{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T19:31:07Z","timestamp":1778787067530,"version":"3.51.4"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2021,3,11]],"date-time":"2021-03-11T00:00:00Z","timestamp":1615420800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,3,11]],"date-time":"2021-03-11T00:00:00Z","timestamp":1615420800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Charit\u00e9"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Oral Invest"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Objective<\/jats:title>\n                <jats:p>To compare the clinical effectiveness of various types of high-level laser therapy (HLLT) toward scalpel excision for the surgical treatment of erosive oral lichen planus (OLP).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Materials and methods<\/jats:title>\n                <jats:p>The total number of 128 individuals were enrolled in the study. The 35 did not meet the inclusion criteria due to malignancy signs and presence of diabetes mellitus. In total, 8 were lost to follow-up, and 10 were excluded from the analysis, due to analgesics intake. This way 75 patients with the erosive form of OLP were analyzed in three intervention groups (Er:YAG, <jats:italic>n<\/jats:italic> = 19; Nd:YAG, <jats:italic>n<\/jats:italic> = 15; Er:YAG + Nd:YAG combination, <jats:italic>n<\/jats:italic> = 20) and one control group with scalpel excision (<jats:italic>n<\/jats:italic> = 21). The therapy effectiveness has been assessed based on the comparison of salivary interleukin (IL)-1\u03b2, IL-6 and interferon (IFN)-\u03b3 preoperative levels to 14, 30 days, and 2 years postoperation, as well as pain level and time of epithelization.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>All HLLT groups demonstrated a significantly (<jats:italic>p<\/jats:italic> &gt; 0.05) higher IL-1\u03b2, IL-6, IFN\u03b3 and pain level reduction and quicker epithelization toward the control group on the 30th day, except Nd:YAG in case of IFN\u03b3 level. The highest IL-1\u03b2, IFN\u03b3 and pain level reduction and quicker epithelization on the 30th day was observed in Er:YAG group, followed by Er:YAG + Nd:YAG combination, Nd:YAG respectively. However no significant difference was observed between the HLLT groups with regard to IL-6 level reduction. After a 2-year follow-up, no significant difference was observed between all study groups with regard to all variables.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>HLLT yields a superior clinical outcome compared to the scalpel excision for the surgical treatment of oral lichen planus, whereby the Er:YAG has been proposed as the most effective laser type at the end of the first postoperative month.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Clinical relevance<\/jats:title>\n                <jats:p>For the surgical treatment of erosive OLP the Er:YAG laser may be a preferable treatment option compared to Nd:YAG and scalpel surgery.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Trial registration<\/jats:title>\n                <jats:p>The present trial was registered retrospectively in the German Clinical Trials Register, as a member of WHO international clinical trials registry platform, on the 18.03.2020 with the following number: DRKS00020986<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00784-021-03867-y","type":"journal-article","created":{"date-parts":[[2021,3,11]],"date-time":"2021-03-11T06:02:56Z","timestamp":1615442576000},"page":"5649-5660","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["High-level laser therapy versus scalpel surgery in the treatment of oral lichen planus: a randomized control trial"],"prefix":"10.1007","volume":"25","author":[{"given":"Svetlana","family":"Tarasenko","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikhail","family":"Stepanov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Morozova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5487-4251","authenticated-orcid":false,"given":"Alexey","family":"Unkovskiy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,3,11]]},"reference":[{"key":"3867_CR1","doi-asserted-by":"publisher","first-page":"370","DOI":"10.2741\/e712","volume":"6","author":"D Di Stasio","year":"2014","unstructured":"Di Stasio D, Guida A, Salerno C et al (2014) Oral lichen planus: a narrative review. Front Biosci (Elite Ed) 6:370\u2013376","journal-title":"Front Biosci (Elite Ed)"},{"issue":"8","key":"3867_CR2","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1007\/s00403-016-1667-2","volume":"308","author":"MS Alrashdan","year":"2016","unstructured":"Alrashdan MS, Cirillo N, McCullough M (2016) Oral lichen planus: a literature review and update. Arch Dermatol Res 308(8):539\u2013551","journal-title":"Arch Dermatol Res"},{"issue":"5","key":"3867_CR3","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1007\/s40257-015-0142-8","volume":"16","author":"L Baykal","year":"2015","unstructured":"Baykal L, Arica DA, Yayli S et al (2015) Prevalence of metabolic syndrome in patients with mucosal lichen planus: a case\u2013control study. Am J Clin Dermatol 16(5):439\u2013445","journal-title":"Am J Clin Dermatol"},{"issue":"3","key":"3867_CR4","doi-asserted-by":"publisher","first-page":"222","DOI":"10.4103\/0019-5154.156315","volume":"60","author":"S Gupta","year":"2015","unstructured":"Gupta S, Jawanda MK (2015) Oral lichen planus: an update on etiology, pathogenesis, clinical presentation, diagnosis and management. Indian J Dermatol 60(3):222\u2013229","journal-title":"Indian J Dermatol"},{"issue":"5","key":"3867_CR5","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1016\/j.oooo.2016.02.002","volume":"121","author":"H Yang","year":"2016","unstructured":"Yang H, Wu Y, Ma H, Jiang L, Zeng X, Dan H, Zhou Y, Chen Q (2016) Possible alternative therapies for oral lichen planus cases refractory to steroid therapies. Oral Surg Oral Med Oral Pathol Oral Radiol 121(5):496\u2013509","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"3867_CR6","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1016\/j.pdpdt.2018.02.001","volume":"21","author":"S Mirza","year":"2018","unstructured":"Mirza S, Rehman N, Alrahlah A, Alamri W\u2019R, Vohra F (2018) Efficacy of photodynamic therapy or low level laser therapy against steroid therapy in the treatment of erosive-atrophic oral lichen planus. Photodiagn Photodyn Ther 21:404\u2013408","journal-title":"Photodiagn Photodyn Ther"},{"key":"3867_CR7","doi-asserted-by":"crossref","unstructured":"Khater MM, Khattab FM (2019) Efficacy of 1064 Q switched Nd:YAG laser in the treatment of oral lichen planus. J Dermatol Treat 1-5","DOI":"10.1080\/09546634.2019.1638881"},{"issue":"3","key":"3867_CR8","doi-asserted-by":"publisher","first-page":"150","DOI":"10.15171\/jlms.2017.27","volume":"8","author":"N Derikvand","year":"2017","unstructured":"Derikvand N, Ghasemi SS, Moharami M, Shafiei E, Chiniforush N (2017) Management of oral lichen planus by 980 nm diode laser. J Lasers Med Sci 8(3):150\u2013154","journal-title":"J Lasers Med Sci"},{"issue":"1","key":"3867_CR9","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1111\/jop.12619","volume":"47","author":"Z Akram","year":"2018","unstructured":"Akram Z, Abduljabbar T, Vohra F, Javed F (2018) Efficacy of low-level laser therapy compared to steroid therapy in the treatment of oral lichen planus: a systematic review. J Oral Pathol Med 47(1):11\u201317","journal-title":"J Oral Pathol Med"},{"issue":"6","key":"3867_CR10","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1089\/pho.2010.2876","volume":"29","author":"HH Jajarm","year":"2011","unstructured":"Jajarm HH, Falaki F, Mahdavi O (2011) A comparative pilot study of low intensity laser versus topical corticosteroids in the treatment of erosive-atrophic oral lichen planus. Photomed Laser Surg 29(6):421\u2013425","journal-title":"Photomed Laser Surg"},{"issue":"1","key":"3867_CR11","first-page":"1","volume":"5","author":"M Hadiuzzaman","year":"2013","unstructured":"Hadiuzzaman M, Hasibur Rahman M, Parvin Ansari N (2013) A case of recalcitrant oral lichen planus. J Dentis Oral Hyg 5(1):1","journal-title":"J Dentis Oral Hyg"},{"issue":"Suppl 1","key":"3867_CR12","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1007\/s12070-014-0768-5","volume":"67","author":"DK Samal","year":"2015","unstructured":"Samal DK, Behera G, Gupta V, Majumdar K, Khurana U (2015) Isolated lichen planus of lower lip: a case report. Indian J Otolaryngol Head Neck Surg 67(Suppl 1):151\u2013153","journal-title":"Indian J Otolaryngol Head Neck Surg"},{"issue":"2","key":"3867_CR13","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1111\/j.1600-0714.2007.00482.x","volume":"36","author":"T Axell","year":"2007","unstructured":"Axell T, Henriksen BM (2007) Treatment of gingival lichen with free palatal grafts. J Oral Pathol Med 36(2):105\u2013109","journal-title":"J Oral Pathol Med"},{"issue":"4","key":"3867_CR14","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1089\/pho.2011.3116","volume":"30","author":"C Fornaini","year":"2012","unstructured":"Fornaini C, Raybaud H, Augros C, Rocca JP (2012) New clinical approach for use of Er:YAG laser in the surgical treatment of oral lichen planus: a report of two cases. Photomed Laser Surg 30(4):234\u2013238","journal-title":"Photomed Laser Surg"},{"key":"3867_CR15","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1089\/pho.2018.4491","volume":"36","author":"PG Arduino","year":"2018","unstructured":"Arduino PG, Cafaro A, Cabras M, Gambino A, Broccoletti R (2018) Treatment outcome of oral leukoplakia with Er:YAG laser: a 5-year follow-up prospective comparative study. Photomed Laser Surg 36:631\u2013633","journal-title":"Photomed Laser Surg"},{"issue":"12","key":"3867_CR16","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1089\/pho.2015.3967","volume":"33","author":"R Broccoletti","year":"2015","unstructured":"Broccoletti R, Cafaro A, Gambino A, Romagnoli E, Arduino PG (2015) Er:YAG laser versus cold knife excision in the treatment of nondysplastic oral lesions: a randomized comparative study for the postoperative period. Photomed Laser Surg 33(12):604\u2013609","journal-title":"Photomed Laser Surg"},{"issue":"2","key":"3867_CR17","doi-asserted-by":"publisher","first-page":"188","DOI":"10.5005\/jp-journals-10005-1432","volume":"10","author":"G Kumar","year":"2017","unstructured":"Kumar G, Rehman F, Chaturvedy V (2017) Soft Tissue Applications of Er,Cr:YSGG laser in pediatric dentistry. Int J Clin Pediatr Dent 10(2):188\u2013192","journal-title":"Int J Clin Pediatr Dent"},{"issue":"2","key":"3867_CR18","first-page":"95","volume":"90","author":"H Gendelman","year":"1993","unstructured":"Gendelman H, Actis AB, Ouri HO (1993) Neodymium-YAG and CO2 lasers in treatment of pre-cancerous lesions of the oral cavity. Acta Stomatol Belg 90(2):95\u2013101","journal-title":"Acta Stomatol Belg"},{"issue":"2","key":"3867_CR19","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1007\/s10103-013-1461-8","volume":"30","author":"R Medeiros Junior","year":"2015","unstructured":"Medeiros Junior R, Gueiros LA, Silva IH et al (2015) Labial frenectomy with Nd:YAG laser and conventional surgery: a comparative study. Lasers Med Sci 30(2):851\u2013856","journal-title":"Lasers Med Sci"},{"issue":"1","key":"3867_CR20","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.otc.2010.09.004","volume":"44","author":"P Parashar","year":"2011","unstructured":"Parashar P (2011) Oral lichen planus. Otolaryngol Clin N Am 44(1):89\u2013107 vi","journal-title":"Otolaryngol Clin N Am"},{"issue":"3","key":"3867_CR21","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1111\/j.1601-0825.2011.01867.x","volume":"18","author":"L Nibali","year":"2012","unstructured":"Nibali L, Fedele S, D'Aiuto F, Donos N (2012) Interleukin-6 in oral diseases: a review. Oral Dis 18(3):236\u2013243","journal-title":"Oral Dis"},{"issue":"5","key":"3867_CR22","doi-asserted-by":"publisher","first-page":"571","DOI":"10.3892\/br.2017.887","volume":"6","author":"M Yin","year":"2017","unstructured":"Yin M, Li G, Song H, Lin S (2017) Identifying the association between interleukin-6 and lichen planus: a meta-analysis. Biomed Rep 6(5):571\u2013575","journal-title":"Biomed Rep"},{"issue":"1","key":"3867_CR23","doi-asserted-by":"publisher","first-page":"103","DOI":"10.5114\/ceji.2018.74880","volume":"43","author":"HR Mozaffari","year":"2018","unstructured":"Mozaffari HR, Sharifi R, Sadeghi M (2018) Interleukin-6 levels in the serum and saliva of patients with oral lichen planus compared with healthy controls: a meta-analysis study. Cent Eur J Immunol 43(1):103\u2013108","journal-title":"Cent Eur J Immunol"},{"issue":"1","key":"3867_CR24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/jop.12142","volume":"44","author":"R Lu","year":"2015","unstructured":"Lu R, Zhang J, Sun W, du G, Zhou G (2015) Inflammation-related cytokines in oral lichen planus: an overview. J Oral Pathol Med 44(1):1\u201314","journal-title":"J Oral Pathol Med"},{"issue":"3","key":"3867_CR25","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1016\/j.clim.2004.12.003","volume":"114","author":"NL Rhodus","year":"2005","unstructured":"Rhodus NL, Cheng B, Myers S, Bowles W, Ho V, Ondrey F (2005) A comparison of the pro-inflammatory, NF-kappaB-dependent cytokines: TNF-alpha, IL-1-alpha, IL-6, and IL-8 in different oral fluids from oral lichen planus patients. Clin Immunol 114(3):278\u2013283","journal-title":"Clin Immunol"},{"issue":"2","key":"3867_CR26","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1111\/j.1600-0714.2007.00593.x","volume":"37","author":"XA Tao","year":"2008","unstructured":"Tao XA, Li CY, Rhodus NL, Xia J, Yang XP, Cheng B (2008) Simultaneous detection of IFN-gamma and IL-4 in lesional tissues and whole unstimulated saliva from patients with oral lichen planus. J Oral Pathol Med 37(2):83\u201387","journal-title":"J Oral Pathol Med"},{"issue":"5","key":"3867_CR27","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1001\/jama.1995.03520290060030","volume":"273","author":"KF Schulz","year":"1995","unstructured":"Schulz KF, Chalmers I, Hayes RJ, Altman DG (1995) Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials. Jama. 273(5):408\u2013412","journal-title":"Jama."},{"issue":"12","key":"3867_CR28","doi-asserted-by":"publisher","first-page":"2415","DOI":"10.1373\/clinchem.2005.051532","volume":"51","author":"RM Lequin","year":"2005","unstructured":"Lequin RM (2005) Enzyme immunoassay (EIA)\/enzyme-linked immunosorbent assay (ELISA). Clin Chem 51(12):2415\u20132418","journal-title":"Clin Chem"},{"issue":"10","key":"3867_CR29","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1111\/jop.12199","volume":"43","author":"A Abdel-Haq","year":"2014","unstructured":"Abdel-Haq A, Kusnierz-Cabala B, Darczuk D, Sobuta E, Dumnicka P, Wojas-Pelc A, Chomyszyn-Gajewska M (2014) Interleukin-6 and neopterin levels in the serum and saliva of patients with Lichen planus and oral Lichen planus. J Oral Pathol Med 43(10):734\u2013739","journal-title":"J Oral Pathol Med"},{"issue":"10","key":"3867_CR30","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1016\/j.adaj.2017.05.007","volume":"148","author":"J Liu","year":"2017","unstructured":"Liu J, Shi Q, Yang S et al (2017) The relationship between levels of salivary and serum interleukin-6 and oral lichen planus: a systematic review and meta-analysis. J Am Dent Assoc 148(10):743\u2013749.e9","journal-title":"J Am Dent Assoc"},{"issue":"2","key":"3867_CR31","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.gene.2012.07.045","volume":"508","author":"Y Ge","year":"2012","unstructured":"Ge Y, Xu Y, Sun W, Man Z, Zhu L, Xia X, Zhao L, Zhao Y, Wang X (2012) The molecular mechanisms of the effect of dexamethasone and cyclosporin A on TLR4 \/NF-kappaB signaling pathway activation in oral lichen planus. Gene. 508(2):157\u2013164","journal-title":"Gene."},{"issue":"5","key":"3867_CR32","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1111\/1523-1747.ep12606990","volume":"104","author":"T Yamamoto","year":"1995","unstructured":"Yamamoto T, Osaki T (1995) Characteristic cytokines generated by keratinocytes and mononuclear infiltrates in oral lichen planus. J Invest Dermatol 104(5):784\u2013788","journal-title":"J Invest Dermatol"},{"issue":"7","key":"3867_CR33","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1111\/j.1600-0714.1994.tb00067.x","volume":"23","author":"T Yamamoto","year":"1994","unstructured":"Yamamoto T, Osaki T, Yoneda K, Ueta E (1994) Cytokine production by keratinocytes and mononuclear infiltrates in oral lichen planus. J Oral Pathol Med 23(7):309\u2013315","journal-title":"J Oral Pathol Med"},{"key":"3867_CR34","doi-asserted-by":"publisher","first-page":"847632","DOI":"10.1155\/2010\/847632","volume":"2010","author":"NA Ghallab","year":"2010","unstructured":"Ghallab NA, el-Wakeel N, Shaker OG (2010) Levels of salivary IFN-gamma, TNF-alfa, and TNF receptor-2 as prognostic markers in (erosive) oral lichen planus. Mediat Inflamm 2010:847632","journal-title":"Mediat Inflamm"},{"issue":"2","key":"3867_CR35","first-page":"3","volume":"52","author":"DJ Zegarelli","year":"1993","unstructured":"Zegarelli DJ (1993) The treatment of oral lichen planus. Ann Dent 52(2):3\u20138","journal-title":"Ann Dent"},{"issue":"4","key":"3867_CR36","first-page":"249","volume":"23","author":"M Tamizi","year":"1992","unstructured":"Tamizi M, Moayedi M (1992) Treatment of gingival lichen planus with a free gingival graft: a case report. Quintessence Int 23(4):249\u2013251","journal-title":"Quintessence Int"},{"issue":"5","key":"3867_CR37","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1007\/s10103-010-0770-4","volume":"25","author":"P Vescovi","year":"2010","unstructured":"Vescovi P, Corcione L, Meleti M, Merigo E, Fornaini C, Manfredi M, Bonanini M, Govoni P, Rocca JP, Nammour S (2010) Nd:YAG laser versus traditional scalpel. A preliminary histological analysis of specimens from the human oral mucosa. Lasers Med Sci 25(5):685\u2013691","journal-title":"Lasers Med Sci"},{"key":"3867_CR38","unstructured":"Convissar R (2010) Principles and practice of laser dentistry. Mosby"},{"key":"3867_CR39","doi-asserted-by":"publisher","first-page":"761704","DOI":"10.1155\/2014\/761704","volume":"2014","author":"U Romeo","year":"2014","unstructured":"Romeo U, Russo C, Palaia G et al (2014) Biopsy of different oral soft tissues lesions by KTP and diode laser: histological evaluation. ScientificWorldJournal. 2014:761704","journal-title":"ScientificWorldJournal."},{"issue":"4","key":"3867_CR40","first-page":"319","volume":"47","author":"SH Jeong","year":"2016","unstructured":"Jeong SH, Na HS, Park SH, Ahn YW, Chung J (2016) Topical sulfasalazine for unresponsive oral lichen planus. Quintessence Int 47(4):319\u2013327","journal-title":"Quintessence Int"},{"key":"3867_CR41","doi-asserted-by":"crossref","unstructured":"Mozaffari HR, Molavi M, Lopez-Jornet P et al (2019) Salivary and serum interferon-gamma\/interleukin-4 ratio in oral lichen planus patients: a systematic review and meta-analysis. Medicina (Kaunas) 55(6)","DOI":"10.3390\/medicina55060257"},{"issue":"2","key":"3867_CR42","first-page":"151","volume":"10","author":"M Tamarit-Borr\u00e1s","year":"2005","unstructured":"Tamarit-Borr\u00e1s M, Delgado-Molina E, Berini-Ayt\u00e9s L, Gay-Escoda C (2005) Removal of hyperplastic lesions of the oral cavity. A retrospective study of 128 cases. Med Oral Patol Oral Cir Bucal 10(2):151\u2013162","journal-title":"Med Oral Patol Oral Cir Bucal"},{"issue":"4","key":"3867_CR43","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1089\/pho.2005.23.369","volume":"23","author":"R Lubart","year":"2005","unstructured":"Lubart R, Kesler G, Lavie R, Friedmann H (2005) Er:YAG laser promotes gingival wound repair by photo-dissociating water molecules. Photomed Laser Surg 23(4):369\u2013372","journal-title":"Photomed Laser Surg"},{"issue":"2","key":"3867_CR44","first-page":"157","volume":"42","author":"H Dan","year":"2011","unstructured":"Dan H, Liu W, Wang J, Wang Z, Wu R, Chen Q, Zeng X, Zhou Y (2011) Elevated IL-10 concentrations in serum and saliva from patients with oral lichen planus. Quintessence Int 42(2):157\u2013163","journal-title":"Quintessence Int"},{"issue":"3","key":"3867_CR45","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1067\/moe.2003.115","volume":"95","author":"MH Thornhill","year":"2003","unstructured":"Thornhill MH, Pemberton MN, Simmons RK, Theaker ED (2003) Amalgam-contact hypersensitivity lesions and oral lichen planus. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 95(3):291\u2013299","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"}],"container-title":["Clinical Oral Investigations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-021-03867-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00784-021-03867-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-021-03867-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,29]],"date-time":"2023-01-29T23:06:31Z","timestamp":1675033591000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00784-021-03867-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,11]]},"references-count":45,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["3867"],"URL":"https:\/\/doi.org\/10.1007\/s00784-021-03867-y","relation":{},"ISSN":["1432-6981","1436-3771"],"issn-type":[{"value":"1432-6981","type":"print"},{"value":"1436-3771","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,11]]},"assertion":[{"value":"11 July 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 February 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 March 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All patients gave their written informed consent for participation in this study and publication of the gathered data. The study was conducted in accordance with the Declaration of Helsinki.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The ethical committee of the First Moscow State Medical University (Sechenov University) voted affirmatively for the present study (11-13). The authors declare that they have no competing interests","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}