"59","author":"WA Fouad","year":"2013","unstructured":"Fouad WA, Youssef R, Yossef R (2013) Clinical and radiographic assessment of vital pulpotomy in primary molars using mineral trioxide aggregate and a novel bioactive cement. Egypt Dent J 59:1\u20137","journal-title":"Egypt Dent J"},{"key":"3707_CR41","doi-asserted-by":"publisher","first-page":"29","DOI":"10.5395\/rde.2016.41.1.29","volume":"41","author":"J Kim","year":"2016","unstructured":"Kim J, Song YS, Min KS, Kim SH, Koh JT, Lee BN, Chang HS, Hwang IN, Oh WM, Hwang YC (2016) Evaluation of reparative dentin formation of ProRoot MTA, biodentine and BioAggregate using micro-CT and immunohistochemistry. Restor Dent Endod 41:29\u201336. https:\/\/doi.org\/10.5395\/rde.2016.41.1.29","journal-title":"Restor Dent Endod"},{"key":"3707_CR42","first-page":"16","volume":"39","author":"JA Coll","year":"2017","unstructured":"Coll JA, Seale NS, Vargas K, Marghalani AA, Al Shamali S, Graham L (2017) Primary tooth vital pulp therapy: a systematic review and meta-analysis. Pediatr Dent 39:16\u2013123","journal-title":"Pediatr Dent"},{"key":"3707_CR43","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1002\/jbm.10026","volume":"58","author":"P Sepulveda","year":"2001","unstructured":"Sepulveda P, Jones JR, Hench LL (2001) Characterization of melt-derived 45S5 and sol-gel-derived 58S bioactive glasses. J Biomed Mater Res 58:734\u2013740. https:\/\/doi.org\/10.1002\/jbm.10026","journal-title":"J Biomed Mater Res"},{"key":"3707_CR44","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1002\/jbm.10207","volume":"61","author":"P Sepulveda","year":"2002","unstructured":"Sepulveda P, Jones JR, Hench LL (2002) In vitro dissolution of melt-derived 45S5 and sol-gel derived 58S bioactive glasses. J Biomed Mater Res 61:301\u2013311. https:\/\/doi.org\/10.1002\/jbm.10207","journal-title":"J Biomed Mater Res"},{"key":"3707_CR45","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.actbio.2018.05.019","volume":"75","author":"FE Ciraldo","year":"2018","unstructured":"Ciraldo FE, Boccardi E, Melli V, Westhauser F, Boccaccini AR (2018) Tackling bioactive glass excessive in vitro bioreactivity: preconditioning approaches for cell culture tests. Acta Biomater 75:3\u201310. https:\/\/doi.org\/10.1016\/j.actbio.2018.05.019","journal-title":"Acta Biomater"},{"key":"3707_CR46","doi-asserted-by":"publisher","first-page":"22063","DOI":"10.1039\/c7ra01480e","volume":"7","author":"CY Cui","year":"2017","unstructured":"Cui CY, Wang SN, Ren HH, Li AL, Qiu D, Gan YH, Dong YM (2017) Regeneration of dental-pulp complex-like tissue using phytic acid derived bioactive glasses. RSC Adv 7:22063\u201322070. https:\/\/doi.org\/10.1039\/c7ra01480e","journal-title":"RSC Adv"},{"key":"3707_CR47","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1111\/ijag.12322","volume":"8","author":"H Ting","year":"2017","unstructured":"Ting H, Page SJ, Poologasundarampillai G, Chen S, Yu B, Hanna JV, Jones JR (2017) Phosphate content affects structure and bioactivity of sol-gel silicate bioactive glasses. Int J Appl Glas Sci 8:372\u2013382. https:\/\/doi.org\/10.1111\/ijag.12322","journal-title":"Int J Appl Glas Sci"},{"key":"3707_CR48","doi-asserted-by":"publisher","first-page":"8928","DOI":"10.1007\/s10853-017-0946-4","volume":"52","author":"AB Houreh","year":"2017","unstructured":"Houreh AB, Labbaf S, Ting HK, Ejeian F, Jones JR, Esfahani MHN (2017) Influence of calcium and phosphorus release from bioactive glasses on viability and differentiation of dental pulp stem cells. J Mater Sci 52:8928\u20138941. https:\/\/doi.org\/10.1007\/s10853-017-0946-4","journal-title":"J Mater Sci"},{"key":"3707_CR49","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.joen.2013.08.018","volume":"40","author":"W Gong","year":"2014","unstructured":"Gong W, Huang Z, Dong Y, Gan Y, Li S, Gao X, Chen X (2014) Ionic extraction of a novel nano-sized bioactive glass enhances differentiation and mineralization of human dental pulp cells. J Endod 40:83\u201388. https:\/\/doi.org\/10.1016\/j.joen.2013.08.018","journal-title":"J Endod"},{"key":"3707_CR50","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1016\/j.joen.2012.11.026","volume":"39","author":"HM Zhou","year":"2013","unstructured":"Zhou HM, Shen Y, Wang ZJ, Li L, Zheng YF, H\u00e4kkinen L, Haapasalo M (2013) In vitro cytotoxicity evaluation of a novel root repair material. J Endod 39:478\u2013483. https:\/\/doi.org\/10.1016\/j.joen.2012.11.026","journal-title":"J Endod"},{"key":"3707_CR51","doi-asserted-by":"publisher","unstructured":"Hassan ST, Alothmani OS, Yousef MK (2015) Biodentine and mineral trioxide aggregate: an analysis of solubility, pH changes and leaching elements. Life Sci J. https:\/\/doi.org\/10.4103\/JCD.JCD_45_17","DOI":"10.4103\/JCD.JCD_45_17"},{"key":"3707_CR52","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1177\/08959374010150010201","volume":"15","author":"Y Nakamura","year":"2001","unstructured":"Nakamura Y, Hammarstr\u00f6m L, Lundberg E, Ekdahl H, Matsumoto K, Gestrelius S, Lyngstadaas SP (2001) Enamel matrix derivative promotes reparative processes in the dental pulp. Adv Dent Res 15:105\u2013107. https:\/\/doi.org\/10.1177\/08959374010150010201","journal-title":"Adv Dent Res"},{"key":"3707_CR53","doi-asserted-by":"publisher","first-page":"90","DOI":"10.4103\/2155-8213.103910","volume":"3","author":"GR Ravi","year":"2012","unstructured":"Ravi GR, Subramanyam RV (2012) Calcium hydroxide-induced resorption of deciduous teeth: a possible explanation. Dent Hypotheses 3:90. https:\/\/doi.org\/10.4103\/2155-8213.103910","journal-title":"Dent Hypotheses"},{"key":"3707_CR54","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.tripleo.2007.06.026","volume":"105","author":"S Yildirim","year":"2008","unstructured":"Yildirim S, Yapar M, Sermet U, Sener K, Kubar A (2008) The role of dental pulp cells in resorption of deciduous teeth. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 105:113\u2013120. https:\/\/doi.org\/10.1016\/j.tripleo.2007.06.026","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"3707_CR55","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1590\/S1806-83242014.50000003","volume":"28","author":"RL Santos","year":"2014","unstructured":"Santos RL, Moura MFL, Carvalho FG, Gu\u00eanes GMT, Alves PM, Pithon MM (2014) Histological analysis of biocompatibility of ionomer cements with an acid-base reaction. Braz Oral Res 28:1\u20137. https:\/\/doi.org\/10.1590\/S1806-83242014.50000003","journal-title":"Braz Oral Res"},{"key":"3707_CR56","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.dental.2018.09.008","volume":"35","author":"T Giraud","year":"2019","unstructured":"Giraud T, Jeanneau C, Rombouts C, Bakhtiar H, Laurent P, About I (2019) Pulp capping materials modulate the balance between inflammation and regeneration. Dent Mater 35:24\u201335. https:\/\/doi.org\/10.1016\/j.dental.2018.09.008","journal-title":"Dent Mater"},{"key":"3707_CR57","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1590\/S1678-77572009000500031","volume":"17","author":"ACO Silva","year":"2009","unstructured":"Silva ACO, Faria MR, Fontes A, Campos MS, Cavalcanti BN (2009) Interleukin-1 beta and interleukin-8 in healthy and inflamed dental pulps. J Appl Oral Sci 17:527\u2013532. https:\/\/doi.org\/10.1590\/S1678-77572009000500031","journal-title":"J Appl Oral Sci"},{"key":"3707_CR58","doi-asserted-by":"publisher","first-page":"6785","DOI":"10.1128\/IAI.68.12.6785-6789.2000","volume":"68","author":"C-L Hahn","year":"2000","unstructured":"Hahn C-L, Best AM, Tew JG (2000) Cytokine induction by Streptococcus mutans and pulpal pathogenesis. Infect Immun 68:6785\u20136789. https:\/\/doi.org\/10.1128\/IAI.68.12.6785-6789.2000","journal-title":"Infect Immun"},{"key":"3707_CR59","doi-asserted-by":"publisher","first-page":"94","DOI":"10.22038\/jdmt.2016.6620","volume":"5","author":"F Mazhari","year":"2016","unstructured":"Mazhari F, Shabzendedar M, Mohtasham N, Nik E, Noorollahian H (2016) Success evaluation of pulpotomy in primary molars with enamel matrix derivative: a pilot study. J Dent Mater Tech 5:94\u201398. https:\/\/doi.org\/10.22038\/jdmt.2016.6620","journal-title":"J Dent Mater Tech"}],"container-title":["Clinical Oral Investigations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-020-03707-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00784-020-03707-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-020-03707-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,20]],"date-time":"2021-05-20T09:27:35Z","timestamp":1621502855000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00784-020-03707-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,6]]},"references-count":59,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["3707"],"URL":"https:\/\/doi.org\/10.1007\/s00784-020-03707-5","relation":{},"ISSN":["1432-6981","1436-3771"],"issn-type":[{"value":"1432-6981","type":"print"},{"value":"1436-3771","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,6]]},"assertion":[{"value":"14 June 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 November 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 January 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in the study involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The study was approved by the Research Ethics Committee, Faculty of Dentistry, Alexandria\u00a0University,\u00a0Egypt, (IRB 00010556)-(IORG 0008839).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from parents of all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Informed consent was obtained from parents of all individual participants regarding publishing any of their data.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}}]}}