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The main aim of this study was to determine whether the RODI might help to discriminate between various causes of oral dryness in dry-mouth patients. The second aim was to ascertain whether the RODI could become an additional diagnostic tool in dry-mouth patients.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Materials and methods<\/jats:title>\n                <jats:p>Data were collected retrospectively from patients who visited a specialized saliva clinic. Salivary flow rates, Xerostomia Inventory scores, and RODI scores were extracted from the medical records. Patients were stratified into subgroups according to their health status.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Five hundred twenty-eight patients participated in this study (mean age of 59.6\u2009\u00b1\u200916.0\u00a0years; 68.4% female). Specific patient groups differed with regard to the region of the mouth they experienced as the most and least dry. The posterior palate was the area perceived as most dry by controls and Sj\u00f6gren patients. In patients using limited or multiple medications, it was the anterior tongue. RODI scores also differed significantly among dry-mouth patient groups: whereas controls and patients using limited medication had the lowest RODI scores and experienced less intra-oral dryness, Sj\u00f6gren patients had the highest RODI scores.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Our use of the RODI questionnaire showed that perceived intra-oral dryness differed between the various dry-mouth patients.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Clinical relevance<\/jats:title>\n                <jats:p>The RODI can be a valuable clinical diagnostic tool in dry-mouth diagnostics, in which it can be used to discriminate between the various causes of oral dryness in patients.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00784-020-03734-2","type":"journal-article","created":{"date-parts":[[2021,1,26]],"date-time":"2021-01-26T14:03:46Z","timestamp":1611669826000},"page":"4031-4043","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Differences in perceived intra-oral dryness in various dry-mouth patients as determined using the Regional Oral Dryness Inventory"],"prefix":"10.1007","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1531-8930","authenticated-orcid":false,"given":"Z.","family":"Assy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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Assy has received research grants from the Nederlands Tijdschrift voor Tandheelkunde (NTVT). C.P. Bots declares that he has no conflict of interest, H.Z. Arisoy declares that she has no conflict of interest, S.S. G\u00fclveren declares that she has no conflict of interest, F.J. Bikker declares that he has no conflict of interest, and H.S. Brand declares that he has no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee (Ethics Review Committee of the Academic Centre for Dentistry Amsterdam, protocol number 201951) and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"For this type of study, formal consent is not required.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}