{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T07:55:51Z","timestamp":1789026951618,"version":"build-2803163510"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T00:00:00Z","timestamp":1611878400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T00:00:00Z","timestamp":1611878400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"the Science and Technology Foundation of Tianjin Health Commission, China","award":["KJ20041"],"award-info":[{"award-number":["KJ20041"]}]},{"name":"the Natural Science Foundation of Tianjin, China","award":["20JCQNJC00200"],"award-info":[{"award-number":["20JCQNJC00200"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Oral Invest"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1007\/s00784-021-03807-w","type":"journal-article","created":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T22:02:56Z","timestamp":1611957776000},"page":"4975-4985","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Non-surgical periodontal treatment improves rheumatoid arthritis disease activity: a meta-analysis"],"prefix":"10.1007","volume":"25","author":[{"given":"Jia","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youli","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowei","family":"Bian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijian","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6954-8790","authenticated-orcid":false,"given":"Zheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,1,29]]},"reference":[{"issue":"Suppl 1","key":"3807_CR1","doi-asserted-by":"publisher","first-page":"S173","DOI":"10.1002\/JPER.17-0721","volume":"89","author":"PN Papapanou","year":"2018","unstructured":"Papapanou PN, Sanz M, Buduneli N, Dietrich T, Feres M, Fine DH, Flemmig TF, Garcia R, Giannobile WV, Graziani F, Greenwell H, Herrera D, Kao RT, Kebschull M, Kinane DF, Kirkwood KL, Kocher T, Kornman KS, Kumar PS, Loos BG, Machtei E, Meng H, Mombelli A, Needleman I, Offenbacher S, Seymour GJ, Teles R, Tonetti MS (2018) Periodontitis: consensus report of workgroup 2 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. J Periodontol 89(Suppl 1):S173\u2013S182. https:\/\/doi.org\/10.1002\/JPER.17-0721","journal-title":"J Periodontol"},{"key":"3807_CR2","doi-asserted-by":"publisher","first-page":"4496","DOI":"10.1038\/s41467-019-12505-x","volume":"10","author":"X Zheng","year":"2019","unstructured":"Zheng X, Tizzano M, Redding K, He J, Peng X, Jiang P, Xu X, Zhou X, Margolskee RF (2019) Gingival solitary chemosensory cells are immune sentinels for periodontitis. Nat Commun 10:4496. https:\/\/doi.org\/10.1038\/s41467-019-12505-x","journal-title":"Nat Commun"},{"key":"3807_CR3","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1902\/annals.1998.3.1.108","volume":"3","author":"RC Page","year":"1998","unstructured":"Page RC (1998) The pathobiology of periodontal diseases may affect systemic diseases: inversion of a paradigm. Ann Periodontol 3:108\u2013120. https:\/\/doi.org\/10.1902\/annals.1998.3.1.108","journal-title":"Ann Periodontol"},{"key":"3807_CR4","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1016\/S2213-8587(18)30038-X","volume":"6","author":"F D\u2019Aiuto","year":"2018","unstructured":"D\u2019Aiuto F, Gkranias N, Bhowruth D, Khan T, Orlandi M, Suvan J, Masi S, Tsakos G, Hurel S, Hingorani AD, Donos N, Deanfield JE, Group T (2018) Systemic effects of periodontitis treatment in patients with type 2 diabetes: a 12 month, single-centre, investigator-masked, randomised trial. Lancet Diabetes Endocrinol 6:954\u2013965. https:\/\/doi.org\/10.1016\/S2213-8587(18)30038-X","journal-title":"Lancet Diabetes Endocrinol"},{"key":"3807_CR5","doi-asserted-by":"publisher","first-page":"6034546","DOI":"10.1155\/2019\/6034546","volume":"2019","author":"F Ceccarelli","year":"2019","unstructured":"Ceccarelli F, Saccucci M, Di Carlo G, Lucchetti R, Pilloni A, Pranno N, Luzzi V, Valesini G, Polimeni A (2019) Periodontitis and rheumatoid arthritis: the same inflammatory mediators? Mediat Inflamm 2019:6034546. https:\/\/doi.org\/10.1155\/2019\/6034546","journal-title":"Mediat Inflamm"},{"key":"3807_CR6","doi-asserted-by":"publisher","first-page":"80","DOI":"10.3389\/fimmu.2016.00080","volume":"7","author":"NR Fuggle","year":"2016","unstructured":"Fuggle NR, Smith TO, Kaul A, Sofat N (2016) Hand to mouth: a systematic review and meta-analysis of the association between rheumatoid arthritis and periodontitis. Front Immunol 7:80. https:\/\/doi.org\/10.3389\/fimmu.2016.00080","journal-title":"Front Immunol"},{"key":"3807_CR7","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1007\/s00784-018-2420-3","volume":"23","author":"R Cosgarea","year":"2019","unstructured":"Cosgarea R, Tristiu R, Dumitru RB, Arweiler NB, Rednic S, Sirbu CI, Lascu L, Sculean A, Eick S (2019) Effects of non-surgical periodontal therapy on periodontal laboratory and clinical data as well as on disease activity in patients with rheumatoid arthritis. Clin Oral Investig 23:141\u2013151. https:\/\/doi.org\/10.1007\/s00784-018-2420-3","journal-title":"Clin Oral Investig"},{"key":"3807_CR8","doi-asserted-by":"publisher","first-page":"397","DOI":"10.2334\/josnusd.16-0677","volume":"59","author":"H Balci Yuce","year":"2017","unstructured":"Balci Yuce H, Gokturk O, Aydemir Turkal H, Inanir A, Benli I, Demir O (2017) Assessment of local and systemic 25-hydroxy-vitamin D, RANKL, OPG, and TNF levels in patients with rheumatoid arthritis and periodontitis. J Oral Sci 59:397\u2013404. https:\/\/doi.org\/10.2334\/josnusd.16-0677","journal-title":"J Oral Sci"},{"key":"3807_CR9","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1177\/154405910608500201","volume":"85","author":"LM Golub","year":"2006","unstructured":"Golub LM, Payne JB, Reinhardt RA, Nieman G (2006) Can systemic diseases co-induce (not just exacerbate) periodontitis? A hypothetical \u201ctwo-hit\u201d model. J Dent Res 85:102\u2013105. https:\/\/doi.org\/10.1177\/154405910608500201","journal-title":"J Dent Res"},{"issue":"23","key":"3807_CR10","doi-asserted-by":"publisher","first-page":"2205","DOI":"10.1056\/NEJMra1004965","volume":"365","author":"IBSG McInnes","year":"2011","unstructured":"McInnes IBSG (2011) The pathogenesis of rheumatoid arthritis. N Engl J Med 365(23):2205\u20132219. https:\/\/doi.org\/10.1056\/NEJMra1004965","journal-title":"N Engl J Med"},{"key":"3807_CR11","doi-asserted-by":"publisher","first-page":"109","DOI":"10.2478\/folmed-2014-0016","volume":"56","author":"AM Mlachkova","year":"2014","unstructured":"Mlachkova AM, Popova CL (2014) Efficiency of nonsurgical periodontal therapy in moderate chronic periodontitis. Folia Med (Plovdiv) 56:109\u2013115. https:\/\/doi.org\/10.2478\/folmed-2014-0016","journal-title":"Folia Med (Plovdiv)"},{"key":"3807_CR12","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.semarthrit.2014.04.009","volume":"44","author":"S Kaur","year":"2014","unstructured":"Kaur S, Bright R, Proudman SM, Bartold PM (2014) Does periodontal treatment influence clinical and biochemical measures for rheumatoid arthritis? A systematic review and meta-analysis. Semin Arthritis Rheum 44:113\u2013122. https:\/\/doi.org\/10.1016\/j.semarthrit.2014.04.009","journal-title":"Semin Arthritis Rheum"},{"key":"3807_CR13","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1016\/j.rbre.2016.11.011","volume":"57","author":"DC Calderaro","year":"2017","unstructured":"Calderaro DC, Correa JD, Ferreira GA, Barbosa IG, Martins CC, Silva TA, Teixeira AL (2017) Influence of periodontal treatment on rheumatoid arthritis: a systematic review and meta-analysis. Rev Bras Reumatol Engl Ed 57:238\u2013244. https:\/\/doi.org\/10.1016\/j.rbre.2016.11.011","journal-title":"Rev Bras Reumatol Engl Ed"},{"key":"3807_CR14","doi-asserted-by":"publisher","first-page":"22","DOI":"10.4103\/0972-124X.94599.","volume":"16","author":"SB Ranade","year":"2012","unstructured":"Ranade SB, Doiphode S (2012) Is there a relationship between periodontitis and rheumatoid arthritis? J Indian Soc Periodontol 16:22\u201327. https:\/\/doi.org\/10.4103\/0972-124X.94599.","journal-title":"J Indian Soc Periodontol"},{"key":"3807_CR15","doi-asserted-by":"publisher","first-page":"2607","DOI":"10.1007\/s00296-013-2781-5","volume":"33","author":"B Biyikoglu","year":"2013","unstructured":"Biyikoglu B, Buduneli N, Aksu K, Nalbantsoy A, Lappin DF, Evrenosoglu E, Kinane DF (2013) Periodontal therapy in chronic periodontitis lowers gingival crevicular fluid interleukin-1beta and DAS28 in rheumatoid arthritis patients. Rheumatol Int 33:2607\u20132616. https:\/\/doi.org\/10.1007\/s00296-013-2781-5","journal-title":"Rheumatol Int"},{"key":"3807_CR16","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1111\/odi.12017","volume":"19","author":"K Erciyas","year":"2013","unstructured":"Erciyas K, Sezer U, \u00dcst\u00fcn K, Pehlivan Y, Kisacik B, \u015eenyurt SZ, Tarak\u00e7io\u01e7lu M, Onat AM (2013) Effects of periodontal therapy on disease activity and systemic inflammation in rheumatoid arthritis patients. Oral Dis 19:394\u2013400. https:\/\/doi.org\/10.1111\/odi.12017","journal-title":"Oral Dis"},{"key":"3807_CR17","doi-asserted-by":"publisher","first-page":"150","DOI":"10.2174\/1874210601509010150","volume":"9","author":"CVG Roman-Torres","year":"2015","unstructured":"Roman-Torres CVG, Neto JS, Souza MA, Schwartz-Filho HO, Diniz WCBREAS (2015) An evaluation of non-surgical periodontal therapy in patients with rheumatoid arthritis. Open Dent J 9:150\u2013153","journal-title":"Open Dent J"},{"key":"3807_CR18","first-page":"741","volume":"67","author":"R Boatca","year":"2016","unstructured":"Boatca R, Scutariu M, Rudnic I, Martu A, Hurjui L, Rezus E, Martu S (2016) Evolution of inflammatory biochemical markers within periodontal therapy to patients with rheumatoid arthritis. Rev Chim -Bucharest- Orig Ed 67:741\u2013744","journal-title":"Rev Chim -Bucharest- Orig Ed"},{"key":"3807_CR19","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1111\/jre.12337","volume":"51","author":"S Kurgan","year":"2016","unstructured":"Kurgan S, Fentoglu O, Onder C, Serdar M, Eser F, Tatakis DN, Gunhan M (2016) The effects of periodontal therapy on gingival crevicular fluid matrix metalloproteinase-8, interleukin-6 and prostaglandin E2 levels in patients with rheumatoid arthritis. J Periodontal Res 51:586\u2013595. https:\/\/doi.org\/10.1111\/jre.12337","journal-title":"J Periodontal Res"},{"key":"3807_CR20","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1111\/jre.12425","volume":"52","author":"S Kurgan","year":"2017","unstructured":"Kurgan S, Onder C, Balci N, Fentoglu O, Eser F, Balseven M, Serdar MA, Tatakis DN, Gunhan M (2017) Gingival crevicular fluid tissue\/blood vessel-type plasminogen activator and plasminogen activator inhibitor-2 levels in patients with rheumatoid arthritis: effects of nonsurgical periodontal therapy. J Periodontal Res 52:574\u2013581. https:\/\/doi.org\/10.1111\/jre.12425","journal-title":"J Periodontal Res"},{"key":"3807_CR21","doi-asserted-by":"publisher","first-page":"e0192365","DOI":"10.1371\/journal.pone.0192365","volume":"13","author":"C Kaneko","year":"2018","unstructured":"Kaneko C, Kobayashi T, Ito S, Sugita N, Murasawa A, Nakazono K, Yoshie H (2018) Circulating levels of carbamylated protein and neutrophil extracellular traps are associated with periodontitis severity in patients with rheumatoid arthritis: a pilot case-control study. PLoS One 13:e0192365. https:\/\/doi.org\/10.1371\/journal.pone.0192365","journal-title":"PLoS One"},{"key":"3807_CR22","doi-asserted-by":"publisher","first-page":"5802","DOI":"10.12659\/MSM.909117","volume":"24","author":"X Zhao","year":"2018","unstructured":"Zhao X, Liu Z, Shu D, Xiong Y, He M, Xu S, Si S, Guo B (2018) Association of periodontitis with rheumatoid arthritis and the effect of non-surgical periodontal treatment on disease activity in patients with rheumatoid arthritis. Med Sci Monit 24:5802\u20135810. https:\/\/doi.org\/10.12659\/MSM.909117","journal-title":"Med Sci Monit"},{"key":"3807_CR23","doi-asserted-by":"publisher","first-page":"506","DOI":"10.4103\/ijdr.IJDR_662_17","volume":"30","author":"D Anusha","year":"2019","unstructured":"Anusha D, Chaly PE, Junaid M, Nijesh JE, Shivashankar K, Sivasamy S (2019) Efficacy of a mouthwash containing essential oils and curcumin as an adjunct to nonsurgical periodontal therapy among rheumatoid arthritis patients with chronic periodontitis: a randomized controlled trial. Indian J Dent Res 30:506\u2013511. https:\/\/doi.org\/10.4103\/ijdr.IJDR_662_17","journal-title":"Indian J Dent Res"},{"key":"3807_CR24","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1093\/rheumatology\/kez368","volume":"59","author":"X Mariette","year":"2019","unstructured":"Mariette X, Perrodeau E, Verner C, Struillou X, Picard N, Schaeverbeke T, Constantin A, Ravaud P, Bouchard P (2019) Role of good oral hygiene on clinical evolution of rheumatoid arthritis: a randomized study nested in the ESPOIR cohort. Rheumatology (Oxford) 59:988\u2013996. https:\/\/doi.org\/10.1093\/rheumatology\/kez368","journal-title":"Rheumatology (Oxford)"},{"key":"3807_CR25","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1007\/s00296-019-04460-z","volume":"40","author":"K Bia\u0142ow\u0105s","year":"2020","unstructured":"Bia\u0142ow\u0105s K, Radwan-Oczko M, Du\u015b-Ilnicka I, Korman L, \u015awierkot J (2020) Periodontal disease and influence of periodontal treatment on disease activity in patients with rheumatoid arthritis and spondyloarthritis. Rheumatol Int 40:455\u2013463. https:\/\/doi.org\/10.1007\/s00296-019-04460-z","journal-title":"Rheumatol Int"},{"key":"3807_CR26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4236\/ojst.2020.101001","volume":"10","author":"RK Pandya","year":"2020","unstructured":"Pandya RK, Shah MA, Raval YH (2020) Effect of non-surgical periodontal therapy on the severity of rheumatoid arthritis\u2014a clinical and hematological study. Open J Stomatol 10:1\u20139. https:\/\/doi.org\/10.4236\/ojst.2020.101001","journal-title":"Open J Stomatol"},{"key":"3807_CR27","unstructured":"Mashchenko IS (1978) Vliianie lecheniia parodontoza na techenie revmatoidnogo poliartrita [Effect of treatment of periodontosis on the course of\u00a0rheumatoid polyarthritis]. Vrachebnoe delo (6):41\u201343"},{"key":"3807_CR28","first-page":"1650","volume":"26","author":"RA Greenwald","year":"1999","unstructured":"Greenwald RA, Kirkwood K (1999) Adult periodontitis as a model for rheumatoid arthritis (with emphasis on treatment strategies). J Rheumatol 26:1650\u20131653","journal-title":"J Rheumatol"},{"key":"3807_CR29","doi-asserted-by":"publisher","first-page":"191","DOI":"10.5177\/ntvt.2012.04.11169","volume":"119","author":"MJ de Smit","year":"2012","unstructured":"de Smit MJ, Brouwer E, Westra J, Nesse W, Vissink A, van Winkelhoff AJ (2012) Effect of periodontal treatment on rheumatoid arthritis and vice versa. Ned Tijdschr Tandheelkd 119:191\u2013197. https:\/\/doi.org\/10.5177\/ntvt.2012.04.11169","journal-title":"Ned Tijdschr Tandheelkd"},{"key":"3807_CR30","doi-asserted-by":"publisher","first-page":"169","DOI":"10.2174\/18715303113139990040","volume":"7","author":"U El-Shinnawi","year":"2013","unstructured":"El-Shinnawi U, Soory M (2013) Associations between periodontitis and systemic inflammatory diseases: response to treatment. Recent Pat Endocr, Metab Immune Drug Discovery 7:169\u2013188. https:\/\/doi.org\/10.2174\/18715303113139990040","journal-title":"Recent Pat Endocr, Metab Immune Drug Discovery"},{"key":"3807_CR31","doi-asserted-by":"publisher","first-page":"409","DOI":"10.2217\/ijr.15.46","volume":"10","author":"BR England","year":"2015","unstructured":"England BR, Coburn BW, Payne JB, Thiele GM, Mikuls TR (2015) Identifying and treating periodontitis in patients with rheumatoid arthritis. Int J Clin Rheumatol 10:409\u2013416. https:\/\/doi.org\/10.2217\/ijr.15.46","journal-title":"Int J Clin Rheumatol"},{"key":"3807_CR32","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1136\/annrheumdis-2017-eular.6098","volume":"76","author":"F Xiao","year":"2017","unstructured":"Xiao F, Zhang P, Li X, Mou Y, Chen H, Cai Y (2017) Effects of periodontal basic treatment on periodontal condition, clinical response and serum inflammatory parameters in rheumatoid arthritis (RA) patients with moderate to severe periodontitis. Ann Rheum Dis 76:1141. https:\/\/doi.org\/10.1136\/annrheumdis-2017-eular.6098","journal-title":"Ann Rheum Dis"},{"key":"3807_CR33","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1136\/annrheumdis-2018-eular.6244","volume":"77","author":"SA Kusumo","year":"2018","unstructured":"Kusumo SA, Isbagio H, Marhamah S, Intan C, Antono D, Harimurti K (2018) Effect of periodontal treatment on e-selectin level in rheumatoid arthritis patients. Ann Rheum Dis 77:941. https:\/\/doi.org\/10.1136\/annrheumdis-2018-eular.6244","journal-title":"Ann Rheum Dis"},{"key":"3807_CR34","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1186\/1745-6215-14-253","volume":"14","author":"P Monsarrat","year":"2013","unstructured":"Monsarrat P, Vergnes JN, Cantagrel A, Algans N, Cousty S, K\u00e9moun P, Bertrand C, Arriv\u00e9 E, Bou C, S\u00e9darat C, Schaeverbeke T, Nabet C, Sixou M (2013) Effect of periodontal treatment on the clinical parameters of patients with rheumatoid arthritis: study protocol of the randomized, controlled ESPERA trial. Trials 14:253. https:\/\/doi.org\/10.1186\/1745-6215-14-253","journal-title":"Trials"},{"key":"3807_CR35","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1016\/j.jbspin.2019.02.006","volume":"86","author":"P Monsarrat","year":"2019","unstructured":"Monsarrat P, Fernandez de Grado G, Constantin A, Willmann C, Nabet C, Sixou M, Cantagrel A, Barnetche T, Mehsen-Cetre N, Schaeverbeke T, Arriv\u00e9 E, Vergnes JN (2019) The effect of periodontal treatment on patients with rheumatoid arthritis: the ESPERA randomised controlled trial. Joint Bone Spine 86:600\u2013609. https:\/\/doi.org\/10.1016\/j.jbspin.2019.02.006","journal-title":"Joint Bone Spine"},{"key":"3807_CR36","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1002\/art.40700","volume":"70","author":"B Moeller","year":"2018","unstructured":"Moeller B, Bender P, Eick S, Midwood K, Potempa J, Reichenbach S, Schwenzer A, Villiger PM, Wong A (2018) Non-surgical periodontal therapy plus short-term antibiotic treatment may improve clinical disease activity: a pilot study in difficult to treat rheumatoid arthritis. Arthritis Rheum 70:615. https:\/\/doi.org\/10.1002\/art.40700","journal-title":"Arthritis Rheum"},{"key":"3807_CR37","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1177\/2380084419833694","volume":"4","author":"S Serban","year":"2019","unstructured":"Serban S, Dietrich T, Lopez-Oliva I, de Pablo P, Raza K, Filer A, Chapple ILC, Hill K (2019) Attitudes towards oral health in patients with rheumatoid arthritis: a qualitative study nested within a randomized controlled trial. JDR Clin Trans Res 4:360\u2013370. https:\/\/doi.org\/10.1177\/2380084419833694","journal-title":"JDR Clin Trans Res"},{"key":"3807_CR38","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1016\/j.jfma.2017.11.006","volume":"117","author":"NY Yang","year":"2018","unstructured":"Yang NY, Wang CY, Chyuan IT, Wu KJ, Tu YK, Chang CW, Hsu PN, Kuo MYP, Chen YW (2018) Significant association of rheumatoid arthritis-related inflammatory markers with non-surgical periodontal therapy. J Formos Med Assoc 117:1003\u20131010. https:\/\/doi.org\/10.1016\/j.jfma.2017.11.006","journal-title":"J Formos Med Assoc"},{"key":"3807_CR39","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1097\/RHU.0b013e3180690616","volume":"13","author":"MK Al-Katma","year":"2007","unstructured":"Al-Katma MK, Bissada NF, Bordeaux JM, Sue J, Askari AD (2007) Control of periodontal infection reduces the severity of active rheumatoid arthritis. J Clin Rheumatol 13:134\u2013137. https:\/\/doi.org\/10.1097\/RHU.0b013e3180690616","journal-title":"J Clin Rheumatol"},{"key":"3807_CR40","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1902\/jop.2009.080447","volume":"80","author":"P Ortiz","year":"2009","unstructured":"Ortiz P, Bissada NF, Palomo L, Han YW, Al-Zahrani MS, Panneerselvam A, Askari A (2009) Periodontal therapy reduces the severity of active rheumatoid arthritis in patients treated with or without tumor necrosis factor inhibitors. J Periodontol 80:535\u2013540. https:\/\/doi.org\/10.1902\/jop.2009.080447","journal-title":"J Periodontol"},{"key":"3807_CR41","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.jobcr.2019.02.002","volume":"9","author":"S Kaushal","year":"2019","unstructured":"Kaushal S, Singh AK, Lal N, Das SK, Mahdi AA (2019) Effect of periodontal therapy on disease activity in patients of rheumatoid arthritis with chronic periodontitis. J Oral Biol Craniofac Res 9:128\u2013132. https:\/\/doi.org\/10.1016\/j.jobcr.2019.02.002","journal-title":"J Oral Biol Craniofac Res"},{"key":"3807_CR42","doi-asserted-by":"publisher","first-page":"484","DOI":"10.5005\/jp-journals-10024-1877","volume":"17","author":"N Khare","year":"2016","unstructured":"Khare N, Vanza B, Sagar D, Saurav K, Chauhan R, Mishra S (2016) Nonsurgical periodontal therapy decreases the severity of rheumatoid arthritis: a case-control study. J Contemp Dent Pract 17:484\u2013488. https:\/\/doi.org\/10.5005\/jp-journals-10024-1877","journal-title":"J Contemp Dent Pract"},{"key":"3807_CR43","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1590\/s0103-64402009000500001","volume":"20","author":"N Pinho Mde","year":"2009","unstructured":"Pinho Mde N, Oliveira RD, Novaes AB Jr, Voltarelli JC (2009) Relationship between periodontitis and rheumatoid arthritis and the effect of non-surgical periodontal treatment. Braz Dent J 20:355\u2013364. https:\/\/doi.org\/10.1590\/s0103-64402009000500001","journal-title":"Braz Dent J"},{"key":"3807_CR44","doi-asserted-by":"publisher","first-page":"e74","DOI":"10.1902\/jop.2013.130079","volume":"84","author":"M Okada","year":"2013","unstructured":"Okada M, Kobayashi T, Ito S, Yokoyama T, Abe A, Murasawa A, Yoshie H (2013) Periodontal treatment decreases levels of antibodies to Porphyromonas gingivalis and citrulline in patients with rheumatoid arthritis and periodontitis. J Periodontol 84:e74\u2013e84. https:\/\/doi.org\/10.1902\/jop.2013.130079","journal-title":"J Periodontol"},{"key":"3807_CR45","unstructured":"Karapetsa D (2015) Rheumatoid arthritis and control of the periodontal infection: epidemiological evaluation and randomized clinical trial. University of Pisa"},{"key":"3807_CR46","doi-asserted-by":"publisher","first-page":"13","DOI":"10.15171\/japid.2018.003","volume":"10","author":"F Atarbashi-Moghadam","year":"2018","unstructured":"Atarbashi-Moghadam F, Rashidi Maybodi F, Dehghan A, Haerian Ardakani A (2018) Effect of non-surgical periodontal treatment on clinical signs of rheumatoid arthritis. J Adv Periodontol Implant Dent 10:13\u201317. https:\/\/doi.org\/10.15171\/japid.2018.003","journal-title":"J Adv Periodontol Implant Dent"},{"key":"3807_CR47","unstructured":"Serban ST (2016) Outcomes of periodontal treatment in patients with rheumatoid arthritis. University of Birmingham"},{"key":"3807_CR48","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1111\/prd.12300","volume":"83","author":"PM Bartold","year":"2020","unstructured":"Bartold PM, Lopez-Oliva I (2020) Periodontitis and rheumatoid arthritis: an update 2012-2017. Periodontol 83:189\u2013212. https:\/\/doi.org\/10.1111\/prd.12300","journal-title":"Periodontol"},{"key":"3807_CR49","doi-asserted-by":"publisher","first-page":"6383","DOI":"10.1038\/s41598-020-63350-8","volume":"10","author":"JS Suh","year":"2020","unstructured":"Suh JS, Lee SH, Fouladian Z, Lee JY, Kim T, Kang MK, Lusis AJ, Bostrom KI, Kim RH, Park NH (2020) Rosuvastatin prevents the exacerbation of atherosclerosis in ligature-induced periodontal disease mouse model. Sci Rep 10:6383. https:\/\/doi.org\/10.1038\/s41598-020-63350-8","journal-title":"Sci Rep"},{"key":"3807_CR50","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1111\/j.1600-051X.2007.01179.x","volume":"35","author":"W Pitiphat","year":"2008","unstructured":"Pitiphat W, Savetsilp W, Wara-Aswapati N (2008) C-reactive protein associated with periodontitis in a Thai population. J Clin Periodontol 35:120\u2013125. https:\/\/doi.org\/10.1111\/j.1600-051X.2007.01179.x","journal-title":"J Clin Periodontol"},{"key":"3807_CR51","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1177\/154405910508400312","volume":"84","author":"F D\u2019Aiuto","year":"2005","unstructured":"D\u2019Aiuto F, Nibali L, Parkar M, Suvan J, Tonetti MS (2005) Short-term effects of intensive periodontal therapy on serum inflammatory markers and cholesterol. J Dent Res 84:269\u2013273. https:\/\/doi.org\/10.1177\/154405910508400312","journal-title":"J Dent Res"},{"key":"3807_CR52","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1007\/s40496-020-00264-4","volume":"7","author":"NN Eezammuddeen","year":"2020","unstructured":"Eezammuddeen NN, Vaithilingam RD, Hassan NHM, Bartold PM (2020) Association between rheumatoid arthritis and periodontitis: recent progress. Curr Oral Health Rep 7:139\u2013153. https:\/\/doi.org\/10.1007\/s40496-020-00264-4","journal-title":"Curr Oral Health Rep"}],"container-title":["Clinical Oral Investigations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-021-03807-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00784-021-03807-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-021-03807-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,5]],"date-time":"2021-08-05T15:11:45Z","timestamp":1628176305000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00784-021-03807-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,29]]},"references-count":52,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["3807"],"URL":"https:\/\/doi.org\/10.1007\/s00784-021-03807-w","relation":{},"ISSN":["1432-6981","1436-3771"],"issn-type":[{"value":"1432-6981","type":"print"},{"value":"1436-3771","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,29]]},"assertion":[{"value":"15 September 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 January 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 January 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This article does not contain any studies with human participants or animals performed by any of the authors.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"For this type of study, formal consent is not required.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}