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After baseline recording of plaque index (PI) and gingival index (GI), collection of salivary samples, and dental prophylaxis, subjects were randomly assigned to OCT or placebo mouthwash in a 3:1 ratio. Rinsing was performed twice daily for 30\u00a0s. Colony forming units in saliva were determined before and after the first rinse. At day 5, PI, GI, and tooth discoloration index (DI) were assessed. Non-parametric van Elteren tests were applied with a significance level of <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Treatment with OCT inhibited plaque formation more than treatment with placebo (PI: 0.36 vs. 1.29; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). OCT reduced GI (0.04 vs. placebo 0.00; <jats:italic>p<\/jats:italic>\u2009=\u20090.003) and salivary bacterial counts (2.73 vs. placebo 0.24 lgCFU\/ml; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). Tooth discoloration was slightly higher under OCT (DI: 0.25 vs. placebo 0.00; <jats:italic>p<\/jats:italic>\u2009=\u20090.0011). Mild tongue staining and dysgeusia occurred.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>OCT 0.1% mouthwash inhibits plaque formation over 5 days. It therefore can be recommended when regular oral hygiene is temporarily compromised.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Clinical relevance<\/jats:title>\n                <jats:p>When individual plaque control is compromised, rinsing with octenidine mouthwash is recommended to maintain healthy oral conditions while side effects are limited.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00784-021-03781-3","type":"journal-article","created":{"date-parts":[[2021,1,22]],"date-time":"2021-01-22T18:16:41Z","timestamp":1611339401000},"page":"4681-4689","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Impact of 0.1% octenidine mouthwash on plaque re-growth in healthy adults: a multi-center phase 3 randomized clinical trial"],"prefix":"10.1007","volume":"25","author":[{"given":"Yvonne","family":"Jockel-Schneider","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Schlagenhauf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hari","family":"Petsos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"R\u00fcttermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Ziebolz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Wehner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Laky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thea","family":"Rott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Noack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Noack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0228-6140","authenticated-orcid":false,"given":"Katrin","family":"Lorenz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,1,22]]},"reference":[{"key":"3781_CR1","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1111\/j.1600-0757.1997.tb00104.x","volume":"15","author":"M Addy","year":"1997","unstructured":"Addy M, Moran JM (1997) Clinical indications for the use of chemical adjuncts to plaque control: chlorhexidine formulations. 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