{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T17:30:22Z","timestamp":1772040622484,"version":"3.50.1"},"reference-count":64,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Oral Invest"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1007\/s00784-021-03774-2","type":"journal-article","created":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T22:03:08Z","timestamp":1612216988000},"page":"4599-4619","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Local delivery natural products to treat periodontitis: a systematic review and meta-analysis"],"prefix":"10.1007","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4009-8597","authenticated-orcid":false,"given":"Emerson Tavares","family":"de Sousa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaiza Samara Macena","family":"de Ara\u00fajo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andressa Cavalcanti","family":"Pires","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elis Janaina","family":"Lira dos Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,2,1]]},"reference":[{"key":"3774_CR1","doi-asserted-by":"publisher","first-page":"S39","DOI":"10.1111\/jcpe.12685","volume":"44","author":"ILC Chapple","year":"2017","unstructured":"Chapple ILC, Bouchard P, Cagetti MG, Campus G, Carra MC, Cocco F, Nibali L, Hujoel P, Laine ML, Lingstr\u00f6m P, Manton DJ, Montero E, Pitts N, Rang\u00e9 H, Schlueter N, Teughels W, Twetman S, van Loveren C, van der Weijden F, Vieira AR, Schulte AG (2017) Interaction of lifestyle, behaviour or systemic diseases with dental caries and periodontal diseases: consensus report of group 2 of the joint EFP\/ORCA workshop on the boundaries between caries and periodontal diseases. J Clin Periodontol 44:S39\u2013S51. https:\/\/doi.org\/10.1111\/jcpe.12685","journal-title":"J Clin Periodontol"},{"key":"3774_CR2","doi-asserted-by":"publisher","first-page":"508-524.e5","DOI":"10.1016\/j.adaj.2015.01.028","volume":"146","author":"CJ Smiley","year":"2015","unstructured":"Smiley CJ, Tracy SL, Abt E et al (2015) Systematic review and meta-analysis on the nonsurgical treatment of chronic periodontitis by means of scaling and root planing with or without adjuncts. J Am Dent Assoc 146:508-524.e5. https:\/\/doi.org\/10.1016\/j.adaj.2015.01.028","journal-title":"J Am Dent Assoc"},{"key":"3774_CR3","doi-asserted-by":"publisher","first-page":"17038","DOI":"10.1038\/nrdp.2017.38","volume":"3","author":"DF Kinane","year":"2017","unstructured":"Kinane DF, Stathopoulou PG, Papapanou PN (2017) Periodontal diseases. Nat Rev Dis Prim 3:17038. https:\/\/doi.org\/10.1038\/nrdp.2017.38","journal-title":"Nat Rev Dis Prim"},{"key":"3774_CR4","doi-asserted-by":"publisher","first-page":"3665","DOI":"10.1128\/JCM.00317-06","volume":"44","author":"PS Kumar","year":"2006","unstructured":"Kumar PS, Leys EJ, Bryk JM, Martinez FJ, Moeschberger ML, Griffen AL (2006) Changes in periodontal health status are associated with bacterial community shifts as assessed by quantitative 16S cloning and sequencing. J Clin Microbiol 44:3665\u20133673. https:\/\/doi.org\/10.1128\/JCM.00317-06","journal-title":"J Clin Microbiol"},{"key":"3774_CR5","doi-asserted-by":"publisher","unstructured":"Hanes PJ, Purvis JP (2003) Local anti-infective therapy: pharmacological agents. A systematic review. Ann Periodontol 8:79\u201398. https:\/\/doi.org\/10.1902\/annals.2003.8.1.79","DOI":"10.1902\/annals.2003.8.1.79"},{"key":"3774_CR6","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1111\/jcpe.12026","volume":"40","author":"P Matesanz-P\u00e9rez","year":"2013","unstructured":"Matesanz-P\u00e9rez P, Garc\u00eda-Gargallo M, Figuero E, Bascones-Mart\u00ednez A, Sanz M, Herrera D (2013) A systematic review on the effects of local antimicrobials as adjuncts to subgingival debridement, compared with subgingival debridement alone, in the treatment of chronic periodontitis. J Clin Periodontol 40:227\u2013241. https:\/\/doi.org\/10.1111\/jcpe.12026","journal-title":"J Clin Periodontol"},{"key":"3774_CR7","doi-asserted-by":"publisher","first-page":"230","DOI":"10.2174\/138161282202151221124307","volume":"22","author":"V Lazar","year":"2016","unstructured":"Lazar V, Saviuc C-MC-M, Chifiriuc MC (2016) Periodontitis and periodontal disease - innovative strategies for reversing the chronic infectious and inflammatory condition by natural products. Curr Pharm Des 22:230\u2013237. https:\/\/doi.org\/10.2174\/138161282202151221124307","journal-title":"Curr Pharm Des"},{"key":"3774_CR8","doi-asserted-by":"publisher","first-page":"4769","DOI":"10.1016\/j.ejmech.2011.07.057","volume":"46","author":"BB Mishra","year":"2011","unstructured":"Mishra BB, Tiwari VK (2011) Natural products: an evolving role in future drug discovery. Eur J Med Chem 46:4769\u20134807. https:\/\/doi.org\/10.1016\/j.ejmech.2011.07.057","journal-title":"Eur J Med Chem"},{"key":"3774_CR9","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1351\/pac200577010007","volume":"77","author":"GM Cragg","year":"2005","unstructured":"Cragg GM, Newman DJ (2005) Biodiversity: a continuing source of novel drug leads. Pure Appl Chem 77:7\u201324. https:\/\/doi.org\/10.1351\/pac200577010007","journal-title":"Pure Appl Chem"},{"key":"3774_CR10","doi-asserted-by":"publisher","first-page":"303","DOI":"10.3390\/metabo2020303","volume":"2","author":"DA Dias","year":"2012","unstructured":"Dias DA, Urban S, Roessner U (2012) A historical overview of natural products in drug discovery. Metabolites 2:303\u2013336. https:\/\/doi.org\/10.3390\/metabo2020303","journal-title":"Metabolites"},{"key":"3774_CR11","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1111\/jre.12525","volume":"53","author":"MG Moro","year":"2018","unstructured":"Moro MG, Silveira Souto ML, Franco GCN, Holzhausen M, Pannuti CM (2018) Efficacy of local phytotherapy in the nonsurgical treatment of periodontal disease: a systematic review. J Periodontal Res 53:288\u2013297. https:\/\/doi.org\/10.1111\/jre.12525","journal-title":"J Periodontal Res"},{"key":"3774_CR12","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1039\/b916096e","volume":"27","author":"M Saleem","year":"2010","unstructured":"Saleem M, Nazir M, Ali MS, Hussain H, Lee YS, Riaz N, Jabbar A (2010) Antimicrobial natural products: an update on future antibiotic drug candidates. Nat Prod Rep 27:238\u2013254. https:\/\/doi.org\/10.1039\/b916096e","journal-title":"Nat Prod Rep"},{"key":"3774_CR13","doi-asserted-by":"publisher","unstructured":"Azab A, Nassar A, Azab AN (2016) Anti-inflammatory activity of natural products. Molecules 21. https:\/\/doi.org\/10.3390\/molecules21101321","DOI":"10.3390\/molecules21101321"},{"key":"3774_CR14","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097","volume":"6","author":"D Moher","year":"2009","unstructured":"Moher D, Liberati A, Tetzlaff J, Altman DG (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med 6:e1000097. https:\/\/doi.org\/10.1371\/journal.pmed.1000097","journal-title":"PLoS Med"},{"key":"3774_CR15","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions version 6.0","author":"C Lefebvre","year":"2019","unstructured":"Lefebvre C, Glanville J, Briscoe S, Littlewood A, Marshall C, Metzendorf M-I, Noel-Storr A, Rader T, Shokraneh F, Thomas JWL (2019) Chapter 4: searching for and selecting studies. In: JPT H, Thomas J, Chandler J, Cumpston M, Li T, Page MJWV (eds) Cochrane Handbook for Systematic Reviews of Interventions version 6.0"},{"key":"3774_CR16","doi-asserted-by":"publisher","first-page":"205","DOI":"10.4103\/0257-7941.131973","volume":"32","author":"S Warad","year":"2013","unstructured":"Warad S, Kolar S, Kalburgi V, Kalburgi N (2013) Lemongrass essential oil gel as a local drug delivery agent for the treatment of periodontitis. Anc Sci Life 32:205\u2013211. https:\/\/doi.org\/10.4103\/0257-7941.131973","journal-title":"Anc Sci Life"},{"key":"3774_CR17","volume-title":"Cochrane handbook for systematic reviews of interventions version 6.1 (updated September 2020). Cochrane","author":"JPT Higgins","year":"2020","unstructured":"Higgins JPT, Thomas J, Chandler J, Cumpston M, Li T, Page MJWV (2020) No title. In: Higgins JPT, Thomas J, Chandler J, Cumpston M, Li T, Page MJWV (eds) Cochrane handbook for systematic reviews of interventions version 6.1 (updated September 2020). Cochrane"},{"key":"3774_CR18","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1016\/0895-4356(92)90054-q","volume":"45","author":"D Follmann","year":"1992","unstructured":"Follmann D, Elliott P, Suh I, Cutler J (1992) Variance imputation for overviews of clinical trials with continuous response. J Clin Epidemiol 45:769\u2013773. https:\/\/doi.org\/10.1016\/0895-4356(92)90054-q","journal-title":"J Clin Epidemiol"},{"key":"3774_CR19","doi-asserted-by":"publisher","first-page":"l4898","DOI":"10.1136\/bmj.l4898","volume":"366","author":"JAC Sterne","year":"2019","unstructured":"Sterne JAC, Savovi\u0107 J, Page MJ, Elbers RG, Blencowe NS, Boutron I, Cates CJ, Cheng HY, Corbett MS, Eldridge SM, Emberson JR, Hern\u00e1n MA, Hopewell S, Hr\u00f3bjartsson A, Junqueira DR, J\u00fcni P, Kirkham JJ, Lasserson T, Li T, McAleenan A, Reeves BC, Shepperd S, Shrier I, Stewart LA, Tilling K, White IR, Whiting PF, Higgins JPT (2019) RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ 366:l4898. https:\/\/doi.org\/10.1136\/bmj.l4898","journal-title":"BMJ"},{"key":"3774_CR20","unstructured":"Sch\u00fcnemann H, Bro\u017cek J, Guyatt G, Oxman A (2013) E GRADE handbook for grading quality of evidence and strength of recommendations. Updated October 2013"},{"key":"3774_CR21","unstructured":"McMaster University (developed by Evidence Prime I (2015) GRADEpro GDT: GRADEpro Guideline Development Tool [Software]"},{"key":"3774_CR22","doi-asserted-by":"publisher","DOI":"10.1002\/9780470743386","volume-title":"Introduction to meta-analysis","author":"M Borenstein","year":"2009","unstructured":"Borenstein M, Hedges LV, Julian PT, Higgins HRR (2009) Introduction to meta-analysis. Wiley, Chichester"},{"key":"3774_CR23","doi-asserted-by":"publisher","first-page":"3127","DOI":"10.1002\/1097-0258(20001130)19:22<3127::aid-sim784>3.0.co;2-m","volume":"19","author":"S Chinn","year":"2000","unstructured":"Chinn S (2000) A simple method for converting an odds ratio to effect size for use in meta-analysis. Stat Med 19:3127\u20133131. https:\/\/doi.org\/10.1002\/1097-0258(20001130)19:22<3127::aid-sim784>3.0.co;2-m","journal-title":"Stat Med"},{"key":"3774_CR24","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1002\/jrsm.1260","volume":"8","author":"R Suurmond","year":"2017","unstructured":"Suurmond R, van Rhee H, Hak T (2017) Introduction, comparison, and validation of meta-essentials: a free and simple tool for meta-analysis. Res Synth Methods 8:537\u2013553. https:\/\/doi.org\/10.1002\/jrsm.1260","journal-title":"Res Synth Methods"},{"key":"3774_CR25","doi-asserted-by":"publisher","first-page":"3470","DOI":"10.1002\/sim.3634","volume":"28","author":"E Lesaffre","year":"2009","unstructured":"Lesaffre E, Philstrom B, Needleman I, Worthington H (2009) The design and analysis of split-mouth studies: what statisticians and clinicians should know. Stat Med 28:3470\u20133482. https:\/\/doi.org\/10.1002\/sim.3634","journal-title":"Stat Med"},{"key":"3774_CR26","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","volume":"327","author":"JPT Higgins","year":"2003","unstructured":"Higgins JPT, Thompson SG, Deeks JJ, Altman DG (2003) Measuring inconsistency in meta-analyses. BMJ 327:557\u2013560. https:\/\/doi.org\/10.1136\/bmj.327.7414.557","journal-title":"BMJ"},{"key":"3774_CR27","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1002\/jrsm.1316","volume":"10","author":"D Langan","year":"2019","unstructured":"Langan D, Higgins JPT, Jackson D, Bowden J, Veroniki AA, Kontopantelis E, Viechtbauer W, Simmonds M (2019) A comparison of heterogeneity variance estimators in simulated random-effects meta-analyses. Res Synth Methods 10:83\u201398. https:\/\/doi.org\/10.1002\/jrsm.1316","journal-title":"Res Synth Methods"},{"key":"3774_CR28","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1034\/j.1600-0765.2002.01640.x","volume":"37","author":"M Hirasawa","year":"2002","unstructured":"Hirasawa M, Takada K, Makimura M, Otake S (2002) Improvement of periodontal status by green tea catechin using a local delivery system: a clinical pilot study. J Periodontal Res 37:433\u2013438. https:\/\/doi.org\/10.1034\/j.1600-0765.2002.01640.x","journal-title":"J Periodontal Res"},{"key":"3774_CR29","doi-asserted-by":"publisher","first-page":"29","DOI":"10.3290\/j.ohpd.a8218","volume":"1","author":"ECE Gebaraa","year":"2003","unstructured":"Gebaraa ECE, Pustiglioni AN, de Lima LAPA, Mayer MPA (2003) Propolis extract as an adjuvant to periodontal treatment. Oral Health Prev Dent 1:29\u201335. https:\/\/doi.org\/10.3290\/j.ohpd.a8218","journal-title":"Oral Health Prev Dent"},{"key":"3774_CR30","first-page":"106","volume":"5","author":"G Sastravaha","year":"2003","unstructured":"Sastravaha G, Yotnuengnit P, Booncong P, Sangtherapitikul P (2003) Adjunctive periodontal treatment with Centella asiatica and Punica granatum extracts. A preliminary study J Int Acad Periodontol 5:106\u2013115","journal-title":"A preliminary study J Int Acad Periodontol"},{"key":"3774_CR31","doi-asserted-by":"publisher","first-page":"159","DOI":"10.4321\/s0213-12852005000300005","volume":"21","author":"ER Funosas","year":"2005","unstructured":"Funosas ER, Mart\u00ednez AB, Pignolo M, Maestri L, Aromando RF, Scozzarro SM, Escovich L, Hermida PS (2005) Efectividad del t\u00e9 verde en el tratamiento de periodontitis cr\u00f3nica. Av Odontoestomatol 21:159\u2013166. https:\/\/doi.org\/10.4321\/s0213-12852005000300005","journal-title":"Av Odontoestomatol"},{"key":"3774_CR32","first-page":"70","volume":"7","author":"G Sastravaha","year":"2005","unstructured":"Sastravaha G, Gassmann G, Sangtherapitikul P, Grimm WD (2005) Adjunctive periodontal treatment with Centella asiatica and Punica granatum extracts in supportive periodontal therapy. J Int Acad Periodontol 7:70\u201379","journal-title":"J Int Acad Periodontol"},{"key":"3774_CR33","first-page":"67","volume":"17","author":"S Taweechaisupapong","year":"2006","unstructured":"Taweechaisupapong S, Intaranongpai K, Suwannarong W, Pitiphat W, Chatrchaiwiwatana S, Wara-aswapati N (2006) Clinical and microbiological effects of subgingival irrigation with Streblus asper leaf extract in chronic periodontitis. J Clin Dent 17:67\u201371","journal-title":"J Clin Dent"},{"key":"3774_CR34","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/j.ctim.2007.12.004","volume":"16","author":"S Rassameemasmaung","year":"2008","unstructured":"Rassameemasmaung S, Sirikulsathean A, Amornchat C, Maungmingsook P, Rojanapanthu P, Gritsanaphan W (2008) Topical application of Garcinia mangostana L. pericarp gel as an adjunct to periodontal treatment. Complement Ther Med 16:262\u2013267. https:\/\/doi.org\/10.1016\/j.ctim.2007.12.004","journal-title":"Complement Ther Med"},{"issue":"9","key":"3774_CR35","first-page":"381","volume":"61","author":"PV Patel","year":"2012","unstructured":"Patel PV, Patel A, Kumar S, Holmes JC (2012) Effect of subgingival application of topical ozonated olive oil in the treatment of chronic periodontitis: a randomized, controlled, double blind, clinical and microbiological study. Minerva Stomatol 61(9):381\u2013398","journal-title":"Minerva Stomatol"},{"key":"3774_CR36","doi-asserted-by":"publisher","first-page":"186","DOI":"10.4103\/0976-237x.114874","volume":"4","author":"SVS Gottumukkala","year":"2013","unstructured":"Gottumukkala SVS, Koneru S, Mannem S, Mandalapu N (2013) Effectiveness of sub gingival irrigation of an indigenous 1% curcumin solution on clinical and microbiological parameters in chronic periodontitis patients: a pilot randomized clinical trial. Contemp Clin Dent 4:186\u2013191. https:\/\/doi.org\/10.4103\/0976-237x.114874","journal-title":"Contemp Clin Dent"},{"issue":"10","key":"3774_CR37","doi-asserted-by":"publisher","first-page":"2330","DOI":"10.7860\/JCDR\/2013\/5793.3517","volume":"7","author":"J Mahendra","year":"2013","unstructured":"Mahendra J, Mahendra L, Muthu J, John L, Romanos GE (2013) Clinical effects of subgingivally delivered spirulina gel in chronic periodontitis cases: a placebo controlled clinical trial. Journal of clinical and diagnostic research : JCDR 7(10):2330\u20132333. https:\/\/doi.org\/10.7860\/JCDR\/2013\/5793.3517","journal-title":"Journal of clinical and diagnostic research : JCDR"},{"key":"3774_CR38","doi-asserted-by":"publisher","unstructured":"Cheng Q, Gao W min, Cao B, et al (2014) Effects of Ginkgo biloba extract on periodontal pathogens and its clinical efficacy as adjuvant treatment. Chin J Integr Med 20:729\u2013736. https:\/\/doi.org\/10.1007\/s11655-014-1824-4","DOI":"10.1007\/s11655-014-1824-4"},{"issue":"1","key":"3774_CR39","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1007\/s10266-014-0190-1","volume":"104","author":"K Rattanasuwan","year":"2014","unstructured":"Rattanasuwan K, Rassameemasmaung S, Sangalungkarn V, Komoltri C (2014) Clinical effect of locally delivered gel containing green tea extract as an adjunct to non-surgical periodontal treatment. Odontology 104(1):89\u201397. https:\/\/doi.org\/10.1007\/s10266-014-0190-1","journal-title":"Odontology"},{"key":"3774_CR40","doi-asserted-by":"publisher","first-page":"ZC41","DOI":"10.7860\/JCDR\/2014\/8817.4856","volume":"8","author":"NN Sanghani","year":"2014","unstructured":"Sanghani NN, Shivaprasad BM, Savita S (2014) Health from the hive: Propolis as an adjuvant in the treatment of chronic periodontitis - a clinicomicrobiologic study. J Clin Diagnostic Res 8:ZC41\u2013ZC44. https:\/\/doi.org\/10.7860\/JCDR\/2014\/8817.4856","journal-title":"J Clin Diagnostic Res"},{"issue":"2","key":"3774_CR41","doi-asserted-by":"publisher","first-page":"67","DOI":"10.4103\/2279-042X.137076","volume":"3","author":"J Yaghini","year":"2014","unstructured":"Yaghini J, Shahabooei M, Aslani A, Zadeh MR, Kiani S, Naghsh N (2014) Efficacy of a local-drug delivery gel containing extracts of Quercus brantii and Coriandrum sativum as an adjunct to scaling and root planing in moderate chronic periodontitis patients. Journal of research in pharmacy practice 3(2):67\u201371. https:\/\/doi.org\/10.4103\/2279-042X.137076","journal-title":"Journal of research in pharmacy practice"},{"key":"3774_CR42","doi-asserted-by":"publisher","first-page":"S554","DOI":"10.4103\/0975-7406.163537","volume":"7","author":"M Nagasri","year":"2015","unstructured":"Nagasri M, Madhulatha M, Musalaiah SVVS et al (2015) Efficacy of curcumin as an adjunct to scaling and root planning in chronic periodontitis patients: a clinical and microbiological study. J Pharm Bioallied Sci 7:S554\u2013S558. https:\/\/doi.org\/10.4103\/0975-7406.163537","journal-title":"J Pharm Bioallied Sci"},{"key":"3774_CR43","doi-asserted-by":"publisher","first-page":"S102","DOI":"10.4103\/0976-9668.166100","volume":"6","author":"A Sreedhar","year":"2015","unstructured":"Sreedhar A, Sarkar I, Rajan P et al (2015) Comparative evaluation of the efficacy of curcumin gel with and without photo activation as an adjunct to scaling and root planing in the treatment of chronic periodontitis: a split mouth clinical and microbiological study. J Nat Sci Biol Med 6:S102\u2013S109. https:\/\/doi.org\/10.4103\/0976-9668.166100","journal-title":"J Nat Sci Biol Med"},{"key":"3774_CR44","doi-asserted-by":"publisher","first-page":"46","DOI":"10.4103\/jisp.jisp_130_17","volume":"21","author":"R Boyapati","year":"2017","unstructured":"Boyapati R, Gojja P, Chintalapani S, Nagubandi K, Ramisetti A, Salavadhi SS (2017) Efficacy of local drug delivery of Achyranthes aspera gel in the management of chronic periodontitis: a clinical study. J Indian Soc Periodontol 21:46\u201349. https:\/\/doi.org\/10.4103\/jisp.jisp_130_17","journal-title":"J Indian Soc Periodontol"},{"key":"3774_CR45","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1002\/ptr.5600","volume":"30","author":"S Grover","year":"2016","unstructured":"Grover S, Tewari S, Sharma RK, Singh G, Yadav A, Naula SC (2016) Effect of subgingivally delivered 10% Emblica officinalis gel as an adjunct to scaling and root planing in the treatment of chronic periodontitis - a randomized placebo-controlled clinical trial. Phytother Res 30:956\u2013962. https:\/\/doi.org\/10.1002\/ptr.5600","journal-title":"Phytother Res"},{"key":"3774_CR46","doi-asserted-by":"publisher","first-page":"374","DOI":"10.2047\/jioh-08-03-14","volume":"8","author":"HP Singh","year":"2016","unstructured":"Singh HP, Muzammil SG et al (2016) Comparative study to evaluate the effectiveness of aloe vera and metronidazole in adjunct to scaling and root planing in periodontitis patients. J Int Oral Heal 8:374\u2013377. https:\/\/doi.org\/10.2047\/jioh-08-03-14","journal-title":"J Int Oral Heal"},{"key":"3774_CR47","doi-asserted-by":"publisher","unstructured":"Mahendra J, Mahendra L, Svedha P, Cherukuri S, Romanos GE (2017) Clinical and microbiological efficacy of 4% Garcinia mangostana L. pericarp gel as local drug delivery in the treatment of chronic periodontitis: a randomized, controlled clinical trial. Journal of investigative and clinical dentistry 8(4). https:\/\/doi.org\/10.1111\/jicd.12262, https:\/\/doi.org\/10.1111\/jicd.12262","DOI":"10.1111\/jicd.12262 10.1111\/jicd.12262"},{"key":"3774_CR48","doi-asserted-by":"publisher","DOI":"10.1111\/jicd.12334","volume":"9","author":"S Ipshita","year":"2018","unstructured":"Ipshita S, Kurian IG, Dileep P, Kumar S, Singh P, Pradeep AR (2018) One percent alendronate and aloe vera gel local host modulating agents in chronic periodontitis patients with class II furcation defects: a randomized, controlled clinical trial. J Investig Clin Dent 9:e12334. https:\/\/doi.org\/10.1111\/jicd.12334","journal-title":"J Investig Clin Dent"},{"key":"3774_CR49","doi-asserted-by":"publisher","DOI":"10.1111\/jicd.12324","volume":"9","author":"IG Kurian","year":"2018","unstructured":"Kurian IG, Dileep P, Ipshita S, Pradeep AR (2018) Comparative evaluation of subgingivally-delivered 1% metformin and aloe vera gel in the treatment of intrabony defects in chronic periodontitis patients: a randomized, controlled clinical trial. J Investig Clin Dent 9:e12324. https:\/\/doi.org\/10.1111\/jicd.12324","journal-title":"J Investig Clin Dent"},{"issue":"2","key":"3774_CR50","doi-asserted-by":"publisher","DOI":"10.1111\/jicd.12318","volume":"9","author":"M Rayyan","year":"2018","unstructured":"Rayyan M, Terkawi T, Abdo H, Abdel Azim D, Khalaf A, AlKhouli Z, Meziad M, Alshamma'a M, Abu Naim H (2018) Efficacy of grape seed extract gel in the treatment of chronic periodontitis: a randomized clinical study. J Investig Clin Dent 9(2):e12318. https:\/\/doi.org\/10.1111\/jicd.12318","journal-title":"J Investig Clin Dent"},{"issue":"Suppl 2","key":"3774_CR51","doi-asserted-by":"publisher","first-page":"S203","DOI":"10.4103\/JPBS.JPBS_295_18","volume":"11","author":"M Jalaluddin","year":"2019","unstructured":"Jalaluddin M, Jayanti I, Gowdar IM, Roshan R, Varkey RR, Thirutheri A (2019) Antimicrobial activity of Curcuma longa L. extract on periodontal pathogens. Journal of pharmacy & bioallied sciences 11(Suppl 2):S203\u2013S207. https:\/\/doi.org\/10.4103\/JPBS.JPBS_295_18","journal-title":"Journal of pharmacy & bioallied sciences"},{"key":"3774_CR52","doi-asserted-by":"publisher","unstructured":"Pappu R, Varghese J, Koteshwara KB et al (2019) Evaluation of biodegradable gel containing flax seed extract (Linum usitatissimum) as a targeted drug delivery for management of chronic periodontitis. J Herb Med 15. https:\/\/doi.org\/10.1016\/j.hermed.2018.100254","DOI":"10.1016\/j.hermed.2018.100254"},{"key":"3774_CR53","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1007\/s10266-020-00500-4","volume":"108","author":"R Nakao","year":"2020","unstructured":"Nakao R, Senpuku H, Ohnishi M, Takai H, Ogata Y (2020) Effect of topical administration of propolis in chronic periodontitis. Odontology 108:704\u2013714. https:\/\/doi.org\/10.1007\/s10266-020-00500-4","journal-title":"Odontology"},{"key":"3774_CR54","doi-asserted-by":"publisher","first-page":"S9","DOI":"10.1111\/jcpe.12936","volume":"45","author":"NP Lang","year":"2018","unstructured":"Lang NP, Bartold PM (2018) Periodontal health. J Clin Periodontol 45:S9\u2013S16. https:\/\/doi.org\/10.1111\/jcpe.12936","journal-title":"J Clin Periodontol"},{"key":"3774_CR55","doi-asserted-by":"publisher","unstructured":"Mark Bartold P, Van Dyke TE (2017) Host modulation: controlling the inflammation to control the infection. Periodontol 2000 75:317\u2013329. https:\/\/doi.org\/10.1111\/prd.1216956","DOI":"10.1111\/prd.1216956"},{"key":"3774_CR56","doi-asserted-by":"publisher","unstructured":"Sanz M, Herrera D, Kebschull M, Chapple I, Jepsen S, Beglundh T, Sculean A, Tonetti MS; EFP Workshop Participants and Methodological Consultants. Treatment of stage I-III periodontitis-the EFP S3 level clinical practice guideline. J Clin Periodontol 2020 47:4\u201360. https:\/\/doi.org\/10.1111\/jcpe.13290","DOI":"10.1111\/jcpe.13290"},{"key":"3774_CR57","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1902\/jop.1998.69.10.1085","volume":"69","author":"NH Stoller","year":"1998","unstructured":"Stoller NH, Johnson LR, Trapnell S, Harrold CQ, Garrett S (1998) The pharmacokinetic profile of a biodegradable controlled-release delivery system containing doxycycline compared to systemically delivered doxycycline in gingival crevicular fluid, saliva, and serum. J Periodontol 69:1085\u20131091. https:\/\/doi.org\/10.1902\/jop.1998.69.10.1085","journal-title":"J Periodontol"},{"key":"3774_CR58","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1902\/jop.2009.080216","volume":"80","author":"Y Shifrovitch","year":"2009","unstructured":"Shifrovitch Y, Binderman I, Bahar H, Berdicevsky I, Zilberman M (2009) Metronidazole-loaded bioabsorbable films as local antibacterial treatment of infected periodontal pockets. J Periodontol 80:330\u2013337. https:\/\/doi.org\/10.1902\/jop.2009.080216","journal-title":"J Periodontol"},{"key":"3774_CR59","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1902\/jop.1997.68.1.32","volume":"68","author":"WA Soskolne","year":"1997","unstructured":"Soskolne WA, Heasman PA, Stabholz A, Smart GJ, Palmer M, Flashner M, Newman HN (1997) Sustained local delivery of chlorhexidine in the treatment of periodontitis: a multi-center study. J Periodontol 68:32\u201338. https:\/\/doi.org\/10.1902\/jop.1997.68.1.32","journal-title":"J Periodontol"},{"issue":"76","key":"3774_CR60","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1111\/prd.12147","volume":"2000","author":"A Mombelli","year":"2018","unstructured":"Mombelli A (2018) Microbial colonization of the periodontal pocket and its significance for periodontal therapy. Periodontol 2000(76):85\u201396. https:\/\/doi.org\/10.1111\/prd.12147","journal-title":"Periodontol"},{"key":"3774_CR61","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1186\/1471-2288-14-64","volume":"14","author":"V Sma\u00efl-Faugeron","year":"2014","unstructured":"Sma\u00efl-Faugeron V, Fron-Chabouis H, Courson F, Durieux P (2014) Comparison of intervention effects in split-mouth and parallel-arm randomized controlled trials: a meta-epidemiological study. BMC Med Res Methodol 14:64. https:\/\/doi.org\/10.1186\/1471-2288-14-64","journal-title":"BMC Med Res Methodol"},{"issue":"4","key":"3774_CR62","first-page":"187","volume":"22","author":"F Muniz","year":"2020","unstructured":"Muniz F, Langa G, Pimentel RP, Martins JR, Pereira DH, R\u00f6sing CK (2020) Comparison between hand and sonic\/ ultrasonic instruments for periodontal treatment: systematic review with meta-analysis. Journal of the International Academy of Periodontology 22(4):187\u2013204","journal-title":"Journal of the International Academy of Periodontology"},{"key":"3774_CR63","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/j.yebeh.2015.05.037","volume":"52","author":"E-M Pferschy-Wenzig","year":"2015","unstructured":"Pferschy-Wenzig E-M, Bauer R (2015) The relevance of pharmacognosy in pharmacological research on herbal medicinal products. Epilepsy Behav 52:344\u2013362. https:\/\/doi.org\/10.1016\/j.yebeh.2015.05.037","journal-title":"Epilepsy Behav"},{"key":"3774_CR64","doi-asserted-by":"publisher","first-page":"363","DOI":"10.3109\/10717544.2014.935531","volume":"23","author":"D Joshi","year":"2016","unstructured":"Joshi D, Garg T, Goyal AK, Rath G (2016) Advanced drug delivery approaches against periodontitis. Drug Deliv 23:363\u2013377. https:\/\/doi.org\/10.3109\/10717544.2014.935531","journal-title":"Drug Deliv"}],"container-title":["Clinical Oral Investigations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-021-03774-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00784-021-03774-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-021-03774-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T18:15:18Z","timestamp":1646072118000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00784-021-03774-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,1]]},"references-count":64,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["3774"],"URL":"https:\/\/doi.org\/10.1007\/s00784-021-03774-2","relation":{},"ISSN":["1432-6981","1436-3771"],"issn-type":[{"value":"1432-6981","type":"print"},{"value":"1436-3771","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,1]]},"assertion":[{"value":"11 September 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 January 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 February 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This article does not contain any studies with human participants or animals performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"For this type of study, formal consent is not required.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}