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The distribution of patients according to the cleft type was 57.9% with CLP, 25.2% with cleft palate (CPO), and 12.8% with cleft lip with\/without alveolus (CL\/A). Seventy-four (27.8%) patients had associated malformations, and 24 (9.2%) a syndrome. The skeletal (27.7%), cardiovascular (19.3%) systems, and eyes (22.9%) were most commonly affected. Pierre Robin Sequence (7 patients) and van der Woude (4) were the most common syndromes. The majority of patients with CPO (19\/24) had an associate syndrome. The families had an average of 2.45 affected members.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Individual and interfamilial phenotypic variability in patients with CL\/P makes the understanding of etiopathogenesis challenging.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Clinical relevance<\/jats:title>\n                <jats:p>The overall prevalence of individuals with CL\/P and their pedigrees with associated malformations and syndromes emphasize the need for early identification, interdisciplinary, and long-term planning.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00784-021-03863-2","type":"journal-article","created":{"date-parts":[[2021,3,24]],"date-time":"2021-03-24T05:02:49Z","timestamp":1616562169000},"page":"5531-5540","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Clinical characterization of 266 patients and family members with cleft lip and\/or palate with associated malformations and syndromes"],"prefix":"10.1007","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8478-2078","authenticated-orcid":false,"given":"Theodosia","family":"Bartzela","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f6rn","family":"Theuerkauf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Reichardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malte","family":"Spielmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Opitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,3,24]]},"reference":[{"key":"3863_CR1","volume-title":"Birth defects surveillance: a manual for program managers","author":"WHO\/CDC\/ICBDSR","year":"2014","unstructured":"WHO\/CDC\/ICBDSR (2014) Birth defects surveillance: a manual for program managers. 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