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Primary outcome measures were changes in probing pocket depth (PPD) and clinical attachment level (CAL). Clinical outcomes were extracted and pooled from 7 eligible trials and meta-analyses conducted using mean difference with standard deviations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>For PPD, adjunctive ICG-PDT resulted in a mean additional reduction of 1.17 mm (95% CI: 0.67\u20131.66 mm) at 3 months and a mean additional reduction of 1.06 mm (95% CI: 0.54\u20131.57 mm) at 6 months. For CAL, adjunctive ICG-PDT resulted in a mean additional gain of 0.70 mm (95% CI: 0.17\u20131.23 mm) at 3 months and a mean additional gain of 1.03 mm (95% CI: 0.83\u20131.24 mm) at 6 months. No adverse events were reported in any studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The adjunctive use of ICG-PDT in NSPT results in improved treatment outcomes at 3 and 6 months post-therapy. Further investigation is needed to evaluate variables such as different photosensitiser concentrations and adjusting parameters associated with the light source.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical relevance<\/jats:title>\n                    <jats:p>Indocyanine green\u2013based photosensitisers may be a novel, clinically efficacious agent for use in the management of periodontitis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00784-021-03871-2","type":"journal-article","created":{"date-parts":[[2021,3,12]],"date-time":"2021-03-12T04:06:05Z","timestamp":1615521965000},"page":"5699-5710","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Indocyanine green\u2013mediated antimicrobial photodynamic therapy as an adjunct to periodontal therapy: a systematic review and meta-analysis"],"prefix":"10.1007","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7416-7610","authenticated-orcid":false,"given":"Nasir Zeeshan","family":"Bashir","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Har-Amrit","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satnam Singh","family":"Virdee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,3,12]]},"reference":[{"issue":"4","key":"3871_CR1","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1038\/nrrheum.2009.28","volume":"5","author":"P de Pablo","year":"2009","unstructured":"de Pablo P, Chapple ILC, Buckley CD, Dietrich T (2009) Periodontitis in systemic rheumatic diseases. 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