{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T23:26:30Z","timestamp":1774308390535,"version":"3.50.1"},"reference-count":63,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T00:00:00Z","timestamp":1611187200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T00:00:00Z","timestamp":1611187200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Oral Invest"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1007\/s00784-021-03782-2","type":"journal-article","created":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T03:03:00Z","timestamp":1611198180000},"page":"1613-1626","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Does enamel matrix derivative application provide additional clinical benefits in the treatment of maxillary Miller class I and II gingival recession? A systematic review and meta-analysis"],"prefix":"10.1007","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4878-9835","authenticated-orcid":false,"given":"Jonathan","family":"Meza Mauricio","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camila Pinheiro","family":"Furquim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Willy","family":"Bustillos-Torrez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Soto-Pe\u00f1aloza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Pe\u00f1arrocha-Oltra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Belen","family":"Retamal-Valdes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo","family":"Faveri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,1,21]]},"reference":[{"key":"3782_CR1","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1902\/annals.1999.4.1.98","volume":"4","author":"G Pini Prato","year":"1999","unstructured":"Pini Prato G (1999) Mucogingival deformities. Ann Periodontol 4:98\u2013101","journal-title":"Ann Periodontol"},{"key":"3782_CR2","doi-asserted-by":"publisher","first-page":"S237","DOI":"10.1002\/JPER.17-0733","volume":"89","author":"S Jepsen","year":"2018","unstructured":"Jepsen S, Caton JG, Albandar JM, Bissada NF, Bouchard P, Cortellini P, Demirel K, de Sanctis M, Ercoli C, Fan J, Geurs NC, Hughes FJ, Jin L, Kantarci A, Lalla E, Madianos PN, Matthews D, McGuire MK, Mills MP, Preshaw PM, Reynolds MA, Sculean A, Susin C, West NX, Yamazaki K (2018) Periodontal manifestations of systemic diseases and developmental and acquired conditions: consensus report of workgroup 3 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. J Periodontol 89:S237\u2013S248","journal-title":"J Periodontol"},{"key":"3782_CR3","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1111\/jcpe.12932","volume":"45","author":"G Rasperini","year":"2018","unstructured":"Rasperini G, Acunzo R, Pellegrini G, Pagni G, Tonetti M, Pini Prato GP, Cortellini P (2018) Predictor factors for long-term outcomes stability of coronally advanced flap with or without CTG in the treatment of single maxillary gingival recessions: 9 years. J Clin Periodontol 45:1107\u20131117","journal-title":"J Clin Periodontol"},{"key":"3782_CR4","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1111\/prd.12059","volume":"68","author":"G Zucchelli","year":"2015","unstructured":"Zucchelli G, Mounssif I (2015) Periodontal plastic surgery. Periodontol 2000 68:333\u2013368","journal-title":"Periodontol 2000"},{"key":"3782_CR5","doi-asserted-by":"publisher","first-page":"1428","DOI":"10.1002\/JPER.18-0201","volume":"89","author":"G Zucchelli","year":"2018","unstructured":"Zucchelli G, Su\u00e1rez-L\u00f3pez del Amo F, Stefanini M et al (2018) Influence of tooth location on coronally advanced flap procedures for root coverage. J Periodontol 89:1428\u20131441","journal-title":"J Periodontol"},{"key":"3782_CR6","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/S0011-8532(22)00341-X","volume":"32","author":"PD Miller","year":"1988","unstructured":"Miller PD (1988) Regenerative and reconstructive periodontal plastic surgery. Mucogingival surgery. Dent Clin N Am 32:287\u2013306","journal-title":"Dent Clin N Am"},{"key":"3782_CR7","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1902\/jop.2011.110382","volume":"83","author":"L Chambrone","year":"2012","unstructured":"Chambrone L, Pannuti CM, Tu Y-K, Chambrone LA (2012) Evidence-based periodontal plastic surgery. II. An individual data meta-analysis for evaluating factors in achieving complete root coverage. J Periodontol 83:477\u2013490","journal-title":"J Periodontol"},{"key":"3782_CR8","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1016\/j.jdent.2008.05.007","volume":"36","author":"L Chambrone","year":"2008","unstructured":"Chambrone L, Chambrone D, Pustiglioni FE, Chambrone LA, Lima LA (2008) Can subepithelial connective tissue grafts be considered the gold standard procedure in the treatment of Miller class I and II recession-type defects? J Dent 36:659\u2013671","journal-title":"J Dent"},{"key":"3782_CR9","first-page":"471","volume":"19","author":"RJ Blanes","year":"1999","unstructured":"Blanes RJ, Allen EP (1999) The bilateral pedicle flap-tunnel technique: a new approach to cover connective tissue grafts. Int J Periodontics Restorative Dent 19:471\u2013479","journal-title":"Int J Periodontics Restorative Dent"},{"key":"3782_CR10","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1902\/jop.1968.39.2.65","volume":"39","author":"DW Cohen","year":"1968","unstructured":"Cohen DW, Ross SE (1968) The double papillae repositioned flap in periodontal therapy. J Periodontol 39:65\u201370","journal-title":"J Periodontol"},{"key":"3782_CR11","doi-asserted-by":"publisher","first-page":"1734","DOI":"10.1902\/jop.2004.75.12.1734","volume":"75","author":"G Zucchelli","year":"2004","unstructured":"Zucchelli G, Cesari C, Amore C, Montebugnoli L, de Sanctis M (2004) Laterally moved, coronally advanced flap: a modified surgical approach for isolated recession-type defects. J Periodontol 75:1734\u20131741","journal-title":"J Periodontol"},{"key":"3782_CR12","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1111\/j.1600-051X.2008.01267.x","volume":"35","author":"F Cairo","year":"2008","unstructured":"Cairo F, Pagliaro U, Nieri M (2008) Treatment of gingival recession with coronally advanced flap procedures: a systematic review. J Clin Periodontol 35:136\u2013162","journal-title":"J Clin Periodontol"},{"key":"3782_CR13","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1111\/jcpe.12834","volume":"45","author":"MS Tonetti","year":"2018","unstructured":"Tonetti MS, Cortellini P, Pellegrini G, Nieri M, Bonaccini D, Allegri M, Bouchard P, Cairo F, Conforti G, Fourmousis I, Graziani F, Guerrero A, Halben J, Malet J, Rasperini G, Topoll H, Wachtel H, Wallkamm B, Zabalegui I, Zuhr O (2018) Xenogenic collagen matrix or autologous connective tissue graft as adjunct to coronally advanced flaps for coverage of multiple adjacent gingival recession: randomized trial assessing non-inferiority in root coverage and superiority in oral health-related quality of life. J Clin Periodontol 45:78\u201388","journal-title":"J Clin Periodontol"},{"key":"3782_CR14","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1902\/jop.2015.150015","volume":"86","author":"HG Keceli","year":"2015","unstructured":"Keceli HG, Kamak G, Erdemir EO, Evginer MS, Dolgun A (2015) The adjunctive effect of platelet-rich fibrin to connective tissue graft in the treatment of buccal recession defects: results of a randomized, parallel-group controlled trial. J Periodontol 86:1221\u20131230","journal-title":"J Periodontol"},{"issue":"4","key":"3782_CR15","first-page":"506","volume":"10","author":"GA Gholami","year":"2013","unstructured":"Gholami GA, Saberi A, Kadkhodazadeh M, Amid R, Karami D (2013) Comparison of the clinical outcomes of connective tissue and acelular dermal matrix in combination with double papillary flap for root coverage: a 6-month trial. Dent Res J 10(4):506\u2013513","journal-title":"Dent Res J"},{"key":"3782_CR16","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1111\/jcpe.13174","volume":"46","author":"C Ahmedbeyli","year":"2019","unstructured":"Ahmedbeyli C, Dirikan Ip\u00e7i S, Cakar G, Y\u0131lmaz S, Chambrone L (2019) Coronally advanced flap and envelope type of flap plus acellular dermal matrix graft for the treatment of thin phenotype multiple recession defects. A randomized clinical trial. J Clin Periodontol 46:1024\u20131029","journal-title":"J Clin Periodontol"},{"key":"3782_CR17","doi-asserted-by":"publisher","first-page":"1506","DOI":"10.1902\/jop.2000.71.9.1506","volume":"71","author":"G Zucchelli","year":"2000","unstructured":"Zucchelli G, De Sanctis M (2000) Treatment of multiple recession-type defects in patients with esthetic demands. J Periodontol 71:1506\u20131514","journal-title":"J Periodontol"},{"key":"3782_CR18","doi-asserted-by":"publisher","first-page":"S8","DOI":"10.1902\/jop.2015.130674","volume":"86","author":"L Chambrone","year":"2015","unstructured":"Chambrone L, Tatakis DN (2015) Periodontal soft tissue root coverage procedures: a systematic review from the AAP Regeneration Workshop. J Periodontol 86:S8\u2013S51","journal-title":"J Periodontol"},{"key":"3782_CR19","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1590\/1807-3107bor-2019.vol33.0006","volume":"33","author":"HS Aydinyurt","year":"2019","unstructured":"Aydinyurt HS, Tekin Y, Ertugrul AS (2019) The effect of enamel matrix derivatives on root coverage: a 12-month follow-up of a randomized clinical trial. Braz Oral Res 33:4\u201312","journal-title":"Braz Oral Res"},{"key":"3782_CR20","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1111\/jre.12039","volume":"48","author":"A Roman","year":"2013","unstructured":"Roman A, Soanc\u01ce A, Kasaj A, Stratul SI (2013) Subepithelial connective tissue graft with or without enamel matrix derivative for the treatment of Miller class I and II gingival recessions: a controlled randomized clinical trial. J Periodontal Res 48:563\u2013572","journal-title":"J Periodontal Res"},{"key":"3782_CR21","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1111\/jcpe.12546","volume":"43","author":"RJ Miron","year":"2016","unstructured":"Miron RJ, Sculean A, Cochran DL, Froum S, Zucchelli G, Nemcovsky C, Donos N, Lyngstadaas SP, Deschner J, Dard M, Stavropoulos A, Zhang Y, Trombelli L, Kasaj A, Shirakata Y, Cortellini P, Tonetti M, Rasperini G, Jepsen S, Bosshardt DD (2016) Twenty years of enamel matrix derivative: the past, the present and the future. J Clin Periodontol 43:668\u2013683","journal-title":"J Clin Periodontol"},{"key":"3782_CR22","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1902\/jop.2016.150459","volume":"87","author":"MK McGuire","year":"2016","unstructured":"McGuire MK, Scheyer ET, Schupbach P (2016) A prospective, case-controlled study evaluating the use of enamel matrix derivative on human buccal recession defects: a human histologic examination. J Periodontol 87:645\u2013653","journal-title":"J Periodontol"},{"key":"3782_CR23","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1002\/JPER.19-0107","volume":"91","author":"IL Fran\u00e7a-Grohmann","year":"2020","unstructured":"Fran\u00e7a-Grohmann IL, Sangiorgio JPM, Bueno MR, Casarin RCV, Silv\u00e9rio Ruiz KG, Nociti FH Jr, Casati MZ, Sallum EA (2020) Treatment of dehiscence-type defects with collagen matrix and\/or enamel matrix derivative: histomorphometric study in minipigs. J Periodontol 91:967\u2013974","journal-title":"J Periodontol"},{"key":"3782_CR24","doi-asserted-by":"publisher","first-page":"1126","DOI":"10.1902\/jop.2003.74.8.1126","volume":"74","author":"MK McGuire","year":"2003","unstructured":"McGuire MK, Cochran DL (2003) Evaluation of human recession defects treated with coronally advanced flaps and either enamel matrix derivative or connective tissue. Part 2: histological evaluation. J Periodontol 74:1126\u20131135","journal-title":"J Periodontol"},{"key":"3782_CR25","first-page":"829","volume":"45","author":"A Sculean","year":"2014","unstructured":"Sculean A, Cosgarea R, St\u00e4hli A et al (2014) The modified coronally advanced tunnel combined with an enamel matrix derivative and subepithelial connective tissue graft for the treatment of isolated mandibular Miller class I and II gingival recessions: a report of 16 cases. Quintessence Int (Berl) 45:829\u2013835","journal-title":"Quintessence Int (Berl)"},{"key":"3782_CR26","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1902\/jop.2011.110266","volume":"83","author":"R Koop","year":"2012","unstructured":"Koop R, Merheb J, Quirynen M (2012) Periodontal regeneration with enamel matrix derivative in reconstructive periodontal therapy: a systematic review. J Periodontol 83:707\u2013720","journal-title":"J Periodontol"},{"key":"3782_CR27","first-page":"133","volume":"31","author":"G Rasperini","year":"2011","unstructured":"Rasperini G, Roccuzzo M, Francetti L, Acunzo R, Consonni D, Silvestri M (2011) Subepithelial connective tissue graft for treatment of gingival recessions with and without enamel matrix derivative: a multicenter, randomized controlled clinical trial. Int J Periodontics Restorative Dent 31:133\u2013139","journal-title":"Int J Periodontics Restorative Dent"},{"key":"3782_CR28","first-page":"e10","volume":"32","author":"L Cordaro","year":"2012","unstructured":"Cordaro L, Di Torresanto VM, Torsello F (2012) Split-mouth comparison of a coronally advanced flap with or without enamel matrix derivative for coverage of multiple gingival recession defects: 6- and 24-month follow-up. Int J Periodontics Restor Dent 32:e10\u2013e20","journal-title":"Int J Periodontics Restor Dent"},{"key":"3782_CR29","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1016\/j.jclinepi.2009.06.005","volume":"6","author":"D Moher","year":"2009","unstructured":"Moher D, Liberati A, Tetzlaff J, Altman DG (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. J Clin Epidemiol 6:1006\u201310012","journal-title":"J Clin Epidemiol"},{"key":"3782_CR30","doi-asserted-by":"publisher","first-page":"j4008","DOI":"10.1136\/bmj.j4008","volume":"358","author":"BJ Shea","year":"2017","unstructured":"Shea BJ, Reeves BC, Wells G, Thuku M, Hamel C, Moran J, Moher D, Tugwell P, Welch V, Kristjansson E, Henry DA (2017) AMSTAR 2: a critical appraisal tool for systematic reviews that include randomised or non-randomised studies of healthcare interventions, or both. BMJ. 358:j4008","journal-title":"BMJ."},{"key":"3782_CR31","first-page":"7","volume":"15","author":"C Schardt","year":"2007","unstructured":"Schardt C, Adams MB, Owens T et al (2007) Utilization of the PICO framework to improve searching PubMed for clinical questions. BMC Med Inform Decis Mak 15:7\u201316","journal-title":"BMC Med Inform Decis Mak"},{"key":"3782_CR32","first-page":"8","volume":"5","author":"PD Miller","year":"1985","unstructured":"Miller PD (1985) A classification of marginal tissue recession. Int J Periodontics Restorative Dent 5:8\u201313","journal-title":"Int J Periodontics Restorative Dent"},{"key":"3782_CR33","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1111\/j.1600-051X.2011.01732.x","volume":"38","author":"F Cairo","year":"2011","unstructured":"Cairo F, Nieri M, Cincinelli S, Mervelt J, Pagliaro U (2011) The interproximal clinical attachment level to classify gingival recessions and predict root coverage outcomes: an explorative and reliability study. J Clin Periodontol 38:661\u2013666","journal-title":"J Clin Periodontol"},{"key":"3782_CR34","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.1136\/bmj.38636.593461.68","volume":"331","author":"T Greenhalgh","year":"2005","unstructured":"Greenhalgh T, Peacock R (2005) Effectiveness and efficiency of search methods in systematic reviews of complex evidence: audit of primary sources. Br Med J 331:1064\u20131065","journal-title":"Br Med J"},{"key":"3782_CR35","first-page":"1","volume":"366","author":"JAC Sterne","year":"2019","unstructured":"Sterne JAC, Savovi\u0107 J, Page MJ et al (2019) RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ 366:1\u20138","journal-title":"BMJ"},{"key":"3782_CR36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2288-14-25","volume":"14","author":"J Inthout","year":"2014","unstructured":"Inthout J, Ioannidis JP, Borm GF (2014) The Hartung-Knapp-Sidik-Jonkman method for random effects meta-analysis is straightforward and considerably outperforms the standard DerSimonian-Laird method. BMC Med Res Methodol 14:1\u201312","journal-title":"BMC Med Res Methodol"},{"key":"3782_CR37","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1002\/jrsm.1316","volume":"10","author":"D Langan","year":"2019","unstructured":"Langan D, Higgins JPT, Jackson D, Bowden J, Veroniki AA, Kontopantelis E, Viechtbauer W, Simmonds M (2019) A comparison of heterogeneity variance estimators in simulated random-effects meta-analyses. Res Synth Methods 10:83\u201398","journal-title":"Res Synth Methods"},{"key":"3782_CR38","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","volume":"327","author":"JPT Higgins","year":"2003","unstructured":"Higgins JPT, Thompson SG, Deeks JJ, Altman DG (2003) Measuring inconsistency in meta-analyses. Br Med J 327:557\u2013560","journal-title":"Br Med J"},{"key":"3782_CR39","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1016\/j.jclinepi.2007.11.010","volume":"10","author":"JL Peters","year":"2008","unstructured":"Peters JL, Sutton AJ, Jones DR, Abrams KR, Rushton L (2008) Contour-enhanced meta-analysis funnel plots help distinguish publication bias from other causes of asymmetry. J Clin Epidemiol 10:991\u2013996","journal-title":"J Clin Epidemiol"},{"key":"3782_CR40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1467-8551.2011.00739.x","volume":"22","author":"JA Sterne","year":"2011","unstructured":"Sterne JA, Sutton AJ, Ioannidis JP et al (2011) Recommendations for examining and interpreting funnel plot asymmetry in meta-analyses of randomised controlled trials. BMJ 22:1\u20138","journal-title":"BMJ"},{"key":"3782_CR41","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1136\/bmj.39489.470347.AD","volume":"336","author":"GH Guyatt","year":"2008","unstructured":"Guyatt GH, Oxman AD, Vist GE, Kunz R, Falck-Ytter Y, Alonso-Coello P, Sch\u00fcnemann HJ, GRADE Working Group (2008) GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. Br Med J 336:924\u2013926","journal-title":"Br Med J"},{"key":"3782_CR42","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13643-018-0770-1","volume":"7","author":"G Castellini","year":"2018","unstructured":"Castellini G, Bruschettini M, Gianola S et al (2018) Assessing imprecision in Cochrane systematic reviews: a comparison of GRADE and trial sequential analysis. Syst Rev 7:1\u201310","journal-title":"Syst Rev"},{"key":"3782_CR43","doi-asserted-by":"publisher","first-page":"619","DOI":"10.11607\/prd.1337","volume":"33","author":"E Alkan","year":"2013","unstructured":"Alkan E, Parlar A (2013) Enamel matrix derivative (Emdogain) or subepithelial connective tissue graft for the treatment of adjacent multiple gingival recessions: a pilot study. Int J Periodontics Restor Dent 33:619\u2013625","journal-title":"Int J Periodontics Restor Dent"},{"key":"3782_CR44","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1034\/j.1600-051x.2002.290106.x","volume":"29","author":"S H\u00e4gewald","year":"2002","unstructured":"H\u00e4gewald S, Spahr A, Rompola E, Haller B, Heijl L, Bernimoulin JP (2002) Comparative study of Emdogain\u00ae and coronally advanced flap technique in the treatment of human gingival recessions: a prospective controlled clinical study. J Clin Periodontol 29:35\u201341","journal-title":"J Clin Periodontol"},{"key":"3782_CR45","doi-asserted-by":"publisher","first-page":"1110","DOI":"10.1902\/jop.2003.74.8.1110","volume":"74","author":"MK McGuire","year":"2003","unstructured":"McGuire MK, Nunn M (2003) Evaluation of human recession defects treated with coronally advanced flaps and either enamel matrix derivative or connective tissue. Part 1: comparison of clinical parameters. J Periodontol 74:1110\u20131125","journal-title":"J Periodontol"},{"key":"3782_CR46","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1902\/jop.2004.75.7.949","volume":"75","author":"MA Cueva","year":"2004","unstructured":"Cueva MA, Boltchi FE, Hallmon WW, Nunn ME, Rivera-Hidalgo F, Rees T (2004) A comparative study of coronally advanced flaps with and without the addition of enamel matrix derivative in the treatment of marginal tissue recession. J Periodontol 75:949\u2013956","journal-title":"J Periodontol"},{"key":"3782_CR47","doi-asserted-by":"publisher","first-page":"1871","DOI":"10.1902\/jop.2005.76.11.1871","volume":"76","author":"A Spahr","year":"2005","unstructured":"Spahr A, Haegewald S, Tsoulfidou F, Rompola E, Heijl L, Bernimoulin JP, Ring C, Sander S, Haller B (2005) Coverage of Miller class I and II recession defects using enamel matrix proteins versus coronally advanced flap technique: a 2-year report. J Periodontol 76:1871\u20131880","journal-title":"J Periodontol"},{"key":"3782_CR48","doi-asserted-by":"publisher","first-page":"2031","DOI":"10.1902\/jop.2006.050390","volume":"77","author":"A Pilloni","year":"2006","unstructured":"Pilloni A, Paolantonio M, Camargo PM (2006) Root coverage with a coronally positioned flap used in combination with enamel matrix derivative: 18-month clinical evaluation. J Periodontol 77:2031\u20132039","journal-title":"J Periodontol"},{"key":"3782_CR49","doi-asserted-by":"publisher","first-page":"463","DOI":"10.2334\/josnusd.52.463","volume":"52","author":"PSG Henriques","year":"2010","unstructured":"Henriques PSG, Pelegrine AA, Nogueira AA, Borghi MM (2010) Application of subepithelial connective tissue graft with or without enamel matrix derivative for root coverage: a split-mouth randomized study. J Oral Sci 52:463\u2013471","journal-title":"J Oral Sci"},{"key":"3782_CR50","doi-asserted-by":"publisher","first-page":"1693","DOI":"10.1902\/jop.2000.71.11.1693","volume":"71","author":"F Modica","year":"2000","unstructured":"Modica F, Del Pizzo M, Roccuzzo M, Romagnoli R (2000) Coronally advanced flap for the treatment of buccal gingival recessions with and without enamel matrix derivative. A split-mouth study. J Periodontol 71:1693\u20131698","journal-title":"J Periodontol"},{"key":"3782_CR51","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1111\/j.1600-051X.2005.00831.x","volume":"32","author":"M Del Pizzo","year":"2005","unstructured":"Del Pizzo M, Zucchelli G, Modica F et al (2005) Coronally advanced flap with or without enamel matrix derivative for root coverage: a 2-year study. J Clin Periodontol 32:1181\u20131187","journal-title":"J Clin Periodontol"},{"key":"3782_CR52","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1902\/jop.2006.77.1.7","volume":"77","author":"TA Castellanos","year":"2006","unstructured":"Castellanos TA, de la Rosa RM, de la Garza M, Caffesse RG (2006) Enamel matrix derivative and coronal flaps to cover marginal tissue recessions. J Periodontol 77:7\u201314","journal-title":"J Periodontol"},{"key":"3782_CR53","doi-asserted-by":"publisher","first-page":"224","DOI":"10.4103\/0972-124X.99266","volume":"16","author":"GR Jaiswal","year":"2012","unstructured":"Jaiswal GR, Kumar R, Khatri PM et al (2012) The effectiveness of enamel matrix protein (Emdogain\u00ae) in combination with coronally advanced flap in the treatment of multiple marginal tissue recession: a clinical study. J Indian Soc Periodontol 16:224\u2013230","journal-title":"J Indian Soc Periodontol"},{"key":"3782_CR54","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1902\/jop.2017.170126","volume":"88","author":"JPM Sangiorgio","year":"2017","unstructured":"Sangiorgio JPM, da Silva Neves FL, Rocha dos Santos M et al (2017) Xenogenous collagen matrix and\/or enamel matrix derivative for treatment of localized gingival recessions: a randomized clinical trial. Part I: clinical outcomes. J Periodontol 88:1309\u20131318","journal-title":"J Periodontol"},{"key":"3782_CR55","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1111\/jre.12199","volume":"50","author":"GL Cheng","year":"2015","unstructured":"Cheng GL, Fu E, Tu YK, Shen EC, Chiu HC, Huang RY, Yuh DY, Chiang CY (2015) Root coverage by coronally advanced flap with connective tissue graft and\/or enamel matrix derivative: a meta-analysis. J Periodontal Res 50:220\u2013230","journal-title":"J Periodontal Res"},{"key":"3782_CR56","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1111\/jre.12715","volume":"55","author":"F Mercado","year":"2020","unstructured":"Mercado F, Hamlet S, Ivanovski S (2020) A 3-year prospective clinical and patient-centered trial on subepithelial connective tissue graft with or without enamel matrix derivative in class I-II Miller recessions. J Periodontal Res 55:296\u2013306","journal-title":"J Periodontal Res"},{"key":"3782_CR57","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1902\/jop.1972.43.10.623","volume":"43","author":"NP Lang","year":"1972","unstructured":"Lang NP, L\u00f6e H (1972) The relationship between the width of keratinized gingiva and gingival health. J Periodontol 43:623\u2013627","journal-title":"J Periodontol"},{"key":"3782_CR58","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1111\/j.1600-051X.1981.tb02041.x","volume":"8","author":"J Wennstr\u00f6m","year":"1981","unstructured":"Wennstr\u00f6m J, Lindhe J, Nyman S (1981) Role of keratinized gingiva for gingival health: clinical and histologic study of normal and regenerated gingival tissue in dogs. J Clin Periodontol 8:311\u2013328","journal-title":"J Clin Periodontol"},{"key":"3782_CR59","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/ma12172790","volume":"12","author":"N Discepoli","year":"2019","unstructured":"Discepoli N, Mirra R, Ferrari M (2019) Efficacy of enamel derivatives to improve keratinized tissue as adjunct to coverage of gingival recessions: a systematic review and meta-analysis. Materials (Basel) 12:1\u201322","journal-title":"Materials (Basel)"},{"key":"3782_CR60","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.1002\/JPER.18-0732","volume":"90","author":"G Zucchelli","year":"2019","unstructured":"Zucchelli G, Tavelli L, Barootchi S, Stefanini M, Rasperini G, Valles C, Nart J, Wang HL (2019) The influence of tooth location on the outcomes of multiple adjacent gingival recessions treated with coronally advanced flap: a multicenter re-analysis study. J Periodontol 90:1244\u20131251","journal-title":"J Periodontol"},{"key":"3782_CR61","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1016\/j.jclinepi.2007.10.007","volume":"61","author":"J Brok","year":"2008","unstructured":"Brok J, Thorlund K, Gluud C, Wetterslev J (2008) Trial sequential analysis reveals insufficient information size and potentially false positive results in many meta-analyses. J Clin Epidemiol 61:763\u2013769","journal-title":"J Clin Epidemiol"},{"key":"3782_CR62","doi-asserted-by":"publisher","first-page":"e25491","DOI":"10.1371\/journal.pone.0025491","volume":"6","author":"K Thorlund","year":"2011","unstructured":"Thorlund K, Imberger G, Walsh M, Chu R, Gluud C, Wetterslev J, Guyatt G, Devereaux PJ, Thabane L (2011) The number of patients and events required to limit the risk of overestimation of intervention effects in meta-analysis-a simulation study. PLoS One 6:e25491","journal-title":"PLoS One"},{"key":"3782_CR63","doi-asserted-by":"publisher","first-page":"e011890","DOI":"10.1136\/bmjopen-2016-011890","volume":"6","author":"G Imberger","year":"2016","unstructured":"Imberger G, Thorlund K, Gluud C, Wetterslev J (2016) False-positive findings in Cochrane meta-analyses with and without application of trial sequential analysis: an empirical review. BMJ Open 6:e011890","journal-title":"BMJ Open"}],"container-title":["Clinical Oral Investigations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-021-03782-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00784-021-03782-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-021-03782-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T10:07:42Z","timestamp":1697623662000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00784-021-03782-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,21]]},"references-count":63,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["3782"],"URL":"https:\/\/doi.org\/10.1007\/s00784-021-03782-2","relation":{},"ISSN":["1432-6981","1436-3771"],"issn-type":[{"value":"1432-6981","type":"print"},{"value":"1436-3771","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,21]]},"assertion":[{"value":"31 October 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 January 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 January 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This article does not contain any studies with human participants or animals performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"For this type of study, formal consent is not required.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}