{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T16:20:30Z","timestamp":1772209230461,"version":"3.50.1"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2021,1,7]],"date-time":"2021-01-07T00:00:00Z","timestamp":1609977600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,1,7]],"date-time":"2021-01-07T00:00:00Z","timestamp":1609977600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100008736","name":"Fondo de Fomento al Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["1160741"],"award-info":[{"award-number":["1160741"]}],"id":[{"id":"10.13039\/501100008736","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002850","name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["1200098"],"award-info":[{"award-number":["1200098"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Oral Invest"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1007\/s00784-020-03738-y","type":"journal-article","created":{"date-parts":[[2021,1,7]],"date-time":"2021-01-07T06:04:15Z","timestamp":1609999455000},"page":"4075-4083","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Localization of interleukin-6 signaling complex in epithelialized apical lesions of endodontic origin"],"prefix":"10.1007","volume":"25","author":[{"given":"C.","family":"Schweitzer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Garrido","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Paredes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Stoore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Reyes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Bologna-Molina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8289-7314","authenticated-orcid":false,"given":"Marcela","family":"Hern\u00e1ndez Rios","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,1,7]]},"reference":[{"issue":"4","key":"3738_CR1","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1016\/j.joen.2014.12.021","volume":"41","author":"M Garrido","year":"2015","unstructured":"Garrido M, Dezerega A, Bordagaray MJ, Reyes M, Vernal R, Melgar-Rodriguez S, Ciuchi P, Paredes R, Garcia-Sesnich J, Ahumada-Montalva P, Hernandez M (2015) C-reactive protein expression is up-regulated in apical lesions of endodontic origin in association with interleukin-6. J Endod 41(4):464\u2013469. https:\/\/doi.org\/10.1016\/j.joen.2014.12.021","journal-title":"J Endod"},{"issue":"2","key":"3738_CR2","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.joen.2018.11.014","volume":"45","author":"M Garrido","year":"2019","unstructured":"Garrido M, Cardenas AM, Astorga J, Quinlan F, Valdes M, Chaparro A, Carvajal P, Pussinen P, Huaman-Chipana P, Jalil JE, Hernandez M (2019) Elevated systemic inflammatory burden and cardiovascular risk in young adults with endodontic apical lesions. J Endod 45(2):111\u2013115. https:\/\/doi.org\/10.1016\/j.joen.2018.11.014","journal-title":"J Endod"},{"issue":"12","key":"3738_CR3","doi-asserted-by":"publisher","first-page":"1951","DOI":"10.1016\/j.joen.2015.08.036","volume":"41","author":"L Bernardi","year":"2015","unstructured":"Bernardi L, Visioli F, N\u00f6r C, Rados PV (2015) Radicular cyst: an update of the biological factors related to lining epithelium. J Endod 41(12):1951\u20131961. https:\/\/doi.org\/10.1016\/j.joen.2015.08.036","journal-title":"J Endod"},{"issue":"11","key":"3738_CR4","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1111\/iej.12554","volume":"49","author":"MK \u00c7al\u0131\u015fkan","year":"2016","unstructured":"\u00c7al\u0131\u015fkan MK, Kaval ME, Tekin U, \u00dcnal T (2016) Radiographic and histological evaluation of persistent periapical lesions associated with endodontic failures after apical microsurgery. Int Endod J 49(11):1011\u20131019. https:\/\/doi.org\/10.1111\/iej.12554","journal-title":"Int Endod J"},{"issue":"12","key":"3738_CR5","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1111\/iej.12567","volume":"49","author":"F Vidal","year":"2016","unstructured":"Vidal F, Fontes TV, Marques TV, Gon\u00e7alves LS (2016) Association between apical periodontitis lesions and plasmatic levels of C-reactive protein, interleukin 6 and fibrinogen in hypertensive patients. Int Endod J 49(12):1107\u20131115. https:\/\/doi.org\/10.1111\/iej.12567","journal-title":"Int Endod J"},{"key":"3738_CR6","doi-asserted-by":"publisher","first-page":"38210","DOI":"10.1155\/2007\/38210","volume":"2007","author":"IB Prso","year":"2007","unstructured":"Prso IB, Kocjan W, Simic H, Brumini G, Pezelj-Ribaric S, Borcic J, Ferreri S, Karlovic IM (2007) Tumor necrosis factor-alpha and interleukin 6 in human periapical lesions. Mediat Inflamm 2007:38210\u201338214. https:\/\/doi.org\/10.1155\/2007\/38210","journal-title":"Mediat Inflamm"},{"issue":"12","key":"3738_CR7","doi-asserted-by":"publisher","first-page":"e114195","DOI":"10.1371\/journal.pone.0114195","volume":"9","author":"KA Kuhn","year":"2014","unstructured":"Kuhn KA, Manieri NA, Liu TC, Stappenbeck TS (2014) IL-6 stimulates intestinal epithelial proliferation and repair after injury. PLoS One 9(12):e114195. https:\/\/doi.org\/10.1371\/journal.pone.0114195","journal-title":"PLoS One"},{"issue":"7","key":"3738_CR8","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1038\/nrrheum.2017.83","volume":"13","author":"S Rose-John","year":"2017","unstructured":"Rose-John S, Winthrop K, Calabrese L (2017) The role of IL-6 in host defence against infections: immunobiology and clinical implications. Nat Rev Rheumatol 13(7):399\u2013409. https:\/\/doi.org\/10.1038\/nrrheum.2017.83","journal-title":"Nat Rev Rheumatol"},{"issue":"8","key":"3738_CR9","doi-asserted-by":"publisher","first-page":"2378","DOI":"10.1002\/eji.1830250838","volume":"25","author":"C Gabay","year":"1995","unstructured":"Gabay C, Silacci P, Genin B, Mentha G, Le Coultre C, Guerne PA (1995) Soluble interleukin-6 receptor strongly increases the production of acute-phase protein by hepatoma cells but exerts minimal changes on human primary hepatocytes. Eur J Immunol 25(8):2378\u20132383. https:\/\/doi.org\/10.1002\/eji.1830250838","journal-title":"Eur J Immunol"},{"issue":"50","key":"3738_CR10","doi-asserted-by":"publisher","first-page":"42959","DOI":"10.1074\/jbc.M111.295758","volume":"286","author":"C Garbers","year":"2011","unstructured":"Garbers C, Thaiss W, Jones GW, Waetzig GH, Lorenzen I, Guilhot F, Lissilaa R, Ferlin WG, Gr\u00f6tzinger J, Jones SA, Rose-John S, Scheller J (2011) Inhibition of classic signaling is a novel function of soluble glycoprotein 130 (sgp130), which is controlled by the ratio of interleukin 6 and soluble interleukin 6 receptor. J Biol Chem 286(50):42959\u201342970. https:\/\/doi.org\/10.1074\/jbc.M111.295758","journal-title":"J Biol Chem"},{"issue":"1","key":"3738_CR11","doi-asserted-by":"publisher","first-page":"7306","DOI":"10.1038\/s41598-019-43617-5","volume":"9","author":"CM Flynn","year":"2019","unstructured":"Flynn CM, Garbers Y, Lokau J, Wesch D, Schulte DM, Laudes M, Lieb W, Aparicio-Siegmund S, Garbers C (2019) Activation of Toll-like receptor 2 (TLR2) induces interleukin-6 trans-signaling. Sci Rep 9(1):7306. https:\/\/doi.org\/10.1038\/s41598-019-43617-5","journal-title":"Sci Rep"},{"key":"3738_CR12","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1111\/iej.12872","volume":"51","author":"A Hern\u00e1ndez-Caldera","year":"2017","unstructured":"Hern\u00e1ndez-Caldera A, Vernal R, Paredes R, Veloso-Matta P, Astorga J, Hern\u00e1ndez M (2017) Human periodontal ligament fibroblasts synthesize C-reactive protein and Th-related cytokines in response to interleukin (IL)-6 trans-signalling. Int Endod J 51:632\u2013640. https:\/\/doi.org\/10.1111\/iej.12872","journal-title":"Int Endod J"},{"key":"3738_CR13","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1111\/iej.13329","volume":"53","author":"A Fern\u00e1ndez","year":"2020","unstructured":"Fern\u00e1ndez A, Veloso P, Astorga J, Rodr\u00edguez C, Torres VA, Vald\u00e9s M, Garrido M, Gebicke-Haerter PJ, Hern\u00e1ndez M (2020) Epigenetic regulation of TLR2-mediated periapical inflammation. Int Endod J 53:1229\u20131237. https:\/\/doi.org\/10.1111\/iej.13329","journal-title":"Int Endod J"},{"key":"3738_CR14","doi-asserted-by":"publisher","first-page":"4571","DOI":"10.1007\/s00784-020-03324-2","volume":"24","author":"P Veloso","year":"2020","unstructured":"Veloso P, Fernandez A, Terraza-Aguirre C, Alvarez C, Vernal R, Escobar A, Hernandez M (2020) Macrophages skew towards M1 profile through reduced CD163 expression in symptomatic apical periodontitis. Clin Oral Investig 24:4571\u20134581. https:\/\/doi.org\/10.1007\/s00784-020-03324-2","journal-title":"Clin Oral Investig"},{"issue":"7","key":"3738_CR15","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1016\/S0099-2399(98)80051-4","volume":"24","author":"GJ Euler","year":"1998","unstructured":"Euler GJ, Miller GA, Hutter JW, D\u2019Alesandro MM (1998) Interleukin-6 in neutrophils from peripheral blood and inflammatory periradicular tissues. J Endod 24(7):480\u2013484. https:\/\/doi.org\/10.1016\/S0099-2399(98)80051-4","journal-title":"J Endod"},{"issue":"7","key":"3738_CR16","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1111\/j.1600-0765.1997.tb00932.x","volume":"32","author":"N Okada","year":"1997","unstructured":"Okada N, Kobayashi M, Mugikura K, Okamatsu Y, Hanazawa S, Kitano S, Hasegawa K (1997) Interleukin-6 production in human fibroblasts derived from periodontal tissues is differentially regulated by cytokines and a glucocorticoid. J Periodontal Res 32(7):559\u2013569","journal-title":"J Periodontal Res"},{"key":"3738_CR17","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1186\/1471-2407-14-99","volume":"14","author":"KG Neiva","year":"2014","unstructured":"Neiva KG, Warner KA, Campos MS, Zhang Z, Moren J, Danciu TE, N\u00f6r JE (2014) Endothelial cell-derived interleukin-6 regulates tumor growth. BMC Cancer 14:99. https:\/\/doi.org\/10.1186\/1471-2407-14-99","journal-title":"BMC Cancer"},{"issue":"8","key":"3738_CR18","doi-asserted-by":"publisher","first-page":"2030","DOI":"10.1111\/j.1462-5822.2007.00935.x","volume":"9","author":"M Triantafilou","year":"2007","unstructured":"Triantafilou M, Gamper FG, Lepper PM, Mouratis MA, Schumann C, Harokopakis E, Schifferle RE, Hajishengallis G, Triantafilou K (2007) Lipopolysaccharides from atherosclerosis-associated bacteria antagonize TLR4, induce formation of TLR2\/1\/CD36 complexes in lipid rafts and trigger TLR2-induced inflammatory responses in human vascular endothelial cells. Cell Microbiol 9(8):2030\u20132039. https:\/\/doi.org\/10.1111\/j.1462-5822.2007.00935.x","journal-title":"Cell Microbiol"},{"issue":"3","key":"3738_CR19","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1080\/0962935031000134905","volume":"12","author":"E Jablonska","year":"2003","unstructured":"Jablonska E, Marcinczyk M (2003) Role of interleukin-15 and interleukin-18 in the secretion of sIL-6R and sgp130 by human neutrophils. Mediat Inflamm 12(3):179\u2013183. https:\/\/doi.org\/10.1080\/0962935031000134905","journal-title":"Mediat Inflamm"},{"issue":"2","key":"3738_CR20","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1161\/HYPERTENSIONAHA.110.163360","volume":"57","author":"Y Wang","year":"2011","unstructured":"Wang Y, Lewis DF, Gu Y, Zhao S, Groome LJ (2011) Elevated maternal soluble Gp130 and IL-6 levels and reduced Gp130 and SOCS-3 expressions in women complicated with preeclampsia. Hypertension 57(2):336\u2013342. https:\/\/doi.org\/10.1161\/HYPERTENSIONAHA.110.163360","journal-title":"Hypertension"},{"issue":"11","key":"3738_CR21","doi-asserted-by":"publisher","first-page":"e270","DOI":"10.1038\/oncsis.2016.71","volume":"5","author":"K Aden","year":"2016","unstructured":"Aden K, Breuer A, Rehman A, Geese H, Tran F, Sommer J, Waetzig GH, Reinheimer TM, Schreiber S, Rose-John S, Scheller J, Rosenstiel P (2016) Classic IL-6R signalling is dispensable for intestinal epithelial proliferation and repair. Oncogenesis 5(11):e270. https:\/\/doi.org\/10.1038\/oncsis.2016.71","journal-title":"Oncogenesis"},{"issue":"1","key":"3738_CR22","first-page":"13","volume":"6","author":"A Polg\u00e1r","year":"2000","unstructured":"Polg\u00e1r A, Br\u00f3zik M, T\u00f3th S, Holub M, Hegyi K, K\u00e1d\u00e1r A, Hodinka L, Falus A (2000) Soluble interleukin-6 receptor in plasma and in lymphocyte culture supernatants of healthy individuals and patients with systemic lupus erythematosus and rheumatoid arthritis. Med Sci Monit 6(1):13\u201318","journal-title":"Med Sci Monit"},{"issue":"1","key":"3738_CR23","doi-asserted-by":"publisher","first-page":"31","DOI":"10.2220\/biomedres.34.31","volume":"34","author":"S Sawada","year":"2013","unstructured":"Sawada S, Chosa N, Ishisaki A, Naruishi K (2013) Enhancement of gingival inflammation induced by synergism of IL-1\u03b2 and IL-6. Biomed Res 34(1):31\u201340","journal-title":"Biomed Res"},{"issue":"1","key":"3738_CR24","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.joen.2013.09.037","volume":"40","author":"IV Bracks","year":"2014","unstructured":"Bracks IV, Armada L, Gon\u00e7alves LS, Pires FR (2014) Distribution of mast cells and macrophages and expression of interleukin-6 in periapical cysts. J Endod 40(1):63\u201368. https:\/\/doi.org\/10.1016\/j.joen.2013.09.037","journal-title":"J Endod"},{"issue":"2","key":"3738_CR25","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1016\/j.intimp.2012.12.011","volume":"15","author":"T Miyagawa","year":"2013","unstructured":"Miyagawa T, Fujita T, Ouhara K, Matsuda S, Kajiya M, Hayashida K, Imai H, Yoshimoto T, Iwata T, Shiba H, Abiko Y, Kurihara H (2013) Irsogladine maleate regulates the inflammatory related genes in human gingival epithelial cells stimulated by Aggregatibacter actinomycetemcomitans. Int Immunopharmacol 15(2):340\u2013347. https:\/\/doi.org\/10.1016\/j.intimp.2012.12.011","journal-title":"Int Immunopharmacol"},{"issue":"8","key":"3738_CR26","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1111\/j.1349-7006.1999.tb00827.x","volume":"90","author":"Y Nakano","year":"1999","unstructured":"Nakano Y, Kobayashi W, Sugai S, Kimura H, Yagihashi S (1999) Expression of tumor necrosis factor-alpha and interleukin-6 in oral squamous cell carcinoma. Jpn J Cancer Res 90(8):858\u2013866","journal-title":"Jpn J Cancer Res"},{"issue":"4","key":"3738_CR27","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1684\/ecn.2010.0211","volume":"21","author":"G Rodr\u00edguez-Berriguete","year":"2010","unstructured":"Rodr\u00edguez-Berriguete G, Prieto A, Fraile B, Bouraoui Y, de Bethencourt FR, Mart\u00ednez-Onsurbe P, Olmedilla G, Paniagua R, Royuela M (2010) Relationship between IL-6\/ERK and NF-\u03baB: a study in normal and pathological human prostate gland. Eur Cytokine Netw 21(4):241\u2013250. https:\/\/doi.org\/10.1684\/ecn.2010.0211","journal-title":"Eur Cytokine Netw"},{"issue":"6","key":"3738_CR28","doi-asserted-by":"publisher","first-page":"e12531","DOI":"10.1111\/pim.12531","volume":"40","author":"JH Kim","year":"2018","unstructured":"Kim JH, Han IH, Kim YS, Noh CS, Ryu JS (2018) Proliferation of prostate epithelia induced by IL-6 from stroma reacted with Trichomonas vaginalis. Parasite Immunol 40(6):e12531. https:\/\/doi.org\/10.1111\/pim.12531","journal-title":"Parasite Immunol"},{"issue":"5","key":"3738_CR29","doi-asserted-by":"publisher","first-page":"e62284","DOI":"10.1371\/journal.pone.0062284","volume":"8","author":"G Zhang","year":"2013","unstructured":"Zhang G, Tsang CM, Deng W, Yip YL, Lui VW, Wong SC, Cheung AL, Hau PM, Zeng M, Lung ML, Chen H, Lo KW, Takada K, Tsao SW (2013) Enhanced IL-6\/IL-6R signaling promotes growth and malignant properties in EBV-infected premalignant and cancerous nasopharyngeal epithelial cells. PLoS One 8(5):e62284. https:\/\/doi.org\/10.1371\/journal.pone.0062284","journal-title":"PLoS One"},{"issue":"12","key":"3738_CR30","doi-asserted-by":"publisher","first-page":"e962397","DOI":"10.4161\/21624011.2014.962397","volume":"3","author":"M Wouters","year":"2014","unstructured":"Wouters M, Dijkgraaf EM, Kuijjer ML, Jordanova ES, Hollema H, Welters M, van der Hoeven J, Daemen T, Kroep JR, Nijman HW, van der Burg SH (2014) Interleukin-6 receptor and its ligand interleukin-6 are opposite markers for survival and infiltration with mature myeloid cells in ovarian cancer. Oncoimmunology 3(12):e962397. https:\/\/doi.org\/10.4161\/21624011.2014.962397","journal-title":"Oncoimmunology"},{"issue":"12","key":"3738_CR31","doi-asserted-by":"publisher","first-page":"8549","DOI":"10.1167\/iovs.11-7956","volume":"52","author":"N Ebihara","year":"2011","unstructured":"Ebihara N, Matsuda A, Nakamura S, Matsuda H, Murakami A (2011) Role of the IL-6 classic- and trans-signaling pathways in corneal sterile inflammation and wound healing. Invest Ophthalmol Vis Sci 52(12):8549\u20138557. https:\/\/doi.org\/10.1167\/iovs.11-7956","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"3738_CR32","doi-asserted-by":"publisher","first-page":"41411","DOI":"10.1038\/srep41411","volume":"7","author":"W Feng","year":"2017","unstructured":"Feng W, Liu H, Luo T, Liu D, Du J, Sun J, Wang W, Han X, Yang K, Guo J, Amizuka N, Li M (2017) Combination of IL-6 and sIL-6R differentially regulate varying levels of RANKL-induced osteoclastogenesis through NF-\u03baB, ERK and JNK signaling pathways. Sci Rep 7:41411. https:\/\/doi.org\/10.1038\/srep41411","journal-title":"Sci Rep"},{"issue":"9","key":"3738_CR33","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.7150\/ijbs.4989","volume":"8","author":"S Rose-John","year":"2012","unstructured":"Rose-John S (2012) IL-6 trans-signaling via the soluble IL-6 receptor: importance for the pro-inflammatory activities of IL-6. Int J Biol Sci 8(9):1237\u20131247. https:\/\/doi.org\/10.7150\/ijbs.4989","journal-title":"Int J Biol Sci"},{"issue":"5","key":"3738_CR34","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1016\/j.bbamcr.2011.01.034","volume":"1813","author":"J Scheller","year":"2011","unstructured":"Scheller J, Chalaris A, Schmidt-Arras D, Rose-John S (2011) The pro- and anti-inflammatory properties of the cytokine interleukin-6. Biochim Biophys Acta 1813(5):878\u2013888. https:\/\/doi.org\/10.1016\/j.bbamcr.2011.01.034","journal-title":"Biochim Biophys Acta"}],"container-title":["Clinical Oral Investigations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-020-03738-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00784-020-03738-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-020-03738-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,20]],"date-time":"2021-05-20T09:28:03Z","timestamp":1621502883000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00784-020-03738-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,7]]},"references-count":34,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["3738"],"URL":"https:\/\/doi.org\/10.1007\/s00784-020-03738-y","relation":{},"ISSN":["1432-6981","1436-3771"],"issn-type":[{"value":"1432-6981","type":"print"},{"value":"1436-3771","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,7]]},"assertion":[{"value":"2 July 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 December 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 January 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The study was approved by the Bioethics Committee of the Faculty of Dentistry, Universidad de Chile, Santiago, Chile (no. 2016\/08; approval date: 29\/06\/2016).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}