{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T11:36:24Z","timestamp":1791891384169,"version":"4.3.4"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2021,1,9]],"date-time":"2021-01-09T00:00:00Z","timestamp":1610150400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,1,9]],"date-time":"2021-01-09T00:00:00Z","timestamp":1610150400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100005760","name":"University of Gothenburg","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005760","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Oral Invest"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Objectives<\/jats:title>\n                <jats:p>Ice chips (IC) have successfully been used to prevent the development of chemotherapy-induced oral mucositis (OM). Although effective, IC entails several shortcomings and may open avenues for systemic infections as the water used may be contaminated by microorganisms, which may jeopardise the medical rehabilitation of an already immunosuppressed patient. This study aimed to investigate the efficacy and tolerability profile of a novel intraoral cooling device (ICD).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Subjects and methods<\/jats:title>\n                <jats:p>In total, 20 healthy volunteers were enrolled in this randomised crossover study. Intraoral temperatures were registered using an IR camera, at baseline and following 30 and 60\u00a0min of cooling with the ICD, set to 8\u00a0\u00b0C or 15\u00a0\u00b0C. Following each cooling session, tolerability was assessed using a questionnaire.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>A statistically significant difference in the intraoral temperature was observed using 8\u00a0\u00b0C compared with 15\u00a0\u00b0C, following both 30 (1.87\u00a0\u00b0C, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and 60\u00a0min (2.48\u00a0\u00b0C, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) of cooling. Thus, the difference of the intraoral temperatures was less than the 7\u00a0\u00b0C difference between 8\u00a0\u00b0C and 15\u00a0\u00b0C. Furthermore, 60\u00a0min of cooling with 15\u00a0\u00b0C compared with 8\u00a0\u00b0C was better tolerated and preferred by 15 out of 20 participants (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Cooling was better tolerated when the ICD was set to 15\u00a0\u00b0C compared with 8\u00a0\u00b0C, although the difference in reduction of the intraoral mucosal temperature was marginal and may not affect cryoprevention of oral mucositis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Clinical relevance<\/jats:title>\n                <jats:p>The ICD has the potential to improve the care for patients with cancer at high risk of developing OM.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00784-020-03765-9","type":"journal-article","created":{"date-parts":[[2021,1,9]],"date-time":"2021-01-09T17:09:19Z","timestamp":1610212159000},"page":"4519-4526","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Can cryoprevention of oral mucositis be obtained at a higher temperature?"],"prefix":"10.1007","volume":"25","author":[{"given":"A.","family":"Mahdi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"St\u00fcbner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Bergling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Jontell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5660-1348","authenticated-orcid":false,"given":"J.","family":"Walladbegi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,1,9]]},"reference":[{"key":"3765_CR1","doi-asserted-by":"publisher","first-page":"2041","DOI":"10.1097\/01.CCM.0000069731.18472.61","volume":"31","author":"SA Bernard","year":"2003","unstructured":"Bernard SA, Buist M (2003) Induced hypothermia in critical care medicine: a review. 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All other authors declare no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All the procedures in this study involving human participants were performed in accordance with the ethical principles established in the WMA Declaration of Helsinki (Fortaleza, October 2013). The study was also reviewed and approved by the Department of Oral Medicine and Pathology, Institute of Odontology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, which was a request by the\u00a0Swedish Ethical Review Authority. The Swedish Ethical Review Authority itself did not consider an ethical application necessary.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"All participants received information concerning the study and were further informed about the rights to withdraw consent to participate at any given time without reprisal. Informed written consent, as well as consent for publication, was obtained from all the participants.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Code availability"}}]}}