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Clinical attachment level (CAL), probing depth (PD), gingival recession (REC), and bleeding on probing (BOP) were recorded at baseline,12, 18, and 24 months after surgery.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>At 24 months, both treatments resulted in statistically significant clinical improvements evidenced by PD-reduction and CAL-gain (<jats:italic>p<\/jats:italic>&lt;0.001). The mean CAL-gain was 2.19\u00b11.11 mm in the test and 2.94\u00b11.12 mm in the control sites (<jats:italic>p<\/jats:italic>=0.067). PD-reduction was statistically significantly higher for the control group (4.5\u00b10.97 mm) than the test group (3.31\u00b10.70 mm), (<jats:italic>p<\/jats:italic>=0.001). CAL-gain \u2264 3 mm was observed in 87.5% and in 62.5% of the test and control sites, respectively. Test sites showed slightly lower REC values than the control sites. No statistically significant differences were found for BOP between treatments.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The present findings indicate that both treatments led to statistically significant clinical improvements compared to baseline, although the application of EMD resulted in statistically significantly higher PD-reduction compared to the use of HA.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Clinical relevance<\/jats:title>\n                <jats:p>The use of HA in conjunction with a SFA resulted in significant PD-reduction and CAL-gain, pointing to the potential clinical relevance of this material in regenerative periodontal surgery.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00784-021-03822-x","type":"journal-article","created":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T07:40:04Z","timestamp":1612942804000},"page":"5095-5107","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":73,"title":["Healing of intrabony defects following regenerative surgery by means of single-flap approach in conjunction with either hyaluronic acid or an enamel matrix derivative: a 24-month randomized controlled clinical trial"],"prefix":"10.1007","volume":"25","author":[{"given":"Andrea","family":"Pilloni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana A.","family":"Rojas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6662-2644","authenticated-orcid":false,"given":"Lorenzo","family":"Marini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Russo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinori","family":"Shirakata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton","family":"Sculean","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Iacono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,2,10]]},"reference":[{"issue":"22","key":"3822_CR1","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1034\/j.1600-0757.2000.2220105.x","volume":"2000","author":"NP Lang","year":"2000","unstructured":"Lang NP (2000) Focus on intrabony defects \u2013 conservative therapy. 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The study was approved by Ethical Committee of \u201cSapienza,\u201d University of Rome (Ref. 3816 \u2013 Prot. 2705\/15). Informed consent was obtained from all individual participants included in the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare that they have no conflict of interest study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}