{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T21:12:15Z","timestamp":1778706735692,"version":"3.51.4"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2021,3,10]],"date-time":"2021-03-10T00:00:00Z","timestamp":1615334400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,3,10]],"date-time":"2021-03-10T00:00:00Z","timestamp":1615334400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Beijing Stomatological Hospital, School of Stomatology, Capital Medical University"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Oral Invest"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1007\/s00784-021-03869-w","type":"journal-article","created":{"date-parts":[[2021,3,10]],"date-time":"2021-03-10T03:02:57Z","timestamp":1615345377000},"page":"5671-5685","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The effect of drug dose and duration of adjuvant Amoxicillin-plus-Metronidazole to full-mouth scaling and root planing in periodontitis: a systematic review and meta-analysis"],"prefix":"10.1007","volume":"25","author":[{"given":"Han","family":"Zhao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingchao","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9308-6808","authenticated-orcid":false,"given":"Li","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,3,10]]},"reference":[{"key":"3869_CR1","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1111\/j.1600-0765.1991.tb01734.x","volume":"26","author":"JM Goodson","year":"1991","unstructured":"Goodson JM, Tanner A, McArdle S, Dix K, Watanabe SM (1991) Multicenter evaluation of tetracycline fiber therapy. III. Microbiological response. J Clin Periodontol 26:440\u2013451. https:\/\/doi.org\/10.1111\/j.1600-0765.1991.tb01734.x","journal-title":"J Clin Periodontol"},{"key":"3869_CR2","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1111\/j.1600-0765.1991.tb01735.x","volume":"26","author":"MF Maiden","year":"1991","unstructured":"Maiden MF, Tanner A, McArdle S, Najpauer K, Goodson JM (1991) Tetracycline fiber therapy monitored by DNA probe and cultural methods. J Clin Periodontol 26:452\u2013459. https:\/\/doi.org\/10.1111\/j.1600-0765.1991.tb01735.x","journal-title":"J Clin Periodontol"},{"key":"3869_CR3","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1111\/j.1600-051X.1987.tb00966.x","volume":"14","author":"DS Harper","year":"1987","unstructured":"Harper DS, Robinson PJ (1987) Correlation of histometric, microbial, and clinical indicators of periodontal disease status before and after root planing. J Clin Periodontol 14:190\u2013196. https:\/\/doi.org\/10.1111\/j.1600-051X.1987.tb00966.x","journal-title":"J Clin Periodontol"},{"key":"3869_CR4","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1034\/j.1600-0757.2002.280103.x","volume":"28","author":"GJ Petersilka","year":"2002","unstructured":"Petersilka GJ, Ehmke B, Flemmig TF (2002) Antimicrobial effects of mechanical debridement. Periodontol 28:56\u201371. https:\/\/doi.org\/10.1034\/j.1600-0757.2002.280103.x","journal-title":"Periodontol"},{"key":"3869_CR5","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1177\/154405910508400409","volume":"84","author":"M Quirynen","year":"2005","unstructured":"Quirynen M, Vogels R, Pauwels M, Haffajee AD, Socransky SS, Uzel NG, van Steenberghe D (2005) Initial subgingival colonization of \u201cpristine\u201d pockets. J Dent Res 84:340\u2013344. https:\/\/doi.org\/10.1177\/154405910508400409","journal-title":"J Dent Res"},{"key":"3869_CR6","first-page":"696","volume":"17","author":"S Sumida","year":"2002","unstructured":"Sumida S, Ishihara K, Kishi M, Okuda K (2002) Transmission of periodontal disease-associated bacteria from teeth to osseointegrated implant regions. Int J Oral Maxillofac Implants 17:696\u2013702","journal-title":"Int J Oral Maxillofac Implants"},{"key":"3869_CR7","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.1177\/00220345950740080501","volume":"74","author":"M Quirynen","year":"1995","unstructured":"Quirynen M, Bollen C, Vandekerckhove B, Dekeyser C, Papaioannou W, Eyssen H (1995) Full-vs. partial-mouth disinfection in the treatment of periodontal infections: short-term clinical and microbiological observations. J Dent Res 74:1459\u20131467. https:\/\/doi.org\/10.1177\/00220345950740080501","journal-title":"J Dent Res"},{"key":"3869_CR8","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1111\/cpe.2008.35.issue-s8","volume":"35","author":"NP Lang","year":"2008","unstructured":"Lang NP, Tan WC, Kr\u00e4henmann MA, Zwahlen M (2008) A systematic review of the effects of full-mouth debridement with and without antiseptics in patients with chronic periodontitis. J Clin Periodontol 35:8\u201321. https:\/\/doi.org\/10.1111\/cpe.2008.35.issue-s8","journal-title":"J Clin Periodontol"},{"key":"3869_CR9","doi-asserted-by":"publisher","first-page":"CD004622","DOI":"10.1002\/14651858.CD004622.pub3","volume":"17","author":"J Eberhard","year":"2015","unstructured":"Eberhard J, Jepsen S, Jerv\u00f8e-Storm PM, Needleman I, Worthington HV (2015) Full-mouth treatment modalities (within 24 hours) for chronic periodontitis in adults. Cochrane Database Syst Rev 17:CD004622. https:\/\/doi.org\/10.1002\/14651858.CD004622.pub3","journal-title":"Cochrane Database Syst Rev"},{"key":"3869_CR10","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1111\/jre.12326","volume":"51","author":"H Fang","year":"2016","unstructured":"Fang H, Han M, Li QL, Cao CY, Xia R, Zhang ZH (2016) Comparison of full-mouth disinfection and quadrant-wise scaling in the treatment of adult chronic periodontitis: a systematic review and meta-analysis. J Periodontal Res 51:417\u2013430. https:\/\/doi.org\/10.1111\/jre.12326","journal-title":"J Periodontal Res"},{"issue":"Suppl 22","key":"3869_CR11","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1111\/jcpe.13290","volume":"47","author":"M Sanz","year":"2020","unstructured":"Sanz M, Herrera D, Kebschull M, Chapple I, Jepsen S, Beglundh T, Sculean A, Tonetti MS, EFP Workshop Participants and Methodological Consultants (2020) Treatment of stage I-III periodontitis\u2014the EFP S3 level clinical practice guideline. J Clin Periodontol 47(Suppl 22):4\u201360. https:\/\/doi.org\/10.1111\/jcpe.13290","journal-title":"J Clin Periodontol"},{"key":"3869_CR12","first-page":"b97","volume":"77","author":"E Baltacioglu","year":"2011","unstructured":"Baltacioglu E, Aslan M, Sara\u00e7 \u00d6, Saybak A, Yuva P (2011) Analysis of clinical results of systemic antimicrobials combined with nonsurgical periodontal treatment for generalized aggressive periodontitis: a pilot study. J Can Dent Assoc 77:b97","journal-title":"J Can Dent Assoc"},{"key":"3869_CR13","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1111\/jre.12680","volume":"54","author":"A Yashima","year":"2019","unstructured":"Yashima A, Morozumi T, Yoshie H, Hokari T, Izumi Y, Akizuki T, Mizutani K, Takamatsu H, Minabe M, Miyauchi S, Yoshino T, Tanaka M, Tanaka Y, Gomi K (2019) Biological responses following one-stage full-mouth scaling and root planing with and without azithromycin: multicenter randomized trial. J Periodontal Res 54:709\u2013719. https:\/\/doi.org\/10.1111\/jre.12680","journal-title":"J Periodontal Res"},{"key":"3869_CR14","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1902\/jop.2007.060247","volume":"78","author":"K Gomi","year":"2007","unstructured":"Gomi K, Yashima A, Nagano T (2007) Effects of full-mouth scaling and root planing in conjunction with systemically administered azithromycin. J Periodontol 78:422\u2013429","journal-title":"J Periodontol"},{"key":"3869_CR15","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.1902\/jop.2009.080403","volume":"80","author":"E Del Peloso Ribeiro","year":"2009","unstructured":"Del Peloso Ribeiro E, Bittencourt S, Zanin ICJ, Ambrosano GMB, Sallum EA, Nociti FH, Gon\u00e7alves RB, Casati MZ (2009) Full-mouth ultrasonic debridement associated with amoxicillin and metronidazole in the treatment of severe chronic periodontitis. J Periodontol 80:1254\u20131264. https:\/\/doi.org\/10.1902\/jop.2009.080403","journal-title":"J Periodontol"},{"key":"3869_CR16","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1902\/jop.2009.080540","volume":"80","author":"N Cionca","year":"2009","unstructured":"Cionca N, Giannopoulou C, Ugolotti G, Mombelli A (2009) Amoxicillin and metronidazole as an adjunct to full-mouth scaling and root planing of chronic periodontitis. J Periodontol 80:364\u2013371. https:\/\/doi.org\/10.1902\/jop.2009.080540","journal-title":"J Periodontol"},{"key":"3869_CR17","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1902\/jop.2012.120281","volume":"84","author":"A Mombelli","year":"2013","unstructured":"Mombelli A, Cionca N, Almaghlouth A, D\u00e9caillet F, Courvoisier DS, Giannopoulou C (2013) Are there specific benefits of amoxicillin plus metronidazole in aggregatibacter actinomycetemcomitans-associated periodontitis? Double-masked, randomized clinical trial of efficacy and safety. J Periodontol 84:715\u2013724. https:\/\/doi.org\/10.1902\/jop.2012.120281","journal-title":"J Periodontol"},{"key":"3869_CR18","doi-asserted-by":"publisher","first-page":"e0179592","DOI":"10.1371\/journal.pone.0179592","volume":"12","author":"R Cosgarea","year":"2017","unstructured":"Cosgarea R, Heumann C, Juncar R, Tristiu R, Lascu L, Salvi GE, Arweiler NB, Sculean A (2017) One year results of a randomized controlled clinical study evaluating the effects of non-surgical periodontal therapy of chronic periodontitis in conjunction with three or seven days systemic administration of amoxicillin\/metronidazole. PLoS One 12:e0179592. https:\/\/doi.org\/10.1371\/journal.pone.0179592","journal-title":"PLoS One"},{"key":"3869_CR19","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1111\/jcpe.12559","volume":"43","author":"R Cosgarea","year":"2016","unstructured":"Cosgarea R, Juncar R, Heumann C, Tristiu R, Lascu L, Arweiler N, Stavropoulos A, Sculean A (2016) Non-surgical periodontal treatment in conjunction with 3 or 7 days systemic administration of amoxicillin and metronidazole in severe chronic periodontitis patients. A placebo-controlled randomized clinical study. J Clin Periodontol 43:767\u2013777. https:\/\/doi.org\/10.1111\/jcpe.12559","journal-title":"J Clin Periodontol"},{"key":"3869_CR20","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1902\/annals.2003.8.1.115","volume":"8","author":"AD Haffajee","year":"2003","unstructured":"Haffajee AD, Socransky SS, Gunsolley JC (2003) Systemic anti-infective periodontal therapy. A systematic review. Ann Periodontol 8:115\u2013181. https:\/\/doi.org\/10.1902\/annals.2003.8.1.115","journal-title":"Ann Periodontol"},{"key":"3869_CR21","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1034\/j.1600-051X.29.s3.8.x","volume":"29","author":"D Herrera","year":"2002","unstructured":"Herrera D, Sanz M, Jepsen S, Needleman I, Rold\u00e1n S (2002) A systematic review on the effect of systemic antimicrobials as an adjunct to scaling and root planing in periodontitis patients. J Clin Periodontol 29:136\u2013159. https:\/\/doi.org\/10.1034\/j.1600-051X.29.s3.8.x","journal-title":"J Clin Periodontol"},{"key":"3869_CR22","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1902\/jop.1992.63.1.52","volume":"63","author":"AJ Van Winkelhoff","year":"1992","unstructured":"Van Winkelhoff AJ, Tijhof CJ, De Graaff J (1992) Microbiological and clinical results of metronidazole plus amoxicillin therapy in Actinobacillus actinomycetemcomitans-associated periodontitis. J Periodontol 63:52\u201357. https:\/\/doi.org\/10.1902\/jop.1992.63.1.52","journal-title":"J Periodontol"},{"key":"3869_CR23","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/s12903-015-0123-6","volume":"16","author":"D Zandbergen","year":"2016","unstructured":"Zandbergen D, Slot DE, Niederman R, Van der Weijden FA (2016) The concomitant administration of systemic amoxicillin and metronidazole compared to scaling and root planing alone in treating periodontitis: a systematic review. BMC Oral Health 16:27. https:\/\/doi.org\/10.1186\/s12903-015-0123-6","journal-title":"BMC Oral Health"},{"key":"3869_CR24","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1902\/jop.2012.110625","volume":"83","author":"F Sgolastra","year":"2012","unstructured":"Sgolastra F, Gatto R, Petrucci A, Monaco A (2012) Effectiveness of systemic amoxicillin\/metronidazole as adjunctive therapy to scaling and root planing in the treatment of chronic periodontitis: a systematic review and meta-analysis. J Periodontol 83:1257\u20131269. https:\/\/doi.org\/10.1902\/jop.2012.110625","journal-title":"J Periodontol"},{"issue":"Suppl 22","key":"3869_CR25","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1111\/jcpe.13264","volume":"47","author":"W Teughels","year":"2020","unstructured":"Teughels W, Feres M, Oud V, Mart\u00edn C, Matesanz P, Herrera D (2020) Adjunctive effect of systemic antimicrobials in periodontitis therapy: a systematic review and meta-analysis. J Clin Periodontol 47(Suppl 22):257\u2013281. https:\/\/doi.org\/10.1111\/jcpe.13264","journal-title":"J Clin Periodontol"},{"key":"3869_CR26","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1111\/adj.12415","volume":"61","author":"A Saleh","year":"2016","unstructured":"Saleh A, Rincon J, Tan A, Firth M (2016) Comparison of adjunctive azithromycin and amoxicillin\/metronidazole for patients with chronic periodontitis: preliminary randomized control trial. Aust Dent J 61:469\u2013481. https:\/\/doi.org\/10.1111\/adj.12415","journal-title":"Aust Dent J"},{"key":"3869_CR27","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1111\/adj.12674","volume":"64","author":"A Liaw","year":"2019","unstructured":"Liaw A, Miller C, Nimmo A (2019) Comparing the periodontal tissue response to non-surgical scaling and root planing alone, adjunctive azithromycin, or adjunctive amoxicillin plus metronidazole in generalized chronic moderate-to-severe periodontitis: a preliminary randomized controlled trial. Aust Dent J 64:145\u2013152. https:\/\/doi.org\/10.1111\/adj.12674","journal-title":"Aust Dent J"},{"key":"3869_CR28","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1111\/jre.2015.50.issue-3","volume":"50","author":"JAJ Keestra","year":"2015","unstructured":"Keestra JAJ, Grosjean I, Coucke W, Quirynen M, Teughels W (2015) Non-surgical periodontal therapy with systemic antibiotics in patients with untreated chronic periodontitis: a systematic review and meta-analysis. J Periodontol 50:294\u2013314. https:\/\/doi.org\/10.1111\/jre.2015.50.issue-3","journal-title":"J Periodontol"},{"key":"3869_CR29","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1111\/jcpe.12830","volume":"45","author":"K McGowan","year":"2018","unstructured":"McGowan K, McGowan T, Ivanovski S (2018) Optimal dose and duration of amoxicillin-plus-metronidazole as an adjunct to non-surgical periodontal therapy: a systematic review and meta-analysis of randomized, placebo-controlled trials. J Clin Periodontol 45:56\u201367. https:\/\/doi.org\/10.1111\/jcpe.12830","journal-title":"J Clin Periodontol"},{"issue":"Suppl 7A","key":"3869_CR30","doi-asserted-by":"publisher","first-page":"1S","DOI":"10.1016\/j.amjmed.2005.05.007","volume":"118","author":"TG Slama","year":"2005","unstructured":"Slama TG, Amin A, Brunton SA, File TM Jr, Milkovich G, Rodvold KA, Sahm DF, Varon J, Weiland D Jr (2005) A clinician\u2019s guide to the appropriate and accurate use of antibiotics: the Council for Appropriate and Rational Antibiotic Therapy (CARAT) criteria. Am J Med 118(Suppl 7A):1S\u20136S. https:\/\/doi.org\/10.1016\/j.amjmed.2005.05.007","journal-title":"Am J Med"},{"key":"#cr-split#-3869_CR31.1","unstructured":"Higgins JPT, Altman D, Sterne J (2011) Chapter 8: Assessing risk of bias in included studies. In: Higgins JPT, Green S"},{"key":"#cr-split#-3869_CR31.2","unstructured":"(ed) Cochrane handbook for systematic reviews of interventions version 5.1.0 (updated March 2011). The Cochrane Collaboration: Copenhagen, pp 187-241."},{"key":"3869_CR32","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","volume":"327","author":"JPT Higgins","year":"2003","unstructured":"Higgins JPT, Thompson SG, Deeks JJ, Altman DG (2003) Measuring inconsistency in meta-analyses. BMJ 327:557\u2013560. https:\/\/doi.org\/10.1136\/bmj.327.7414.557","journal-title":"BMJ"},{"key":"3869_CR33","doi-asserted-by":"publisher","first-page":"5001","DOI":"10.3892\/etm.2019.7856","volume":"18","author":"S Boia","year":"2019","unstructured":"Boia S, Boariu M, Baderca F, Rusu D, Muntean D, Horhat F, Boia ER, Borza C, Anghel A, Stratul \u015eI (2019) Clinical, microbiological and oxidative stress evaluation of periodontitis patients treated with two regimens of systemic antibiotics, adjunctive to non-surgical therapy. A placebo-controlled randomized clinical trial. Exp Ther Med 18:5001\u20135015. https:\/\/doi.org\/10.3892\/etm.2019.7856","journal-title":"Exp Ther Med"},{"key":"3869_CR34","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1902\/jop.2012.110513","volume":"83","author":"RCV Casarin","year":"2012","unstructured":"Casarin RCV, Del Peloso Ribeiro E, Sallum EA, Nociti FH Jr, Gon\u00e7alves RB, Casati MZ (2012) The combination of amoxicillin and metronidazole improves clinical and microbiologic results of one-stage, full-mouth, ultrasonic debridement in aggressive periodontitis treatment. J Periodontol 83:988\u2013998. https:\/\/doi.org\/10.1902\/jop.2012.110513","journal-title":"J Periodontol"},{"key":"3869_CR35","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1111\/j.1600-051X.2011.01795.x","volume":"39","author":"M Aimetti","year":"2012","unstructured":"Aimetti M, Romano F, Guzzi N, Carnevale G (2012) Full-mouth disinfection and systemic antimicrobial therapy in generalized aggressive periodontitis: a randomized, placebo-controlled trial. J Clin Periodontol 39:284\u2013294. https:\/\/doi.org\/10.1111\/j.1600-051X.2011.01795.x","journal-title":"J Clin Periodontol"},{"key":"3869_CR36","doi-asserted-by":"publisher","first-page":"1096","DOI":"10.1111\/j.1600-051X.2005.00814.x","volume":"32","author":"A Guerrero","year":"2005","unstructured":"Guerrero A, Griffiths GS, Nibali L, Suvan J, Moles DR, Laurell L, Tonetti MS (2005) Adjunctive benefits of systemic amoxicillin and metronidazole in non-surgical treatment of generalized aggressive periodontitis: a randomized placebo-controlled clinical trial. J Clin Periodontol 32:1096\u20131107. https:\/\/doi.org\/10.1111\/j.1600-051X.2005.00814.x","journal-title":"J Clin Periodontol"},{"key":"3869_CR37","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1902\/jop.2011.100656","volume":"82","author":"VM Varela","year":"2011","unstructured":"Varela VM, Heller D, Silva-Senem MX, Torres MC, Colombo AP, Feres-Filho EJ (2011) Systemic antimicrobials adjunctive to a repeated mechanical and antiseptic therapy for aggressive periodontitis: a 6-month randomized controlled trial. J Periodontol 82:1121\u20131130. https:\/\/doi.org\/10.1902\/jop.2011.100656","journal-title":"J Periodontol"},{"key":"3869_CR38","doi-asserted-by":"publisher","first-page":"2113","DOI":"10.1007\/s00784-014-1187-4","volume":"18","author":"AA Almaghlouth","year":"2014","unstructured":"Almaghlouth AA, Cionca N, Cancela JA, D\u00e9caillet F, Courvoisier DS, Giannopoulou C, Mombelli A (2014) Effect of periodontal treatment on peak serum levels of inflammatory markers. Clin Oral Investig 18:2113\u20132121. https:\/\/doi.org\/10.1007\/s00784-014-1187-4","journal-title":"Clin Oral Investig"},{"key":"3869_CR39","doi-asserted-by":"publisher","first-page":"832","DOI":"10.1111\/jcpe.12441","volume":"42","author":"I Harks","year":"2015","unstructured":"Harks I, Koch R, Eickholz P, Hoffmann T, Kim TS, Kocher T, Meyle J, Kaner D, Schlagenhauf U, Doering S, Holtfreter B, Gravemeier M, Harmsen D, Ehmke B (2015) Is progression of periodontitis relevantly influenced by systemic antibiotics? A clinical randomized trial. J Clin Periodontol 42:832\u2013842. https:\/\/doi.org\/10.1111\/jcpe.12441","journal-title":"J Clin Periodontol"},{"issue":"Suppl 20","key":"3869_CR40","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1111\/jcpe.12935","volume":"45","author":"JG Caton","year":"2018","unstructured":"Caton JG, Armitage G, Berglundh T, Chapple ILC, Jepsen S, Kornman KS, Mealey BL, Papapanou PN, Sanz M, Tonetti MS (2018) A new classification scheme for periodontal and peri-implant diseases and conditions. Periodontology 45(Suppl 20):S1\u2013S8. https:\/\/doi.org\/10.1111\/jcpe.12935","journal-title":"Periodontology"},{"key":"3869_CR41","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1034\/j.1600-051X.2002.290410.x","volume":"29","author":"J Rooney","year":"2002","unstructured":"Rooney J, Wade W, Sprague SV, Newcombe RG, Addy M (2002) Adjunctive effects to non-surgical periodontal therapy of systemic metronidazole and amoxycillin alone and combined. J Clin Periodontol 29:342\u2013350. https:\/\/doi.org\/10.1034\/j.1600-051X.2002.290410.x","journal-title":"J Clin Periodontol"},{"key":"3869_CR42","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1111\/jcpe12004","volume":"39","author":"M Feres","year":"2012","unstructured":"Feres M, Soares GMS, Mendes JAV, Silva MP, Faveri M, Teles R, Socransky SS, Figueiredo LC (2012) Metronidazole alone or with amoxicillin as adjuncts to non-surgical treatment of chronic periodontitis: a 1-year double-blinded, placebo controlled, randomized clinical trial. J Clin Periodontol 39:1149\u20131158. https:\/\/doi.org\/10.1111\/jcpe12004","journal-title":"J Clin Periodontol"},{"key":"3869_CR43","doi-asserted-by":"publisher","first-page":"281","DOI":"10.3290\/j.qi.a34723","volume":"47","author":"T Taiete","year":"2016","unstructured":"Taiete T, Casati MZ, Del Peloso Ribeiro E, Sallum EA, Nociti FH Jr, Casarin RC (2016) Amoxicillin\/metronidazole associated with nonsurgical therapy did not promote additional benefits in immunologic parameters in generalized aggressive periodontitis: a randomized controlled clinical trial. Quintessence Int 47:281\u2013292. https:\/\/doi.org\/10.3290\/j.qi.a34723","journal-title":"Quintessence Int"},{"key":"3869_CR44","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1111\/jcpe.2017.44.issue-8","volume":"44","author":"I Borges","year":"2017","unstructured":"Borges I, Faveri M, Figueiredo LC, Duarte PM, Retamal-Valdes B, Montenegro SCL, Feres M (2017) Different antibiotic protocols in the treatment of severe chronic periodontitis: a 1-year randomized trial. J Clin Periodontol 44:822\u2013832. https:\/\/doi.org\/10.1111\/jcpe.2017.44.issue-8","journal-title":"J Clin Periodontol"},{"key":"3869_CR45","first-page":"1107","volume":"59","author":"S Boia","year":"2018","unstructured":"Boia S, Stratul \u015eI, Boariu M, Ursoniu S, Go\u0163ia SL, Boia ER, Borza C (2018) Evaluation of antioxidant capacity and clinical assessment of patients with chronic periodontitis treated with non-surgical periodontal therapy and adjunctive systemic antibiotherapy. Romanian J Morphol Embryol 59:1107\u20131113","journal-title":"Romanian J Morphol Embryol"},{"key":"3869_CR46","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1034\/j.1600-051X.2002.290809.x","volume":"29","author":"M Feres","year":"2002","unstructured":"Feres M, Haffajee AD, Allard K, Som S, Goodson JM, Socransky SS (2002) Antibiotic resistance of subgingival species during and after antibiotic therapy. J Clin Periodontol 29:724\u2013735. https:\/\/doi.org\/10.1034\/j.1600-051X.2002.290809.x","journal-title":"J Clin Periodontol"},{"key":"3869_CR47","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1016\/j.adaj.2015.01.028","volume":"146","author":"CJ Smiley","year":"2015","unstructured":"Smiley CJ, Tracy SL, Abt E, Michalowicz BS, John MT, Gunsolley J, Cobb CM, Rossmann J, Harrel SK, Forrest JL, Hujoel PP, Noraian KW, Greenwell H, Frantsve-Hawley J, Estrich C, Hanson N (2015) Systematic review and meta-analysis on the nonsurgical treatment of chronic periodontitis by means of scaling and root planing with or without adjuncts. J Am Dent Assoc 146:508\u2013524. https:\/\/doi.org\/10.1016\/j.adaj.2015.01.028","journal-title":"J Am Dent Assoc"},{"key":"3869_CR48","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.ijantimicag.2006.09.026","volume":"29","author":"JC Pech\u00e8re","year":"2007","unstructured":"Pech\u00e8re JC, Hughes D, Kardas P, Cornaglia G (2007) Non-compliance with antibiotic therapy for acute community infections: a global survey. Int J Antimicrob Agents 29:245\u2013253. https:\/\/doi.org\/10.1016\/j.ijantimicag.2006.09.026","journal-title":"Int J Antimicrob Agents"},{"key":"3869_CR49","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1034\/j.1600-051x.2001.028004296.x","volume":"28","author":"EG Winkel","year":"2001","unstructured":"Winkel EG, Van Winkelhoff AJ, Timmerman MF, Van der Velden U, Van der Weijden GA (2001) Amoxicillin plus metronidazole in the treatment of adult periodontitis patients. A double-blind placebo-controlled study. J Clin Periodontol 28:296\u2013305. https:\/\/doi.org\/10.1034\/j.1600-051x.2001.028004296.x","journal-title":"J Clin Periodontol"},{"key":"3869_CR50","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1902\/jop.2005.76.5.749","volume":"76","author":"B Ehmke","year":"2005","unstructured":"Ehmke B, Moter A, Beikler T, Milian E, Flemmig TF (2005) Adjunctive antimicrobial therapy of periodontitis: long-term effects on disease progression and oral colonization. J Clin Periodontol 76:749\u2013759. https:\/\/doi.org\/10.1902\/jop.2005.76.5.749","journal-title":"J Clin Periodontol"},{"key":"3869_CR51","doi-asserted-by":"publisher","first-page":"828","DOI":"10.1111\/j.1600-051X.2011.01763.x","volume":"38","author":"MP Silva","year":"2011","unstructured":"Silva MP, Feres M, Sirotto TA, Soares GM, Mendes JA, Faveri M, Figueiredo LC (2011) Clinical and microbiological benefits of metronidazole alone or with amoxicillin as adjuncts in the treatment of chronic periodontitis: a randomized placebo-controlled clinical trial. J Clin Periodontol 38:828\u2013837. https:\/\/doi.org\/10.1111\/j.1600-051X.2011.01763.x","journal-title":"J Clin Periodontol"},{"key":"3869_CR52","doi-asserted-by":"publisher","first-page":"e0145262","DOI":"10.1371\/journal.pone.0145262","volume":"10","author":"CM Santos","year":"2015","unstructured":"Santos CM, Lira-Junior R, Fischer RG, Santos AP, Oliveira BH (2015) Systemic antibiotics in periodontal treatment of diabetic patients: a systematic review. PLoS One 10:e0145262. https:\/\/doi.org\/10.1371\/journal.pone.0145262","journal-title":"PLoS One"},{"key":"3869_CR53","doi-asserted-by":"publisher","first-page":"1518","DOI":"10.1902\/jop.2010.100192","volume":"81","author":"M Angaji","year":"2010","unstructured":"Angaji M, Gelskey S, Nogueira-Filho G, Brothwell D (2010) A systematic review of clinical efficacy of adjunctive antibiotics in the treatment of smokers with periodontitis. J Periodontal 81:1518\u20131528. https:\/\/doi.org\/10.1902\/jop.2010.100192","journal-title":"J Periodontal"}],"container-title":["Clinical Oral Investigations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-021-03869-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00784-021-03869-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-021-03869-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T10:11:57Z","timestamp":1631700717000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00784-021-03869-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,10]]},"references-count":54,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["3869"],"URL":"https:\/\/doi.org\/10.1007\/s00784-021-03869-w","relation":{},"ISSN":["1432-6981","1436-3771"],"issn-type":[{"value":"1432-6981","type":"print"},{"value":"1436-3771","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,10]]},"assertion":[{"value":"23 September 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 March 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 March 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 March 2021","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Update","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The email of the author Li Zhao was corrected from lizhao2010@hospital.c0071mu.edu.cn to lizhao2010@hospital.cqmu.edu.cn.","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This article does not contain any studies with human participants or animals performed by any of the authors. For this type of study, formal consent is not required. Informed consent was obtained from all individual participants included in the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Author Han Zhao declares that he has no conflict of interest. Author Jingchao Hu declares that he has no conflict of interest. Author Li Zhao declares that he has no conflict of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}